The study reveals that bacterial defense mechanisms are highly organized in response to nutrient stress, but become disorganized when faced with antibiotics. The researchers used experimental and computational methods to understand the workings of the bacterial defense system.
A new machine learning program developed by researchers at Case Western Reserve University appears to outperform other methods for diagnosing Alzheimer's disease before symptoms begin. The program integrates various indicators of the disease, including mild cognitive impairment, to predict who has Alzheimer's and those with mild cognit...
A new study found that women with early-stage breast cancer are more likely to consider double mastectomy due to their decision-making habits and values. Researchers surveyed 2,362 women and discovered that those who were worried about making a bad decision and wanted to make their own choices were more likely to consider the aggressiv...
North Carolina State University engineers have developed a hands-free method for filling complex microchannels with liquid metal using vacuum, eliminating the need for outlets and reducing defects. This approach enables broader use of liquid metals in electronic and microfluidic applications.
A University of Texas at Arlington civil engineer will model large-diameter water transmission pipes' behavior in different types of soils to establish modeling standards. The research aims to improve the reliability and economics of large diameter pipelines, ensuring a long-lasting and sustainable way of building drinking water infras...
PCORI's Board of Governors approved nearly $74 million for seven studies on palliative care. The projects will compare different strategies to deliver care and examine their impact on quality of life, hospitalizations, and caregiver burden.
A new study by Georgia Institute of Technology researchers has found that a widespread biological concept affecting cancer research could be incorrect up to two-thirds of the time. The study's findings suggest that targeting proteins based on messenger RNA levels may not be optimal, potentially leading to drug targeting errors.
A high-intensity exercise program combined with a diet plan resulted in improved blood glucose levels among adults with type 2 diabetes. The study found that 73.5% of lifestyle participants required fewer glucose-lowering medications, compared to 26.4% in the standard care group.
Researchers have discovered a critical role for type III interferon signaling in controlling Yellow Fever Virus (YFV) infection, particularly in preventing viral brain invasion and maintaining blood-brain barrier integrity. This finding provides new insights into the complex mechanisms regulating YFV infection.
A randomized controlled trial found that a brief behavioral treatment delivered by community lay workers significantly reduced psychological distress in women exposed to gender-based violence. The study tested the effectiveness of Problem Management Plus, a WHO-developed intervention, and showed promising results with a moderate effect...
Researchers have identified a gene, H2-Ob, that enables mice to resist persistent viral infections by producing specific antibodies. This gene is part of the MHC locus and acts as a negative regulator of the immune response, keeping chronic infections in check.
Researchers found that ECT had no specific anti-insomnia effect on older patients with depression. In fact, their insomnia problems persisted despite treatment improvements in non-insomnia symptoms. The study suggests that ECT may not be a reliable option for addressing sleep issues in this population.
Researchers developed a novel method to identify neural structures associated with impaired auditory word comprehension after stroke. The study mapped white matter connections beyond the damaged area, revealing crucial networks involved in speech comprehension and proposing targeted therapy approaches.
Scientists at the University of Oxford have developed a new method to 3D-print laboratory-grown cells into high-resolution tissue constructs. The approach improves cell survival rates and enables the fabrication of patterned cellular constructs that mimic natural tissues.
A new study in The American Journal of Geriatric Psychiatry found that middle-aged and older adults can successfully use a smartphone-based intervention to self-manage their serious mental illness. The app takes patients through 10 sessions over three months, covering topics such as stress vulnerability and medication adherence.
Research examines alternative reasons for climate change denial in Louisiana, highlighting economic and cultural influences. Despite high rates of denial, parish residents show environmental awareness, suggesting a focus on local issues like coastal erosion.
A new study reveals that beets can produce a pigment with high antioxidant properties, boosting crop nutrition and resistance to disease. The researchers successfully engineered plants to produce this pigment, which also showed promise in controlling gray mold in crops.
Researchers developed laser-driven plasma acceleration using low-energy, ultrashort mid-infrared laser pulses, producing relativistic electron beams. The team's findings demonstrate the potential of long-wavelength femtosecond lasers for compact and high-repetition-rate accelerators.
Researchers created a device using graphene and boron nitride, achieving unprecedented spin transport efficiency at room temperature. The device showed significant improvements in spin polarization and detection, opening up possibilities for applications such as spin-based logic and transistors.
The University of Bristol team has developed a 3D-printed acoustic levitator, allowing users to levitate liquids and insects at home. This technique has the potential to improve diagnosis in blood tests and support innovative processes in pharmaceuticals and biology.
