Emerging research highlights the pivotal role of circular RNAs in disease progression, influencing tumor proliferation, metastasis, immune evasion, and drug resistance. Specific circRNAs have been identified as key players in HCC progression, affecting crucial signaling pathways like PI3K/Akt, Wnt/β-catenin, and NF-κB.
Scientists at Xi'an Jiaotong-Liverpool University developed a new nanoparticle capable of carrying high doses of chemotherapy drugs while staying stable for extended periods. This innovation could make treatments more effective and reduce side effects.
Researchers at the University of Malaga have identified factors involved in the propagation of toxic protein aggregates, which accumulate in patients' brains. These brain accumulations are formed as a consequence of abnormal folding of soluble proteins and can lead to the spread of disease to different brain regions.
Researchers at Tufts University created Anthrobots by growing human cells in a novel environment, revealing that these tiny organisms can express ancient and embryonic genes without genetic manipulation. This process resets the cellular aging clock, making the Anthrobots biologically younger than their original adult cells.
IGF2BP1 binds to methylated mRNA, stabilizing oncogenic transcripts and promoting cancer progression. Elevated expression of IGF2BP1 correlates with poor prognosis and therapy resistance in multiple cancers.
Researchers found a huge filament of hot gas in the Shapley Supercluster, containing some of the Universe's 'missing' matter. The discovery was made using XMM-Newton and Suzaku space telescopes, revealing a thread of gas stretching over 23 million light-years.
A new bedtime recall exercise significantly improved memory performance in individuals with Alzheimer's Disease and healthy older adults. The study suggests that this cost-free intervention could be an easily adopted approach to enhancing memory function.
The review highlights the potential of hydrogel electrolytes to create rechargeable zinc-ion batteries that can withstand extreme temperatures, mechanical deformations, and environmental damages. Hydrogel electrolyte technology paves the way for next-generation energy storage devices.
Researchers developed lenacapavir, a potent medication that prevents HIV infection and can be administered only twice a year. The drug's high efficacy in clinical trials has sparked hope for ending the global HIV epidemic by 2030.
A new hypothesis suggests that prenatal sex steroid hormones and placental function played a crucial role in shaping the human brain and its cognitive traits. This may have led to increased brain size and reduced competition among males, allowing for the emergence of large social groups.
The Anti-Autocracy Handbook reveals how autocracies follow a common script using the three Ps: populism, polarization, and post-truth. To help researchers defend themselves, the handbook provides tools for digital security, continuous documentation, and setting up distributed archives.
Ateneo de Manila University has maintained its position as the highest-ranked Filipino institution in the latest THE Impact Rankings, ranking among the world's top 100 in several Sustainable Development Goals (SDGs). The university's commitment to sustainability is highlighted by its consistent leadership in Philippine institutions.
A machine learning model developed by researchers at Washington University in St. Louis can predict the risk of persistent post-operative pain and provide uncertainty estimates for each prediction. The model achieves better performance than other prediction algorithms and offers a valuable tool for doctors to guide their decisions.
Researchers developed a technology that precisely analyzes 21 types of reactants simultaneously using high-resolution fluorine nuclear magnetic resonance spectroscopy. This breakthrough contributes to new drug development and catalyst optimization in AI-driven autonomous synthesis.
Dry eye disease affects one-third of adults and one-in-five children, causing discomfort and blurred vision. A new app, MyDryEye, has been developed with optimized blinking exercises that have been shown to decrease symptom severity and frequency, with participants experiencing improved symptoms within two weeks.
A study of 403 Italian adolescents suggests that low social support and a tendency to compare oneself to others are associated with an increased risk of problematic social media use. The longitudinal study found that these factors predict trajectories of adolescent social media use over time.
Researchers propose Intrinsic Health as a measure of the body's ability to maintain internal balance, enabling resilience and performance. The study aims to shift focus from disease treatment to health optimization, catalyzing transformative advances in public health and medicine.
A recent study found that wildfires in the US West Coast in 2020 led to the disruption of outdoor activities, which in turn shaped the circulation of respiratory pathogens such as influenza and COVID-19. This research highlights the indirect health impacts of extreme weather events.
A research team at TU Wien has demonstrated how electrical current can be generated using 'traffic jam of electrons' in certain materials. By incorporating additional immobile charge carriers into the material, they were able to create a significant improvement in thermoelectric properties.
The Journal EuroIntervention has recorded an impressive Impact Factor of 9.5, making it one of the most cited publications in interventional cardiology. This achievement is attributed to the journal's commitment to publishing high-quality clinical articles and expert commentaries.
