A study of 403 Italian adolescents suggests that low social support and a tendency to compare oneself to others are associated with an increased risk of problematic social media use. The longitudinal study found that these factors predict trajectories of adolescent social media use over time.
Researchers propose Intrinsic Health as a measure of the body's ability to maintain internal balance, enabling resilience and performance. The study aims to shift focus from disease treatment to health optimization, catalyzing transformative advances in public health and medicine.
A recent study found that wildfires in the US West Coast in 2020 led to the disruption of outdoor activities, which in turn shaped the circulation of respiratory pathogens such as influenza and COVID-19. This research highlights the indirect health impacts of extreme weather events.
A research team at TU Wien has demonstrated how electrical current can be generated using 'traffic jam of electrons' in certain materials. By incorporating additional immobile charge carriers into the material, they were able to create a significant improvement in thermoelectric properties.
The Journal EuroIntervention has recorded an impressive Impact Factor of 9.5, making it one of the most cited publications in interventional cardiology. This achievement is attributed to the journal's commitment to publishing high-quality clinical articles and expert commentaries.
Researchers found that cytotoxic NK cells can prevent T cells from attacking tumors in patients resistant to immune checkpoint blockade therapies. Targeting these cells could lead to more effective immunotherapy.
Researchers at Ohio State University found that executives with subprime credit scores tend to follow the advice of advisers, even when it's inaccurate, while those with prime credit scores critically evaluate data and make objective decisions.
A study identified distinct trajectories of addictive social media, mobile phone, and video game use in US youths, finding links to increased suicidal ideation and worse mental health outcomes. The research suggests that high or increasing addictive screen use may warrant further clinical evaluation and intervention design.
A new study found that babies are born with the ability to sense physical pain but lack the cognitive understanding of it. The research, led by UCL researchers, used brain imaging data from infants and adults to map the development of pain-processing networks in the brain.
A new seaborgium isotope, seaborgium-257, has been discovered at the GSI/FAIR accelerator facilities. The research team detected 22 decays of the nucleus and measured its half-life as 12.6 milliseconds.
Global education leaders call for collaboration, ethics, and human-centered teaching as they confront the benefits and challenges of AI in education. The discussion emphasized the need for responsible use policies, equitable access to AI tools, and preserving uniquely human qualities in education.
The Princess Máxima Center has implemented whole genome sequencing as the standard of care for children with cancer, enabling precise diagnosis and tailored treatment. This comprehensive approach also provides valuable data for developing new treatments and researching childhood cancer development.
A new study found that extreme weather events worsen resource insecurities and increase risks of sexual and gender-based violence, transactional sex, and menstruation insecurity among refugee youth in Uganda. Climate-related pressures push young women into early marriage and transactional sex to access food.
A community-based mentoring scheme in Sierra Leone has been found to save lives and help girls return to education, doubling survival rates. The pilot trial reduced maternal and perinatal deaths by almost half, with one baby's life saved for every 18 mentored girls.
Researchers have discovered a gene that allows queuosine to enter cells, opening the door for potential therapies to leverage its role in cancer suppression, memory, and brain function. The identification of SLC35F2 sheds light on the vital micronutrient's importance in human health.
Researchers used time-restricted feeding to restore microbial rhythms in mice fed a high-fat diet, identifying bile salt hydrolase as a key enzyme protecting metabolic health. Engineered gut bacteria showed improved glucose control and reduced body fat in mice, suggesting potential targeted therapies for obesity and diabetes.
A new review reveals significant limitations in existing perinatal palliative care (PPC) evidence, leaving critical gaps in understanding its safety and effectiveness. This comprehensive review calls for more rigorous research to inform policy and ensure appropriate care for vulnerable families.
A nearly complete hominin skull discovered near Harbin has been confirmed as part of the Denisovan lineage through advanced proteomic and ancient DNA analysis. The study provides crucial insights into the wide distribution of Denisovans in Asia, shedding light on their morphology and evolutionary history.
Christian Jones, a Naval Research Lab electronics engineer, received the 2024 Robert T. Hill Best Dissertation Award for his dissertation on robust and efficient structure-based radar receive processing. His research focuses on improving the robustness and efficiency of advanced radar signal processing techniques to provide warfighters...
A research team from Tampere University and Université Marie et Louis Pasteur has demonstrated a novel way to process information using light and optical fibers. The study used femtosecond laser pulses and an optical fiber to mimic the processing of artificial intelligence, achieving accuracy of over 91% in under one picosecond.
Researchers have discovered the gene SLC35F2, which allows queuosine to enter cells, a micronutrient vital for health but previously unknown. This breakthrough opens doors to potential therapies for various diseases, including cancer and neurological disorders.
Certain dietary patterns, such as high-salt foods and processed meats, create an environment conducive to GC development. Beneficial bacteria like Akkermansia muciniphila help protect against cancer by strengthening the immune response and maintaining healthy stomach conditions.
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
A recent study published in Child Development found that early social-emotional learning curriculum led to improved teen behavior and mental health. The intervention, which focused on developing friendship skills and emotional knowledge, had a positive effect on students' social adjustment and parent involvement.
Researchers developed a five-dimensional Langevin model to accurately predict fission fragment distributions and kinetic energies in medium-mass mercury isotopes. The model captures unusual 'double-humped' fragment mass distribution observed in mercury-180, providing new insights into nuclear shell effects.
Researchers have identified amino acids that enable collagen to maintain its structure despite being structurally unstable at body temperature. These findings may lead to better treatments for collagen-associated diseases such as brittle bone disease and Ehlers-Danlos Syndrome.
