A multicentre Asian registry reported early experience confirming TAVI efficacy and safety in a physically smaller population. Low stroke and mortality rates were observed, with high procedural success rates, supporting the feasibility of TAVI in Asian patients.
Two genetic mutations, PDGFRB and NOTCH3, have been identified as potential therapeutic targets for infantile myofibromatosis (IM), a rare and debilitating disorder. Current treatment options involve repeated surgical removal of tumors, which can be invasive and disfiguring.
Researchers used blazar observations to estimate the extragalactic background light (EBL) by measuring the attenuation of high-energy gamma rays. By applying this methodology to blazars at different distances, they were able to study EBL evolution and characterize its build-up over cosmic time.
A new investigational device, Helio System (TF-FA), was successfully deployed in four patients with high-risk aortic insufficiency. The device helps stabilize the Sapien XT Transcatheter Heart Valve and improves aortic insufficiency from moderate to trivial.
Scientists have simulated the sliding of 'cold ions' on a substrate, discovering that it transitions from smooth to stick-slip regime based on hole depth and chain inhomogeneity. This study contributes to understanding friction at every scale, with implications for nanotechnology development.
A new paper validates a fundamental assumption in space-for-time substitution, a popular approach for predicting relationships between complex variables. The study used fossilized pollen data to reconstruct ancient ecosystems and found that the model explained about 72 percent of the variation in their time data.
Researchers at Rockefeller University have developed a multicolor fluorescence labeling method to visualize miRNAs in tissue sections, enabling the identification of tumor-specific miRNAs and distinguishing between different tumor types. This technology shows promise as a molecular diagnostic tool for clinical settings.
Researchers have discovered that targeting regulatory T cells can help eliminate cancer cells, while a new fluorescence labeling method enables the visualization of microRNAs in tissue sections. Additionally, studies suggest that malnourishment exacerbates Giardia infection in mice, leading to severe gastrointestinal problems and growt...
A study by researchers at Empa and ETH Zurich found that none of Switzerland's households meet the 2000-watt society target, but those with high standards of living consume significantly less energy. Improving transportation and living habits are key to achieving a sustainable future.
A study found that routinely measuring fractional flow reserve (FFR) during coronary angiography changes the management of one in four patients with stable angina, according to results from the RIPCORD trial. The use of FFR led to a change in the judgement of whether a coronary artery had a 'significant' lesion in 64 patients.
Researchers discovered that targeting CTLA-4 and OX-40 proteins on regulatory T cells can help eliminate cancer cells. Mice treated with antibodies against these proteins had smaller tumors and improved survival, including clearance of brain metastases.
A recent study published in Frontiers in Human Neuroscience reveals that healthy individuals who experience auditory hallucinations have a unique brain response compared to those without mental illness. The researchers discovered that the primary auditory cortex of these individuals reacts less to external stimuli, allowing them to dir...
The American College of Physicians recommends targeting a blood glucose level of 140-200 mg/dL for surgical and medical intensive care unit patients when using intensive insulin therapy. The guidelines aim to balance the benefits and harms of hyperglycemia management in hospitalized patients.
A new study challenges traditional hypotheses on human evolution by suggesting that bipedalism emerged as a response to the terrain, rather than climate-driven vegetation changes. The research proposes that the development of upright gait was driven by the need for security and food in rocky outcrops and gorges.
A new study published in PLOS ONE found that potatoes provide a high nutritional value per penny, making them an affordable source of essential nutrients. Potatoes were ranked among the lowest-cost sources of potassium and fiber, highlighting their potential as a nutritious staple in a balanced diet.
Children who develop Type 2 diabetes are at high risk for early complications, including heart and kidney problems. The study found that young patients were more likely to develop hypertension and fatty liver due to obesity.
Researchers at OHSU have discovered a strategy to increase the number of viral peptides that T cells recognize, allowing them to more effectively respond to HIV. The method uses cytomegalovirus (CMV) to generate SIV-specific T cells that can target multiple viral peptides, providing a better targeting system for the immune system.
The British Menopause Society and Women's Health Concern have released updated guidelines on Hormone Replacement Therapy (HRT), providing clearer guidance on its role, benefits, and risks. The new recommendations aim to optimize clinical decisions and offer balanced advice for health professionals and women considering HRT treatment.
Researchers infected ferrets and pigs with the human-derived H7N9 virus, showing that both species can be infected and transmit the virus. While transmission was more efficient in ferrets, the study highlights potential public health implications of the avian virus.
