A novel molecular pathway has been identified that causes aggressive medulloblastoma, and suggests repurposing an anti-depressant medication could help combat the disease. Elevated levels of cAMP may enhance the potency of Sonic hedgehog inhibitors, currently being tested in clinical trials.
Researchers found that acrylamide exposure damages the blood-cerebrospinal fluid barrier and impairs its secretory and transport functions. These changes may underlie acrylamide-induced neurotoxicity in central and peripheral neuropathy.
A study published in Nature Geoscience suggests that intermediate vegetation growth is key to stabilizing river deltas. This 'just right' amount of vegetation slows water flow and promotes sediment deposition, helping prevent sea-level rise from damaging sensitive marshlands.
A global analysis of honeybee genome variation reveals high levels of genetic diversity and suggests the species originated from Asia. The study also identifies specific mutations linked to adaptation to climate and pathogens, providing new insights into evolution and genetic adaptation.
Brown University neuroscientists report that they have directly controlled the cells producing gamma brainwaves in mice, resulting in increased touch sensitivity. The study confirms the first direct evidence of gamma brainwaves affecting perception and attention, suggesting a more complex role for these brainwaves than previously thought.
A new study reveals that p38 MAPK is activated by low nutrient levels and age-related signals, leading to the decline of immune function in older T lymphocytes. Blocking this pathway may help restore their function, potentially improving immunity in older adults.
A new review paper explores the use of dimensionality reduction in neuroscience to uncover the complexity of brain function. By analyzing the activity of hundreds of neurons concurrently, researchers can gain a deeper understanding of how the brain distinguishes between different odors, makes decisions under uncertainty, and thinks abo...
Researchers found that repeated-pulse transcranial magnetic stimulation at the Guangming point induces distinct electroencephalogram signal patterns compared to other stimulation points. The study also revealed changes in visual response complexity in parietal, central, and temporal regions following this stimulation.
Researchers at Stanford University School of Engineering have successfully reprogrammed yeast cells to produce opioids in stainless steel vats, eliminating the need for poppy cultivation. The breakthrough could lead to reliable manufacture of essential medicines while mitigating diversion to illegal use.
A revolutionary new scientific method developed at the University of Leeds uses 'promiscuous reactions' to improve the diversity of biologically active molecules, such as antibiotics and anti-cancer agents. The approach has successfully identified three biologically active molecules with potential applications in cancer treatment.
A new study reveals that neurons in the brain's inferotemporal cortex fire strongly and selectively when exposed to familiar images, especially those seen many times before. This finding suggests that the brain uses this mechanism to track a rapidly changing visual environment and may lead to improvements in perception and cognition.
Researchers found that apolipoprotein E-derived therapeutic peptide improved synaptic stability and learning and memory performance after diffuse brain injury. The peptide also protected against brain injury by reducing oxidative stress, suppressing the ERK1/2-Bax mitochondrial apoptotic pathway, and decreasing neuronal death.
A recent study reveals that genetic selection has imprinted its signature on the genomes of poplars, a finding that could improve predictive climate change models and tree breeding programs. By analyzing over 1,100 wild poplar trees, researchers identified 397 genomic regions contributing to adaptive traits.
Researchers found that carbon-reduction policies can lead to significant health savings, with benefits ranging from 26% to 10.5 times the cost of implementation. A transportation policy was the most expensive option, costing over $1 trillion in 2006 dollars, while a clean energy standard fell between the costs of other policies.
A new study published in Neurobiology of Aging found that exercising improves cardiovascular strength, which may protect against cognitive impairment as we age. The researchers tested 31 young people and 54 older adults, finding that those with better aortic elasticity and aerobic fitness performed better on cognitive tests.