The TRILOGY ACS trial found prasugrel did not reduce cardiovascular events among patients managed medically for acute coronary syndrome. However, it was associated with lower rates of cardiovascular disease, heart attack, and stroke, but higher rates of bleeding when compared to clopidogrel.
The American Urological Association has released four new clinical practice guidelines aimed at improving the quality of patient care. The guidelines cover diagnosis and treatment of overactive bladder, adult urodynamics, asymptomatic microhematuria, and vasectomy.
Scientists from NASA's Goddard Space Flight Center directly observed Kelvin-Helmholtz waves in the solar wind, allowing energy transfer into near-Earth space. The presence of these waves enables charged particles to breach Earth's magnetic shield, altering the magnetosphere's behavior.
The study reveals that disparate chromosome structures, rather than separate gene adaptations, underlie the separation of the two flycatcher species. Genome sequencing and analysis identified specific regions in the chromosomes involved in meiosis and gender cell production as key to understanding species divergence.
Researchers developed a mouse model of obesity where the proopiomelanocortin gene can be turned on and off to study the impact of chronic weight gain. Turning the gene back on after prolonged obesity reduced its effectiveness.
A study comparing sepsis mortality rates in Europe and the US found higher mortality rates in Europe, but differences may reflect varying critical care approaches rather than healthcare quality. The study also revealed disparities in ICU admission and length of stay between the two regions.
Pitt researchers find neurons wire and fire together in clusters to dominate brain activity, with weak stimuli triggering imbalance. The model shows how clustered connections influence stochastic brain dynamics, shedding light on the brain's default spontaneous state.
A team led by University of Delaware researchers aims to create a robot that can drive vehicles, navigate environments, use tools, and manipulate equipment in disaster relief scenarios. The robot will focus on key tasks such as getting into and out of vehicles, driving factoring in difficult conditions.
Researchers at Berkeley Lab's Accelerator and Fusion Research Division develop a new method to measure the energy spread of electron beams in laser plasma accelerators. The experiment finds that local energy spread can be as small as half a percent, enabling more precise control over the beam.
A comprehensive review of herbal and dietary supplement interactions reveals potentially harmful drug combinations, particularly among those with central nervous or cardiovascular systems. The study emphasizes the need for increased awareness and monitoring to mitigate risks.
Researchers identified a distinct patient population that may benefit from prasugrel, a novel anti-platelet therapy, in those triaged to medical therapy following angiography. This subgroup showed lower rates of cardiovascular events and bleeding compared to clopidogrel.
A large-scale study has defined the complexity of underlying mutations responsible for pancreatic cancers, revealing that 'pancreatic cancer' is not one disease but many. The analysis found over 2,000 mutated genes, with some associated with poorer outcomes.
The partnership enables the publication of high-quality stem cell research in an open-access venue, promoting outreach and quality in the field. Stem Cell Reports will feature various article types and allow authors to retain full copyright over their work.
Multicellular bacteria have been found to function as living power cables, transmitting electrons across large distances as part of their respiration and ingestion processes. The discovery reveals a previously unknown type of long, multicellular bacteria that act as biological power cables.
Dr. Thomas H. Jordan, a renowned geophysicist, received the AGI Outstanding Contribution to the Public Understanding of the Geosciences Award in 2013. He is recognized for his efforts to increase public awareness of earthquake processes, probabilities, preparedness, and risk at an international level.
Palliative care discussions can improve symptoms, stress, and survival time for patients with terminal illnesses. Physicians should discuss palliative care with patients during initial talks about prognosis and at subsequent visits to help them plan their remaining lives.
The Antarctic ozone hole reached its maximum size this year, covering an area of 8.2 million square miles, but was smaller than expected due to warmer temperatures. The average size of the ozone hole was 6.9 million square miles, with scientists attributing the change to natural fluctuations in weather patterns.
A nine-year study found that high compliance with hand hygiene and infection control measures reduced MRSA infections by 95% in medical, surgical, and neuroscience intensive care units. The approach also improved patient safety and reduced the need for costly isolations.
Researchers at the University of Illinois have developed a new approach to inhibit the transfer of antibiotic-resistance genes in Streptococcus pneumoniae. By targeting a protein called CSP, they found that artificial versions of this protein can block gene transfer and reduce the infectious capacity of the bacteria.
The DARPA director stresses the need for radical innovation and collaboration between government, academia, and industry to develop next-generation cruise missiles with autonomous guidance. This partnership is crucial for giving U.S. warfighters a decisive edge in future battles.
