The partnership aims to increase enrollment in clinical trials, making research opportunities more accessible to patients. UCCCC and Lilly will work together to open studies faster and connect more patients with research opportunities.
Researchers at the University of Chicago report a promising new strategy using BifidoSumIL-2, an engineered bacterial strain, to deliver an immune-stimulating therapy directly into pancreatic tumors. The treatment selectively activates cancer-fighting T cells and slows tumor growth, even when combined with chemotherapy or radiotherapy.
Researchers found no correlation between SuperAgers' exceptional memory and low inherited Alzheimer's disease risk. Instead, they identified unique biological and psychosocial characteristics associated with SuperAging.
A groundbreaking quadruple-organ transplant at UChicago Medicine has saved the life of a young woman with cystic fibrosis. The surgery, performed by a team of experts, successfully transplanted her liver, kidney, and two lungs, offering her a second chance at life.
A new study found that nonprofit hospitals spent at least $7.8 billion on management consulting services between 2010-2022, but saw no significant changes in finances, staffing, operations, or patient outcomes. The study suggests greater transparency and public accountability for how hospitals use tax-subsidized dollars.
Researchers developed a DNA methylation-based biomarker associated with arsenic exposure that can predict toxicity risk. The biomarker identified sites in the genome linked to arsenic exposure and showed strong evidence of causal relationships between arsenic exposure and chronic conditions like cancer and cardiovascular disease.
The study examines the cumulative physical, cognitive and psychological demands of a Formula 1 season on team personnel. Researchers aim to develop targeted interventions to support performance, recovery and well-being in one of the world's most demanding team environments.
Research at UChicago Medicine found that clinicians who perceive patients with sickle cell disease as opioid users are more likely to experience bias and provide lower quality care. The study highlights the need for increased awareness and education on overcoming biases related to chronic pain management.
A new study finds that heart failure and atrial fibrillation share similar genetic and molecular mechanisms, suggesting a more nuanced understanding of these two conditions. The research reveals that the pathological response involves multiple cell types communicating with each other, leading to a fundamental shift in how atrial fibril...
A recent study found that the opening of a trauma center in Chicago's South Side reduced firearm mortality by nearly 4% due to faster and closer emergency treatment. The study analyzed data on over 45,000 firearm-related incidents between 2010 and 2024.
A new spinosaurid species, S. mirabilis, with a distinctive scimitar-shaped crest has been discovered in Niger's central Sahara, adding to the understanding of spinosaurid evolution. The fossil find challenges the long-held hypothesis that these fish-eating theropods lived in an oceanic habitat.
The Merck Foundation grant will support a new primary care initiative focused on the cardiovascular health of formerly incarcerated Black men in Chicago. The program aims to provide integrated, comprehensive care that addresses high blood pressure and reduces the risk for heart attacks and strokes.
The new intraoperative MRI technology enables real-time functional scans during neurosurgery, allowing doctors to detect complications and tailor their approach. This innovation saves time, labor, and improves safety and recovery for patients.
Researchers developed polygenic risk score models to predict breast cancer risk in women of African ancestry, improving accuracy and performance compared to existing models. The new tools could lead to earlier screening, tailored care, and increased survival rates for high-risk women.
The new clinic brings advanced OB/GYN services to the Southland, addressing longstanding gaps in complex maternal and women's healthcare. It offers cervical cancer screening, contraception, minimally invasive surgery for conditions like fibroids and endometriosis, and high-risk pregnancy care.
A recent study published in The Lancet Neurology found that patients with acute ischemic stroke who experience prolonged transfer times are more likely to leave the hospital with significant disability. The study of over 20,000 patients highlighted the need for shorter transfer times to improve patient outcomes.
The Ralph Lauren Corporate Foundation has awarded a grant to establish the UChicago Medicine Ralph Lauren Center, expanding access to high-quality cancer screening and care in Chicago's South Side. The new center will focus on personalized and comprehensive approaches to patient navigation and prevention services.
