A University of Alaska Fairbanks professor has proposed a new three-dimensional time theory that could help solve some of the biggest questions in physics. The theory argues that time comes in multiple dimensions rather than just one, and space emerges as a secondary manifestation.
Marine food webs could be impacted as ocean 'greening' shifts phytoplankton biomass. Phytoplankton act like sponges absorbing CO2 during photosynthesis, influencing climate warming.
An international team directly observes highly charged muonic ions, a new class of exotic atomic systems, in a gas-phase experiment. This achievement demonstrates the capabilities of advanced spectroscopic techniques and paves the way for expanded research into muonic atomic systems.
Researchers at the University of Michigan have discovered that HIV can attach directly to dynein motor proteins without relying on a specific cargo adaptor protein. This flexibility allows the virus to hijack different microtubule transport mechanisms, expanding its options for entering host cells.
Researchers developed an automated program to rapidly identify anti-glycation active compounds in natural resources. The CTM-AM strategy accelerates the discovery of natural products with anti-AGE activity.
A research team from The University of Osaka developed a self-regulating mRNA medicine that adapts to changes in the body, producing just the right amount of therapeutic protein. This innovation could be particularly useful for conditions like chronic pain or inflammatory diseases.
Researchers developed a new class of lanthanide-doped nanomaterials with ultra-high optical nonlinearity, exceeding 500. This enables super-resolution imaging and highly sensitive chemical and biosensing. The material's nonlinear response amplifies light output, turning minor changes into large increases in emission intensity.
The addition of perioperative toripalimab to platinum-based chemotherapy has demonstrated significant improvements in disease-related outcomes, including event-free survival and major pathologic response rates. However, this is associated with a small increase in grade 3–5 toxicities and immune-related adverse events.
Patients with chronic limb-threatening ischaemia (CLTI) are at risk of serious complications, including major amputations and heart attacks. A new statement from the European Society of Cardiology recommends using dual pathway inhibition (DPI) to prevent blood clots in CLTI patients after leg artery procedures.
Researchers warn that declining response rates and concerns about data accuracy are causing a 'quiet crisis' due to foreign aid cuts and COVID-19 disruptions. The lack of census data compromises public administration and can lead to inadequate resource allocation, resulting in pernicious effects.
Researchers developed a reliable method to join B4C–TiB2 ceramics using spark plasma sintering with a Ti interlayer. The joining process was found to be temperature-dependent, resulting in a stable TiB2–TiC–TiB ceramic assemblage. The mechanical strength of the joint increased with temperature, up to 72 MPa at 1300°C.
Researchers found that stronger alcohol exposure caused more significant changes in gene activity and metabolism, particularly in ectodermal cells. The study suggests that even minor changes in gene function during early pregnancy may influence development and contribute to conditions like FASD.
The Digits framework uses compressed air to produce shape changes, vibrations, and haptic feedback, offering a versatile platform for virtual reality and physical therapy. The device's modular design and pneumatic actuation enable adaptable and scalable control methods.
Research finds Arctic peatlands expanding due to warming climate, with 16 sites showing strong evidence of expansion. Peatlands store about 600 billion tons of carbon, and their expansion could slow climate change but also poses risks if temperatures continue to rise.
The review explores the epigenetic regulatory network of lncRNAs in hepatocellular carcinoma, highlighting DNA methylation, histone modifications, RNA methylation, and microRNAs. These mechanisms drive liver cancer progression, offering insights for diagnostic and therapeutic strategies.
Researchers have discovered a synthetic peptide that attracts Crown-of-Thorns Starfish at low concentrations and with no toxicity, offering an efficient pest-management solution. This breakthrough may lead to the development of potent attractins to control CoTS outbreaks, protecting coral reefs from devastating damage.
A new US study reveals that plastic bag regulations, including bans and consumer fees, effectively reduce shoreline litter by 25-47%. Policies involving fees have the largest impact, while complete bag bans are less effective.
