Researchers led by Dr. Michael A. Weiss are developing a rapid-acting, glucose-responsive insulin that can reduce the risk of hypoglycemia in diabetes patients. The new form of insulin will be designed to detect high or low glucose levels and release only as needed.
Researchers at Case Western Reserve University developed a new MRI method that can differentiate white matter from gray matter in the brain in about 12 seconds. The technology uses unique fingerprinting to identify tissues and diseases, promising faster and cheaper scans with more accurate diagnoses.
Researchers at Case Western Reserve University found that normal prion protein PrPc plays a crucial role in regulating iron metabolism, which may contribute to neuronal death in CJD. Iron imbalance caused by prion aggregation leads to neurotoxicity and brain cell death.
Researchers at Case Western Reserve University School of Medicine found that rats use sniffing behavior to signal social hierarchy and prevent aggressive behavior. This discovery may help understand how neurological disorders impact social behaviors.
Case Western Reserve University professor Colin McLarty has simplified the proof of Fermat's Last Theorem by using only finite-order arithmetic, reducing reliance on strong set theory. This breakthrough, inspired by Grothendieck's work, opens new avenues for number theorists to tackle similar problems.
A comprehensive study has identified seven new regions of the human genome associated with increased risk of age-related macular degeneration (AMD). The study, led by Case Western Reserve University School of Medicine, found that AMD is not caused by a single genetic change but rather by many events that accumulate over time.
Researchers at Case Western Reserve University have validated a questionnaire to assess youth participation in Alcoholics Anonymous (AA)-related helping activities. The Service to Others in Sobriety (SOS) questionnaire shows promise in identifying youths at risk of relapse and promoting recovery.
Researchers at Case Western Reserve University are enrolling participants in a pilot clinical trial to assess the safety and feasibility of recording brain activity for control of assistive devices. The goal is to bypass severed connections between the brain and paralyzed muscles using brain-computer interfaces.
New research finds that standard bacterial culture tests may overlook certain germs, highlighting the need for multiple detection methods. The study analyzed 44 premature babies and detected over 20 uncultured bacterial species using DNA genomic analysis.
Yvon Chouinard, Patagonia's founder, receives the 2013 Inamori Ethics Prize for prioritizing people and the planet in his business philosophy. He has promoted sustainable practices throughout his company, including using organic cotton, reducing water footprint, and supporting grassroots environmental organizations.
A study by Case Western Reserve University researchers explores how family members cope with anger toward God during a loved one's death. The findings show that lower levels of religiosity and spiritual connection are associated with increased anger, while prayer and seeking forgiveness can be effective coping strategies.
The shift from four-footed walking to bipedalism has resulted in various physical challenges, including flat feet, bunions, and slipped discs. As humans adapted to upright walking, the spine developed an S-shaped structure, leading to conditions like lordosis and scoliosis.
Researchers at Case Western Reserve University discovered a missing RNA element that significantly improves the effectiveness of gene therapy. The element, called Genomic RNA Packaging Enhancer element (GRPE), coordinates the production and filling of genetic material in viral vectors.
Researchers used Modified Newtonian Dynamics (MOND) to predict velocity dispersion in faint dwarf galaxies of Andromeda. In 16 out of 17 cases, their predictions matched the measured velocity dispersions, suggesting that MOND may be a viable alternative to dark matter.
Researchers found that young adults who interacted with computerized avatars experienced a significant reduction in depressive symptoms over three months. The avatar-based intervention improved self-management skills and helped participants rehearse office visits ahead of time.
A team of researchers led by Case Western Reserve University is investigating a new material that can operate at extremely high temperatures without cooling. They aim to develop heat-tolerant electronics with the potential to withstand over 200 degrees Celsius, benefiting industries such as aerospace and automotive.
The Case Western Reserve University School of Medicine has received a grant to study gastric cancers and explore the role of interleukin-33 (IL-33) in inflammation and its potential link to gastrointestinal cancers. The research aims to identify more effective treatments for these deadly diseases, which are currently incurable.
