A consortium of researchers identified a rare but important gene target, NRG1, responsible for development of various cancer types. The study suggests that targeting this gene fusion could effectively shut down cancers, offering a new therapy possibility.
A new study warns that global warming could lead to the spread of disease-carrying mosquitoes to areas previously too cold for them, putting 1 billion people at risk. The research suggests that temperatures are expected to rise, leading to year-round transmissions in tropical regions and seasonal risks elsewhere.
Researchers have developed a novel brain map that tracks early brain atrophy in people with HIV, revealing a two-stage model of brain damage. The study suggests that the frontal lobe is affected early on, while the caudate/striatum area becomes more damaged as clinical symptoms appear.
Researchers found that Dot had a typical-use failure rate of 5 percent and a perfect-use failure rate of 1 percent, comparable to other fertility awareness-based methods. The study also found no association between pregnancy and sociodemographic characteristics.
Researchers found that nilotinib increases dopamine levels by reducing toxic alpha-synuclein protein, allowing normal dopamine release. The study also showed a significant reduction in alpha-synuclein levels and increased TREM-2 activity, indicating an elevated immune response against misfolded proteins.
Researchers at Georgetown Lombardi Comprehensive Cancer Center found that immunotherapy checkpoint inhibitors are both safe and effective in treating advanced cancer patients with HIV. The therapy offers similar objective response rates as non-infected patients, with benefit also seen in Kaposi's sarcoma treatment.
A novel online questionnaire found that most CFS patients do not receive proper care in EDs, with only a third receiving appropriate treatment. Researchers call for more training on the disorder to improve patient outcomes.
A Georgetown University Medical Center study found that nursing homes experience improved quality of care during periods of recession and worsened care when the economy is good. Higher unemployment rates are linked to higher nursing staff levels, leading to better retention and reduced turnover.
A comprehensive analysis found a strong inverse relationship between vaping and smoking among youth and young adults. Vaping became more popular around 2014, resulting in accelerated reductions in youth and young adult smoking prevalence.
A team of neurologists at Georgetown University Medical Center found that inhibiting the USP13 protein eliminates Lewy bodies and stops their buildup in mouse models of Parkinson's disease. The study suggests targeting USP13 as a therapeutic target for treating Parkinson's and other neurodegenerative diseases.
Research suggests that adolescents with a particular variant of an opioid receptor gene may be more vulnerable to substance abuse due to altered reward processing. The G-allele carriers showed a muted response in the prefrontal cortex, leading to an increased risk for future substance use problems.
A study published in Scientific Reports found that forced expression of the natural protein FGFBP3 in obese mice reduced their fat mass by over a third. The treatment also improved obesity-related disorders such as hyperglycemia and fatty liver disease, with no side effects observed.
A first-of-its-kind study found that a fertility app called Dot is as effective as other modern methods for avoiding unplanned pregnancies. The app provided women with information about their fertility status each day of their menstrual cycle, resulting in a typical-use failure rate of 3.5%.
A study published in Cell Death Discovery found that a critical switch during breaks in nursing controls whether breast cells survive or die, potentially providing a strategy to block cancer. The researchers identified the unfolded protein response (UPR) pathway as a key player in this process.
A new mouse study builds on human findings that link chemotherapy and the APOE4 gene variant to cognitive problems. The research, published in Neurotoxicity Research, reveals that APOE4 works with doxorubicin to cause significant brain changes and impair learning.
The study, involving hundreds of breast cancer patients, found that chemotherapy and hormonal treatments do not have major adverse effects on cognitive function for most older women. A small subset of patients with the APOE4 gene showed a decline in cognitive test scores after chemotherapy.
Researchers found that deep space bombardment can significantly damage gastrointestinal tissue, leading to long-term functional alterations and high risk of tumor development. The study's findings raise concerns about the health of astronauts on long voyages, such as Mars.
Researchers from Georgetown University Medical Center found that electrical brain stimulation can enhance creative thinking. However, the use of these devices in children raises concerns about safety and regulation. The authors suggest educating users and making safer tools available to mitigate risks.
A review of twelve studies found that probiotics reduced antibiotic prescriptions by 29-53% in infants and children. The study suggests that probiotics may be a way to combat antibiotic resistance, with potential mechanisms including immune regulation and pathogen inhibition.
A study found that Medicaid expansion under the ACA did not increase access to complex surgeries at high-volume hospitals among ethnic/racial minorities and low-income populations. Despite overall increased surgical care access, disparities in complex surgery utilization persisted.
Researchers found that only 8% of studies included some primary care patients, and none were conducted solely in primary care settings. Primary care physicians should be represented in advisory boards, considered for study grants, and primary care patients need to be included in trials of drugs used in primary care.
The REMBRANDT dataset, hosted by Georgetown University Medical Center, contains genomic information on 671 adult patients with brain tumors. Researchers can analyze and visualize the datasets using a simple web interface, facilitating discovery and treatment development for brain cancer.
Researchers have found a new test that significantly improves the identification of bladder tumors likely to recur and progress. The test involves examining STAG2 gene expression in removed tumors, offering additional predictive discrimination.
The Elizabeth R. Griffin Program aims to strengthen evidence base for implementing biosafety, biosecurity, and occupational health programs globally. The program will conduct collaborative research, promote safe work practices, and strengthen global health security networks.
The study found that the brain uses a two-step process to learn and categorize visual and auditory stimuli, allowing for easy building on previous content to learn novel information. This discovery could lead to the development of new methods to restore sensory deficits in individuals with disabilities.
