A new study found that empagliflozin lowers blood pressure in patients with Type 2 diabetes and hypertension. The drug also reduced blood glucose levels by 0.62-0.65 percentage points, suggesting a potential to reduce cardiovascular events.
A Monash University study reveals the detailed structure of milk during digestion, providing insights into its interaction with the human digestive system. The research could lead to the development of new milk products and a new system for drug delivery.
Biologists at UC San Diego found the missing link to protein factory production, revealing a novel regulatory system that produces ribosomal proteins. This discovery provides new insights into controlling cell growth and potentially treating diseases like cancer.
Researchers at Duke University, University of Michigan, and Stanford University have determined the underlying architecture of a cellular signaling complex involved in responding to stimuli such as light and pain. The findings reveal a two-step mechanism that has been hypothesized previously but not directly documented.
A study found that vitamin D treatment improved glucose tolerance and insulin sensitivity in obese rats, reducing food intake and weight. The findings suggest a potential role of vitamin D in the onset of obesity and Type 2 diabetes through its action in the brain.
A multinational study found that long-term denosumab treatment in postmenopausal women with osteoporosis leads to significant increases in bone density and sustained low rates of fractures. The treatment also shows a favorable benefit/risk profile, with no increase in overall risk of cancer, infection, or cardiovascular disease.
Researchers at Kansas State University have found evidence that the Higgs boson is responsible for generating mass in fundamental particles, such as electrons. This discovery reinforces existing theories and provides new insights into how the universe works.
Scientists at EMBL and DKFZ identified two sister genes, GFI1B and GFI1, as major drivers of Group 3 medulloblastoma. Large-scale DNA rearrangements relocate these genes, activating them and driving tumour formation.
A new survey reveals that nearly 70% of adults with Type 1 diabetes do not use their blood glucose self-monitoring devices or insulin pumps to download historical data about their blood sugar levels and insulin doses. Only 12% of patients regularly review their past glucose and insulin pump data at home.
A study in Australia discovered that some nutritional sports supplements marketed to athletes are secretly fortified with androgens, which are banned from use in sports. The presence of these substances poses recognized health risks to both athletes and the general public.
A new study from Turkey finds that women with gestational diabetes perform worse on cognitive function tests, including a 30-point test for mild cognitive impairment and visual memory tests. The researchers suggest that early interventions and therapies may delay cognitive impairment in diabetes.
A collaborative study has identified two oncogenes, GFI1 and GFI1B, that drive the development of medulloblastoma, the most common malignant brain tumor in children. The findings suggest these genes are worthy candidates for molecular-targeted therapy.
Researchers have identified a new therapeutic target for certain myeloproliferative diseases by targeting the microenvironment that sustains hematopoietic stem cells. The treatment involves using clinically approved medications to prevent or reverse damage to this microenvironment.
A study found that individuals with growth hormone receptor deficiency have increased insulin sensitivity, preventing Type 2 diabetes and lowering their risk for cancer. Despite higher body fat content, their bodies were more responsive to insulin, suggesting a potential protective effect against these diseases.
A new study finds that ambient temperatures can influence brown fat growth or loss in humans. Brown fat burns energy to generate heat and improves insulin sensitivity when stimulated by cool environments.
Case Western Reserve scientists pinpoint the channeling of cell's energy flow in moving metal ions using advanced imaging technologies. This finding has the potential to inform future research on treating diseases such as Parkinson's, chronic liver disease, and heart disease.
Researchers found that long-term mild cold exposure increased brown fat amount and activity in humans, while mild warmth suppressed it. This discovery may lead to new avenues in treating impaired glucose metabolism and obesity.
Scientists have found a constant ratio between excitatory and inhibitory neurons that maintains the brain's internal balance. This E/I ratio allows for subtle control over response to stimuli, preventing runaway firing or permanent quiescence.
Researchers found that mice exposed to tolylfluanid developed metabolic changes similar to those of human metabolic syndrome, including increased blood sugar and body fat. The study suggests potential health risks for humans exposed to the fungicide.
A recent study has found that hypothyroidism can cause impaired driving abilities, comparable to the effects of drinking alcohol. The research suggests that patients with significant hypothyroidism should avoid driving until they have been treated with thyroid hormone.
A new study found that testosterone replacement therapy can improve aerobic capacity and lessen its decline with age in older men with limited mobility. The therapy showed a significant reduction in the rate of decline of an important marker of physical fitness in these men.
A new study reveals that regional weather extremes are strongly related to large-scale wave patterns in the atmosphere. The research found that certain regions of Europe, Asia, and the US are more prone to prolonged bouts of unseasonal weather, including hot and cold spells, droughts, and wet periods.
Researchers at Johns Hopkins University deciphered the inner workings of YiiP, a protein that prevents zinc toxicity in bacteria. The study reveals how protons drive the transport of zinc ions across cell membranes, shedding light on potential targets for modulating ZnT proteins and treating type 2 diabetes.
Scientists observe a mysterious geologic object on Ligeia Mare, the second-largest sea on Saturn's moon Titan, which may be the first observation of dynamic geological processes. The 'Magic Island' is thought to result from changing seasons and could provide insights into Titan's liquid environments.
A study found that older adults have fewer taste buds, leading to higher fasting blood sugar levels and lower adiponectin levels. The researchers suggest a link between the number of taste buds and glucose metabolism during aging.
Researchers have successfully detected the Higgs boson decaying directly into fermions, a discovery that confirms theoretical predictions. The analysis of data gathered at the Large Hadron Collider reveals an accumulation of decays near 125 GeV and with a significance of 3.8 sigma.
A team of international researchers has created 'molecular tadpoles' with unique properties, allowing for improved detergent performance and potential applications in flexible electronics. These molecules are formed by modifying 'bucky balls' with long chains, enabling them to assemble into extended structures.
Patients with metabolic syndrome who exercise before dieting show less muscle loss, according to a new study. Exercising prior to weight loss initiation preserves muscle mass and reduces frailty.
A new study suggests that concentrating solar power (CSP) can provide a substantial amount of current energy demand, particularly in the Mediterranean region. CSP systems can store energy as heat and convert it to electricity only when needed, making them more viable for large-scale energy production. The study also found that CSP coul...
Researchers found that high blood glucose levels increase neurotransmitter associated with depression and alter brain connections in patients with Type 1 diabetes. The study suggests a biological mechanism for the increased risk of depression in these individuals.
A new study found that soy protein supplements containing phytoestrogens do not reduce testosterone levels in men with Type 2 diabetes. Instead, they improve diabetes control and cardiovascular risk factors. The supplements also show promise in reducing the risk of heart disease.
A new study by the Endocrine Society found that BPA reprograms human fetal prostate tissue, increasing the risk of precancerous lesions. Exposure to low doses of BPA was shown to alter fetal prostate formation and increase stem cells, potentially leading to disease with aging.
A major new Series in The Lancet emphasizes the critical role of midwifery in saving millions of women and children worldwide. Effective midwifery can prevent up to three-quarters of stillbirths and maternal deaths, and even modest improvements in coverage could halve current rates by 2030.
A study published by the Endocrine Society found that low testosterone levels are linked to a higher risk of declining physical function in older men. The researchers also discovered that muscle weakness, possibly caused by decreased testosterone levels, may explain most of this relationship.