A genetic study has identified a link between irritable bowel syndrome and lipid metabolism, specifically triglyceride regulation. The research found that variations in the GCKR gene play a key role in this connection, highlighting a new approach to treating IBS
The study reveals that the protein ASPA acts as a natural brake on cancer-associated fibroblasts, which play a critical role in tumour growth and metastasis. ASPA's loss is associated with more aggressive disease progression across different types of cancer.
A new study found that genetic differences in vitamin B1 transport and activation are linked to bowel movement frequency, highlighting potential new pathways for research on gut motility disorders. The analysis also supports the idea of a biological overlap between bowel movement frequency and IBS.
Researchers at CIC bioGUNE discovered a mechanism that reformulates our understanding about polyamine actions in health and disease. Polyamines alter the phosphoproteomic landscape, affecting protein function and alternative splicing.
Researchers have identified CNNM4 as overexpressed in cholangiocarcinoma and found that inhibiting it, combined with GalNAc siRNA technology, can slow tumor growth and increase sensitivity to treatment. This approach could lead to personalized therapies for patients with limited treatment options.
A new 'metabolic clock' uses data from over 13,500 participants to predict a person's biological age and detect early markers of disease. The tool analyzes blood samples using NMR metabolomics and machine learning to estimate health parameters.
Researchers developed an 'aging clock' that can assess the biological age of brain cells and identify potential rejuvenating interventions. The study found 453 unique compounds with therapeutic potential, some of which are known to extend lifespan in animal models.
Researchers identified a specific mutation in the cystathionine beta-synthase enzyme that affects its ability to metabolize homocysteine, leading to accumulation and organ damage. The study proposes new potential therapeutic strategies, including drug design and personalized therapies.
A CIC bioGUNE study reveals that integrating genetic, metabolomic, and lipoproteomic data can identify stable risk profiles in seemingly healthy individuals. The research identified four distinct biomolecular profiles, including one linked to an increased risk of cardiovascular disease.
Researchers at CIC bioGUNE have made a significant breakthrough in understanding the most aggressive form of prostate cancer, revealing that it behaves differently from other types. The study shows that cancer cells use a unique 'language' to communicate with normal cells, altering their behavior and benefiting the tumor.
A new study has found a significant link between defective sucrase variants and an increased risk of irritable bowel syndrome (IBS), while those with isomaltase defects were not affected. Individuals with sucrase defects experienced more severe bowel symptoms and avoided sucrose-rich foods.
A collaborative work led by CIC bioGUNE successfully designed and synthesized a carbohydrate sequence capable of folding into a stable secondary structure. The glycans were generated using an automated synthesizer, which rapidly prepared the scaffold, revealing potential new properties for sugars in medicine, catalysis, or nanotechnology.
A multidisciplinary team has revealed the atomic-level organization of ESCPE-1, a key player in tubular-based cargo sorting. The study provides insights into membrane interactions, cargo recognition, and coat formation, enhancing understanding of membrane protein recycling and its role in cellular processes.
Researchers elucidated Siglec-15's crystal structure and binding epitope, revealing its interaction with T cells and CD11b. The study shows that Siglec-15 binds to α(2,3)- and α(2,6)-linked sialic acids, providing new insights into glycosylation-dependent immune responses.
The study reveals that SARS-CoV-2 infection alters hepatocyte metabolism towards glycolysis, while impairing mitochondrial activity, leading to liver damage. Metformin is proposed as a potential therapeutic option to attenuate SARS-CoV-2 infection in patients with fatty liver.
A recent study published in Frontiers in Microbiology reveals the correlation between sugar identity and flexibility in SARS-CoV-2 spike glycoprotein. The researchers used high-resolution cryo-electron microscopy and computer simulation to understand the impact of glycans on antibody recognition and protein shielding.
Researchers at CIC bioGUNE identified microRNA 873 as a potential therapeutic agent for acute liver failure due to APAP overdose. The study found that anti-miR-873-5p treatment rescues the liver and extends the therapeutic window by 24 hours.
Researchers identified three NAFLD subtypes with unique lipidomic profiles and varying cardiovascular disease risk. Subtype A shows a lower CVD risk profile, differing from other subtypes, which may explain variation in hepatic versus cardiovascular outcomes.
The study reveals the Spike protein of SARS-CoV-2 directly binds exogeneous sialic acids, providing a new understanding of the virus's infection mechanism. This discovery opens up new therapeutic opportunities by targeting this interaction.
A study found that specific DNA changes influence bowel habits and predisposition to IBS. Genetic profiles were correlated with questionnaire data, identifying regions of the genome involved in gut motility. This discovery may lead to new drug targets for treating constipation, diarrhoea, and dysmotility syndromes.