A 2.6-million-year-old partial jaw of Paranthropus, discovered in Afar, Ethiopia, expands the known geographic distribution of the genus northward by 1000 km. The fossil reveals that Paranthropus was as widespread and versatile as Homo, challenging previous assumptions about its dietary specialization and competition with other hominins.
A new study found that breast milk carries a distinct mix of bacterial species dominated by Bifidobacterium longum, which is highly prevalent in the infant gut. The researchers also discovered
A study found that hospitals sold to REITs were more than five times as likely to close or file for bankruptcy compared to similar hospitals. The researchers analyzed nearly 20 years of data and found no immediate improvements in finances or quality, but long-term harms, including increased risk of closure or bankruptcy.
Two new studies found that ambient clinical documentation tools can cut down on administrative time and help physicians be more mentally healthy and present with patients. Clinicians who used the tool reported lower burnout and lighter cognitive load, while also spending less time interacting with electronic health records.
Researchers at the University of Chicago discovered that YTHDF2 regulates RNA metabolism to suppress inflammatory responses, potentially preventing skin cancer. The study found that UV exposure triggers a decrease in YTHDF2 levels, leading to increased inflammation and tumorigenesis.
A team of UChicago paleontologists unveiled fossil specimens of the duck-billed dinosaur Edmontosaurus annectens, revealing its fleshy external anatomy in unprecedented detail. The 'mummies' preserved fine details of scales and hooves, including a spike row over its tail and hooves sheathing its toes.
Researchers found that nearly all patients (94.8%) had at least one legal need, with income support being the most frequent. The Recovery Legal Care program helped secure $1.2 million in payments to patients, aiming to disrupt cycles of violence by stabilizing housing, food access, and employment.
Researchers found a significant association between financial toxicity and worse emotional and physical well-being among cancer patients. Financial toxicity, which includes stress, expense, and instability caused by healthcare costs, can have far-reaching consequences, including psychological distress and lower quality of life.
A study published in Cell Reports Medicine found that zeaxanthin, a plant-derived carotenoid, strengthens the activity of immune cells that kill tumor cells. The findings suggest that zeaxanthin could complement and strengthen advanced cancer treatments like immunotherapy.
A new study found that walking at a pace 14 steps per minute faster than usual can improve physical function in frail or at-risk older adults. Researchers developed a smartphone app to accurately measure walking cadence, making it easier for daily use.
A global ecology study reveals that birds migrating through tropical regions travel at a steadier pace but with more variation in altitude compared to temperate regions. Birds adjust their flight altitudes to avoid strong winds, a key finding with implications for conservation efforts in tropical cities.
Researchers developed an AI model that screens for cardiac amyloidosis with high accuracy, outperforming existing methods. The tool analyzes routine heart ultrasound images to quickly detect the condition and differentiate it from other heart issues.
Researchers at the University of Chicago Medicine discovered a new phenomenon where high doses of radiation cause growth in existing metastatic tumors. The 'badscopal effect' is attributed to increased production of amphiregulin, which weakens the immune system and makes cancer cells more resistant.
A new clinical study found that a universal community resource program reduced acute care for children of food-insecure families, saving thousands of dollars in healthcare expenditures. The program, called CommunityRx-Hunger, required only 50 staff hours and delivered benefits to both food-secure and food-insecure caregivers.
A team of researchers has identified a novel oncometabolite that accumulates in tumors and impairs immune cells' ability to fight cancer. The study highlights how the metabolic environment of tumors influences T cell function, opening new possibilities for improving cancer immunotherapy by targeting tumor metabolism.
A Phase 2 clinical trial found that a neoadjuvant chemo-immunotherapy regimen achieved a 53% deep response rate, exceeding historical data with chemotherapy alone. The treatment approach led to impressive survival outcomes and fewer toxic side effects in patients with advanced HPV-negative head and neck cancer.
