Researchers at Karolinska Institutet discovered that a deficiency in the endoglin protein weakens tumor blood vessels, allowing cancer cells to spread more easily. This finding suggests that strengthening blood vessel protective function may prevent cancer spread.
Research reveals a steady increase in UK children's emergency hospital admissions since 2003, primarily driven by common infections. The trend shows a particularly significant rise among under-5s, with projected population increases suggesting up to 230,000 more admissions by 2020.
Researchers at Rice University propose combining synthetic and natural toxins to create a 'one-two punch' therapy against cancer and drug-resistant bacteria, potentially reducing side effects and preventing resistance. The approach targets the unique membranes of both cancer cells and Gram-negative bacteria.
A study found that obese pregnant women who followed a healthy lifestyle program were more likely to stay within the recommended weight gain limit, with a lower risk of hypertension, preterm delivery, and gestational diabetes. The program included a 1500 kcal/day diet and mild physical activity.
The study found that using the laborist model resulted in significant reductions in labor inductions (15% fewer), maternal length of stay (0.09 days less), and preterm delivery (17%). This improvement in pregnancy outcomes is attributed to continuous coverage without competing duties.
Researchers found that implementing a standardized comprehensive maternal hemorrhage protocol significantly reduced blood product utilization, resulting in a 45% reduction in puerperal hysterectomy. The study also showed a significant decrease in morbidity, with reductions in red blood cells, platelets, and cryoprecipitate usage.
Researchers led by Ken Williams are studying cell types that contribute to an HIV viral reservoir and developing new therapies to control the virus's debilitating effects. The team aims to target specific cells and cellular activity linked to conditions like dementia, cardiovascular disease, and nerve damage.
Researchers found a potential therapeutic candidate, miR-506, which blocks epithelial-to-mesenchymal transition and inhibits mesenchymal markers in ovarian cancer cells. Higher miR-506 expression is associated with longer overall survival.
A new study finds that a genetic variant in the inflammation gene interleukin-6 is associated with developmental problems in females after preterm birth, but not in males. The research may help identify prevention strategies for preterm brain injury and improve understanding of how it occurs.
Researchers have developed a sophisticated tool to reconstruct protolanguages, the precursors of modern languages, with high accuracy. The system analyzes sound changes at the phonetic level and has been applied to 142,000 word forms from 637 Austronesian languages, producing results that are 85% accurate compared to manual reconstruct...
A new study found that infants born by cesarean delivery and those strictly formula-fed have different gut bacteria than those delivered vaginally and breastfed. The researchers suggest that these early-life influences may impact the development of conditions like asthma, obesity, and type 1 diabetes.
The study found that Medicaid drug selection committees' conflicts of interest (COI) policies are not transparent and vary widely. Current policies often rely on disclosure and self-recusal, but only a small percentage ban certain industry relationships.
Researchers at UCLA have identified a natural protein called cholesterol-25-hydroxylase (CH25H) that can block the entry of HIV and other deadly viruses into cells. The protein, which is activated by interferon, produces an oxysterol that can permeate cell walls and inhibit viral growth.
A systematic review of clinical interventions found only a few psychotherapeutic treatments showing promise for reducing symptoms in children exposed to trauma. School-based cognitive behavior therapy interventions were associated with changes in post-traumatic stress, anxiety, depression, and anger.
New isotopic data shows that Neolithic farmers introduced agriculture to Central Europe from the Near East through colonizers. This discovery sheds light on the spread of farming across Europe and challenges previous theories about its adoption.
A study found that perinatal outcomes of frozen/thawed embryo replacement (FER) were better than those of fresh in vitro fertilization (IVF), but poorer than the general population. FER resulted in higher rates of low birth weight, preterm birth, and macrosomia compared to spontaneous conceptions.
A study found that nulliparous women with a short cervix who have intra-amniotic debris are at a higher risk of early preterm birth. The presence of debris was associated with worse outcomes for the babies, likely due to earlier delivery. Women with debris had a longer funnel and a higher body mass index than those without debris.
A Wayne State University researcher has identified characteristics in benign breast disease associated with future cancer risk in African-American women. The study found that women with proliferative breast disease with atypia were three times as likely to develop breast cancer.
Researchers found racial and ethnic disparities in adverse obstetric outcomes, including postpartum hemorrhage, peripartum infection, and severe perineal laceration. The study also revealed differences in types of intrapartum care, with certain groups receiving more intensive or less invasive treatments.
Scientists have identified a molecule called Gfi1 that represents the disease's Achilles' heel and could be targeted to develop a new approach. This discovery has direct implications for the treatment of acute lymphoblastic leukemia, a cancer of the bone marrow and blood that progresses rapidly.