The Biophysical Society has announced its 2018 award recipients, honoring outstanding contributions to the field of biophysics. The winners include Jue Chen, Wonhwa Cho, Bianxiao Cui, Taekjip Ha, Leslie Loew, Carrie Partch, Madeline Shea, and James Spudich for their innovative research and advancements in biophysics.
The study examined three types of distracting elements: sensorimotor, cognitive, and emotional. Researchers found that texting led to more dangerous driving, while a 'sixth sense' protected drivers from emotional upset or absent-mindedness.
Researchers found that only half of Accelerated Approval post-approval studies were completed within three years, and the characteristics did not differ much from pre-approval studies. The proportion of randomized or blinded trials was also similar.
Researchers found immigrant detention centers function like jails, with inmates required to wear orange jumpsuits and color-coded by threat level. The centers are often built in remote locations, making it difficult for detainees to communicate with families or access legal assistance.
A NASA-led CubeSat mission, CUVE, is designed to investigate the nature of a mysterious absorber in Venus' uppermost cloud layer. The mission will utilize ultraviolet-sensitive instruments and a novel carbon-nanotube light-gathering mirror to gather data.
A study by Justin Knoll found that individuals with a high tolerance for incivility are more likely to engage in online behaviors such as commenting on news stories, participating in discussions, and donating to candidates. In contrast, activities like signing petitions and circulating content were not affected.
A study published in JAMA found that drugs granted accelerated FDA approval often relied on nonrandomized studies and surrogate measures to confirm efficacy, with many lacking statistically detectable differences in design features between pre- and post-approval trials. Despite positive results from postmarketing studies, clinical bene...
Researchers at University of Cambridge and Natural History Museum analyze 450 anatomical characteristics to place Chilesaurus in dinosaur family tree. The study reveals Chilesaurus fills a large gap between two major dinosaur groups, with implications for understanding the origins of Ornithischia.
A team of UK researchers investigated the impact of water droplets on spherical soft surfaces, revealing that surface curvature enhances retraction of impacted drops. The effects of impact parameters, including diameter ratios and polymer elastic modulus, were also studied.
Research reveals distinct molecular patterns in premature infants' cerebellum, indicating a cellular response to interrupted development. The findings may offer insights into long-term complications of pre-term birth and potential interventions to improve outcomes.
A new chewing gum-based diagnostic test can detect inflammation in the oral cavity within five minutes, allowing for early diagnosis and treatment. The test uses bittering agents to identify inflammatory conditions, which can help prevent serious complications such as bone loss.
A new AI system developed by MIT researchers reduces online video rebuffering and improves quality, adapting to different network conditions. The system achieves higher-quality streaming with less rebuffering than existing approaches.
Children from low-income families who grow up in counties with high upward mobility show significant gains in cognitive test scores between ages 3 and 9. Behavioral problems, such as aggression and rule-breaking, also decrease at age 3 and remain stable over time.
According to a new literature review, therapeutic modalities such as physical therapy can improve bone-and-joint function affected by pain and/or injury. The study highlights the utility of various modalities, including cryotherapy, neuromuscular electrical stimulation, hot and cold therapies, cupping therapy, and iontophoresis, in man...
A new study found that partners who have low power in their relationships are stuck with their partner's preferred brands, leading to a death-by-a-thousand-cuts feeling and decreased happiness. The researchers used brand preferences in various products to study individuals and couples over two years.
Researchers studied viruses from different eras to understand how they evade the host's immune response. Viruses collected in the 1990s are more effective at suppressing immune systems than those from the 1950s, leading to severe symptoms and high mortality rates.
The USGS has awarded $4.9 million to six universities and a non-profit organization to support the transition of the ShakeAlert system into a production system. The partnership aims to improve the sensor and telemetry infrastructure across the western United States.
A Johns Hopkins study found that individuals with mild cognitive decline have lower levels of serotonin transporters, suggesting a possible driver of the disease. The research suggests increasing serotonin function may prevent memory loss and slow disease progression.
Researchers at Mayo Clinic have identified a link between SPOP gene mutations and treatment resistance in prostate cancer. The discovery suggests ways to improve therapy by using these mutations as biomarkers. This breakthrough could lead to more effective treatments for this common and deadly form of cancer.
Researchers from NIST and Michigan State University have developed an algorithm that automates the key decision point in fingerprint analysis, reducing human subjectivity and improving reliability. The new system uses machine learning to score latent prints based on their quality, allowing for more efficient processing of evidence.