A global roadmap aims to incorporate biological measurements in psychiatric diagnoses over the next 15-20 years, improving accurate treatment for patients. Current diagnostic methods rely on subjective responses and can be vague, leading to misdiagnosis and ineffective treatments.
Researchers discovered that fungal enzymes cellobiose dehydrogenase (CDH) and lytic polysaccharide monooxygenase (LPMO) can efficiently degrade plant biomass, allowing for the extraction of valuable components. This breakthrough suggests a promising method for using diverse, non-edible plant biomass in biotechnology applications.
Researchers at La Jolla Institute for Immunology discovered that T cell reactivity is highest during the prodromal period in Parkinson's disease, which can last for decades before noticeable symptoms. This finding may guide the development of early diagnostic tools and provide a new timeline for Parkinson's disease detection.
The National Urea Cycle Disorders Foundation is establishing a multistakeholder Partner Network to guide health care decisions and build a sustainable infrastructure for UCD research. The project aims to empower the broad UCD community to work together effectively, identify research needs, and create a roadmap for future studies.
Researchers identified three subgroups of patients with large B-cell lymphoma who have different levels of benefit from CD19 CAR T cell therapy. The study provides new insights to guide physicians toward the best clinical pathways for patients based on tumor biology.
Alternate day fasting shows small benefits in body weight reduction compared to continuous energy restriction and other intermittent fasting approaches, but longer trials are needed to confirm these findings. Intermittent fasting may also lead to lower cholesterol levels.
The UNC Lineberger Comprehensive Cancer Center has developed an adaptive clinical trial for metastatic breast cancer, leveraging $28 million in funding from the Advanced Research Projects Agency for Health (ARPA-H). The study aims to adapt treatment plans in near real-time using tumor biopsies, blood samples, and biomarkers.
A 16-year study of over 10,000 individuals aged 50+ found that those with higher wellbeing were more likely to have better scores on memory tests. The association was independent of depressive symptoms and suggested that psychological factors affect brain health.
A study of over 1,000 twins found that cognitive tests in infancy can predict adult intelligence and cognition, with environmental influences playing a significant role. Early life environments, including pre-preschool years, matter more than previously thought, suggesting potential interventions to support cognitive aging.
Researchers at MIT and Scripps Research Institute developed a vaccine that generates many more HIV-targeting B cells in mice with just one dose, using two adjuvants. The dual-adjuvant vaccine produces a wider diversity of antibodies against an HIV antigen, allowing the immune system to build up a stronger response.
The UCLA team introduces a framework for arbitrary 3D point spread function engineering, enabling adaptive optical imaging systems with precise control of light distribution in three dimensions. This development has significant implications for advanced imaging modalities, such as snapshot 3D multispectral imaging.
A new study identifies critical barriers and promising strategies to scale up low-barrier wound care services for PWUD. The research highlights the urgent need for accessible and empathetic approach to wound care, proposing practical steps to reach those who need it most.
Critical Path Institute's Translational Therapeutics Accelerator awards $250,000 to researchers advancing a promising therapeutic pathway for type 1 diabetes. The project aims to address key challenges in T1D treatment, including beta-cell preservation and immune system modulation.
Researchers at PSI developed an AI-based model to simulate and optimize cement formulations with lower CO₂ emissions. The model, trained on existing data, can generate practical recipe suggestions in seconds, accelerating the development cycle.
The Fraunhofer Institute's miniaturized quantum magnetometer provides precise measurements of magnetic fields with minimal interference. This technology enables new possibilities in biochemical measurements, microelectronics, and navigation systems, including GNSS-safe navigation without GPS.
The University of Gothenburg, AstraZeneca, Knut and Alice Wallenberg Foundation, and Region Västra Götaland are partnering to tackle metabolic disorders. The SEK 200 million initiative aims to deepen understanding of obesity's mechanisms and develop effective treatments.
Researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine aim to reduce falls and adverse drug events among older adults by using personalized approach tailored to individual genetic profiles.
Researchers developed a new robot navigation system called LENS, which uses brain-inspired computing to set a low-energy benchmark for robotic place recognition. The system combines a spiking neural network with a special camera and low-power chip to enable fast and energy-efficient location tracking.
Researchers from Shanghai Jiao Tong University develop innovative solutions to enhance performance and reduce costs in PEM fuel cells and water electrolysis. The study addresses critical oxygen transport challenges, paving the way for high-performance, low-cost hydrogen technologies.
The SETI Institute and SpaceX have launched a collaboration to reduce satellite interference on radio astronomy observations at the Allen Telescope Array. This effort aims to preserve the integrity of radio astronomy while accommodating expanding global connectivity. By implementing new coordination techniques, the initiative successfu...
A new study found that people recycle 47% more bottles when offered a lottery-style refund, rather than the traditional 10-cent deposit return. This approach increases the thrill of possibly winning a big prize, making recycling more enjoyable and motivating.
The new edition of Mark Bear's neuroscience textbook emphasizes accessibility and excitement, presenting the hard science without making it hard. The book features over 100 'Path of Discovery' essays by prominent neuroscientists, including several Nobel prize winners.
A new study has found that addictive use of social media, but not total screen time, is associated with worse mental health among preteens. The study analyzed data from nearly 4,300 children and found that high or increasingly addictive screen use was linked to increased risk of anxiety, depression, aggression, and suicidal behaviors.
Researchers at UMass Amherst created integrated arrays of gate-tunable silicon photodetectors that can capture dynamic visual information and classify static images with high accuracy. The technology has the potential to reduce latency in computer vision tasks, enabling applications like self-driving vehicles and bioimaging.
