A study of US military combat casualties in Afghanistan found that prehospital blood transfusions within minutes of injury or prior to hospitalization resulted in greater 24-hour and 30-day survival rates compared to delayed or no transfusion. Early transfusion also showed a reduced risk of death over 24 hours when administered up to 1...
The Choosing Wisely movement has successfully started conversations about low-value care, but its impact is limited by the difficulty in changing doctor behavior. Researchers recommend prioritizing recommendations, consolidating guidelines, and evaluating efforts to make a greater difference in quality and value in healthcare.
A two-week intervention program focusing on reducing risky behavior was found to be effective in reducing aggression and future incarceration rates among clinically aggressive juvenile offenders. The program, PHAT Life, taught youth to identify triggers for high-risk behavior and develop coping strategies.
The study confirms Einstein's theoretical analysis of Brownian motion by observing the Kramers turnover in levitated nanoparticles. The researchers found that the transition rate between states depends on friction and grows with decreasing friction before decreasing again at low friction levels.
Scientists have discovered two new classes of histone modifications that couple cellular metabolism to gene activity, providing a potential mechanism for environmental influences on gene expression. The novel marks, propionylation and butyrylation, are linked to fatty acid metabolism and can drive transcription in test tube experiments.
A study using noninvasive brain imaging found that simulator-trained medical students demonstrated increased cortical activity and faster completion times for cutting tasks compared to those with no training. The researchers believe this approach can objectively assess surgical skill transfer, providing a more accurate representation o...
African teams join forces with UK experts to develop novel treatments for malaria and sleeping sickness, as part of the £7 million Tackling Infections to Benefit Africa (Tiba) project. The initiative aims to strengthen health systems across the continent.
A new $1.85 million grant will support a Phase 2 clinical trial of AMX0035, a combination of sodium phenylbutyrate and tauroursodeoxycholic-acid, to test its effectiveness in slowing or stopping brain cell death in people with mild cognitive impairment or Alzheimer's disease.
Geneticists at Emory University School of Medicine have discovered a mysterious DNA modification in animals, specifically adenine methylation, which increases four-fold under conditions of stress in the brain. This epigenetic modification may play a role in neuropsychiatric disorders.
A study led by the University of Plymouth found that people with strong psychopathic traits are more likely to generate harmful actions with greater physical power to save a larger group. This suggests that psychopathic traits could be beneficial in certain circumstances, leading to a more vigorous response for the 'greater good'.
Researchers found that ancient volcanic eruptions caused significant melting of the northern European ice sheet, with some eruptions leading to 20 centimeters of ice loss. The study suggests that modern ice sheets may be vulnerable to similar effects, highlighting a potential positive feedback loop between volcanism and climate change.
A new article in PLOS Biology argues that universities should support the sharing of educational resources to benefit society. The author proposes several ways institutions can counter practices that inhibit open information flow, including awarding faculty prizes for community engagement.
A team of researchers from the University of Pennsylvania and Yale University have identified the posterior cingulate cortex as a key brain region that motivates behavior change. By stimulating this area, people can become more exploratory and creative, suggesting its role in foraging efficiency and landscape adaptation.
Researchers at the University of Eastern Finland found no association between long-term opioid use and Alzheimer's disease. Despite this, they highlight potential adverse effects such as drowsiness and addiction, suggesting restricted use for severe pain conditions.
Researchers found significant increases in glyphosate and its metabolite in the urine of older adults from Southern California between 1993 and 2016. Average glyphosate levels increased by 13 years, with detectable levels present in more than 70% of samples.
Typhoon Lan caused extreme flooding, landslides, and seven deaths when it hit Japan. NASA's Global Precipitation Measurement mission analyzed the storm and found rain totals of up to 800 mm (31.5 inches) in parts of Honshu.
Peter Winzer, a renowned expert in optical communication systems, has been awarded the 2018 John Tyndall Award by The Optical Society and the IEEE Photonics Society. His significant advancements involving modulation formats and spatial multiplexing have greatly expanded the field of optical communication systems.
Researchers tracked mortality rates in Chileans exposed to arsenic-contaminated drinking water, finding increased risk of lung, bladder, and kidney cancer up to 40 years after exposure ended. Long-term interventions may help mitigate the effects of past exposures.
Researchers at the University of Luxembourg found that the financial press can have a significant impact on investor behavior and opinions. The experiment showed that positive news coverage led to a positive evaluation of stocks, while negative coverage had the opposite effect.
Researchers at Northwestern University have discovered that cerium's electronic entropy is the underlying reason for its success in water-splitting technologies. Cerium's large entropy makes it ideal for hydrogen production, opening up possibilities for future work in creating a more efficient and environmentally friendly energy system.