Researchers found that conscious sedation allowed for real-time brain function monitoring, enabling adjustments mid-surgery to reduce ischemic injury risk. The study shows promise in improving outcomes and decreasing risk associated with brain aneurysm surgery.
A new study found that cognitive abilities in adolescence are positively related, suggesting a 'mutualism' model where skills help each other develop. This research has implications for understanding developmental challenges and life outcomes, such as academic success and longevity.
A genome-scale analysis of 82 mammalian species reveals continuous placental mammal diversification despite the KPg extinction. The findings support the fossil record and challenge the notion that the event hindered their diversification.
Research suggests that traumatic brain injuries in childhood and adolescence can increase the risk of alcohol abuse problems in adulthood. The study found a clearer link between brain injury and alcohol abuse in people who suffered an injury before age 5, with children under 5 being over 3.6 times more likely to exhibit substance abuse...
Research reveals that testosterone plays a crucial role in regulating canary birdsong by targeting specific brain regions involved in singing. The nucleus of the arcopallium (RA) regulates song unit production, while HVC influences syntactical features such as syllable repetition and trill duration.
A study by the European Center of Pharmaceutical Medicine at the University of Basel compared regulatory requirements for new drugs across 12 countries, revealing significant variations. Harmonization could improve efficiency and reduce prices, making innovative drugs available faster.
Astronomers have caught a cosmic event in great detail, observing a supernova and its explosive ejecta slamming into a nearby companion star. The discovery was made possible by a specialized survey taking advantage of recent advances in linking telescopes across the globe.
Researchers have developed a novel blood biopsy test that reads platelets to detect human lung cancer with high accuracy. The thromboSeq test analyzes tumor RNA absorbed by circulating platelets and has shown promising results in diagnosing non-small cell lung cancer, achieving up to 90% accuracy.
Patients with newly diagnosed cancer face a substantially increased short-term risk of arterial thromboembolism. Lung, gastric, and pancreatic cancers are associated with the highest risk, while advanced disease increases overall tumor burden.
Researchers found knee OA in 16% of postindustrial individuals 50+, but only 6% and 8% in early industrial and prehistoric samples. The findings suggest an approximate doubling of knee OA prevalence since the mid-20th century.
Researchers have successfully enhanced spider silk's strength and toughness by incorporating carbon nanotubes or graphene. The resulting silk boasts up to three times the strength and ten times the toughness of regular material.
Researchers found that oxytocin increased generosity towards refugees, but only when combined with social norms. Donations from individuals with a defensive attitude towards migrants nearly doubled when presented with the average donation of their peers.
Researchers found that NS1 suppresses the body's immune responses to viral infection, suggesting a new approach to combat influenza A virus infection. The study proposes developing a live attenuated vaccine based on an engineered influenza A virus lacking NS1 and designing antiviral drugs targeting NS1.
A University of Michigan professor analyzed sailors' mouths for clues in the 1845 Franklin expedition disaster. The study found that tuberculosis resulting in adrenal insufficiency, or Addison's disease, likely contributed to the crew's deaths.
A study found that visually stimulated cross-modal activation of auditory brain regions in deaf individuals improved speech comprehension after cochlear implantation. Auditory cortex activation developed in tandem with both auditory and visual speech following implantation, suggesting a positive effect on hearing restoration.
Researchers have discovered that cancer-fighting T cells can recognize infected cells with much less evidence of cancer than previously believed. The study, which used optical tweezers to apply a tiny amount of force to the T cells, found that they can bind to just two peptides for activation
A new study by Cedars-Sinai Medical Center suggests that cardiac stem cell infusions could reverse aging in the human heart. Cardiosphere-derived cells secrete tiny vesicles containing RNA and proteins, which may turn back the clock for age-related heart conditions.
Researchers identified the 57th plate using multibeam sonar soundings and plate-motion circuits. The discovery resolves a misfit in the Pacific-Cocos-Nazca circuit, indicating another unknown plate's presence.
Tropical Storm Jova formed on August 11, but just two days later, it was being torn apart by strong vertical wind shear. The storm weakened into a post-tropical cyclone by August 14, with maximum sustained winds near 35 mph and an estimated minimum central pressure of 1005 millibars.
A global analysis of rainfall and rivers reveals more intense flooding in cities and smaller catchments, coupled with a drier countryside. This is attributed to rising local temperatures causing more evaporation from moist soils, leading to reduced water flows in rural areas.