The new ESC Guidelines on Cardiac Pacing and Resynchronization Therapy offer a practical 'how-to' approach for users, including a logical decision tree and clinical perspectives. The guidelines aim to increase access to the latest evidence-based medicine for patients with cardiac arrhythmias and heart failure.
A Johns Hopkins study of over 1,800 men aged 52-62 suggests that African-Americans with very-low-risk prostate cancers are more likely to have aggressive disease. The study found a higher rate of Gleason score upgrading and organ-confined cancers among black men, highlighting the need for race-specific surveillance entry criteria.
A recent study found that lung cancer in women who have never smoked is more frequently associated with EGFR mutations and estrogen receptor (ER) overexpression. The researchers observed a higher percentage of these genetic abnormalities in patients who had not previously smoked, suggesting potential new treatment targets for this group.
Researchers at NC State University are using video game technology to remotely control cockroaches on autopilot. They use Microsoft's Kinect system to track the insects' progress and steer them along a digitally plotted path. This technology has potential for mapping dynamic environments, such as collapsed buildings, with rescue teams.
A new study by St. Michael's Hospital found that the flu shot is effective in preventing the flu, even if the virus going around does not match the vaccine. The review of over 40 years of data showed significant protection against both matched and mismatched flu strains.
A study published in JAMA found that 20.2% of adolescents in Ontario experienced traumatic brain injury, with sports injuries accounting for over half of cases. The study also identified associations between TBI and substance use, highlighting the need for improved prevention and response strategies among adolescents.
D.J. Seo's research will provide timely and location-specific information for dispatching emergency personnel in flash-flooding situations, reducing response times by up to 30 minutes. The prototype will also examine the impact of development on rainfall-runoff response and improve water conservation programs in North Texas.
Lauren Sciences LLC has received a second grant from the Michael J. Fox Foundation to further develop its V-Smart therapeutic platform for treating Parkinson's disease. The grant will investigate the efficacy of V-Smart vesicles in delivering GDNF to brain regions affected by PD.
Researchers used CSIRO's Australia Telescope Compact Array to study distant star-forming clumps and discovered massive amounts of molecular hydrogen gas, a key fuel for star formation. The telescope's upgraded bandwidth and sensitivity enabled the detection of carbon monoxide, allowing scientists to estimate galaxy star-formation rates.
Death rates from heart disease have decreased in most EU countries since the early 1980s, but some nations are experiencing a slowdown in progress due to rising obesity and diabetes rates. The study found that cardiovascular disease remains a leading cause of death in Europe, with significant variation between individual countries.
Researchers found that cutlery can alter how we experience food, with weight and color affecting perceived density, saltiness, and sweetness. The study suggests that subtly changing eating implements and tableware can impact our enjoyment of food.
A study found that 20% of adolescents in Ontario reported having suffered a traumatic brain injury, with males and those with lower grades more likely to experience injuries during sports. The prevalence of TBI among young people is much higher than previously thought.
A study by the European Society of Cardiology found that excessive cola consumption can cause unusual syncope and symptoms of arrhythmia due to high fructose corn syrup content and caffeine effects. Consuming honey made from Rhododendron pollen may also lead to similar issues.
Researchers at Cedars-Sinai Medical Center have uncovered the crucial role of Caveolin-1 protein in prostate cancer tumor microenvironment. A decreased level of this protein in the stroma indicates worse prognosis and higher chance of disease relapse.
A study questions the 'read-through' drug PTC124's efficacy, suggesting it may not work as intended. Researchers found that PTC124 deceives a screening system rather than causing read-through, casting doubt on its effectiveness in treating genetic diseases like cystic fibrosis and Duchenne muscular dystrophy.
Use of advanced treatment technologies like IMRT and robotic prostatectomy has increased among men with low-risk disease, despite clinical guidelines recommending local treatment for those with a low life expectancy. The authors suggest that aggressive direct-to-consumer marketing and incentives may promote the use of these treatments.
Researchers at IDIBELL and ICO aim to study pathogenicity of variants in DNA repair genes MSH2 and MSH6. The funding will improve molecular diagnostics of Lynch syndrome, enabling better risk assessment and prevention measures.
A recent study published in PLOS Medicine found a causal relationship between adiposity and heart failure, as well as elevated liver enzymes. The research analyzed genetic data from nearly 200,000 individuals and discovered that higher BMI is associated with increased risk of heart failure and other cardiometabolic traits.
A three-year longitudinal study found that students receiving consistent individualized instruction from first to third grade showed the strongest reading skills. This led to a significant improvement in reading proficiency among these students compared to those without such instruction.