The West coast log and lumber exports from the United States decreased in the first quarter of 2013, with log exports dropping 33% to $297 million. Meanwhile, total US log exports increased by 11%, while total US lumber exports also rose by 2%.
A new study found that children and adolescents with seizures involving the temporal lobe are at risk for clinically significant behavioral problems and psychiatric illness, especially depression. Routine psychiatric evaluation is crucial before epilepsy surgery to improve quality of life.
Researchers suggest focusing on boosting natural killer cells to better eliminate influenza virus, potentially overcoming drug resistance issues. Current drugs can boost NK cell activity, improving flu recovery without mutating strain susceptibility.
Researchers at UEA have made a breakthrough in breast cancer research showing that an enzyme called MMP-8 could be acting as a locator to the immune system, which then becomes activated to attack tumors. The findings suggest that this enzyme may help explain why some patients with breast tumors experience better outcomes.
Despite improvements, one-third of advanced heart failure patients don't survive three years. The study found decreased mortality and sudden cardiac death rates, but patient mortality from progressive heart failure increased.
Scientists at Emory Vaccine Center found that IL-21 is necessary for long-lasting antibody responses in mice against viral infections. The molecule stimulates germinal centers and supports T helper cells, leading to the generation of virus-specific long-lived plasma cells.
Researchers used a revolutionary X-ray laser to freeze the motion of atoms in gold nanocrystals, revealing unusual supersonic vibrations. The new images support theoretical models for light interaction with metals and have potential applications in understanding material response after perturbation.
EPFL scientists have identified the molecular basis behind sulfonamide antibiotics' neurological side effects, which can include nausea, hallucinations, and psychosis. By understanding how sulfonamides interact with a patient's nervous system, doctors may be able to customize therapeutic regimes to minimize these side effects.
A population-based study suggests that high-potency statins like atorvastatin and rosuvastatin increase the risk of developing new-onset diabetes. In contrast, fluvastatin and lovastatin appear to have a lower risk. Researchers recommend considering individual patient risk when prescribing statins.
The HERCULES Center at Emory University will investigate the impact of environmental exposures on human health. The center, funded by the National Institute of Environmental Health Sciences, aims to promote a holistic understanding of the human exposome and its effects on complex disorders such as autism, asthma, and Alzheimer's disease.
A new imaging technique developed by Jean Gotman and his colleagues combines electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) to more precisely localize the areas generating epileptic seizures. This allows neurosurgeons to better understand the optimal ways of intervention for patients with epilepsy.
A new study found that individuals whose brains are better at automatically suppressing background motion perform better on standard measures of intelligence. The test, which measures the brain's unconscious ability to filter out visual movement, shows a strong correlation with IQ scores.
Researchers found that EGFR gummed up the cell's miRNA-processing machinery, preventing tumor-suppressing microRNAs from developing. The epidermal growth factor receptor, known to promote cancer progression, fuels this effect by attaching phosphate groups to a key protein, disrupting its ability to process miRNAs.
The Institute of Medicine recommends a Whole-of-School approach to strengthen physical activity in schools. This approach targets physical education, active commuting and other opportunities to help children meet the recommended 60 minutes of daily vigorous or moderate intensity physical activity.
Pacific Northwest National Laboratory honored 165 staff for their intellectual property creations, including Inventor of the Year Jun Liu for his battery materials work. Liu's innovations have potential to create IP, with four U.S. patents and 300 peer-reviewed journal articles to his name.
The newly reported technique can greatly speed the process of discovering therapeutic antibodies with desired biological effects. The team discovered an antibody that potently mimics thrombopoietin, a hormone essential for blood clotting.
A new liposomal formulation of anthracycline-based chemotherapy has shown promising results in treating pediatric leukemia patients, with high survival rates and minimal heart toxicity. The treatment regimen was found to be effective at higher-than-standard doses without causing added cardiotoxicity.
Research confirms memory problems are a real symptom of menopause, exacerbated by hot flashes and negative emotions. Women experiencing more severe symptoms struggled with memory retention.
A new metal-organic framework (MOF) material has been developed to separate the highest-octane components of gasoline, potentially making petroleum refining cheaper and more efficient. The MOF selectively traps lower-octane isomers, allowing for a more efficient separation process.
Researchers at Salk Institute discover that protein TGF-β can promote cancer growth and survival in premalignant cells, offering hope for new treatment methods. The study's findings suggest that novel treatments may be able to halt cancer development in these cells.
A recent study found that nearly four out of ten medical students harbor unconscious biases against obese individuals, affecting clinical care and patient relationships. Medical schools are urged to incorporate bias training into their curricula to mitigate this issue.
