Fauci highlights lessons learned from COVID-19, including success in basic research and vaccine development. He notes failures in public health infrastructure, coordination, and supply chain, emphasizing the need for sustained interest and support to prevent future pandemics.
A small pilot study found that drinking kombucha for four weeks reduced fasting blood glucose levels in people with type-II diabetes. The fermented tea drink was shown to lower average blood sugar levels by 48 milligrams per deciliter, with no significant difference between the group consuming kombucha and those consuming a placebo.
Researchers at Georgetown University Medical Center discovered the biological mechanism of TTP488, an experimental drug that impairs aggressive triple-negative breast cancer from metastasizing. The finding enables clinical trials to explore the drug's effectiveness in preventing TNBCs from spreading, offering new hope for patients with...
Researchers at Georgetown University Medical Center have discovered a new location for the brain's spoken word lexicon, which is located in the front of the primary auditory cortex. This finding has significant implications for recovery and rehabilitation following a stroke or other brain injury.
A team of researchers at Georgetown University's Lombardi Comprehensive Cancer Center has discovered a key role for glucose in regulating DNA synthesis and cancer cell response to chemotherapy. By targeting this pathway, the researchers hope to develop new treatments that make lung cancer more responsive to radiotherapy and chemotherapy.
Research found an association between Agent Orange exposure and increased risk of developing myeloproliferative neoplasms, a precursor to deadly leukemias. The study analyzed data from 93,269 veterans and found possible links to cardiovascular factors like blood clots and bleeding.
Researchers found varying microbiome compositions in early-onset (age 45 or younger) and late-onset (age 65 or older) colorectal cancer tumors, with distinct species present in each group. The discovery may help explain the rise in young-onset disease cases without known risk factors.
Scientists at Georgetown University Medical Center successfully transformed spoken words into patterns of vibration that activated the brain's auditory speech recognition system. The study opens doors to novel sensory substitution devices replacing lost sensory function, aiming for effortless and natural perception.
A study of over 300 extreme altruists reveals they share unselfish traits, not higher levels of empathy or agreeableness. Researchers found that their choices reflect a genuine value for strangers' wellbeing and communities.
A recent study by researchers at Georgetown University found a significant association between discrimination and frailty among Black cancer survivors. The study, which surveyed over 2,200 participants, revealed that those who experienced more discrimination had higher frailty scores, regardless of their socioeconomic status.
A Georgetown University study found that black people in rural North Carolina have better mental health than white people, with rural black residents experiencing fewer mentally unhealthy days. The paradoxical finding has implications for addressing mental health disparities in rural areas.
Researchers at Georgetown University Medical Center found that Anopheles mosquito populations are gaining an average of 6.5 meters per year in elevation and moving south by 4.7 kilometers annually. Climate change is helping these species reach colder parts of the continent, potentially explaining recent changes in malaria transmission.
A recent study by Georgetown University Medical Center found that climate-related events have a profound impact on mental health outcomes in Bangladesh. The research, published in Lancet Planetary Health, reveals a high correlation between temperature increases, humidity levels, and the prevalence of depression and anxiety.
A phase III clinical trial showed efgartigimod significantly improved sustained platelet response and doubled platelet counts in patients with chronic ITP. The treatment demonstrated effectiveness across various patient demographics, with minimal side effects.
A study using a mouse model found that over-expression of the Esr1 gene increased the risk of developing estrogen receptor-positive breast cancer in older women. Giving anti-hormonal drugs to mice with Esr1 over-expression lowered or reversed this risk.
A new study suggests that estrogen-blocking drugs can not only prevent breast cancer but also reduce the risk of dying from the disease. Researchers used computer models to determine the lifetime benefits and harms of these treatments for women at high risk, finding a significant impact on mortality.
A recent study found that mindfulness-based stress reduction (MBSR) was as effective as the gold-standard antidepressant drug escitalopram in reducing anxiety symptoms. MBSR showed a significant 30% drop in anxiety severity, similar to escitalopram.
A study found that infant brains can reorganize language abilities to the right side of the brain after a stroke in the left hemisphere. Participants showed consistent pattern of language activation on the right hemisphere, regardless of damage extent.
A recent clinical trial found that patients with advanced melanoma who received immunotherapy first had a 20% higher two-year overall survival rate compared to those who initially got targeted therapies. The study also showed improved progression-free survival rates for those on immunotherapy.
A novel imaging approach developed in mice may help detect early signs of cancer in dense breasts, which is essential for improved breast imaging and prognosis. Researchers created an analytic computer program that sorts mammary gland tissue into two assessments, resulting in better detection accuracy.
The National Science Foundation has awarded Georgetown University $12.5 million to establish a collaborative institute focused on viral emergence and education. The Verena Biology Integration Institute aims to advance cross-disciplinary research and train the next generation of researchers in this field.
A study found that informing children about their mother's genetic cancer risk has no impact on their lifestyle or quality of life. Children of mothers with BRCA gene mutations were more concerned and knowledgeable about cancer, but this did not influence their behavior.
A national, randomized trial found that intensive telephone-based cessation counseling resulted in a two-fold greater cigarette quit rate than minimal counseling and nicotine replacement. The study also showed significant benefits for people with higher nicotine dependence and those who engaged more with the counseling.
Biomarkers have been identified that could be targeted by novel drugs to treat glioblastoma brain tumors, which are highly lethal. The researchers found that temozolomide-resistant glioblastoma relies on a protein called CLK2, and that inhibiting its activity can cause widespread cancer cell death.
A systematic review found that reduced gut microbiome diversity and elevated trimethylamine-N-oxide (TMAO) metabolite levels are associated with increased risk of death and hospital visits in heart failure patients. Further research on the impact of diet and potential interventions is underway.