A Case Western Reserve University researcher is creating ultra-high molecular weight polyethylene with embedded magnetic nanoparticles to monitor degradation and wear. The goal is to make implants more resistant to the environment inside the body.
Mothers of newborns in neonatal intensive care units struggle to find private spaces for breastfeeding due to hospital design. This lack of privacy can lead to missed feedings and increased health risks for low-weight premature babies. The study's findings highlight the need for innovative solutions to address mothers' concerns.
Researchers at Case Western Reserve University have discovered a faint dwarf galaxy and another possible young dwarf galaxy in the constellation Ursa Major. They also found evidence pointing to two already known dwarf galaxies as probable forces that pulled the pinwheel-shaped disk galaxy, M101, out of shape.
A team of researchers from Case Western Reserve University School of Medicine has discovered the definitive answer to how insulin binds to cells. This breakthrough could lead to dramatic improvements in treating diabetes, including alternative oral medications and fewer injections per day.
Researchers at Case Western Reserve University will study ways to integrate patients' strengths into assessment and treatment to improve outcomes. The project aims to provide patients with better-informed health decisions, leveraging strengths such as resilience and mindfulness.
Researchers identified miR-181a as a molecule linked to aggressive breast cancer forms. Elevated levels of miR-181a prevented metastasis and extended mouse lifespans in test models.
A regional team led by Case Western Reserve University has won $4 million to design a 9-turbine Lake Erie wind farm, with the potential for an additional $46 million in funding. The goal is to demonstrate cost-competitive power production and explore materials and designs to reduce costs.
A Phase 2a trial is being conducted to assess the effectiveness of AZD5847, a new test drug for patients with tuberculosis, including those with HIV co-infection. The study aims to improve treatment options for TB, a leading infectious cause of death among people with HIV/AIDS.
Research reveals distinct genetic mechanisms behind similar adaptations to low oxygen levels in Tibetan and Ethiopian populations, shedding light on convergent evolution. The study finds no long-term adaptation among the Oromo group, highlighting variations in biological responses to high-altitude environments.
Researchers will study how maternal parasite infections affect fetal immune systems to identify effective interventions promoting healthy growth in children. The goal is to understand the causes of stunted growth and develop affordable solutions.
Scientists from Case Western Reserve University discovered unique spin and valley properties in a 2-dimensional crystal, leading to potential applications in optoelectronics and solar cells. The research found that charged quasi-particles called negative trions can be manipulated to change light absorption and emission.
Researchers at Case Western Reserve University aim to increase the power density of their iron flow battery, enabling greater energy storage capacity while maintaining a lower cost. The new design could replace traditional storage technologies like pumped hydro and compressed air systems, offering flexibility for grid-scale energy supply.
The Collaborative Home for Oral Heath, Medical Review and Health Promotion (CHOMP) project brings together dental and nursing students to deliver one-stop patient care. CHOMP will provide oral exams, health screenings, and treatment for acute health issues, as well as referrals to local health providers.
Researchers at Case Western Reserve University School of Medicine identified a genetic factor KLF4 that prevents blockages from forming in blood vessels. The study found that a shortage of KLF4 makes the lining more prone to plaque buildup and clot formation, while sufficient levels protect against toxins and disease.
A recent study published in Journal of Pediatric Health Care found a strong correlation between childhood obesity and dental cavities among homeless children. Researchers analyzed data from 157 children aged 2-17 years old at an urban homeless shelter, revealing that as body mass index increased with age, so did cavity counts.
Dr. Jonathan Lass will receive the 2012 Paton Award for his outstanding contributions to corneal preservation and clinical eye care. The award recognizes his 30-plus-year career as an ophthalmologist and medical educator at Case Western Reserve University.