Research by Northwestern Medicine cardiologist Jeffrey Goldberger combines evidence-based guidelines with tailored treatment for patients, reducing over-treatment and under-treatment. By analyzing clinical data and individual characteristics, physicians can make more precise decisions, leading to better patient care.
Researchers evaluate immunohistochemistry for detecting ALK rearrangement in lung adenocarcinoma, finding it a reliable and cost-effective method. The study suggests that IHC can effectively detect ALK rearrangement and identify suitable candidates for targeted therapy.
Researchers found that people who are blindfolded employ the same strategy to intercept a running ball carrier as people who can see, suggesting multiple areas of the brain cooperate to accomplish the task. The constant target-heading angle strategy allows for effective capture in various situations.
Researchers developed a single-pixel imaging technique using coded apertures to quickly manipulate THz waves, producing high-fidelity images in seconds. The technique has the potential to revolutionize areas like chemical fingerprinting, security imaging, and real-time skin cancer detection.
Researchers at USC Norris Comprehensive Cancer Center have discovered a promising new way to treat primary effusion lymphoma (PEL), a rare and aggressive blood cancer often found in people with HIV. BRD4 inhibitors show effectiveness against PEL, which has a poor prognosis, offering hope for new therapies.
Researchers at the University of Zurich found that brain areas communicate differently based on the task to be solved, with specific neurons activated for distinct tasks, and this can help develop therapies for impaired cognitive abilities in patients with Alzheimer's disease, Autism, and Schizophrenia.
Yinsheng Wang, a UC Riverside professor of chemistry, has received the prestigious Biemann Medal for his significant contributions to mass spectrometry. The award recognizes his work on DNA damage and anti-tumor drugs, highlighting the importance of mass spectrometry in understanding genetic information.
NREL is enhancing its research capabilities through a 2-year loan of four Fuel Cell Hybrid Vehicles from Toyota. The vehicles will help investigate hydrogen fueling infrastructure, renewable hydrogen production, and vehicle performance. Testing includes observing durability and reliability.
Researchers at NYU-Poly developed streamloading, a technique that splits videos into two layers for efficient streaming. By pre-downloading the enhancement layer, users can improve video quality while reducing data usage and delays.
The GAP-AF study found that complete ablation with complete linear lesions around pulmonary veins was more effective than incomplete lesions in preventing AF recurrence. This approach resulted in higher success rates and longer periods of sinus rhythm compared to incomplete procedures.
Researchers at Case Western Reserve University have developed a therapeutic approach to restore nitric oxide levels in donated blood, improving tissue oxygen delivery and kidney function. The treatment, called renitrosylation therapy, may hold great promise for millions of patients who receive regular blood transfusions.
Researchers found a 65% increase in IBD hospital discharges from 2000 to 2009, with specific increases seen in Crohn's disease and ulcerative colitis. The study suggests an unclear reason behind the trend, with potential contributors including increased disease severity and co-existing conditions.
A study by Kessler Foundation researchers found that brain reserve and cognitive reserve can protect against cognitive decline in multiple sclerosis patients. The research used imaging studies to estimate brain reserve and disease burden in 62 patients, as well as measuring early-life cognitive leisure as a source of cognitive reserve.
Scientists at the Wyss Institute have engineered E. coli bacteria to mass-produce medium-chain fatty acids, which can be converted into an energy-packed liquid fuel for internal-combustion engines. This breakthrough could lead to a sustainable replacement for gasoline in cars and other vehicles.
A study published by Max-Planck-Gesellschaft found that hunger modifies brain pathways and behavior, causing hungry individuals to take more risks. In fruit flies, a specific nerve cell transports carbon dioxide information to the mushroom body, triggering flight responses in hungry but not fed animals.
Researchers found that hydropower could accommodate unexpected variations in wind energy, but only if operating guidelines were relaxed over a two-week period. Changing these guidelines is complex and may require congressional action, according to Penn State researchers.
The Energy Systems Integration Facility (ESIF) is a new research center that aims to boost clean energy technologies on a smarter grid. The facility will house experimental laboratories and outdoor test beds, including a petascale supercomputer, to support large-scale modeling and simulation. Advanced Energy Industries has already sign...
A study has found that human and canine B-cell lymphoma expression profiles are similar, providing a new model for understanding the disease. This discovery may facilitate faster development of new therapies for both humans and dogs with lymphoma.
Researchers discovered that low-molecular-weight PAHs, such as 1-MeA, can promote cancer growth by disrupting cell communication and upregulating inflammatory genes. These findings suggest that even less toxic PAHs can contribute to cancer development when exposed to secondhand smoke.
A new study published in EPJ B suggests that specific parameters can help avert economic collapses. By optimizing macro-economic parameters, economists can move an economy around a tipping point, thus averting disaster.