A study by Georgetown University researchers found that regional differences in COVID-19 mortality rates persisted throughout the pandemic. The South had higher mortality rates than the rest of the US, with 48% of COVID-19 deaths occurring in this region since October 2020.
A new study predicts climate change will lead to a viral jump to humans, increasing the risk of the next pandemic. Rising temperatures will have a devastating impact on bats, allowing them to travel long distances and share viruses with unprecedented rates.
A team of researchers has identified a biological pathway that drives genetic changes and bone metastasis in Ewing sarcoma, a rare childhood cancer. The study found that blocking the receptor Y5R can limit metastasis, offering new potential targets for treatment.
Researchers at Georgetown University Medical Center have discovered new genetic and cellular factors that can determine breast cancer recurrence. The study's findings have the potential to improve treatment choices and screening methods, and may also benefit women who have not had breast cancer.
A new study by Georgetown University Medical Center scientists found that geoengineering the climate could shift malaria transmission regions, increasing the risk of infection in some areas. The research used climate models to simulate malaria transmission under different warming scenarios with and without geoengineering.
A study by Georgetown University researchers found that humans have transmitted diseases to wild animals nearly 100 times, with most cases occurring in captive settings like zoos. The study highlights the need for long-term monitoring and better understanding of wildlife disease to mitigate risks for human health and conservation.
A study led by Georgetown University scientists demonstrates the power of artificial intelligence in predicting viruses that could infect humans, such as SARS-CoV-2. The research team identified 40 new bat hosts of betacoronaviruses and found that models harnessing data on bat ecology performed well at predicting new hosts.
A study in mice found that senescent cells can lead to chronic stress and tissue damage, causing kidney problems. Eliminating these cells can reverse some premature tissue damage and potentially alleviate cardiovascular disease.
A clinical trial found that giving immunotherapy before targeted therapy improves survival in advanced melanoma patients, with a two-year overall survival rate of 72% compared to 52%. The study suggests that immunotherapy should be the initial approach for treating metastatic melanoma patients, regardless of BRAF mutation status.
Researchers identified a significant vascular defect in patients with moderately severe Parkinson's disease, which may explain earlier study findings and provide a new target for therapeutic intervention. The discovery highlights the blood-brain barrier's crucial role in neurodegenerative diseases like Parkinson's.
Researchers found that an experimental dipeptidyl peptidase inhibitor enhanced immunotherapy effectiveness by boosting immune cells around the tumor, reducing growth and eliminating cancer in some mice. The combination treatment also instilled an immune-cell memory, allowing the immune system to recognize and kill cancer cells later.
A survey of US dentists found that an overwhelming majority believe nonsteroidal anti-inflammatory drug (NSAID)-acetaminophen combinations are as effective or more effective in managing dental pain as opioids. However, nearly half still prescribe opioids, highlighting a disconnect between their knowledge and prescribing habits.
Breast cancer deaths can be reduced by 57% in Black women if they start mammography screening every other year at age 40. This approach is consistent with the US Preventive Services Task Force's guidance for biennial mammography.
A phase II clinical trial found that intensive rehabilitation of arm and hand use after a stroke is most effective 60 to 90 days after the event. The study showed significant improvement in hand and arm function, with benefits also seen when rehabilitation started at less than 30 days post-stroke.
Researchers found that strokes affecting specific brain regions can cause distinct reading problems, which could help clinicians develop personalized therapies. The study's findings have implications for understanding post-stroke language and reading deficits.
New research from Georgetown University Medical Center found that certain brain functions associated with attention and executive control can improve in older individuals. These improvements may be due to lifelong practice and skill-building.
Studies of cell-free DNA (cfDNA) shed into the blood reveal that modifications, such as methyl groups, can identify specific cell types. This allows for non-invasive assessment of tissue damage and origin, enabling researchers to evaluate treatment effectiveness and detect adverse effects.
A recent study found that a small percentage of cells in aggressive tumors can enable metastasis by recruiting surrounding cells. This discovery could lead to new approaches in preventing malignant progression of breast cancer, particularly in triple-negative types.
Researchers have identified a neurologic pathway that explains how non-damaging brain impacts cause long-term problems with learning and memory. A new treatment approach may reactivate and normalize cognitive function.
Asymptomatic and pre-symptomatic transmission poses a significant challenge in controlling the COVID-19 pandemic. Experts warn that relying solely on vaccination is unlikely to be effective in preventing transmission, highlighting the need for robust surveillance measures.
Researchers found reduced functional connectivity between brain regions in people with HIV and APOE4, leading to poorer memory function. Severe immunosuppression further exacerbated the impact of APOE4 on memory performance.
Researchers found that older gay men living with HIV reported having supportive relationships with family, friends, or informal partners, whereas those without HIV relied mainly on primary romantic partnerships. The study highlights the importance of social support in managing chronic illness, including HIV.
Researchers discovered that pancreatic cancer changes its microenvironment to evade immune cells, which can be reversed by targeting a specific protein called STAT1. This finding offers a new approach to immunotherapy for this deadly cancer.
Artificial intelligence can learn new visual concepts faster using a technique that mirrors human visual learning, improving its ability to quickly recognize objects from sparse data. The approach enables computers to leverage prior learning and simplify complex visual concept representations, leading to improved learning efficiency.
A team of researchers identified a process that promotes the growth of pancreatic cancers and developed a method to disrupt it. By inhibiting adhesion molecule CDH11, they were able to reduce tumor growth, increase the effectiveness of chemotherapy, and extend mouse survival.