Researchers at USC have identified two molecular signaling pathways that control the formation of head and face structures, shedding light on certain birth defects. The study used time-lapse photography to study organ development at the single-cell level in zebrafish embryos, providing insights into human health and disease.
Researchers at Boston Children's Hospital used a social networking approach to investigate the magnitude of hypoglycemia and promote healthy behaviors among participants with diabetes. The study showed that engaging patients in research through social media can help augment traditional surveillance methods and lead to meaningful behavi...
Researchers found that preemptive treatment with Diclectin significantly decreases risk of severe nausea and vomiting in pregnant women. The study also showed a lower recurrence rate of hyperemesis gravidarum when treatment is started before symptoms appear.
Recent AGU journal publications explore the global climatology of explosive cyclones and their impact on U.S. biomes under climate change. A study found that extreme precipitation patterns decrease vegetative productivity by 20% in some regions, while others show neutral or negative effects.
Studies show that mouse models do not reflect the human genomic response to inflammatory injury, including major burns and trauma. Despite similar responses among humans, mouse models exhibit limited correlation with gene expression changes.
A new report shows a 50% increase in speech comprehension in background noise after a three-week auditory training program for children with hearing impairments. The effect was still evident three months later, indicating the development of new hearing and listening strategies.
Scientists at Caltech have developed a unique microscope that captures the motion of DNA structures in both space and time, allowing them to directly measure stiffness and map its variation. This breakthrough technique has far-reaching implications for understanding biological nanomaterials and their properties.
Researchers observed that bisphenol A exposure altered behavior in California mice differently for males and females. In females, BPA reduced exploratory behavior essential for foraging, while in males, it affected territorial marking crucial for defending a home range and mate.
A Michigan State University study suggests that physical bullying, cyberbullying, and mobile phone bullying have similar effects on students' behavior and suicidal thoughts. Parents and policymakers are urged to consider both online and offline forms of bullying when creating anti-bullying policies.
A federally funded study found that nearly 90% of preschoolers with ADHD continue to struggle with symptoms six years after diagnosis, regardless of medication use. Children with co-occurring oppositional defiant disorder or conduct disorder were more likely to experience persistent symptoms.
Prompt identification and treatment of perioperative strokes can significantly improve neurologic outcomes. The article reviews management options for perioperative stroke, including blood thinners, clot-busting drugs, mechanical devices, ultrasound, and hemicraniectomy.
Researchers developed a new mouse model to study clear cell sarcoma (CCS), a rare and aggressive soft tissue cancer. The model can potentially speed the development of drugs targeting genes required for CCS formation.
A randomized controlled trial found that community health workers led by a nurse case-manager improved blood sugar levels among Samoans with type 2 diabetes. The intervention, which included culturally tailored education and home visits, resulted in clinically significant improvements in HbA1c levels.
Researchers found that young adults who interacted with computerized avatars experienced a significant reduction in depressive symptoms over three months. The avatar-based intervention improved self-management skills and helped participants rehearse office visits ahead of time.
A study published in JAMA Internal Medicine found that men's decisions to undergo prostate-specific antigen (PSA) screening are influenced by how information is presented. The researchers discovered that men who were given a balance sheet with relevant features of PSA screening were more likely to choose the screening option, while tho...
Scientists have successfully observed protein unfolding at atomic resolution, revealing the intermediate forms that occur during folding. The study may contribute to a better understanding of how proteins misfold in diseases like Alzheimer's, Parkinson's, and Huntington's Chorea.
A recent study found that hotter temperatures triggered a widespread die-off of Colorado trembling aspen trees, with the drought from 2000-2003 exacerbating the damage. The researchers used oxygen isotope analysis to determine that summer temperatures were the key factor in drying out surface soil and stressing the trees' water-transpo...
A large study of nearly 60,000 patients found that stage at diagnosis only partly explains the wide variation in lung cancer survival rates among different developed countries. Treatment differences also played a key role, with some countries experiencing lower survival rates due to delays in diagnosis or suboptimal staging.
Researchers at the University of Texas M.D. Anderson Cancer Center have developed a synthetic gene circuit that can dial up or down gene expression in human cells, enabling refined research for drug resistance and cancer treatment. The circuit's precision will allow scientists to test the boundaries of genes known to confer resistance ...
Researchers found Asian needle ant successfully displacing Argentine ants in an urban environment, suggesting it may be the next dominant invasive species. The Asian needle ant's ability to tolerate cooler temperatures gives it a head start over Argentine ants, allowing it to reproduce and build nests earlier.