The HonorHealth Research Institute's HALO program uses over 1 million variables to track brain stroke patient outcomes and guide treatment decisions. This data-driven approach has led to improved recovery rates for patients, including a high clearance rate for mechanical thrombectomy procedures.
Twelve globally recognized English-language journals from AIMS are now accessible on SciOpen, a digital publishing platform. The partnership aims to boost global readership and increase visibility among potential readers and authors worldwide.
A cross-sectional study of 23,000 adolescents found significant racial and ethnic disparities in mental health service use among minority groups. Adolescents from minority groups were less likely to receive mental health visits or psychotropic medications, underscoring the importance of improving access for these populations.
Researchers found that low-cost genetic testing methods can effectively detect BRCA2 and HOXB13 mutations linked to increased prostate cancer risk. These findings support the adoption of precision medicine in prostate cancer care, enabling better diagnosis and personalized treatment plans.
Scientists at MSK found that certain metabolites play a key role in driving differentiation in stem cells, potentially leading to improved tissue regeneration and healing for conditions involving chronic inflammation. APOBEC3 enzymes were linked to breast cancer resistance and growth, with implications for treatment.
The collaboration aims to enhance global capabilities in food safety risk assessment through the application of AI, digital modelling, and other innovations. The project will leverage expertise from NTU Singapore, WHO, and partners to develop robust methodologies for assessing novel food systems.
DEBRA Research invites academic researchers to submit proposals for Basic Science and Research Grants to improve quality of life for those with inherited Epidermolysis bullosa. The organization focuses on translational research and clinical development to address the unmet needs of people living with EB.
A new international study identified two distinct genetic signatures for complex forms of Alzheimer's disease, with one primarily driven by apolipoprotein E and the other involving a combination of 75 additional genetic variants. This shared biological mechanism is largely consistent across global populations.
Researchers develop innovative technology to control black rot disease in cauliflower, achieving high precision and reducing pesticide use by 72.5%. The system uses spectral sensors, machine learning models, and intelligent spraying, successfully identifying and treating diseased plants while avoiding mis-spraying of healthy ones.
A UC Riverside study found that Toxoplasma gondii can significantly disrupt brain function by interfering with communication between brain cells. Infected neurons release fewer extracellular vesicles, which can lead to seizures, neural damage, or altered brain connectivity.
Daniel Hebert's life's work details how carbohydrate-related chaperones direct the protein folding process and guide proteins to their ultimate locations. The study highlights the crucial role of N-glycans in tagging misfolded proteins for destruction or correction.
Surgical patients in the US are at a significant risk of experiencing food insecurity, according to a recent study published in JAMA Surgery. The research highlights the need for interventions such as food insecurity screening to improve food access and overall health outcomes for this vulnerable population.
A study by the University of Florida found that CEOs exhibiting more Machiavellian traits are likely to secure higher executive pay, severance pay, and bonuses. This suggests a positive relationship between CEO personality and compensation outcomes, highlighting the potential for biases in pay decisions.
ASTRO welcomes Karen Davis as its first Vice President of Business Development and Marketing, leading the organization's business growth strategy. Davis will focus on public- and private-sector partnerships to advance ASTRO's mission and broaden its impact on cancer care.
A new study reveals that OECD countries are not converging in energy diversification, financial development, and per-capita income, but instead formulating their own development paths. The research identifies 'convergence clubs' of countries with similar trajectories, suggesting a need for tailored policymaking approaches.
A new study confirms that dockless bike-sharing significantly increases household consumption, especially in dining-out expenses, by 3.9-6.8%. This boost is attributed to reduced commuting costs, increased leisure time, and improved access to lifestyle services.
Insilico Medicine has completed the first-in-patient dosing of ISM3412, a novel MAT2A inhibitor with potential as a best-in-class treatment for locally advanced and metastatic solid tumors. The Phase 1 study aims to evaluate safety, tolerability, and preliminary anti-tumor efficacy of ISM3412.
Researchers have discovered that Bogong moths use constellations of stars and the Milky Way to navigate long distances, making them the first known invertebrate to rely on a stellar compass for navigation. The moths also use the Earth's magnetic field to maintain their direction even when clouds obscure the stars.
Research reveals that children with OCD have significantly higher rates of rare copy number variants in their DNA compared to healthy children. The study's findings support previous studies and pave the way for future research into earlier diagnosis and targeted treatments.
The University of Texas Health Science Center at San Antonio is targeting hard-to-treat cancers and boosting HPV vaccination rates with a $3.4 million funding from CPRIT. The institution will expand its core facilities laboratories to increase researchers' ability to identify therapeutic targets and develop new cancer technologies.
Children's Hospital of Philadelphia researchers found that rare instances of SYNGAP1-related disorders can be caused by inherited genetic variants, which could help guide clinical care and influence family planning decisions. The study identified eight individuals with inherited protein-truncating variants in the SYNGAP1 gene.
A review of AI eye imaging devices approved for patient care found significant gaps in evidence, including lack of transparency on training data and limited diversity in clinical evaluations. The study highlights the importance of rigorous, transparent evidence and data to ensure equitable and effective AI-based solutions.
Scientists developed a method to store short messages in frozen ice by manipulating bubble size and distribution. Binary coding proved more effective than Morse code for longer messages, with potential applications beyond messaging, such as improving metal smelting and manufacturing processes.
A comparative genome study reveals that earthworms and their marine relatives underwent massive genomic reorganisation when transitioning to land, consistent with a punctuated equilibrium model. This phenomenon could have enabled rapid adaptation to new environments, driving evolution and challenging established laws of genome evolution.