Most Medicare beneficiaries will likely see their drug costs go up due to Part D plans' shifting cost-sharing burden. The new $2,000 annual out-of-pocket limit won't reach most beneficiaries, leading to higher deductibles and coinsurance for many.
In a groundbreaking pilot project, South Sioux City has constructed a 4,000-foot stretch of Foundry Road using two million recycled plastic bags. This innovative asphalt blend aims to reduce plastic waste while improving road durability under varied weather conditions.
The collaboration aims to co-develop new treatment paradigms and accelerate innovation in cardiac care, with a focus on Asian populations. The partnership will create opportunities for breakthrough research, knowledge exchange, and training for healthcare professionals.
Researchers developed a technique to study moral decision-making while driving, testing it on 274 philosopher participants. The results showed consistency across different philosophical schools of thought regarding what constitutes moral behavior in the context of driving.
Researchers have developed a new method to 3D-print glass structures with nanoscale precision, achieving nearly 100% reflectance in the visible spectrum. This breakthrough opens up a broader role for glass in nanophotonics, including wearable optics, integrated displays, and sensors.
Researchers have developed a two-step fermentation technique that controls acidification without allowing bacteria to grow, reducing the use of starter culture by up to 80%. This method extends shelf life, eliminating post-acidification issues and improving planning and logistics for dairy production.
A study of 151 bluebottle specimens found four distinct species with unique morphologies and genetics, contradicting the long-held assumption of a single globally distributed species. The research team matched genomic lineages with physical forms identified from citizen-science images, verifying previously proposed but dismissed species.
Researchers discovered genes related to extracellular matrix and Wnt signaling pathway drive lip hypertrophy in East African Great Lakes cichlids. The study provides insights into the evolutionary biology of lip hypertrophy, highlighting the importance of proteoglycans and Wnt signaling pathway.
A new study has revealed that wheat plants actively influence the microbial communities living on and inside their roots, with certain microbes favored under dry conditions and others under irrigation. This dynamic relationship allows the plant to select its microbial partners, shaping its microbiome over time.
A study comparing two species of transparent worms reveals that gene expression patterns tend to remain unchanged in basic cell types, while diverging more rapidly in specialized cells involved in sensing and responding to the environment. The findings provide new insights into the pace of evolution in organisms.
A large-scale analysis of US water quality data reveals that many toxic chemicals remain poorly characterized or undetected. The findings suggest that the true scale of chemical risk to biodiversity and ecosystems may be significantly underestimated due to sparse monitoring data and detection limits.
Researchers have successfully synthesized a new allohexaploid wheat, Triticum kiharae, by hybridizing Timopheevii wheat and goat-grass. This approach allows for the simultaneous introgression of genetic variations from wild relatives into common wheat, potentially enhancing its intraspecific genomic diversity.
Researchers found that co-exposure to bisphenol A and retinoic acid disrupts neurodevelopmental gene signaling, leading to brain abnormalities. The study suggests a potential link between chemical exposure and neurodevelopmental disorders like autism spectrum disorder and attention deficit hyperactivity disorder.
Researchers at UBC propose a silicon-based device that can convert microwave to optical signals with high efficiency, paving the way for long-distance quantum communication. The technology preserves entangled links between particles, essential for quantum networking.
A team of scientists developed a Cu+-doped glass scintillator with excellent thermal stability and efficient broadband blue-cyan emission. The material shows improved radiation stability, X-ray absorption capacity, and anti-thermal-quenching luminescence, surpassing most reported scintillator materials in X-ray imaging applications.
A recent theoretical study maps several isotopes' potential energy surfaces, uncovering a range of ground-state and isomeric shapes that depend sensitively on nuclear pairing interactions. The research reveals rare prosperous shape coexistence in a single nucleus, challenging traditional nuclear structure models.
Bio Integration has a new institutional partner, University of South China's Institute of Sports Medicine, Fudan University, to support its interdisciplinary research in biomaterials, regenerative medicine, and translational healthcare. Professor Chaozong Liu joins as Co-Editor-in-Chief to shape the journal's editorial direction.
