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Science News for May 9, 2013


Advance in tuberous sclerosis brain science

A new study in mice reveals that the timing of gene mutation during thalamus development significantly affects TSC-like behavioral symptoms and disease severity. The research highlights the importance of the thalamus in brain function and suggests a potential target for future treatments.

SourceBrown University·JournalNeuron·DateMay 9, 2013

Study finds brain system for emotional self-control

A new study from UCL Institute of Cognitive Neuroscience and Ghent University found that different brain areas are activated when individuals choose to suppress an emotion compared to when they are instructed to do so. This discovery could have implications for therapies targeting mental health conditions.

SourceUniversity College London·JournalBrain Structure and Function·DateMay 9, 2013

The Liverpool Care Pathway -- improvement in quality of end-of-life care

This study assesses the effectiveness of the Liverpool Care Pathway on quality of end-of-life care for adult cancer patients. The LCP provides a structured programme to improve care dimensions, resulting in clinically significant improvements in respect, kindness, dignity, family emotional support, self-efficacy, and coordination of care.

SourceSAGE·JournalPalliative Medicine·DateMay 9, 2013

Operating without interrupting warfarin reduces risk of bleeding after cardiac device surgery

A new study found that patients who underwent cardiac device surgery without interrupting warfarin treatment had a 80% lower risk of developing significant hematomas compared to those bridged with heparin. This approach also reduced prolonged hospital stays, re-interruption of anticoagulation, and re-operations.

SourceUniversity of Ottawa Heart Institute·JournalNew England Journal of Medicine·DateMay 9, 2013

New advance in biofuel production

Joint BioEnergy Institute researchers have made a breakthrough in biofuel production by developing an enzyme-free ionic liquid pre-treatment method. This technique reduces the cost of producing advanced biofuels and decreases water consumption, making it a more sustainable alternative to traditional methods.

SourceDOE/Lawrence Berkeley National Laboratory·JournalBiotechnology for Biofuels·DateMay 9, 2013

Turning old hearts

Harvard Stem Cell Institute researchers have identified a protein, GDF-11, that reverses the effects of aging on mouse hearts. The protein was found to reduce heart size and thickness, similar to healthy younger mice.

SourceHarvard University·JournalCell·DateMay 9, 2013

Exit discovered in cellular garbage truck

A team of researchers led by Professor Jean Gruenberg has identified an exit in the cellular garbage truck, a structure responsible for sorting molecules and ensuring inter-cell digestion and regulation. The study reveals how Alix protein uses this route to avoid cellular digestion and how vesicular stomatitis uses it to infect cells.

SourceUniversité de Genève·JournalDevelopmental Cell·DateMay 9, 2013

Patients should have right to control genomic health information

Bioethicists argue that patients should not be forced to receive genomic information about future health risks without their consent. The ACMG recommendations on reporting incidental findings in clinical genome sequencing are seen as problematic due to concerns over patient autonomy and cost implications.

SourceCell Press·JournalTrends in Biotechnology·DateMay 9, 2013

Early infant growth rate linked to composition of gut microbiota

A study published in PLOS Computational Biology found a link between the composition of an infant's gut microbiota and their growth rate. The researchers identified specific bacterial groups associated with expected or reduced growth rates, shedding light on the potential impact of early life gut microbiota on infant development.

SourcePLOS·JournalPLOS Computational Biology·DateMay 9, 2013

NASA's Hubble Space Telescope finds dead stars 'polluted with planet debris'

Researchers have found evidence of building blocks for Earth-sized planets in the atmospheres of two burned-out stars called white dwarfs. The silicon and low levels of carbon in these dead stars suggest that asteroid-like debris is falling onto them, potentially creating rocky planet assembly around stars.

SourceNASA/Goddard Space Flight Center·JournalMonthly Notices of the Royal Astronomical Society·DateMay 9, 2013

Mapping the embryonic epigenome

A large research team elucidated how precise chemical modifications across the genome turn genes on and off during early human development. The study found that master genes governing development are silenced by histone methylation, while genes orchestrating cellular differentiation are primarily silenced by DNA methylation.

Air pollution increases risk of insulin resistance in children

A new study published in Diabetologia found that growing up in areas with high air pollution increases the risk of insulin resistance in children. The research used data from two prospective German birth cohort studies and found a significant association between air pollution exposure and increased levels of insulin resistance.

SourceDiabetologia·JournalDiabetologia·DateMay 9, 2013

Bacterial infection in mosquitoes renders them immune to malaria parasites

Researchers have successfully infected mosquitoes with the Wolbachia bacterium, rendering them immune to malaria parasites. The scientists maintained a stable infection in Anopheles stephensi mosquitoes for 34 generations, and all infected female mosquitoes became infected within eight generations when mated with uninfected males.

Positive social support at work shown to reduce risk of diabetes

A 3.5-year-long study found that employees with high social support at work have a 22% lower chance of developing type 2 diabetes, while those with low social support are 18% more likely to develop the disease. The study highlights the importance of finding the right balance in terms of workload and providing necessary social support.