Researchers found that Black women with triple-negative breast cancer are less likely to receive immunotherapy treatment, even when accounting for socioeconomic factors. The study analyzed data from over 10,000 patients and found a significant disparity in immunotherapy response between racial groups.
Researchers identified vitamin E succinate as an effective agent controlling tumor growth by promoting FTO degradation. The compound enhances T-cell mediated cytotoxicity through tumor-intrinsic FTO suppression, showing potential as a therapeutic strategy for cancers resistant to immunotherapy.
Researchers developed a brain-computer interface that recreates tactile feedback to give prosthetic hands nuanced 'feeling'. The technology uses electrical stimulation to recreate sensations of touch, movement, and shape on the prosthetic hand, allowing users to develop confidence in motor control and sense of touch.
A new study found that clinicians who hear patients described with negatively biased language develop less empathy towards the patient and become less accurate in recalling their critical health details. Standardized handoffs with neutral, medically relevant facts can help prevent bias and improve patient care.
Primary progressive aphasia is a rare form of dementia that affects language skills, with significant implications for patients' quality of life. Researchers at the University of Chicago Medicine have developed new methods to measure its impact on daily living and demonstrate the feasibility of international telemedicine interventions.
Researchers found that genetic collisions between transcription and DNA replication lead to large tandem duplications in cancer cells, which can be identified through dosage imbalance. These duplicates are associated with poor patient survival and high correlation with mutations in genes TP53, CDK12, and SPOP.
The University of Chicago Medical Center will build a state-of-the-art cancer pavilion with a $75 million donation from the AbbVie Foundation. The facility aims to address health inequities in cancer outcomes and provide access to cutting-edge treatments, as part of UChicago Medicine's efforts to advance global cancer care.
A recent study found that men who conform to traditional masculine norms are less likely to report receiving diagnoses or treatment for cardiovascular disease risk factors. This highlights a missed opportunity to prevent serious cardiovascular conditions later in life.
A phase 1b/2 clinical trial found a combination of immunotherapy and FGFR inhibitor to be safe and tolerable in patients with locally advanced or metastatic bladder cancer. The treatment showed increased response rates, including 54% for patients with high FGFR mRNA expression.
Researchers found that people with sensory disabilities tend to have worse mental health, with vision impairment most strongly associated with loneliness and poor self-rated mental health. Strategies like patient communication, public policies, and technology interventions can help mitigate the negative effects of sensory decline.
Researchers found significant associations between social vulnerability and mental health and substance use disorders in the US. Socially vulnerable populations are at greater risk of specific disorders, including schizophrenia spectrum disorder, with a 17-fold increase in prevalence.
Research shows that GLP-1 receptor agonist drugs are highly effective for weight management and Type 2 diabetes treatment, but they come with complex considerations such as dosages, side effects, and comparisons between specific drugs. Experts caution against overusing these drugs or viewing them as a universal cure-all for obesity.
Researchers developed a machine learning model that predicts ideal oxygen levels for individual patients based on characteristics such as age, sex, and heart rate. The results suggest personalized oxygenation targets could reduce mortality rates, offering new hope for critical care patients.
The COVID-19 pandemic has had a profound impact on mental health, with increased rates of anxiety, depression, and attempted suicides. The interruption of major life milestones and prolonged social isolation have been particularly traumatizing for children and adolescents.
Researchers evaluated over 15,000 abstracts from the American Society for Clinical Oncology Annual Meeting and found a significant increase in AI-generated content. Despite limitations, AI content detectors can be used as a screening tool to indicate the need for additional scrutiny.
A recent study analyzed health information on TikTok to identify trends in video quality, finding that nearly half of the videos contained non-factual information. The researchers also found that non-medical influencers were more likely to produce misleading content, which can lead to detrimental health outcomes.
Resmetirom, a new medication, has been approved to treat metabolic dysfunction-associated steatohepatitis (MASH), a more advanced stage of MASLD characterized by liver inflammation and scarring. The drug was shown to improve fibrosis and reduce disease progression in patients with MASLD.