A new study from Michigan State University found that spatial training significantly improves addition and subtraction scores in children aged 6-8. The researchers also discovered a causal connection between spatial reasoning and math performance.
Researchers developed a technique to promote nerve regeneration after spinal cord injury, restoring bladder function in paralyzed adult rats. The findings suggest similar strategies may be useful for human patients and offer great hope for the future of treating bladder dysfunction.
A new study published in Radiology found that moderate-intensity exercise significantly decreases fat volume in the abdomen, liver, and around the heart in patients with type 2 diabetes. The results suggest that exercise can reduce cardiovascular risk by targeting specific fat deposits.
According to Newen and Barlassina's integrative embodiment theory of emotions, feelings of bodily processes are combined with cognitive contents to form a separate mental state. This model addresses the limitations of earlier theories, such as James-Lange and cognitive theories, which neglect the role of bodily states in emotion.
Scientific studies estimate Colorado River flow declines of 6-45% by 2050, varying due to climate models and spatial resolution. The new study provides a framework for comparison, identifying key factors affecting predictions.
A long-term study measuring the association between PTSD and heart disease found that male twin Vietnam veterans with PTSD were almost twice as likely to develop heart disease, even after accounting for lifestyle factors. The study suggests a link between PTSD and cardiovascular health.
Researchers at Columbia University Medical Center have found that caspase-2 is a key regulator of cognitive decline in Alzheimer's disease. The study suggests that inhibiting this protein could prevent neuronal damage and cognitive decline associated with the disease.
Studies explore the benefits of behavioral interventions for managing diabetes, as well as the impact of insulin pump therapy and fetal outcomes in diabetic women. Researchers from Montefiore Medical Center and Albert Einstein College of Medicine present their findings on these topics at the American Diabetes Association meeting.
Researchers at H. Lee Moffitt Cancer Center have developed a new method to rapidly identify genetic changes in small protein fragments unique to melanoma cancer cells. The approach harnesses tumor-infiltrating lymphocytes, which have been shown to reduce cancerous lesions and improve outcomes.
Prader-Willi syndrome is associated with the loss of non-coding RNAs, resulting in dysregulation of circadian and metabolic genes. The study found that mice engineered with the loss of a long non-coding RNA showed altered energy use and metabolic differences during sleep.
A team of Johns Hopkins graduate students has designed a device to inspect breast tissue in real-time, reducing the need for follow-up surgeries. The device applies an adhesive film to the tissue, preventing damage and allowing pathologists to quickly review samples within 20 minutes.
Researchers at Concordia University have found that oxytocin can increase a person's trust in others following social rejection. In a double-blind experiment, participants who received oxytocin prior to being subjected to social rejection reported greater trust in other people compared to those who received a placebo.
A new study published in The Veterinary Journal found that high-quality microchip scanners can accurately read horse transponders, contradicting the claim that identification failure rates are too high. Researchers tested over 400 horses and found that even low-end scanners performed better than traditional branding methods.
Researchers found that women who had taken at least one computer science class were less likely to mention stereotypical characteristics, while men's descriptions remained unchanged. The studies also showed that exposing students to accurate portrayals of computer scientists increased interest in the field among women.
A new framework, telecoupling, describes how distance is shrinking and connections are strengthening between nature and humans. It shows how environmental and socioeconomic actions lead to reactions and feedbacks that reverberate globally, affecting global sustainability.
An international team of astronomers has detected six to seven planets around the nearby star GJ667C, including three 'super-Earths' in its habitable zone. This is the first time that so many super-Earths have been found in a single system. The discovery provides insight into the possibility of life on these potentially rocky planets.
A research team at Ruhr-University Bochum has identified a new type of signalling mechanism in plant cells, involving the glutamate-like receptor AtGLR1.4. The receptor responds to multiple amino acids, including methionine, which is an essential nutrient for humans but can be produced by plants.
A study by MassGeneral Hospital for Children found that pediatric practices can effectively implement a smoking cessation program for parents, reaching nearly half of smoking parents. The program, CEASE, was trained in 20 practices and resulted in significant increases in tobacco control assistance and physician referrals.
The study reveals that species with low muscle activation frequency and high body stiffness are most successful in swimming. The researchers found the optimal values for each property, including a predicted stiffness similar to that of undulatory swimmers with a backbone.
Research reveals Ailanthus tree's rapid growth and dominance in Pennsylvania clearcuts, displacing native plants. The tree's spread has accelerated with human activities like logging, mining, and drilling.
A new paper by Sapna Cheryan and colleagues found that downplaying the stereotype of a 'computer nerd' in print media increases women's interest in further education in computer science. The researchers manipulated students' images of a computer scientist using fabricated newspaper articles, revealing that exposure to a non-stereotypic...