A team of astronomers has solved a decade-old puzzle by accurately measuring the distance to star system SS Cygni at 372 light years. The team used radio telescopes and coordinated with amateur astronomers to pinpoint the exact location of the system, confirming their understanding of exotic objects like black holes.
Researchers found that caregivers experience lower care-related stressors and more positive events when their dementia patients attend adult day services. This reduces anger and decreases the impact of non-care stressors on depressive symptoms, demonstrating a buffering effect of adult day services on caregiver well-being.
A recent study found that anxious men experience significantly greater impairments from anxiety during job interviews compared to women. The researchers suggest that societal stereotypes and expectations may contribute to this disparity. Strategies for reducing interview anxiety, such as preparation and practice, are also discussed.
A new technique using primate tooth analysis has been applied to Neanderthal fossils, revealing that Neanderthal babies were weaned around 7 months old, similar to modern human infants. This method provides a precise estimate of the timing of weaning in extinct species.
A bacterium discovered in the Canadian High Arctic can survive at –15°C, the coldest temperature ever recorded for bacterial growth. This microbe adapts to extreme conditions by modifying its cell structure and producing molecular antifreeze, providing insights into the possibility of life on Mars.
A study from Western University has identified the Numb-p53 pathway as a key mechanism underlying chemotherapy resistance in triple-negative breast cancer. By targeting this pathway, researchers hope to develop novel therapies that can sensitize cancer cells to chemotherapy.
Researchers have identified a new gene in the jasmonate pathway that controls plant defenses without affecting growth. This finding could lead to improved crop resistance in agriculture by manipulating the jasmonate signaling pathway.
Soldiers at risk of PTSD if public support for war is low, social validation shapes distress from killing. Narcissists woo women more easily, while virtuous people's happiness varies across cultures, influenced by antisocial punishment and geographical distance in politics.
Researchers found that aortic arch pulse wave velocity is a strong predictor of white matter hyperintensities, which are associated with accelerated cognitive decline and Alzheimer's disease. The study used MRI to measure aortic arch pulse wave velocity in 1,270 participants and found a significant association between the two variables.
Researchers found King Richard III in a hastily dug, lozenge-shaped grave under a Leicester car park, suggesting gravediggers were in a hurry to bury him. The grave was too short for the king's body, and his torso was crammed in, with evidence of hands being tied during burial.
Researchers discovered a regenerative process involving damaged nerve fibers in the spinal cord that can improve functional recovery after stroke. The study found significant improvement in voluntary movement in mice whose axons were not severed, suggesting potential treatment targets for enhancing neurological recovery.
A team of economists found that offering gift cards increased the likelihood of donating by 26-52%, and even motivated people to donate for the first time. The authors argue that such incentives can help address blood shortages, particularly in low-income countries where donations are scarce.
Researchers from Syracuse University argue that the Earth's mantle plays a significant role in shaping the coastline and estimating long-term sea-level rise. The team's findings suggest that the shoreline has been uplifted by over 210 feet, indicating less ice melting than expected.
The Lotus Valve System demonstrated successful valve implantation in all 60 patients, meeting the primary device performance endpoint. The rate of moderate or greater aortic regurgitation decreased significantly, while mortality rates remained low.
A study found that individuals with chronic kidney disease who have a heart-healthy lifestyle are less likely to develop kidney failure. Those with four ideal factors for life's simple 7 tool had nearly half their risk cut, while those with five ideal factors didn't develop kidney failure.
The Ring Nebula's true shape has been revealed by NASA's Hubble Space Telescope, showing a more complex structure than previously thought. The new observations have allowed researchers to construct the most precise 3-D model of the nebula, revealing details such as a blue, football-shaped structure and dark, irregular knots of dense gas.
Researchers have developed a flat spray-on material that can act as a flat lens, allowing for arbitrary aperture sizes and potentially revolutionizing imaging devices. The technology has significant advancements in ultraviolet light imaging of biological specimens.
Researchers at University of Illinois developed a cradle that uses iPhone's built-in camera and processing power as a biosensor to detect toxins, proteins, bacteria, viruses and other molecules. The device can perform on-the-spot tests for environmental toxins, medical diagnostics and food safety.
Researchers used next-generation sequencing to analyze DNA alterations in adjacent Gleason patterns of the same tumor. The study found that some aggressive prostate cancers have identical genetic markers, enabling better prediction of cancer progression and management.
People with high IQ scores have more selective visual perception, discriminating between small moving objects and larger background motions. This ability helps them efficiently process information in a world filled with distractions.