A low-carbon hybrid energy system is proposed to integrate coal with nuclear, wind, solar, biomass, and hydro power to reduce CO2 emission and recycle carbon. The system utilizes carbon recycling to produce useful materials while increasing energy efficiency.
Researchers sequenced genes responsible for light-sensitive pigment in 40 bird species, revealing at least 14 shifts between violet and ultraviolet color vision. This evolution is driven by single nucleotide changes in DNA, resulting in unique visual adaptations among birds.
An international team of scientists has discovered 24 new genes associated with refractive errors and myopia, a major cause of blindness worldwide. The findings could lead to new treatments or prevention strategies for this condition.
Researchers report a gigantic jet event over a thunderstorm in mainland China, with a tree-like shape and unique storm characteristics. The study uses multiple data sets to analyze the event and its associated storm.
A team of researchers at the University of Michigan's Life Sciences Institute has found that amlexanox, an off-patent drug, can reverse obesity, diabetes, and fatty liver in mice. The study suggests that the drug works by inhibiting two genes involved in metabolic balance, leading to increased metabolism and weight loss.
Researchers created an optimized parvalbumin protein, ParvE101Q, that acts as a 'calcium sponge' for heart muscle, allowing efficient relaxation after contraction. This discovery offers a promising step forward in solving diastolic heart failure, a common killer of both men and women.
NIH researchers discovered a critical transport system in Staphylococcus aureus that produces deadly toxins, paving the way for new antibiotic treatments. The system, called Pmt, is thought to play a similar role in other staphylococci, such as S. epidermidis.
A new randomized controlled trial compared the effectiveness of mechanical clot removal with standard medical therapy in treating severe strokes. The study, led by Georgetown University Medical Center, found that removing blood clots within eight hours of stroke symptoms improved survival outcomes and reduced disability levels.
A study by Johns Hopkins Bloomberg School of Public Health found that physicians who believe overconsumption of food contributes to obesity are more likely to advise patients to modify nutritional habits. The study analyzed data from 500 US primary care physicians and found a significant correlation between physician beliefs and counse...
Researchers successfully identified individual whale sharks in 85% of cases using public photographs, comparable to professional photographer identification rates. The study suggests that citizen-sourced photos can be a valuable tool for tracking whale shark populations and monitoring conservation efforts.
Researchers evaluated CT scans of patients with localized esophageal cancer before and after chemotherapy to identify changes in tumor texture. Smaller change in skewness following chemotherapy was a significant prognostic factor, with median overall survival increasing from 11.1 months to 36.1 months.
Researchers investigated genetic changes responsible for species divergence, developed new approaches to Drosophila genome manipulation, and found minimal effect of gene clustering on expression in bacteria. These findings shed light on mechanisms driving speciation and gene regulation.
A study published in the Journal of Clinical Investigation found that TGF-β is highly expressed in triple negative breast cancer cells after chemotherapy. In a mouse model, blocking TGF-β prevented tumor recurrence and enhanced chemotherapy action against triple negative breast cancer.
Research suggests that highly powerful individuals often ignore constraints, but low-power team members can serve as a check. The study found that powerful people are less likely to consider risks, while their lower-powered colleagues are more aware of potential pitfalls.
Researchers found that removing blood clots in the brain from patients experiencing severe strokes delivered no better outcomes than non-invasive standard medications. Imaging techniques were also not helpful in identifying patients who potentially would benefit most from clot removal.
A new study from Washington State University finds that mothers' eating habits at the dinner table can significantly impact their preschoolers' obesity risk. The researchers analyzed surveys of low-income African-American and Latino Head Start preschoolers and caregivers, discovering that moms who exhibit high levels of control while f...
Researchers used transgenic mice to study the effects of RAS pathway alterations on lymphatic system development. They found that excess ERK activation leads to lymphatic defects in RASopathies, which can be reversed by ERK inhibitor treatment.
Researchers at Virginia Tech discovered that Helicobacter pylori, a bacterium blamed for health issues like gastritis and gastric cancer, helps balance the stomach's ecosystem and control body weight and glucose tolerance in mice. The findings suggest that H. pylori may provide important metabolic traits required to combat diabetes.
Studies reveal that blocking TGF-β can prevent tumor recurrence in mice with triple negative breast cancer. Additionally, targeting specific subsets of immune cells, such as CD8+ regulatory T-cells, may provide a new approach to treating rheumatoid arthritis.
This study found that SUVmax is a significant and clinically independent marker for progression-free survival in stage I non-small cell lung cancer (NSCLC) patients. The research included 95 medically inoperable patients who received stereotactic body radiation therapy (SBRT), with median overall survival of 25.3 months and progression...