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DOE/Joint Genome Institute


All in the family: Focused genomic comparisons

A team of researchers sequenced and annotated the genomes of six Aspergillus species, identifying biosynthetic gene clusters for secondary metabolites of interest. The study highlights a new analysis method that pinpointed candidate genes for diverse compounds, providing potential tools for improving biofuel production.

SourceDOE/Joint Genome Institute·JournalProceedings of the National Academy of Sciences·DateJan 11, 2018

Liverwort genes and land plant evolution

The liverwort's genome has provided insight into the transition from algae to land plants, identifying genes critical for plant growth and development. The study also found that early plants developed strategies for water retention and distribution, which are still employed by modern plants.

SourceDOE/Joint Genome Institute·JournalCell·DateOct 5, 2017

Benchmarking computational methods for metagenomes

The Critical Assessment of Metagenome Interpretation (CAMI) Challenge evaluated computational tools for metagenomes, assessing assemblers, binners, and taxonomic profilers. The benchmarking results provide performance overviews for developers and applied scientists, informing the selection of suitable software for research questions.

SourceDOE/Joint Genome Institute·JournalNature Methods·DateOct 3, 2017

Uncovered: 1,000 new microbial genomes

The U.S. Department of Energy Joint Genome Institute has released 1,003 phylogenetically diverse bacterial and archaeal reference genomes, which will aid in understanding the functions of genes, enzymes, and metabolic pathways with wide applications in bioenergy, biomedicine, agriculture, and environmental sciences.

SourceDOE/Joint Genome Institute·JournalNature Biotechnology·DateJun 12, 2017

Discovered: Novel group of giant viruses

A new group of giant viruses, dubbed Klosneuviruses, has been discovered with a more complete set of translation machinery genes than any other virus known to date. These viruses are thought to have evolved from smaller viruses and encode proteins involved in protein biosynthesis, expanding our understanding of viral evolution.

SourceDOE/Joint Genome Institute·JournalScience·DateApr 6, 2017

Tracking Antarctic adaptations in diatoms

A comparative genomic analysis of Antarctic diatom Fragillariopsis cylindrus reveals its ability to adapt to extreme cold by selectively expressing variant genes. The study provides insights into the organism's genome structure and evolution, highlighting its unique genetic features that enable survival in harsh environments.

SourceDOE/Joint Genome Institute·JournalNature·DateJan 16, 2017

How fungi help trees tolerate drought

Researchers sequenced the genome of C. geophilum and found specific adaptations that could help host trees be more resistant to drought stress. The fungus has a reduced number of plant cell wall degrading enzymes and a large set of symbiosis-induced lineage-specific genes, including water channel genes.

SourceDOE/Joint Genome Institute·JournalNature Communications·DateSep 7, 2016

Unveiled: Earth's viral diversity

Researchers at the DOE JGI have discovered over 125,000 viral genomes infecting microbes, increasing the number of known microbial phyla by a factor of 16. The study provides a unique resource for viral sequence information and has implications for understanding global cycles and energy challenges.

SourceDOE/Joint Genome Institute·JournalNature·DateAug 17, 2016

Expanding the stable of workhorse yeasts

A team of researchers has sequenced the genomes of over 29 yeast species, revealing a wider diversity than expected. The study identifies new genetic pathways and enzymes that can be used to produce biofuels and other valuable products from a range of sugars.

SourceDOE/Joint Genome Institute·JournalProceedings of the National Academy of Sciences·DateAug 15, 2016

See and sort: Developing novel techniques to visualize uncultured microbial cell activity

Researchers developed novel techniques to visualize uncultured microbial cell activity using BONCAT, a high-throughput and cost-effective approach. This method identifies individual active cells and clusters within microbial communities, providing insights into the ecological function of microorganisms.

SourceDOE/Joint Genome Institute·JournalProceedings of the National Academy of Sciences·DateJun 28, 2016

Cuing environmental responses in fungi

Researchers analyzed genome sequences of fungi to understand their environmental response mechanisms. They found that whole-genome duplication led to the development of specialized genes enabling refined signal perception, which could aid in natural control of metabolic processes and biofuels production.

SourceDOE/Joint Genome Institute·JournalCurrent Biology·DateMay 26, 2016

Dirty, crusty meals fit for (long-dormant) microbes

Researchers used exometabolomics to study the interactions between soil microbes and their adaptations in desert biocrusts. The team found that diverse microbes target specific metabolites, supporting diverse microbial communities. This discovery suggests a possible mechanism for promoting soil biodiversity by specialization.

SourceDOE/Joint Genome Institute·JournalNature Communications·DateSep 22, 2015

Keeping algae from stressing out

Researchers identify two transcription factors that regulate lipid accumulation in stressed algae, enabling sustainable fuels production. The study also demonstrates a strategy for overexpressing PSR1 to trick cells into producing lipids without dying.

SourceDOE/Joint Genome Institute·JournalNature Plants·DateAug 4, 2015

A tale of 2 data sets: New DNA analysis strategy helps researchers cut through the dirt

Researchers have developed a simple yet elegant solution to analyze large amounts of soil DNA data, reducing computational requirements by up to 200-fold. This breakthrough enables scientists to extract more science from the noise, paving the way for new discoveries in fields like agriculture and carbon cycling.

SourceDOE/Joint Genome Institute·JournalProceedings of the National Academy of Sciences·DateMar 10, 2014