The study highlights the importance of pro-inflammatory cytokines and CXC chemokines in tumor development and immune system modulation. Age-related changes in the tumor microenvironment, including extracellular matrix stiffening and inflammatory immune mediator accumulation, contribute to tumor growth, metastasis, and immune evasion.
Researchers at Colorado State University have developed a more efficient light-based process for transforming fossil fuels into useful modern chemicals, effective even at room temperatures. The organic photoredox catalysis system uses visible light to alter chemical compounds, reducing energy demands and pollution in various industries.
The Genome of Europe initiative is conducting a public awareness survey in five European countries to evaluate citizens' knowledge of genetics and attitudes toward using genomics in personalized healthcare. The results will help identify knowledge gaps and guide future communication strategies.
Researchers found that starter packs contributed to nearly 20% of all follow relationships on Bluesky and helped users receive up to 85% more followers. However, they also reinforced existing communities rather than creating new ones, raising concerns about deepening popularity inequalities.
Ateneo de Manila University ranks 511th globally among top institutions, making it the leading private university in the Philippines. The institution has seen improvements in Academic Reputation, Faculty-Student Ratio, and Sustainability, according to QS World University Rankings.
Researchers developed a new approach to generate CAR T cells directly inside the body using targeted lipid nanoparticles, showing rapid and sustained immune reprogramming. This in vivo method holds promise for treating cancer and autoimmune diseases by harnessing a patient's own immune cells.
Researchers identify key hormones and genes involved in tomato resistance to dodder, a devastating agricultural parasite. The study reveals a linear model of defense mechanism, providing new possibilities for controlling dodder and other parasitic species.
The BMJ finds serious misreporting in two key platelet studies used to gain FDA approval for ticagrelor, a multibillion-dollar heart drug. The investigation reveals inaccurate primary endpoint results and unreported data, casting fresh doubts on the drug's safety and effectiveness.
Researchers discovered that a lack of sleep affects how people with migraines process pain signals in the brain. This can lead to increased sensitivity and severity of migraine symptoms, highlighting the importance of adequate sleep for migraine management.
Researchers created a comprehensive genetic resource for Australian chickpea varieties, uncovering previously uncharacterized genetic diversity. The pangenome analysis identified 34,345 gene families, including those associated with key agronomic traits like yield, flowering time, and disease resistance.
A new study predicts that a 2°C temperature rise could double the frequency of short-lived summer downpours in the Alpine region, causing severe damage and posing risks to lives. The analysis of nearly 300 mountain weather stations found that warm air retains more moisture, intensifying thunderstorm activity.
A new study has identified consistent blood differences associated with chronic inflammation, insulin resistance, and liver disease in ME/CFS patients. The results support the long-term goal of developing a blood test to diagnose ME/CFS.
Chronic cough is a common symptom in the Asian general adult population, related to risk factors such as age, allergy, smoking, and air pollution. The physical and psychological burden of chronic cough is notable, particularly among older patients or those with comorbidities.
Researchers from The University of Osaka develop a method to prepare high-fidelity 'magic states' for use in quantum computers with less overhead and unprecedented accuracy. This breakthrough aims to overcome the significant obstacle of noise in quantum systems, which can ruin computer setups.
FGF8 regulates embryonic development, craniofacial structures, limb formation, kidney development, heart development, and the nervous system. Disruptions in its function lead to developmental disorders, including skeletal malformations and congenital anomalies.
A new study from the University of Delaware and Columbia University found that plastic bag bans and fees can reduce plastic bag litter on shorelines by 25-47%, with more effective impacts at state-level policies. However, overall plastic pollution continues to grow, albeit at a slower rate in places with these policies.
Researchers have developed a new 3D-IHC technique that improves the speed, depth, and sensitivity of immunolabeling in thick tissue samples using nanobodies fused with peroxidase. The method enables ultra-fast and high-resolution mapping of neurons and glia in 1-mm-thick brain tissues.