A sense of control over events reduces emotion-driven time distortions, regardless of individual's emotional state or illusion of control. Previous studies found that highly arousing images lead to time distortions, but this study shows that giving participants a feeling of control eliminates these effects.
Researchers explore how membranes influence self-assembly and structure formation in cells, revealing that membranes promote self-assembly and reproduce structures similar to those found in nature.
A breakthrough study found that brainwave training enhances a cognitive-control network in just 30 minutes, leading to reduced mind-wandering. The study used neurofeedback to train participants' brains and showed significant changes in brain activity and behavior.
Two papers connect long non-coding RNAs to inherited conditions in humans, revealing a chromosomal translocation disrupting expression of PTHLH and SOX9 genes. A lncRNA on chromosome 12 is also linked to the development of the placenta.
A study published in Science Communication found that media messages describing paranormal investigators as 'scientific' make people more likely to believe in ghosts and haunted houses. Researchers found that such descriptions increase credibility ratings and lead to increased belief in paranormal claims.
The PARTNER Cohort B trial found TAVR to be beneficial for patients with severe aortic stenosis, with lower mortality rates and fewer cardiac deaths at three years compared to standard therapy. The study confirms the role of TAVR as the standard-of-care for symptomatic patients who are not surgical candidates.
The study identified mutations in genes involved in chromatin modification and axon guidance, which are not previously linked to pancreatic cancer. New information on these genes could lead to exciting treatment strategies for the disease.
A study published in PLOS ONE found that older adults are worse at distinguishing between lifted weights than younger counterparts. The researchers assessed the ability of participants in two age groups to estimate weight ratios and found that older adults consistently estimated the ratios as much higher than they actually were.
A study found that protected areas in Catalonia have a high number of animal deaths on the roads, with amphibians being most susceptible. Researchers suggest building tunnels for amphibians to reduce mortality rates.
The Navy plans to reduce its fleet size and workforce due to sequestration, but will focus on investing in cutting-edge technologies like the Electromagnetic Railgun. This commitment to innovation is seen as crucial for maintaining the service's technological advantage.
Researchers use electroencephalography to analyze brain activity before training on Space Fortress, a cognitive research video game. The study found that subjects with more powerful alpha wave oscillations tend to learn faster and improve reaction time and working memory.
A new guidebook provides a performance-based approach to police staffing and allocation, taking into account multiple factors such as crime rate, shift length, and community policing. The approach offers a more efficient way for agencies to determine the number of officers needed and deploy them effectively.
A nationwide study led by Dana-Farber Cancer Institute found that 69% of advanced lung cancer and 81% of advanced colorectal cancer patients believe chemotherapy can cure their disease. However, skilled clinicians can set realistic expectations without losing hope or trust.
A new study found that over 80% of flu-positive pigs showed no signs of illness, highlighting the risk of transmission between pigs and humans. The research also identified genetic similarities between human and pig viruses, confirming interspecies transmission.
A new study suggests that obesity can become a self-perpetuating disorder, making it harder to lose weight, especially if it persists over time. The longer mice remained overweight, the more irreversible their obesity became.
A new Harvard study found over half of people in northeastern Madagascar engage in geophagy, a widespread behavior previously thought to be non-existent. Researchers also discovered high rates of geophagy among men and young children, contradicting earlier studies that linked the practice mainly to pregnant women or adolescents.
Researchers suggest that small numbers of stars kicked to the edges of space during galaxy collisions may explain infrared light 'halos'. This theory proposes that only one-tenth of 1 percent of stars are distributed like dark matter, producing fluctuations in the cosmic background.
Researchers have created a new family of compounds that could slow Parkinson's disease progression by shutting down the Cav1.3 channel, which allows calcium to flood into dopamine neurons. The compounds were developed by Northwestern University scientists and show promise in animal trials without obvious side effects.
Tropical Storm Sandy is expected to become a hurricane before reaching Jamaica and Cuba, prompting hurricane warnings and watches for the region. The storm's strongest thunderstorms are surrounded by cloud top temperatures as cold as -63F (-52C), indicating hurricane-force winds.
The FAME 2 trial demonstrated that FFR-guided percutaneous coronary intervention (PCI) is a cost-effective strategy compared to medical therapy for patients with stable coronary artery disease (CAD). This approach improves clinical outcomes and quality of life, with a projected cost-effectiveness of $53,000 per quality-adjusted life year.