A new study uses multilayer network analysis to investigate the interconnectedness between financial sectors and new energy companies in China. The research provides a more granular understanding of systemic risk propagation between critical sectors, offering insights into monitoring financial stability during green transformation.
A new study published in JAMA found that youth who become increasingly addicted to social media, mobile phones, or video games are at greater risk of suicidal thoughts and behaviors. The research suggests that limiting screen time may not be effective in reducing the risk of mental health problems.
Children born to obese mothers are at higher risk of developing metabolic disorders due to reprogrammed liver cells. Researchers found that Kupffer cells, which help protect the body, can act as conductors that instruct liver cells to take up more fat.
The study found that the remaining carbon budget for 1.5°C is 130 billion tonnes of CO2, which would be depleted in less than three years at current emission rates. This would lead to catastrophic climate impacts and exceed the carbon budget for 1.6°C or 1.7°C within nine years.
A research team developed an advanced adaptive aerodynamic model inspired by finite vortex theory to predict rotor performance in complex two-phase flow environments. The Finite Vortex Rotor Model (FVRM) incorporates water surface deformation and accounts for the complex feedback between rotor downwash and liquid response.
A McGill-led study found that combining ketamine with psychotherapy and a supportive environment can lead to longer-lasting depression relief. Patients experienced significant improvements in depression scores, suicidal thoughts, and anxiety after at least eight weeks.
Scientists observe subtle structural distortions and interactions influencing exciton relaxation dynamics in individual CNTs. The study reveals a new understanding of the local nanoscale environment's role in shaping exciton behavior.
Researchers at The University of Osaka have discovered a molecular mechanism behind genome ejection from adeno-associated virus (AAV) vectors. The study reveals that the N-terminal region of the VP1 protein undergoes structural changes upon heating, facilitating genome release.
A study found that brain age gap plays a key role in the connection between cognitive impairment risk factors and thinking memory skills. Researchers discovered that accelerated brain aging influences the relationship between cognitive decline and risk factors like high blood pressure and diabetes.
Researchers at UT Health San Antonio have made a major discovery in understanding cancer drug resistance, specifically in BRCA1-deficient cancers treated with PARP inhibitors. The study reveals that problems in the CST complex can cause resistance to these drugs, opening doors to new therapies and personalized treatments.
A team of researchers from Shibaura Institute of Technology, Japan, has developed a novel fluorinating quaternary ammonium complex with extremely low hygroscopicity, making it an excellent reagent for electrochemical fluorination. The new agent was synthesized by combining KF with tetrabutylammonium bromide and showed promise in pharma...
Researchers have visualized how zebrafish embryos defend themselves against bacteria through a process called phagocytosis. This ability is also present in human embryos, providing an early defense mechanism before the formation of the immune system.
A multiyear study will assess individual differences in placekeeping, a cognitive ability crucial for complex tasks. The researchers aim to develop tools that can identify the right person for the right job at the right time, reducing procedural errors and improving personnel selection.
Researchers have found a promising new method for gene therapy by bringing dormant genes closer to enhancer switches on the DNA. This 'delete-to-recruit' strategy has potential for treating genetic diseases such as sickle cell disease and beta-thalassemia, offering an alternative to expensive current treatments.
Researchers have developed a more efficient method for producing green ammonia using artificial intelligence and machine learning. The new process achieves a sevenfold improvement in production rate while being nearly 100% efficient, making it a viable alternative to traditional methods.
A study published in the American Journal of Human Genetics identified a novel gene, BSN, linked to neurodevelopmental disorders and epilepsy. The research used large biorepositories and computational techniques to analyze data from patients with variants of the BSN gene. Key findings include the common symptoms of epilepsy, febrile se...
A meta-analysis of over 10,000 patients found that knee braces, hydrotherapy, and exercise are the most effective non-drug therapies for reducing pain and improving mobility in knee osteoarthritis. These treatments offer a safer alternative to anti-inflammatory drugs with fewer gastrointestinal and cardiovascular risks.
A new analytical criterion effectively compares the aerodynamic performance of different distributed ducted propeller configurations, revealing potential for similar total thrust despite varying numbers of rotors. This innovation enables optimization of complex eVTOL systems, reducing size and weight while maintaining comparable thrust.
A study by the University of Texas at Austin reveals that car dealers provide implicit subsidies to subprime borrowers. The dealers incur a loss of an average of $301 when arranging loans for these buyers.
Researchers have discovered a way to enhance the effectiveness of mRNA vaccines by disguising them as virus-like particles, prompting a stronger immune response in mice. The innovation could lead to lower doses and longer-lasting immunity.
Frank Buchholz's ERC project DC-PGE aims to develop fully programmable DNA editing enzymes that minimize off-target effects and increase safety in gene therapy. The goal is to create a platform for efficient and accurate genome editing tools to treat various genetic disorders.
Researchers successfully produce artificial cells with model nuclei, allowing for protein synthesis and demonstrating potential applications in biotechnology. The development of these uniform artificial cells is a significant step towards creating artificial cells that can replace natural ones.
The study examines how ESG lending and technology investment impact BRICS banking performance, offering timely guidance for banks and policymakers. It analyzes the effects of high-ESG firms and borrowers' technology-related capital expenditures on return on risk-weighted assets and non-performing loans.
Four researchers have been awarded early-career grants from the ATS Research Program to study pulmonary vascular disease. The $100,000 grants will support investigations into pathways and pathophysiology of the disease.
A study found that straw mulching significantly increases soil CO2 emissions in bamboo forests, with effects persisting for at least three years. The mulching material acts like a thermal blanket, raising soil temperatures and stimulating microbial activity, leading to increased carbon emissions.