SourceAmerican Friends of Tel Aviv University·JournalJournal of Occupational Health Psychology·DateMay 9, 2013

No holes in Swiss online networking theory

Researchers from MIT found that individuals with strong connections to successful people in their online networks are more likely to succeed. Affiliation with prominent academic institutions like ETH Zurich also plays a significant role in predicting success.

SourceInderscience Publishers·JournalInternational Journal of Organisational Design and Engineering·DateMay 9, 2013

Using bacteria to stop malaria

A study at Michigan State University demonstrates that using a strain of the bacteria Wolbachia can interrupt the transmission of malaria via mosquitoes. This approach could provide an important tool in fighting the disease, particularly in areas where poverty and lack of resources are prevalent.

SourceMichigan State University·JournalScience·DateMay 9, 2013

Research finds identifies social needs of young people with cancer

Researchers found that adolescents and young adults with cancer are at higher risk for social isolation due to lack of understanding from friends and family. The study suggests developing targeted support programs to address these social information needs, including online connections and communication tools.

SourceLouisiana State University Health Sciences Center·JournalJournal of Adolescent and Young Adult Oncology·DateMay 9, 2013

Could eating peppers prevent Parkinson's?

Research suggests that eating foods containing edible Solanaceae, such as peppers and tomatoes, may reduce risk of developing Parkinson's. The study found a strong association between increased consumption of these foods and decreased risk of Parkinson's, with peppers displaying the strongest association.

SourceWiley·JournalAnnals of Neurology·DateMay 9, 2013

Unleashing the watchdog protein

McGill University researchers have discovered the three-dimensional structure of the Parkin protein, which protects neurons from cell death due to damaged mitochondria. The study's findings suggest that designing mutations in Parkin could provide better protection for nerve cells and potentially slow disease progression.

SourceMcGill University·JournalScience·DateMay 9, 2013

Doctor's choice of words may influence family's decision to permit CPR in critically ill

A study by University of Pittsburgh researchers found that physicians' word choices significantly impact families' decisions about end-of-life care, particularly the use of cardiopulmonary resuscitation (CPR). The study suggests a change in terminology from 'DNR' to 'allow natural death' can lead to a 10% decrease in CPR choice.

Scientists define a new mechanism leading to tumor hypoxia

Scientists from the University of Pennsylvania define a novel mechanism of tumor hypoxia induced by the longitudinal gradient of residual oxygen along tumor vessels as they transverse the tumor. The researchers found large regions of moderate hypoxia that were not easily explained by existing concepts, suggesting a new scale for unders...

SourceDe Gruyter·JournalTumor Microenvironment and Therapy·DateMay 9, 2013

The Lancet Series on bipolar disorder

The Lancet Series on bipolar disorder offers a comprehensive overview of the condition, including its genetic basis, diagnostic challenges, and treatment limitations. The series highlights the need for more accurate diagnosis and personalized treatments, with neuroimaging research potentially transforming bipolar diagnosis.

SourceThe Lancet_DELETED·JournalThe Lancet·DateMay 9, 2013

Elevated cadmium levels linked to disease

A recent study by Johns Hopkins scientists reveals an association between elevated cadmium levels and increased risk of liver disease in men. Higher levels of cadmium in urine were found to be nearly 3.5 times more likely to lead to liver-related deaths compared to lower levels.

SourceJohns Hopkins Medicine·JournalJournal of Gastrointestinal Surgery·DateMay 9, 2013

Researchers identifies gene associated with eczema in dogs

A novel gene associated with canine atopic dermatitis has been identified by researchers. The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure. This finding opens new possibilities in understanding the disease mechanism leading to atopic dermatitis.

SourceUppsala University·JournalPLOS Genetics·DateMay 9, 2013

Heady mathematics

University of California, Berkeley researchers James A. Sethian and Robert I. Saye describe the mathematical evolution and disappearance of foamy bubbles, a feat that could help model industrial processes and solid foam formation. They developed scale-separated equations to treat different aspects of foams with distinct sets of equations.

Geologists study mystery of 'eternal flames'

Geologists at Indiana University studied the 'Eternal Flame' in Erie County, N.Y., which may feature high concentrations of ethane and propane. The researchers identified natural gas seeps in the region, suggesting they could contribute to atmospheric concentrations of greenhouse gases.

SourceIndiana University·JournalMarine and Petroleum Geology·DateMay 9, 2013

No-win situation for agricultural expansion in the Amazon

A new study finds that agricultural expansion in the Amazon will reduce the region's natural carbon sink and inflict climate feedbacks, leading to decreased productivity of pasture and soybeans. By 2050, precipitation decrease caused by deforestation could reduce pasture productivity by up to 30% and soybean yield by up to 28%.

SourceIOP Publishing·JournalEnvironmental Research Letters·DateMay 9, 2013