The ISAR-LEFT MAIN 2 trial presented at TCT 2012 found that second-generation drug-eluting stents are safe and effective for treating left main coronary artery lesions. The study showed similar clinical outcomes between zotarolimus-eluting and everolimus-eluting stents in patients with high-risk lesions.
New research uses satellite images to estimate species richness and turnover, achieving nearly 100% accuracy. The method could improve biodiversity monitoring and conservation efforts by reducing costs and increasing efficiency.
Researchers at Moffitt Cancer Center investigated a novel combination of danusertib and bosutinib to overcome resistance in BCR-ABL gatekeeper mutation-specific disease. They found the synergy was not due to direct inhibition, but rather through the downstream MAPK signaling cascade and impaired activity of c-MYC gene regulator.
The TRMM satellite monitored rainfall and towering clouds as the first tropical cyclone of the season formed in the Arabian Sea. Rainfall rates reached up to 41 mm/hour, with thunderstorms surrounding the center of the storm.
Slowing container ships to 14mph reduced emissions of carbon dioxide, nitrogen oxides, and soot by 60-70% compared to traditional speeds. Imposing speed limits near ports could significantly reduce pollution and protect local populations' health.
Research found that self-affirmation enhances performance by making individuals more receptive to errors and allowing for better correction, as indicated by a stronger error-related negativity response in the brain. This study suggests that self-affirmation can be an effective strategy to improve self-control and reduce distress.
Researchers found a direct relationship between neighborhood income and racial composition and the probability of receiving bystander-initiated CPR. The study suggests that targeted, low-cost CPR training efforts are needed to address disparities in life-saving interventions.
Researchers at OHSU have successfully demonstrated a new gene therapy method that can replace mutated mitochondrial DNA with healthy copies in human cells. This breakthrough has the potential to prevent devastating diseases passed from mother to infant.
A study found gene polymorphisms in hormone metabolism and growth factor pathways associated with breast density, which increases breast cancer risk. Variants in genes like PRL, TNF, and SULT1A1/2 were linked to breast density in both hormone therapy users and non-users.
Prominent wildlife biologists advocate for a national network to coordinate state, federal, and private initiatives. The proposed network aims to identify at-risk species, coordinate conservation efforts, and share information to address threats like climate change and novel diseases.
Meat from wild animals like antelope and rodents is increasingly important in African diets due to scarcity of traditional livestock. Researchers highlight the nutritional value of bushmeat, providing protein, calories, vitamins, and minerals.
Experts from the US FDA argue that few global initiatives focus on strengthening medical product regulatory systems in low-and middle-income countries. Strengthening these systems is crucial to assure product efficacy, safety, and quality, particularly as globalization increases access to medicines and vaccines.
The Beutler laboratory has released its ENU mutagenesis data, which underpin the Nobel Prize-winning discoveries, for public use. The dataset is available in an online open access repository called Mutagenix, linked permanently to a 'Data Note' article published in BMC Research Notes.
A new study of marine fossils reveals that ocean animals with small geographic ranges are more likely to go extinct, even when populations are large. The research found that habitat breadth played a secondary role in extinction risk, and population size had little effect.
A new study suggests that bacteria cue choanoflagellates, the closest living relatives of animals, to form colonies. The discovery implies that bacteria may have helped kick off multicellular life, a development that eventually led to all animals, including humans.
The new Big Data journal will publish peer-reviewed content on novel technologies, policies, and innovations in the field. It aims to facilitate collaboration among researchers, analysts, and business leaders to address challenges and discover breakthroughs in big data.
A study published in Annals of Oncology found that acupuncture can relieve symptoms of dry mouth (xerostomia) caused by radiotherapy for head and neck cancers. Patients who received acupuncture reported improved dry mouth symptoms, while those receiving oral care education showed no significant improvement.
Researchers will use x-ray crystallography and NMR to understand the structural rules governing nuclear receptors' activity. The goal is to fill gaps in knowledge about these proteins' role in metabolism, cancer, inflammation, and bone health.
A new study shows that New Jersey's decal law for novice drivers has prevented over 1,600 crashes and helped enforce regulations. The law, which requires a red decal on license plates, led to a 9% decrease in crashes involving peer passengers.
A team of neuroscientists proposes a new method to determine neuronal connectivity using high-throughput DNA sequencing. The BOINC barcoding technique labels neurons with specific DNA barcodes, which are then shared across synapses through engineered viruses. This approach promises to be faster and cheaper than current methods.