Researchers at Rutgers University have identified a protein complex called TldD that activates the antibiotic microcin B17 by removing its protective coating. This discovery could lead to the development of new antibacterial agents and drugs to combat toxins.
Researchers argue that identifying molecular subtypes of different cells within tumors can improve breast cancer treatment. They advocate for more accurate diagnostic tests to capture irregularities between tumor cells, which are often treated as a whole.
Scientists at Chalmers University of Technology have created a new method to map individual nanoparticles, allowing for improved nanomaterials and safer technologies. The discovery paves the way for the development of more efficient hydrogen detectors and other applications.
A new study found that parents who acknowledge their adolescent children's perspectives and encourage them to express themselves have youths with stronger self-worth, intrinsic motivation, and engagement. However, the benefits of autonomy and decision-making differ across cultures.
Researchers have developed a new medicine, tarloxitinib, that brings high doses of anti-EGFR drugs to tumors while keeping toxic levels in healthy tissues. The prodrug-based approach has shown promising results in tests against lung cancer cells with EGFR exon 20 insertions.
Researchers evaluated the impact of eating dried cranberries on gut microbiome health, finding positive but statistically insignificant changes. The study's findings motivate further exploration into the role of dried cranberries in whole-body health.
Researchers from Lancaster University found that teenagers who do not access healthcare when needed are at greater risk of dropping out of high school. More than one in five young people globally experience this issue, leading to increased unemployment, poor health, and crime.
Researchers will count and catalog cell types in mouse brain using single-cell transcriptomics, aiming to build a comprehensive atlas of cell types that can be applied to the human brain.
Scientists from Boston College and Harvard have successfully created a copper iridate metal oxide that meets the Kitaev model's standards, enabling a chemical entity known as a 'spin liquid' with free-flowing properties. The material's unique honeycomb structure disrupts natural magnetic order, producing geometric frustration.
A study by Oakland trauma surgeons found that acoustic gunshot sensor technology can lead to quicker hospital arrival times and equal survival rates despite more severe injuries. The technology detects gunshots and provides responders with accurate information, helping paramedics treat and transport patients faster.
The New York Stem Cell Foundation (NYSCF) has selected six promising researchers and neuroscientists to join the NYSCF - Robertson Investigators program, providing critical seed funding of $1.5 million over five years. The program supports high-risk/high-reward research that aims to accelerate treatments and cures for various diseases.
Lehigh University engineers developed an optimization model, IADSS, which streamlines the assignment of inmates to Pennsylvania's 25 correctional institutions, saving millions and reducing recidivism. The system has been credited with achieving cost savings in four areas: treatment programs, prison assaults, staffing, and transportation.
The Society of Nuclear Medicine and Molecular Imaging (SNMMI) has published appropriate use criteria (AUC) for FDG PET/CT imaging in cancer patients. The AUC aims to improve the utilization of this technology and provide guidance for providers across specialties.
Dr. Paul Tesar receives the 2017 NYSCF Robertson Stem Cell Prize for his pioneering work on pluripotent epiblast stem cells, which holds promise for treating neurological disorders like multiple sclerosis and pediatric leukodystrophies.
A study by researchers at the University of Basel and FMI identified specific neuron types in the brainstem that regulate high-speed locomotion. These neurons are intermingled with others that can elicit immediate stopping, and their activation can induce full body locomotion.
A team of FSU scientists outlines a methodology that uses rainfall rates to mark the span of the Indian Summer Monsoon. The new system has been shown to capture ISM evolution comprehensively, enabling easy real-time monitoring.
Researchers develop algorithm to transform healthy and diseased cells into desired cell types, leveraging gene expression and transcription factor data. The approach aims to regenerate tissue and fight cancer, offering a shortcut to traditional cell transformation techniques.
The US FDA has awarded a grant to I-ACT for Children to establish an alliance among leading institutions and health systems to address gaps in pediatric clinical trials. The network aims to improve the efficiency of trials through innovative design, operational efficiency, and stakeholder engagement.
Researchers from NUS have developed a novel organic thin film that stores and processes data for 1 trillion cycles, significantly outperforming existing flash memory devices. The new device consumes 1,000 times less power and has the potential to be made even smaller.
Scientists have developed intelligent nanoparticles that can heat cancer cells to a high temperature, but then self-regulate and lose heat before causing harm to healthy tissue. This breakthrough could lead to a more effective treatment method for cancer patients.