Researchers identified two natural products, pandorabactin A and B, produced by Pandoraea bacteria to complex iron. These molecules may play a role in the survival of these pathogens in iron-poor environments.
Researchers have developed Shadow-Assisted Sidewall Emission (SASE), a novel method to create submicron linewidth light sources using normal UV photolithography. This breakthrough enables the fabrication of high-resolution light sources for various scientific and technological fields.
A recent study found that ATG5-mediated autophagy in alveolar epithelial cells protects against Pseudomonas infection by preventing inflammation. The mechanism involves the formation of gasdermin D pores, which amplify inflammation through macrophage activation.
A new study suggests that afforestation may not be a viable method for offsetting carbon dioxide emissions from fossil fuel reserves due to spatial requirements and financial viability. The analysis found that planting trees on an area larger than North America would be needed to offset the potential emissions, raising concerns about d...
Researchers discovered two-band superconductivity in rhombohedral ZrNCl, exceeding previous reports, and found a large diffusivity ratio suggesting weaker intraband scattering. The material exhibits bulk superconductivity with strong vortex pinning and decoupled rotational symmetry.
A recent study at the University of Jyväskylä found that central adiposity increases the risk for stress urinary incontinence in middle-aged women. Larger fat mass and waist circumference are key factors associated with this increased risk, highlighting the importance of body composition in understanding pelvic floor disorders.
Researchers found that low blood flow at rest may predict heart failure or death, while low stress flow may indicate heart attack risk. A new PET scan method also showed promise for Alzheimer's detection with high accuracy and minimal discomfort.
A recent study published in Science found that only a small fraction of potentially environmentally relevant chemicals are monitored. The researchers analyzed large datasets to assess the environmental risks of highly toxic chemicals, highlighting the limitations of current chemical monitoring.
A multi-institutional group of researchers demonstrates reliable transfer of ultrastable optical signals through deployed multicore fiber alongside simulated telecom traffic. The achievement achieves a fractional frequency instability of just 3 × 10⁻¹⁹ over nearly 3 hours, suitable for demanding timekeeping and scientific measurements.
Researchers have developed a wearable system that reads respiratory patterns directly from wrist pulse signals, enabling continuous monitoring with high comfort and precision. The device offers a promising alternative to traditional respiratory monitors, particularly for people living with chronic conditions or recovering from illness.
Researchers found that HSV-1 deliberately reshapes the human genome within hours of infection, rearranging host genes to facilitate replication. Blocking a single host enzyme, topoisomerase I, completely halted the virus's ability to hijack the genome.
Researchers developed a tool to monitor treatment response in patients with solid tumours using circulating tumour DNA analysis, anticipating clinical relapses up to 68 months before symptoms become apparent. The technology is minimally invasive and can be tailored to each tumour type, reducing unnecessary treatments and costs.
Research highlights the significant consequences of diagnostic delays for lupus patients, who often experience multiple misdiagnoses before receiving an accurate diagnosis. The study found that 'diagnostic overshadowing' is a major cause of these delays, leading to irreparable organ damage and poor quality of life.
Researchers observe anomalous saturable absorption behavior in CsPbBr3 thin films under sub-bandgap excitation, revealing a new mechanism for ultrafast nonlinear optical absorption. The study proposes that band energy fluctuations induced by lattice polarons enable polaronic states to facilitate saturable absorption.
A decline in global population data collection threatens crucial evidence-based government planning. Accurate demographic information is fundamental to effective governance, yet many countries are undercounting marginalized populations and failing to publish census findings.
A Cochrane review found that virtual reality (VR) can help stroke survivors regain arm movement and increase therapy time. VR may also improve balance and reduce activity limitations, but effects on mobility and quality of life are uncertain.
A research team at Hiroshima University found the presence of djerfisherite, a potassium-containing iron-nickel sulfide, in a Ryugu grain. The mineral's occurrence is unexpected, as it typically forms in very reduced environments and has never been reported in CI chondrites or other Ryugu grains.