Research suggests that the intention to have a child is complicated and nuanced, with many women uncertain about their ability to meet this goal. Women with higher education and income levels are more likely to say they will have children, but even those with a bachelor's degree show a decline in certainty over time.
A team of astronomers created a galactic masterpiece using the European Southern Observatory’s VLT, revealing previously unseen features in the Sculptor Galaxy. The map comprises thousands of colors, providing insights into the stars, gas, and dust within the galaxy.
Researchers found that instructing individuals on how to think scientifically reduces the causal illusion, a common error in detecting cause-and-effect relationships. Providing adequate information and advice can help overcome this error, suggesting that rewarding people for correct answers may not be the most effective approach
Researchers at Texas A&M University found that websites use browser fingerprinting to track people across browser sessions and sites. Even users who opt out of tracking under privacy laws may still be silently tracked through fingerprinting.
Researchers aim to recreate the engulfment of cyanobacteria to gain insight into photosynthesis and its evolution. The project explores how this partnership is maintained, with potential applications in sustainable biofuels.
A new lateral-flow test for mucormycosis has shown swift and accurate results in identifying the disease. The test detects the disease in 30 minutes with high sensitivity and specificity, making it a critical milestone in its development and potential commercialization.
A new study reveals that Rapamycin has a comparable life-extending effect to dietary restriction in eight species of vertebrates. The compound, originally developed as an immunosuppressant, offers similar benefits without the need for caloric restriction.
Researchers at IIT have successfully demonstrated the first flight of a humanoid robot, iRonCub3, which can lift off the floor and maintain stability. The robot's AI-powered control system enables it to handle high-speed turbulent airflows, extreme temperatures, and complex dynamics.
A new study by Carnegie Mellon University researchers suggests that investing in EV charging infrastructure is more effective than offering consumer tax credits to boost adoption. The study found that increasing EV adoption could reduce emissions by 51% and increase sales by 26% by building Level 3 fast-charging stations.
Researchers developed a new fabrication process that integrates high-performance GaN transistors onto standard silicon CMOS chips in a low-cost and scalable way. This technology reduces the temperature of the overall system and improves signal strength, bandwidth, and battery life in mobile phones.
A recent USC study found associations between increased exposure to wildfire smoke and heat stress during preconception and the first trimester with the odds of having a small-for-gestational-age infant. Living in a climate-vulnerable neighborhood can increase these risks, particularly for women exposed to heat stress.
The INSIGHT Clinical Research Network has received $13.5 million in funding to expand its patient data network, increasing capacity for observational studies and retrospective studies. The network will support research on conditions including depression, diabetes, breast cancer, heart disease, and Alzheimer’s disease.
Researchers from Ruhr University Bochum have successfully developed a new method for miniaturized hydrogen production, utilizing the ferredoxin protein as a catalyst. This breakthrough simplifies industrial processes by reducing the complexity and sensitivity of natural enzymes.
Researchers discovered a new tumor-suppressive response targeting RNA Polymerase 1, inhibiting cancer cell growth and enhancing responsiveness to immunotherapies. The Pol 1 inhibitor BOB-42 reduced tumor growth by up to 77% in melanoma and colorectal cancers.
This article highlights the regulatory effects of copper metabolism on cuproptosis in intestinal diseases like colitis and carcinogenesis. Cuproptosis exhibits a bidirectional regulatory role in modulating oxidative stress responses, metabolic reprogramming, and immunotherapeutic efficacy.
Researchers at UTA are developing an AI-powered system to promote healthy behaviors in cancer survivors, which can significantly improve quality of life and reduce risk of death.
Prescribed burns contribute to significant air pollution in the southeast, particularly in minority and low-income areas. Climate change may exacerbate these impacts as fewer burn days become available.
Researchers reveal how hydrogen position affects molecular dynamics in triazole anions under low-energy electron interaction. This study provides new insights into transient negative ions, potentially impacting pharmaceutical development and environmental chemistry.
A recent study found that acupuncture and traditional Chinese medicine significantly improves patient-reported levels of stress, pain, and anxiety during IVF treatment. Clinically meaningful improvements were seen with average reductions of 2.2 units in anxiety, 2.1 in stress, and 1.4 in pain.
The project aims to improve capacity for local health departments and increase knowledge of law among public health graduates. Three institutions will receive $10,000 each to develop and teach a first-time course in Public Health Law.
Researchers at Aston University have developed a new class of ultralow loss optical microresonators that can be widely tunable and precisely controlled. The devices, formed at the intersection of two optical fibers, hold potential applications in communication, computing, sensing and more.
Despite clinical recommendations, genetic testing is underutilized among Medicaid-enrolled children with autism spectrum disorder and intellectual disability. The study found stark racial disparities, with Black children less likely to receive genetic testing than their white peers.
A new hybrid Gravitational Search-Simulated Annealing algorithm optimizes helicopter main transmission systems, reducing vibration and achieving global optimal solutions. The approach balances multiple load cases, subjective and objective evaluation, and solving speed, showing promise for revolutionizing helicopter design.
Researchers developed models to quantify the risk of catastrophic blackouts during hurricanes and forecast climate impacts on energy systems. Their work aims to inform grid upgrades and navigate clean energy targets while maintaining reliability.
International Journal of Extreme Manufacturing (IJEM) achieves a new Impact Factor of 21.3, surpassing 20 for the first time and maintaining its position as top journal in the field. IJEM has attracted submissions from 853 institutions in 81 countries.
