Researchers discovered that adding lovastatin to traditional antimalarial treatment decreases neuroinflammation and protects against cognitive impairment in a mouse model of cerebral malaria. Statins may be worthy of consideration in clinical trials for treating cerebral malaria.
The first genomic sequence of Chinese plum (Prunus mume) has been completed, providing a valuable resource for improving fruit trees. The genome sequence reveals important genetic information for understanding the evolution and diversity of Rosaceae family.
A Penn team has developed a new class of malaria drugs by mimicking a natural reaction with a synthesized molecule, inhibiting the calpain enzyme. The innovation uses an alpha-helical shape to block the enzyme's activity, offering a highly specific and potentially safer alternative.
The MBL physiology course fosters a culture of curiosity and innovation among students, leading to the generation of 23 research papers and 59 meeting abstracts. The course's unique approach combines cell biology and physical sciences, and encourages students to think beyond their comfort zones.
A Vanderbilt study predicts cuts in Medicare and Medicaid disproportionate share funds for hospitals serving low-income patients, even if Medicaid is not expanded. States that don
Garen Wintemute believes broader background checks and denials on gun purchases can reduce harm and ensure public safety. He cites research showing that individuals with a history of misdemeanor violent crime are nine times more likely to be arrested for violence later.
Researchers at Tufts University developed a novel method for fabricating collagen structures that maintain the protein's natural strength and fiber structure. The new technique, called bioskiving, creates scaffolds with tensile strength stronger than those made using common processing techniques.
Studies using new technology show that our ability to imitate facial expressions depends on learning through visual feedback. In two studies, researchers found that participants who could see their imitation attempts improved over time, while those relying solely on proprioception got worse.
A new study comparing neural responses of birds and humans to music suggests that both share a neural reward system, with females in the breeding state responding similarly to human music. Male birds also exhibit an amygdala response to discordant sounds.
The inaugural issue of Clinical Psychological Science (CPS) publishes diverse and boundary-crossing perspectives on topics such as targeted rejection, major depressive disorder, youth mentoring, and mind wandering. The journal aims to define a new way of studying clinical phenomena through innovative research.
The Johns Hopkins Bloomberg School will provide relief agencies and governments with technical assistance on using oral cholera vaccine. The DOVE program aims to detect outbreaks in remote areas and contain the disease, improving global efforts to combat cholera.
Researchers at Rush University Medical Center identified a chemokine known as monocyte chemoattractant protein-1 (MCP)-1 and its receptor, chemokine receptor 2 (CCR2), as central to the development of osteoarthritis pain. This finding could lead to new treatments for this debilitating condition.
Researchers develop thermodynamically rigorous analysis to parse free energy of polymodal voltage- and ligand-dependent ion channels. This new approach offers a model-independent way to study ion channel gating, useful for constraining future atomic-scale models and understanding disruptions caused by genetic mutations.
Researchers at the University of Exeter have developed a new genetic sequencing technology to identify novel mutations causing congenital hyperinsulinism. This breakthrough will enable clinicians to make more informed decisions about treatment, reducing the need for invasive procedures.
Researchers at UNC School of Medicine identified polycomb-like proteins as key regulators in stem cell development and cancer. The study found that these proteins interact with epigenetic signals to control gene expression, implications for both stem cell biology and cancer development.
Researchers have discovered two new species of Caribbean orchid belonging to the Laeliinae family. The new species, Encyclia navarroi and Tetramicra riparia, were found in Cuba's eastern and western zones respectively.
Three WHOI projects will investigate the complex interactions between marine microbes, nutrients, and their environments using advanced technologies and methods. The grants aim to improve understanding of microbial communities and their impact on ocean health and productivity.
A new study reveals how a 'transcription factor' called ELF5 causes aggressive breast cancer to develop, making it resistant to oestrogen therapies. Researchers found that manipulating ELF5 levels could be a potential treatment option for this type of breast cancer.
A team of researchers at the University of Pennsylvania School of Medicine has identified a powerful new weapon against malaria by mimicking a natural defense found in human blood platelets. They discovered that a synthetic molecule, PMX1207, targets and destroys the parasite's digestive vacuole, killing it without harming the host cell.
Researchers at McGill University have discovered AMPK's role in restricting cancer cell growth by regulating metabolism and preventing the use of sugar to fuel growth. AMPK, a tumour suppressor, can help control tumour development by targeting energy levels and promoting healthy cellular function.
Researchers found that stem cell protein Ell3 marks enhancers that regulate gene expression, priming them for future activation. This discovery has significant implications for understanding cancer and development.
Researchers have discovered a way to manipulate the hepatitis C RNA to block its hijacking of cell machinery, potentially leading to new treatments.
A study at Ben-Gurion University predicts course grades based on students' online and offline social connections. The researchers found that students with good social networks tend to excel academically and are more likely to pair with peers who share similar strengths.
Researchers identified the mechanism by which Staphylococcus aureus colonizes nasal passages, finding that Clumping factor B (ClfB) binds to skin protein loricrin with high affinity. This interaction is crucial for successful colonization and opens new avenues for developing therapeutic strategies.
Researchers at Arizona State University have fabricated an artificial protein and examined its effects on living cells, revealing a peculiar set of adaptations including filamentation, ATP depletion, and the formation of endoliposomes. These findings may lead to the development of novel therapeutic agents.
Researchers at Case Western Reserve University will study ways to integrate patients' strengths into assessment and treatment to improve outcomes. The project aims to provide patients with better-informed health decisions, leveraging strengths such as resilience and mindfulness.
A new study links vector-borne diseases to economic development across the globe, finding that these diseases have a substantial effect on income between tropical and temperate countries. The study's results suggest that infectious diseases can undermine economic growth similarly to crime or government corruption.
The Geological Society of America published a special series of invited papers to mark its 125th anniversary, including a revised geologic time scale. The articles cover various topics such as mammal fossils, sediment delivery rates, volcanic material provenance, and ecosystem changes.
A recent study published in PLOS Biology has discovered the role of ELF5 in aggressive breast cancer subtypes and its potential to overcome anti-estrogen therapies. The research suggests that manipulating ELF5 levels could lead to new treatment strategies for breast cancer patients.