A research team from the Alfred Wegener Institute found that a current in the Barents Sea affects Arctic sea ice formation. Warmer Atlantic water flowing into the Barents Sea can warm it up and lead to less new sea ice formation, causing existing ice to melt faster.
A novel study in Biological Psychiatry highlights the layered and complex interactions between clinical symptoms and neurobiological sources of variation in depression. The research found that multiple brain profiles may manifest as the same clinical symptoms, supporting the presence of both one-to-one and many-to-one heterogeneity.
A recent study led by WVU student Isabella Tuzzio found microplastics in every fish sampled from seven central Appalachian streams. The researchers discovered significant environmental risks and potential human health hazards due to the accumulation of microplastics in the food chain.
Researchers at DTU Biosustain have developed a new tool, TUNE YALI, that accelerates and simplifies the genetic engineering of yeast strains used in industrial biotechnology. The breakthrough enables rapid testing and selection of optimal strains, making it easier to develop yeast-based production systems.
A comprehensive review highlights the impact of anti-cancer treatments on bone health, increasing the risk of fractures and bone fragility. The International Osteoporosis Foundation advocates for a multidisciplinary approach to early screening and proactive bone-protective strategies.
Research led by City St George's University of London found pregnant women exposed to lower levels of toxic chemicals if they vape during pregnancy compared with smoking. Exposure levels varied significantly between groups, with some chemicals showing up to a 97% reduction in those who exclusively vaped.
A USC study found that high levels of iron in the brain contribute to cell damage and oxidative stress, accelerating Alzheimer’s symptoms in individuals with Down syndrome. This connection could lead to targeted treatments and improved outcomes for those at risk.
TsRNAs emerge as promising biomarkers for a wide range of diseases, particularly cancers. These non-coding RNA fragments exhibit remarkable stability in diverse body fluids and show disease-specific expression patterns.
Scientists have found that photons trapped inside an optical cavity carry detailed information about the material placed within it. By measuring the properties of these emitted photons, researchers can probe how an optical cavity modifies the properties of the embedded materials. The discovery opens new possibilities for experimental t...
Researchers found that eukaryotes could survive in shallow pools of water atop ice sheets, similar to modern-day meltwater ponds in Antarctica. These environments supported diverse communities of early complex life, influenced by salinity levels.
A scoping review highlights Europe's fragmented approach to biliary atresia screening, citing inconsistent practices and parental unawareness. The authors advocate for a unified approach merging cost-effective tools with innovation to ensure timely diagnoses and improved outcomes.
The mitochondrial ribosomal protein family (MRPs) is dysregulated in various cancers, influencing tumor initiation and progression. MRPs regulate metabolic reprogramming of immune cells within the tumor microenvironment, affecting growth, migration, invasion, and chemoresistance.
A new time-division MIMO technology enables phased-array receivers to operate at high speeds while reducing power and circuit area, addressing limitations in traditional systems. The innovation achieves a record-setting 38.4 Gbps data rate across eight streams, paving the way for practical large-scale MIMO systems.
Scientists at Northwestern University have developed an algorithm that enables smartwatches to more accurately monitor the calories burned by people with obesity during various physical activities. The technology bridges a critical gap in fitness technology, allowing for more accurate tracking and tailored interventions.
A powerful earthquake struck Myanmar, causing widespread collapse of vulnerable buildings that led to majority of deaths and destruction. The report calls for adopting modern seismic building codes and prioritizing retrofitting of existing structures.
Marine microalgae Heterosigma akashiwo forms aggregates of buoyant microplastics through extracellular polymeric substances, increasing their density and causing them to sink. The sinking velocity of these aggregates is significant for understanding the behavior of microplastics in marine ecosystems.
Schisandrin A, a natural compound found in traditional Chinese medicine, relaxes pig coronary arteries and blocks calcium channels to prevent heart attacks. The study suggests that schisandrin A could be a novel approach to preventing coronary artery spasms and reducing the risk of ischemic heart disease.