A study led by Anthony Jack from Case Western Reserve University shows that the brain fires up one network for empathy and suppresses another for analysis, limiting their simultaneous use. This finding suggests established theories about two competing networks in the brain must be revised.
Scientists have developed a technology to visualize how circulating blood affects the developing heart, potentially uncovering triggers for heart defects. The study maps shear stress on the endothelial cells lining the growing heart, which has been linked to gene expression changes and defect formation.
CWRU's Maxwell J. Mehlman examines the emerging issues in genetic engineering, balancing innovation with caution. The book discusses the potential for evolutionary engineering, which allows parents to form the next generation by altering reproductive cells to remove disease risks.
Case Western Reserve University researchers have won a $1.2 million grant to develop technology for mass-producing flexible electronic devices. The team aims to create flexible electronics that can be worn on the skin, foldable devices as thin as plastic wrap, and implantable nerve-stimulating electrodes.
The university will extend its world-class structural biology facilities by developing a state-of-the-art instrument for the new synchrotron user facility. The grant aims to provide detailed structural information that can benefit the entire scientific community.
Researchers at Case Western Reserve University discovered that magnesium reduces inflammation by reducing NF-kB activity and subsequent cytokine production. This new insight offers a promising immunotherapeutic strategy for treating diseases such as asthma, atherosclerosis, and sepsis.
Researchers at Case Western Reserve University have developed a new technology that aims to make terabyte storage cheaper and easier. They use similar optical data storage technology as commercially available Blu-ray discs but write data in dozens of layers instead of two or four, resulting in lower manufacturing costs.
Researchers at Case Western Reserve University School of Medicine have discovered a promising treatment for Rett syndrome by reversing abnormalities in brain activity with an FDA-approved anesthesia drug, ketamine. This study provides new evidence that drug treatment can improve neurological function in individuals with Rett syndrome.
Scientists at CWRU will lead an international effort to reduce oil dependency by creating lighter, stronger materials for wind turbine blades and solar panels from biomaterials like plants, bacteria, and fungi. The project aims to educate the next generation of scientists working in sustainability.
A team of three from Case Western Reserve University will demonstrate their 'Budget It Yourself' app, which tracks home electricity use and costs, at the Department of Energy's Energy Datapalooza. The app, developed with Android devices in mind, aims to help users budget their power consumption and costs via a smartphone.
Researchers developed a new nanotechnology that detects micrometastases in mouse models of breast cancer, marking them for early diagnosis and treatment. The technology uses nanochains to target cancer cells with integrins, allowing doctors to guide surgery or deliver cancer-killing drugs directly to the cells before a tumor forms.
Case Western Reserve University researcher Nicole Ward is leading a study to identify the mechanistic link between psoriasis and heart attack/stroke. The study aims to provide first-ever evidence that cell-specific events in psoriasis can be targeted for treatment, potentially improving cardiovascular disease outcomes.
Researchers at Case Western Reserve University have found a way to map the spread and structure of the universe using the light of quasars. By analyzing patterns of light variation over time, they were able to calculate the relative size of the universe when the light was emitted, compared to today.
Researchers at Case Western Reserve University have developed novel antivirulence drugs that block toxin production in bacteria, rendering them harmless. The discovery has the potential to combat antibiotic-resistant infections like MRSA and strep.
Researchers have discovered a way to store diverse forms of artificial short-term memories in isolated brain tissue. They demonstrated that neural circuits in the hippocampus can maintain memories for more than 10 seconds and recognize specific contexts, such as sequences of stimuli. This breakthrough has significant implications for u...
A study by CWRU nurse researchers found that the physical, mental, emotional, and time-related cost of home caregiving saps caregivers' energy. Higher effort correlated with higher depressive symptoms in caregivers.
Case Western Reserve University honored David Suzuki, a renowned environmental activist and academic, as the fifth recipient of the Inamori Ethics Prize. The prize recognizes individuals who have made a profound impact through philanthropic service.