Researchers found that cytotoxic NK cells can prevent T cells from attacking tumors in patients resistant to immune checkpoint blockade therapies. Targeting these cells could lead to more effective immunotherapy.
Researchers at Ohio State University found that executives with subprime credit scores tend to follow the advice of advisers, even when it's inaccurate, while those with prime credit scores critically evaluate data and make objective decisions.
A study identified distinct trajectories of addictive social media, mobile phone, and video game use in US youths, finding links to increased suicidal ideation and worse mental health outcomes. The research suggests that high or increasing addictive screen use may warrant further clinical evaluation and intervention design.
A new study found that babies are born with the ability to sense physical pain but lack the cognitive understanding of it. The research, led by UCL researchers, used brain imaging data from infants and adults to map the development of pain-processing networks in the brain.
A new seaborgium isotope, seaborgium-257, has been discovered at the GSI/FAIR accelerator facilities. The research team detected 22 decays of the nucleus and measured its half-life as 12.6 milliseconds.
Global education leaders call for collaboration, ethics, and human-centered teaching as they confront the benefits and challenges of AI in education. The discussion emphasized the need for responsible use policies, equitable access to AI tools, and preserving uniquely human qualities in education.
The Princess Máxima Center has implemented whole genome sequencing as the standard of care for children with cancer, enabling precise diagnosis and tailored treatment. This comprehensive approach also provides valuable data for developing new treatments and researching childhood cancer development.
A new study found that extreme weather events worsen resource insecurities and increase risks of sexual and gender-based violence, transactional sex, and menstruation insecurity among refugee youth in Uganda. Climate-related pressures push young women into early marriage and transactional sex to access food.
A community-based mentoring scheme in Sierra Leone has been found to save lives and help girls return to education, doubling survival rates. The pilot trial reduced maternal and perinatal deaths by almost half, with one baby's life saved for every 18 mentored girls.
Researchers have discovered a gene that allows queuosine to enter cells, opening the door for potential therapies to leverage its role in cancer suppression, memory, and brain function. The identification of SLC35F2 sheds light on the vital micronutrient's importance in human health.
Researchers used time-restricted feeding to restore microbial rhythms in mice fed a high-fat diet, identifying bile salt hydrolase as a key enzyme protecting metabolic health. Engineered gut bacteria showed improved glucose control and reduced body fat in mice, suggesting potential targeted therapies for obesity and diabetes.
A new review reveals significant limitations in existing perinatal palliative care (PPC) evidence, leaving critical gaps in understanding its safety and effectiveness. This comprehensive review calls for more rigorous research to inform policy and ensure appropriate care for vulnerable families.
A nearly complete hominin skull discovered near Harbin has been confirmed as part of the Denisovan lineage through advanced proteomic and ancient DNA analysis. The study provides crucial insights into the wide distribution of Denisovans in Asia, shedding light on their morphology and evolutionary history.
Christian Jones, a Naval Research Lab electronics engineer, received the 2024 Robert T. Hill Best Dissertation Award for his dissertation on robust and efficient structure-based radar receive processing. His research focuses on improving the robustness and efficiency of advanced radar signal processing techniques to provide warfighters...
A research team from Tampere University and Université Marie et Louis Pasteur has demonstrated a novel way to process information using light and optical fibers. The study used femtosecond laser pulses and an optical fiber to mimic the processing of artificial intelligence, achieving accuracy of over 91% in under one picosecond.
Researchers have discovered the gene SLC35F2, which allows queuosine to enter cells, a micronutrient vital for health but previously unknown. This breakthrough opens doors to potential therapies for various diseases, including cancer and neurological disorders.
Certain dietary patterns, such as high-salt foods and processed meats, create an environment conducive to GC development. Beneficial bacteria like Akkermansia muciniphila help protect against cancer by strengthening the immune response and maintaining healthy stomach conditions.
A landmark review highlights how diabetes alters bone microarchitecture and increases fracture risk in people with type 2 diabetes, despite normal or elevated bone mineral density. The authors advocate for updated diagnostic tools, including a revised TBS algorithm, to more accurately reflect bone quality in individuals with central ob...
A recent study published in Child Development found that early social-emotional learning curriculum led to improved teen behavior and mental health. The intervention, which focused on developing friendship skills and emotional knowledge, had a positive effect on students' social adjustment and parent involvement.
Researchers developed a five-dimensional Langevin model to accurately predict fission fragment distributions and kinetic energies in medium-mass mercury isotopes. The model captures unusual 'double-humped' fragment mass distribution observed in mercury-180, providing new insights into nuclear shell effects.