Researchers at Georgetown University Medical Center have created a web-based tool to integrate control measures for co-endemic diseases like schistosomiasis and malaria. The tool allows users to assess the outcome of combining control measures based on local conditions and political constraints.
A study by Georgetown University Medical Center found that babies who suffered a perinatal stroke regained language function in the opposite side of their brain. The research, led by Elissa L. Newport, PhD, discovered that teenagers and young adults used the right sides of their brains for language after a left-brain injury.
A large study found that family history of breast cancer significantly increases the risk of developing invasive breast tumors in women aged 65 and older. The researchers suggest that women with a first-degree family history should consider continuing mammography screening even beyond age-based recommendations.
A study combining axitinib and pembrolizumab found the treatment to be tolerable and doubling efficacy in patients with advanced kidney cancer. Over 90% of patients exhibited tumor shrinkage, keeping disease under control for over 20 months.
Researchers at Georgetown University Medical Center used a novel approach to find that the FDA-approved drug clofarabine can shut down Ewing sarcoma cells in lab tests. The study suggests that clofarabine may be effective in treating this rare and aggressive cancer, which primarily affects young people.
New research suggests that language is learned in brain systems also used for tasks like remembering shopping lists and driving. Children learn their native language in evolutionarily ancient brain circuits, while adults learn foreign languages in both declarative and procedural memory.
A new study provides a model for accurately measuring HIV mortality rates in Zambia, which is crucial for improving treatment outcomes. The study found that mortality is substantially underreported in routine data, with some provinces showing mortality rates up to 23-fold higher than reported.
A new study by Georgetown University Medical Center researchers found that a widely used gene expression profile test to predict breast cancer recurrence is less cost-effective in real-world practice. The test, Oncotype DX, was initially considered cost-effective but its accuracy and implementation in community settings make it less so.
Breast cancer survivors who consumed more soy foods and cruciferous vegetables experienced fewer menopausal symptoms and fatigue. Phytochemicals in these foods may modulate inflammation and estrogen levels, potentially reducing treatment-related side effects.
A new biomarker test developed by researchers at Georgetown University Medical Center can predict, with up to 90 percent certainty, which chemical compounds can cause DNA damage that could lead to cancer. The test, called TGx-DDI, is based on genes that are actively transcribed in a cell and can identify stress due to DNA damage.
Researchers discovered that fibroblast growth factors (FGFs) can regulate blood pressure and control disease associated with hypertension. FGF inhibitors could be used to target high blood pressure by altering sensitivity to angiotensin II.
Researchers found that a genetic variant in the dopamine receptor gene delayed maturation of a brain region involved in reward planning in boys, but not girls. In girls, the opposite effect was seen, with the same variant delaying cortical maturation while promoting healthy development in boys.
A study at Georgetown University Medical Center reveals distinct molecular signatures in two brain disorders, CFS and GWI, with implications for diagnosis and treatment. The research found changes in miRNA levels after exercise, differing from other conditions like depression and Alzheimer's disease.
Researchers at Georgetown University Medical Center found that physicians who received pharmaceutical gifts prescribed more branded drugs and had higher costs per claim. The study, which analyzed data from Medicare Part D prescriber reports, suggests that even small gifts can influence prescribing behavior.
A survey of young white women found that over one in five have signs of indoor tanning addiction and three times more likely to meet criteria for dependence. Women with depression were most likely to weigh benefits against risks.
A new study from Georgetown University found that the 2001 NY State Medicaid expansion significantly increased racial disparities in access to high-quality cancer surgery. The proportion of minority Medicaid patients treated at top hospitals decreased, while white patients' access improved.
Researchers at Georgetown University Medical Center discovered a novel agent YK-4-279 that, when combined with vincristine, halts the ability of Ewing sarcoma to grow and progress. The combination produces a microtubule catastrophe in cancer cells, targeting their ability to divide and multiply.
A study has identified a new strategy to treat HPV-related cancers, targeting the virus's E6 oncoprotein and its interaction with myc protein. This approach could lead to a more specific and less toxic treatment option.
A recent study suggests that switching from cigarette smoking to vaping can lead to significant gains in life expectancy. Researchers estimate that around 6.6 million cigarette smokers could live substantially longer with e-cigarettes over a ten-year period.
Researchers found that bilingual brains rely more on native language processes when learning a new language, but learn it faster. This study supports the hypothesis that early bilingualism is beneficial for language learners in later life.
A new web-based tool developed by Georgetown University's Center for Global Health Science and Security allows national leaders to calculate the cost of developing health capacities. The tool provides a realistic, country-specific estimate of the costs needed to be compliant with International Health Regulations.
Research supports e-cigarette use as a smoking cessation aid with consistent daily use increasing the odds of quit success by 10%, but those using e-cigarettes less frequently face lower quit rates.
Researchers have found that inhibiting cell receptors can clear toxic protein buildup, reduce brain inflammation, and improve cognitive performance in animal models of Parkinson's and Alzheimer's diseases. The study also suggests that this inhibition may help insulate the brain from circulating inflammatory cells.
A high-fat diet during pregnancy significantly increases breast cancer susceptibility in offspring for three generations, according to a Georgetown University Medical Center study. Genetic changes were observed in mammary tissue of high-fat diet progeny compared to control group's offspring.
Researchers identified significant gene mutations and differences in the upper digestive tract that could help develop tailored treatment options for cancer patients. The study found a set of frequently mutated genes in small bowel adenocarcinomas, which may affect therapy choice and targeting.