A study employed CFD simulations and AHP-TOPSIS multi-criteria decision analysis to optimize the aeration system in deep bed dryers. The results showed that the
Mount Sinai Health System will participate at the 2025 Aspen Ideas: Health festival, discussing emerging science of aging and inflammation, and harnessing AI for healthcare innovation. The system will also provide complimentary dermatologic screenings for attendees.
A new study reveals that lagerpetids, relatives of pterosaurs, were able to tolerate a wide range of climate conditions and distributed widely across the globe. In contrast, pterosaurs initially required more humid tropical conditions to fly.
Researchers found a significant association between the big hike in California's tobacco tax and an increase in smoking cessation over the next three years. The study also reported differences in state tobacco spending and daily smoking rates.
Researchers found that humans increased their ability to exploit different habitat types in Africa around 70,000 years ago, paving the way for a successful dispersal into Eurasia. This ecological flexibility allowed human groups to adapt to challenging climates and overcome geographic barriers.
Deepshika Ramanan, a Salk Assistant Professor, has been recognized as a Rita Allen Foundation Scholar for her innovative research on maternal immunity and lactation. She will receive annual grants of up to $110,000 to conduct groundbreaking work in neuroscience, cancer, immunology, and pain.
Researchers from Northumbria University found that smokers have tell-tale signs of their smoking habits ingrained deep within their teeth. The study revealed evidence of smoking damage in 70% of ex-smokers and 33% of current smokers, compared to just 3% of non-smokers.
Researchers propose integrated solution combining ultrasonic vibration-assisted grinding, heat pipe grinding wheels, and minimum quantity lubrication to achieve high-efficiency precision machining with environmental sustainability. This process reduces grinding forces, minimizes thermal damage, and improves surface quality.
A brain age gap refers to the difference between predicted age and actual chronological age. The study found that higher cognitive impairment risk factor scores were consistently associated with poorer cognitive performance, especially in areas like executive function and language. Researchers developed a brain age prediction model to ...
A research team at Nanjing University of Chinese Medicine discovered that plant-derived extracellular vesicles can deliver miRNAs across kingdoms to treat psoriasis. The researchers isolated perilla leaf-derived extracellular vesicle-like particles, which demonstrated potent antioxidant and anti-inflammatory activity.
Boston College researchers create MapID-tRNA-seq, a method to map chemical modifications and expression of human transfer RNA. The study reveals that tRNA expressions are largely dysregulated in cancerous cells compared to benign cells.
A new study found that gut microbiome composition is associated with cognitive impairment in adults, and that food insecurity may jointly influence brain function. Adults with lower microbial diversity and specific imbalances in gut bacteria were more likely to experience cognitive impairment.
Water erosion models in China have been dominated by empirical approaches, but these lack reliable validation and are limited to specific regions. Research has identified challenges, including a verification gap and regional limitation, which hinder accurate predictions and optimization.
Researchers at Uppsala University have created a model of human nerve tissue using 3D printing, enabling the testing of new drug treatments in a lab environment. This innovation allows for more precise medicine and could potentially lead to improved treatment options for ALS patients.
Nancy A. Speck has been recognized for her groundbreaking research on hematopoiesis and leukemogenesis, with a focus on the transcription factor complex core binding factor. Her work has provided critical knowledge to understand how certain blood cancers develop, leading to significant insights in embryonic blood cell formation.
A new study from the University of Notre Dame finds that returnless returns can increase brand support by up to 25%. The strategy involves allowing customers to keep returned items and receive a refund, rather than processing returns. This approach fosters goodwill and customer loyalty.
A cohort study found that CT angiography was associated with modest improvements in healthier lifestyle behaviors, acceptance of recommended preventive therapy, and risk factor modification. The study suggests that this strategy may reduce coronary events, but further research is needed to confirm the findings.
A recent study demonstrates a transformative approach to enhance sodium-ion battery performance by incorporating lithium salt into the electrolyte. The formation of a robust SEI layer and stabilization of the O3-type cathode surface significantly improve cycleability and capacity retention.
A large-scale study identified early indicators of frailty decline in older adults, including health deficits such as sleep disturbances and muscle weakness. Early intervention programs addressing these modifiable health issues can contribute to disease control and slow frailty progression.
A new study by the University of Missouri researchers demonstrates that hope is a powerful emotional force that gives life meaning. The team found that only hope consistently predicted a stronger sense of meaning, which is linked to various positive outcomes, including happiness, quality relationships, and better physical health.
Physicians from Ruhr-University Bochum used CAR T-cell therapy to treat two patients with chronic inflammatory demyelinating polyneuropathy (CIDP), a rare autoimmune disease causing paralysis and loss of sensation. The treatment showed rapid and long-lasting effects, with significant improvements in symptoms and functional abilities.
A research team developed AI technology that analyzes individual personality traits and values to generate personalized analogies, allowing people to understand others' feelings through familiar experiences. This approach significantly improved emotional understanding and empathy in participants compared to traditional methods.
A new study by Carnegie Mellon University finds that foreign multinational firms shift a modest amount of income out of the US for tax reasons. This income shifting supports a modest amount of employment and investment in the US, with results informing the potential effects of upcoming tax bills.
A study published in Chinese Journal of Aeronautics reveals that DSJ combines the stability of steady jets and efficiency of pulsed jets, providing better control effects under similar momentum coefficients. The unique quasi-steady characteristics of DSJ avoid large fluctuations in real-time aerodynamics.
Researchers confirm human presence in the Americas between 23,000 and 21,000 years ago with a new study that uses ancient mud to date footprints. The findings contradict previous understanding of the peopling of North America and have sparked a reevaluation of archaeological theories.