Researchers have identified amino acids that enable collagen to maintain its structure despite being structurally unstable at body temperature. These findings may lead to better treatments for collagen-associated diseases such as brittle bone disease and Ehlers-Danlos Syndrome.
A global roadmap aims to incorporate biological measurements in psychiatric diagnoses over the next 15-20 years, improving accurate treatment for patients. Current diagnostic methods rely on subjective responses and can be vague, leading to misdiagnosis and ineffective treatments.
Researchers discovered that fungal enzymes cellobiose dehydrogenase (CDH) and lytic polysaccharide monooxygenase (LPMO) can efficiently degrade plant biomass, allowing for the extraction of valuable components. This breakthrough suggests a promising method for using diverse, non-edible plant biomass in biotechnology applications.
Researchers at La Jolla Institute for Immunology discovered that T cell reactivity is highest during the prodromal period in Parkinson's disease, which can last for decades before noticeable symptoms. This finding may guide the development of early diagnostic tools and provide a new timeline for Parkinson's disease detection.
The National Urea Cycle Disorders Foundation is establishing a multistakeholder Partner Network to guide health care decisions and build a sustainable infrastructure for UCD research. The project aims to empower the broad UCD community to work together effectively, identify research needs, and create a roadmap for future studies.
Researchers identified three subgroups of patients with large B-cell lymphoma who have different levels of benefit from CD19 CAR T cell therapy. The study provides new insights to guide physicians toward the best clinical pathways for patients based on tumor biology.
Alternate day fasting shows small benefits in body weight reduction compared to continuous energy restriction and other intermittent fasting approaches, but longer trials are needed to confirm these findings. Intermittent fasting may also lead to lower cholesterol levels.
The UNC Lineberger Comprehensive Cancer Center has developed an adaptive clinical trial for metastatic breast cancer, leveraging $28 million in funding from the Advanced Research Projects Agency for Health (ARPA-H). The study aims to adapt treatment plans in near real-time using tumor biopsies, blood samples, and biomarkers.
A 16-year study of over 10,000 individuals aged 50+ found that those with higher wellbeing were more likely to have better scores on memory tests. The association was independent of depressive symptoms and suggested that psychological factors affect brain health.
A study of over 1,000 twins found that cognitive tests in infancy can predict adult intelligence and cognition, with environmental influences playing a significant role. Early life environments, including pre-preschool years, matter more than previously thought, suggesting potential interventions to support cognitive aging.
Researchers at MIT and Scripps Research Institute developed a vaccine that generates many more HIV-targeting B cells in mice with just one dose, using two adjuvants. The dual-adjuvant vaccine produces a wider diversity of antibodies against an HIV antigen, allowing the immune system to build up a stronger response.
The UCLA team introduces a framework for arbitrary 3D point spread function engineering, enabling adaptive optical imaging systems with precise control of light distribution in three dimensions. This development has significant implications for advanced imaging modalities, such as snapshot 3D multispectral imaging.
A new study identifies critical barriers and promising strategies to scale up low-barrier wound care services for PWUD. The research highlights the urgent need for accessible and empathetic approach to wound care, proposing practical steps to reach those who need it most.
Critical Path Institute's Translational Therapeutics Accelerator awards $250,000 to researchers advancing a promising therapeutic pathway for type 1 diabetes. The project aims to address key challenges in T1D treatment, including beta-cell preservation and immune system modulation.
Researchers at PSI developed an AI-based model to simulate and optimize cement formulations with lower CO₂ emissions. The model, trained on existing data, can generate practical recipe suggestions in seconds, accelerating the development cycle.
The Fraunhofer Institute's miniaturized quantum magnetometer provides precise measurements of magnetic fields with minimal interference. This technology enables new possibilities in biochemical measurements, microelectronics, and navigation systems, including GNSS-safe navigation without GPS.
The University of Gothenburg, AstraZeneca, Knut and Alice Wallenberg Foundation, and Region Västra Götaland are partnering to tackle metabolic disorders. The SEK 200 million initiative aims to deepen understanding of obesity's mechanisms and develop effective treatments.
Researchers from Florida Atlantic University's Charles E. Schmidt College of Medicine aim to reduce falls and adverse drug events among older adults by using personalized approach tailored to individual genetic profiles.
Researchers developed a new robot navigation system called LENS, which uses brain-inspired computing to set a low-energy benchmark for robotic place recognition. The system combines a spiking neural network with a special camera and low-power chip to enable fast and energy-efficient location tracking.
Researchers from Shanghai Jiao Tong University develop innovative solutions to enhance performance and reduce costs in PEM fuel cells and water electrolysis. The study addresses critical oxygen transport challenges, paving the way for high-performance, low-cost hydrogen technologies.