Researchers analyzed blood and brain tissue data to find epigenetic marks that control gene expression, revealing key connections between genes and immune function. This study suggests that understanding epigenetic connections could lead to new treatments for autism by targeting specific biological pathways.
Tropical Storm Saola has strengthened to a tropical storm near Guam, with NASA's Aqua satellite analyzing its cloud top temperatures in infrared light. The storm is expected to continue strengthening and become a typhoon by Oct. 25, bringing strong winds and hazardous surf.
Kent State University professor Jonathan Maletic has received a three-year, $290,610 NSF grant to develop eye-tracking software that can track programmers' working environments. This project will enable more realistic studies of programmers' behavior, leading to better understanding of program comprehension and development.
Insilico Medicine showcases its use of artificial intelligence to identify disease targets, generate molecular structures, and track interventions for metabesity. The company aims to prevent metabolic-rooted disorders such as diabetes and dementia.
The pilot project identified significant bottlenecks in data sharing practices among IDRC-funded projects, including lack of resources, expertise, and tailored data management platforms. The study recommends empowering Program Officers with training and support to enhance policy implementation.
A new study analyzes Google Trends data across eight countries, finding summer and fall seasons correlate with greater hair loss. The findings provide evidence for seasonality in hair loss at a population level, supporting future research into the physiology of the hair cycle.
A new experimental drug has been found to block deadly muscle scarring that contributes to chronic heart failure and skeletal muscle disorders. The treatment targets alpha V integrins on scar-forming cells, reducing scarring even when the process has already started.
A team of scientists from UC Santa Barbara tested the effect of sulfurized nano-zero-valent iron on a common freshwater alga and found that it picked up cadmium and alleviated toxicity. Organic material produced by the algae mitigated the nanoparticle's toxicity, allowing for greater remediation.
A UK study aims to improve mental health identification in autistic individuals with learning difficulties, who face unique challenges. The research will develop an assessment tool to distinguish between anxiety/depression and physical health-related distress.
A new combination therapy using registered drugs albendazole and antibiotics has dramatically shortened treatment time for lymphatic filariasis and onchocerciasis, reducing it from weeks to just seven days. This breakthrough could accelerate elimination of these debilitating diseases, prioritized by the UN's Sustainable Development Goals.
The NIH BRAIN Initiative has launched a major effort to discover and catalog the brain's diverse cell types. The BICCN will generate knowledge that is prerequisite to solving the mysteries of brain disorders such as schizophrenia, Alzheimer's disease, and autism spectrum disorder.
A new study analyzes genetic material from people in Western Asia, identifying DNA sequences inherited from Neanderthals. The research suggests that this region is the most likely spot where humans first encountered Neanderthals, with implications for human health and well-being.
A University of Colorado Boulder study found more than 1,800 earthquakes in southern Colorado and northern New Mexico between 2008 and 2010 were likely caused by fluids pumped deep underground during oil and gas wastewater disposal. Elevated pore pressures in the basement rock underlie the Raton Basin's oldest stratified layers.
A study found that proton beam therapy in combination with chemotherapy prior to surgery reduces postoperative heart and lung problems and mortality rates in elderly patients. Researchers followed 571 patients treated with traditional radiation therapy and chemotherapy followed by surgery at Mayo Clinic Cancer Center.
Researchers at UBC Okanagan campus have created a definitive method to detect wildfire-tainted wine grapes, providing accurate and quick results. The new test detects volatile phenols present in the fruit prior to wine production, helping wine producers and grape growers manage the impact of smoke exposure on wine flavor.
A new study found that weight loss after bariatric surgery can lead to significant improvements in heart health, including a return to natural shape and function. The study also showed a decrease in ventricle size by 15.7 percent, reducing the risk of heart failure.
Human exposure to glyphosate has increased significantly since the introduction of genetically modified crops, with 70% of study participants having detectable levels by 2016. Glyphosate use has also increased 15-fold since 1994.
Researchers at Nara Institute of Science and Technology identified CRABS CLAW as a key molecule that controls the termination of stem cell growth and the formation of gynoecium in flowers, promoting floral reproduction. The study also shows auxin homeostasis is regulated by TORNADO2, providing insight into flower development.
A study published in Nature Communications has identified five genetic risk loci associated with food allergies in children, highlighting the importance of skin and mucous membrane barriers. The research, involving over 1,500 participants, also found that four of the five risk loci are linked to other chronic inflammatory diseases.
Researchers used a mathematical equation to analyze how our self-esteem is shaped by what others think of us. They found that self-esteem changes are guided by whether we expect to be liked and that increased prediction errors in the brain can confer risk for mental health problems.