Researchers have developed a technique to observe phonon dynamics in nanoparticle self-assemblies, enabling the creation of reconfigurable metamaterials with desired mechanical properties. This advance has wide-ranging applications in fields such as robotics, mechanical engineering, and information technology.
A new study published in the Journal of the American Heart Association found that residents in U.S. coastal counties near ocean waters with high concentrations of microplastics are at higher risk for Type 2 diabetes, coronary artery disease, and stroke. The study analyzed data from 152 counties and found a significant association betwe...
Nearly half of Mesoamerica's 4,000+ tree species are at risk of extinction, primarily driven by agriculture and logging. Conservation efforts are urgently needed to protect these species.
Researchers are exploring potassium channel blockers to reduce seizures caused by genetic mutations in the KCNT1 gene. The treatment holds promise for reducing life expectancy and improving symptoms, with potential clinical trials starting as early as 2026.
A CIC bioGUNE study reveals that integrating genetic, metabolomic, and lipoproteomic data can identify stable risk profiles in seemingly healthy individuals. The research identified four distinct biomolecular profiles, including one linked to an increased risk of cardiovascular disease.
A study from the University of Edinburgh found that young children with difficulty managing intense emotions are more likely to experience mental health issues like depression and anxiety as teenagers. The research suggests that helping children develop emotion regulation skills early on could reduce these issues in adolescence.
Research from Chalmers University of Technology found that one type of electric vehicle's warning signal is hard for humans to locate at low speeds, even with background noise. The signal was designed for acoustical standards, but its detectability was tested in a real-world setting.
Research from Stanford University estimates that climate change will reduce global crop yields by 24% by 2100, even after accounting for economic development and adaptation by farmers. The study finds that regions in the US, Canada, China, and Russia will be among the hardest hit, while others may benefit.
Researchers discovered dynamic cells coordinate movements to sculpt living tissue in developing fruit flies, highlighting a powerful role of migrating cells in organ formation. This finding suggests similar systems may shape different organs, including the brain and testis.
A team of researchers at Kyoto University has identified four species of snail parasites in Japanese sea cucumbers, including two previously unknown species. The study provides insights into the geographic distribution and invasion routes of these tiny parasites, which have a significant impact on the health of their host species.
Researchers propose machine learning for efficient and eco-friendly weed control in farmland, enabling precision strikes and reducing environmental burdens. By analyzing vast amounts of agricultural data, algorithms can differentiate between crops and weeds, predict weed growth trends, and optimize weeding strategies.
Researchers created patterns on plastic surfaces that trap bacteria, preventing biofilm formation and making it easier for the host's immune system to clear infecting cells. This breakthrough could help reduce healthcare-associated infections linked to medical devices.
A new study reveals that large language models exhibit 'position bias', favoring information at the beginning and end of documents or conversations. Researchers identified design choices and training data as contributing factors to this phenomenon, which can be mitigated through adjustments in model architecture and fine-tuning.
Researchers used nonsense words to test ChatGPT's language processing capabilities, finding it excelled at discovering relationships and providing definitions for extinct words. However, the AI also generated incorrect or made-up answers in some cases, highlighting its limitations.
A study of 23 European mountain regions identifies climate change and population loss as major threats to these areas' biodiversity and value chains. Local agents proposed over 160 adaptation mechanisms to mitigate the impact, which could reduce vulnerability by up to 50%.
The European Research Council has awarded ERC Advanced grants to Inga Kamp, Wouter Roos, and Syuzanna Harutyunyan from the University of Groningen for their innovative research projects. Kamp's project focuses on deciphering rocky planet building blocks using the James Webb Space Telescope, while Roos investigates RNA-containing viruse...
The Dyson-Harrop CubeSat system harnesses high-density energy from the solar wind and offers a compact, modular solution for space-based clean energy. It generates approximately 1 kilowatt of power, more than ten times greater than similarly sized conventional solar panels.
The CASHeart database integrates large-scale datasets to reveal cell type heterogeneity and therapeutic targets in the human heart. It improves clustering accuracy and batch effect correction, supporting multi-level analyses of differential chromatin accessibility and gene activation.
A new study on ancient dog DNA shows that dogs slowly spread southward alongside early farming societies in the Americas. The research found that all pre-contact dogs in Central and South America descended from a single maternal lineage.
A recent paper by SwRI-led researchers summarizes the scientific community's notable progress in advancing the understanding of the formation and evolution of the inner rocky planets. The study focuses on late accretion's role in controlling the long-term evolution of these planets, with implications for their habitability.
Scientists have identified four biomarkers in ear wax that may indicate Parkinson's disease, and an AI-based screening model can detect them with 94% accuracy. This technology could pave the way for earlier diagnosis and improved patient care.
A two-part delivery strategy combining adjuvants improves antibody responses and follicular buildup of HIV protein in mouse model, offering new hope for effective HIV vaccine. The dual-adjuvant approach yields stronger and more potent immune responses than individual adjuvants alone.
A recent study across 3,058 populations reveals that 24% of Wadden Sea species are declining significantly, while only 14% are increasing. The declines affect native species and those at the base of the food web, highlighting a potential warning signal of local extinction.
The GVHD Alliance has expanded into Europe under the leadership of the European Society for Blood and Marrow Transplantation (EBMT). This move aims to foster collaboration among healthcare professionals, patient advocacy groups, researchers, and policy leaders to improve care and access for patients living with Graft-versus-Host Diseas...
A new systematic review reveals a significant connection between the gut microbiome and brain function in bipolar patients, affecting treatment responses. Patients who responded to treatment had distinct gut microbiome profiles similar to healthy individuals.