A new study found that self-esteem scores doubled within one year of weight-loss surgery, with the highest increases seen among those who lost the most weight. The study also highlighted the importance of understanding and addressing weight stigma in obesity treatment.
Researchers found that some AI prompts create up to 50 times more CO2 emissions than others, with reasoning-enabled models producing the most emissions. Users can significantly reduce emissions by prompting AI to generate concise answers or limiting high-capacity model use.
Emerging research highlights the pivotal role of circular RNAs in disease progression, influencing tumor proliferation, metastasis, immune evasion, and drug resistance. Specific circRNAs have been identified as key players in HCC progression, affecting crucial signaling pathways like PI3K/Akt, Wnt/β-catenin, and NF-κB.
Scientists at Xi'an Jiaotong-Liverpool University developed a new nanoparticle capable of carrying high doses of chemotherapy drugs while staying stable for extended periods. This innovation could make treatments more effective and reduce side effects.
Researchers at the University of Malaga have identified factors involved in the propagation of toxic protein aggregates, which accumulate in patients' brains. These brain accumulations are formed as a consequence of abnormal folding of soluble proteins and can lead to the spread of disease to different brain regions.
Researchers at Tufts University created Anthrobots by growing human cells in a novel environment, revealing that these tiny organisms can express ancient and embryonic genes without genetic manipulation. This process resets the cellular aging clock, making the Anthrobots biologically younger than their original adult cells.
IGF2BP1 binds to methylated mRNA, stabilizing oncogenic transcripts and promoting cancer progression. Elevated expression of IGF2BP1 correlates with poor prognosis and therapy resistance in multiple cancers.
Researchers found a huge filament of hot gas in the Shapley Supercluster, containing some of the Universe's 'missing' matter. The discovery was made using XMM-Newton and Suzaku space telescopes, revealing a thread of gas stretching over 23 million light-years.
A new bedtime recall exercise significantly improved memory performance in individuals with Alzheimer's Disease and healthy older adults. The study suggests that this cost-free intervention could be an easily adopted approach to enhancing memory function.
The review highlights the potential of hydrogel electrolytes to create rechargeable zinc-ion batteries that can withstand extreme temperatures, mechanical deformations, and environmental damages. Hydrogel electrolyte technology paves the way for next-generation energy storage devices.
Researchers developed lenacapavir, a potent medication that prevents HIV infection and can be administered only twice a year. The drug's high efficacy in clinical trials has sparked hope for ending the global HIV epidemic by 2030.
A new hypothesis suggests that prenatal sex steroid hormones and placental function played a crucial role in shaping the human brain and its cognitive traits. This may have led to increased brain size and reduced competition among males, allowing for the emergence of large social groups.
The Anti-Autocracy Handbook reveals how autocracies follow a common script using the three Ps: populism, polarization, and post-truth. To help researchers defend themselves, the handbook provides tools for digital security, continuous documentation, and setting up distributed archives.
Ateneo de Manila University has maintained its position as the highest-ranked Filipino institution in the latest THE Impact Rankings, ranking among the world's top 100 in several Sustainable Development Goals (SDGs). The university's commitment to sustainability is highlighted by its consistent leadership in Philippine institutions.
A machine learning model developed by researchers at Washington University in St. Louis can predict the risk of persistent post-operative pain and provide uncertainty estimates for each prediction. The model achieves better performance than other prediction algorithms and offers a valuable tool for doctors to guide their decisions.
Researchers developed a technology that precisely analyzes 21 types of reactants simultaneously using high-resolution fluorine nuclear magnetic resonance spectroscopy. This breakthrough contributes to new drug development and catalyst optimization in AI-driven autonomous synthesis.
Dry eye disease affects one-third of adults and one-in-five children, causing discomfort and blurred vision. A new app, MyDryEye, has been developed with optimized blinking exercises that have been shown to decrease symptom severity and frequency, with participants experiencing improved symptoms within two weeks.