A phase I clinical trial shows that diffuse, large B-cell lymphomas resistant to chemotherapy can be reprogrammed to respond using the drug azacitidine. Patients whose tumors do not respond to standard therapies are being treated with a combination of approaches, including high-dose chemotherapy and stem cell transplant.
In a study of gray tree frogs, females preferred calls that were longer and more frequent, which is a challenging task. The findings support the multitasking hypothesis, suggesting that high-quality males can produce multiple signals at once.
Tropical Storm Erin weakened to a tropical depression due to cooler waters and dry air in the Eastern Atlantic. Its maximum sustained winds dropped to near 35 mph, with no significant changes expected over the next couple of days.
Tropical Storm Pewa has formed in the central Pacific, according to NASA's satellite imagery. System 90C, located about 775 miles south-southwest of Kauai, Hawaii, has a medium chance (30%) of developing into a tropical cyclone within the next 48 hours.
A new study suggests that a half-dose of prasugrel, an anti-platelet drug used to treat heart attacks, works as well as the typical dosage in older patients over 75. The research found no greater risk of bleeding problems with a lower dose of 5-mg/day prasugrel compared to the standard 75-mg clopidogrel dosage.
A UCSF team discovered that a chemical found in an anti-wrinkle cream can increase mutant PINK1 enzyme activity to near normal levels, reversing cell death caused by Parkinson's-disease mutations. This finding suggests potential for new treatment strategies and raises hope for combatting other diseases, including diabetes and cancer.
UMass Amherst microbiologist Jim Holden launches new studies on microbes living deep in undersea volcanoes, funded by private philanthropists. His work addresses questions about the first life on Earth and potential microbial life on other planets.
Researchers at MIT have developed nanosensors that can detect variations in binding strength of antibody drugs, enabling more efficient production. The sensors also measure weak interactions with sugar chains, which are essential for drug effectiveness.
Dozens of fires detected in southeastern Africa, primarily in Mozambique and Malawi, indicating intentional burning by farmers. The fires, mainly during the main growing season, have been linked to agricultural practices to enhance crop yields and manage land.
A BIDMC research team will assess the use of microRNAs as biomarkers in predicting complications in patients who have suffered heart attacks. The goal is to identify microRNA biomarkers that can predict poor health outcomes after heart attacks.
Researchers investigate calving barchan dunes, stress fields on the West Salton detachment fault, and chemical interaction between peridotite and intruding melts. These studies provide insights into geological processes, such as landscape evolution and global climate models.
A new rechargeable flow battery has been engineered by MIT researchers, generating three times as much power per square centimeter as other membraneless systems. The device stores and releases energy through laminar flow, without relying on expensive membranes, and may enable cheaper, large-scale energy storage.
Children with autism exhibit exceptional math skills compared to non-autistic peers, linked to altered patterns of brain activity in visual object processing areas. The study suggests that atypical brain development can lead to remarkable cognitive strengths, contradicting the idea that autism only brings deficits.
University of East Anglia researchers found that female salmon and trout eggs prefer their own species' sperm for fertilization, even when given a simultaneous choice. The preference is driven by the ovarian fluid surrounding the egg, which contains a chemical signal that guides the sperm towards the egg.
Researchers used large-scale computer simulations to gain a detailed understanding of the cellular recognition process of MutS and MSH2-MSH6 proteins. The study found that DNA bending facilitates the initial recognition of mismatched base pairs, leading to repair initiation.
A new study found that middle-aged men are at a greater risk for having a first heart attack due to high cholesterol levels, unlike women who are also at risk but to a lesser extent. The study suggests that men with high cholesterol should be treated more aggressively to prevent infarctions and save lives.
Fires in eastern Russia's Siberia and Urals are often set by farmers to return nutrients to the soil and clear unwanted plants. These fires produce smoke degrading air quality, highlighting the need for fire management teams to limit uncontrolled wildfires.
Researchers found that giving chemotherapy drug carboplatin before radiotherapy could reduce relapse rates and allow radiation doses to be lowered in men with stage IIA and IIB testicular seminoma. The study showed improved treatment outcomes and reduced long-term side effects.
A psoriasis researcher has received a third NIH grant to explore the nervous system's involvement in psoriasis. The study aims to identify new targets for drug development and improve patient care by investigating nerve-derived peptides critical to sustaining the disease.
A new study published in The Journal of Pediatrics found that soft drink consumption in young children is associated with increased aggressive behavior, attention problems, and withdrawal symptoms. Children who consumed four or more servings per day were nearly twice as likely to exhibit these behaviors.
The study found that the proportion of patients on antiretroviral therapy (ART) has increased, with virologic suppression rising from 35.5% to 63%, among perinatally infected HIV patients now approaching adulthood. However, older patients are more likely to experience higher viremia and advanced immunosuppression.
A new study finds that soft drink consumption is associated with aggressive behavior, attention problems, and withdrawal behavior in young children. Approximately 43% of the children consumed at least 1 serving of soft drinks per day, and those who drank 4 or more were more than twice as likely to engage in problem behaviors.