A new consensus statement emphasizes the need for increased chemosensory testing to address growing concerns about smell and taste dysfunction. The statement highlights seven broad challenges and opportunities to implement universal chemosensory testing, including developing methods for reimbursement and standardizing data collection.
The Supreme Court's decision increases the likelihood of states limiting or eliminating family access to medical care. Medical professionals emphasize the need for individualized assessments and patient-centered care.
Two key proteins, Oxr1 and Ncoa7, regulate V-ATPase to maintain optimal luminal pH for glycosylation within the Golgi apparatus and trans-Golgi network. This discovery provides new insight into congenital disorders of glycosylation and their cellular mechanisms.
A research article proposes a systematic framework for engineering cell state-responsive synthetic promoters to study T cell exhaustion. The SPECIFIC framework identifies conserved transcription factor binding motifs associated with exhaustion and enables the construction of gene circuits sensing and responding to T cell dysfunction.
A new database, the Israeli Face Database (IFD), presents face images of real individuals from an ethnically diverse population in Israel. The IFD features multiple highly controlled images per face identity and provides detailed demographic data, addressing a lacuna in the field by including non-Western populations.
Researchers identified nearly 500 switch-like genes, which express at high or low levels, and linked them to various ailments like vaginal atrophy and COVID-19. The study suggests that hormones and genetic variation drive this 'switch-like' behavior.
Utah State University evolutionary biologist Zachariah Gompert has received a $1.85 million NIH grant to explore chromosomal rearrangements that may drive rapid evolutionary changes. He will study these arrangements in stick insects, butterflies, and seed beetles using genomics research and computational data analysis.
PerDeCT is a device designed to monitor cardiac patients after surgery and provide early diagnosis of cardiac tamponade. The device aims to balance the benefit and risk of using devices to monitor cardiac output and detect tamponade easily, before damage is done.
Researchers found social integration, urban living, formal education, and religion impact how people view animals. This affects their willingness to engage with conservation programs.
Scientists have discovered a strong correlation between the Earth's magnetic field and atmospheric oxygen levels over the past 540 million years. The study, published in Science Advances, suggests that fluctuations in the magnetic field may be influencing the planet's habitability.
Longer winter sea ice duration is associated with a 20% increase in atmospheric CO2 absorption by the Southern Ocean. Sea ice protects the ocean from strong winds, allowing it to absorb more CO2 during winter.
A study published in Neurology Clinical Practice found that people with poor access to food, living in disadvantaged neighborhoods, and lacking strong social support experienced worse outcomes after stroke. Despite these challenges, they had better survival rates, with 78% survival rate three months after stroke and 62% one year after.
Researchers will investigate fire smoke carcinogens and cancer biomarkers in active, retired, and cadet firefighters to understand the impacts of firefighting on their lifelong health. The study aims to identify groups most at risk for cancer and recommend policies and programs to protect firefighter health.
A new system combines machine vision and deep learning to automate fruit grading, improving accuracy and reducing labor costs. The system uses traditional image processing algorithms and convolutional neural networks to detect defects and classify fruits, achieving high validation accuracies for mangoes and tomatoes.
Research highlights the critical role of epigenetic changes in hepatocellular carcinoma development, including DNA methylation and histone modifications. Noncoding RNAs also play a key role in HCC pathogenesis and may serve as biomarkers for diagnosis and prognosis.
Researchers developed a technology that improves the lifespan of next-generation anode-free all-solid-state batteries by sevenfold using cost-effective MoS₂ thin films. The application of MoS₂ sacrificial layers on stainless steel current collectors enhances interfacial stability and suppresses dendritic lithium growth, leading to impr...
Researchers found associations between influenza A infection, disrupted gut and nasal microbiomes, and detrimental changes in hippocampal gene expression. Maternal vaccination during pregnancy appeared to offer protection from these changes.
Researchers found that combining selinexor with Irinotecan shrunk tumors in preclinical models of colorectal cancer, suggesting a new potential treatment. The study also identified XPO1 mutations linked to rare cancers like endometrial cancer and found that these mutations make cells resistant to chemotherapy.
A new study from the University of Sydney found that non-concussive heading of a soccer ball alters the brain, causing subtle changes in brain structure and function. The researchers identified altered chemistry in a region involved in motor control and decreased electrical conductivity across several areas.
Researchers estimate that temperatures several degrees above the 2022 UK heatwave are plausible in today's climate, with a simulated maximum of over 45°C (113°F). The likelihood of 40°C will continue to rise as the climate warms.
Researchers Mostafa Bedewy and Ahmed Aziz Ezzat are advancing nanomanufacturing by using machine learning to control the formation of nanoparticles and grow carbon nanotubes. The team aims to reveal which nanoparticles act as seeds for growing nanotubes, a key step towards creating ideal high-density structures.
A new study by USC researchers demonstrates an unconditional exponential quantum scaling advantage on IBM quantum processors, solving Simon's problem with a significant performance gap over classical computers. The team achieved this through optimal circuit design and error correction techniques.
A new study reveals how nanoparticles can interfere with photosynthesis in plants, reducing their ability to convert sunlight into food. The research team found that nanoparticles undergo changes in pH and pick up lipid coatings from plant membranes, boosting their binding to RuBisCO and impairing its function.
Recent research highlights the gut microbiome's pivotal role in IBD pathogenesis, alongside metabolomic and immunological dysregulation. An integrative model links microbiome shifts to reduced butyrate, disrupting Th17/Treg balance and elevating IL-6/IL-17.
Researchers at ETH Zurich have developed a novel solution for image sensors, utilizing lead halide perovskite to capture every photon of light. This allows for improved color recognition and higher resolution, as well as advantages in hyperspectral imaging.