Researchers report a link between methamphetamine self-administration and imbalance of brain circuits responsible for addiction. Noninvasive brain stimulation may help control compulsive drug use in humans by targeting these circuit imbalances.
Research finds increased indicators of despair, including depression and suicidal ideation, among Gen X-ers in their late 30s and early 40s, regardless of demographic group.
Researchers from the University of Illinois at Chicago found that injured miners who worked shifts longer than 9 hours tended to have irregular schedules or less than two years on the job. Long work shifts were associated with a 32% increased risk of injury resulting in death and a 73% increased risk of multiple worker injuries.
Researchers have found that logging practices can cause significant bedrock incision, eroding geology at a rate of up to 100 times the natural rate. The study, conducted on the Teanaway River in Washington state, shows that human activity has transformed the riverbank, creating new terraces and altering the landscape.
Spiders, including wolf spiders, react to irritating chemicals like allyl isothiocyanate in a similar way to mammals and humans, who have transient receptor potential channels that activate sensations like pain and taste. This reaction causes them to avoid eating insects coated with these chemicals.
Researchers found cold-resistant phenotypes in Alaskan Iñupiat and immune response genes in central Mexican and southeastern US populations. Genetic adaptations varied depending on population history and geography.
The study highlights the devastating impact of Venezuela's socioeconomic and political crisis on public health, with a significant increase in malaria cases. The country is now facing an 'epidemic of unprecedented proportions', with diseases turning into epidemics due to the collapse of healthcare systems.
Scientists at the University of Groningen have created a light-controlled switch that can be used to inhibit or stimulate bacterial communication. The molecule was tested on Pseudomonas aeruginosa and showed a strong response to light, inducing quorum sensing signals.
A new study in JAMA Pediatrics found that intimate partner homicide among teens is a serious public health issue, with 90% of victims being girls. The study analyzed data from the National Violent Death Reporting System and found that guns were the most common weapon used in these homicides.
Researchers develop a new method to create detailed structural models of proteins using force-driven simulations, reducing computational power requirements. The technique, inspired by metallurgy, allows for faster computation and more accurate results than existing approaches.
Aphid soldiers expel lipid-rich fluids to create a soft clot around the gall wound, which is swiftly hardened and melanin-darkened through phenoloxidase. This collective action amplifies an immune response for social defense, providing molecular clues to altruistic social defense mechanisms.
Researchers discovered close kin relationships among Stone Age individuals buried in megalithic tombs, suggesting a patrilineal society. The study found paternal continuity and an overrepresentation of males in some tombs.
Dr. Kelly Dorgan received a CAREER grant to study ecosystem engineering and bioturbation rates in marine sediments. She aims to improve nutrient regeneration and predict bioturbation patterns, benefiting ocean health.
A new study found that nearly half of dementia cases in low- to middle-income countries, such as China and India, could be prevented by addressing modifiable risk factors like education, hearing loss, and obesity. Improving childhood education and health outcomes throughout life may lead to significant reductions in dementia rates.
Scientists have developed a catalogue of DNA mutation 'fingerprints' caused by 41 environmental agents linked to cancer. The 'mutational signatures' can help doctors pinpoint the culprit responsible for a patient's tumour.
Researchers at the Santa Fe Institute and MIT find that continuous-time systems must have hidden states and finite hidden timesteps to exhibit two-time dynamics. This discovery has implications for understanding biomolecular processes, ecosystem evolution, and financial market behavior.
Researchers found threshold levels of circulating factor VIIa that prevented bleeding episodes in animal models, potentially leading to a new preventive treatment for patients with hemophilia who develop antibodies to standard maintenance therapy.
A new study estimates that the FDA's added sugar labeling policy could prevent nearly 1 million cases of cardiometabolic disease, including heart disease and type 2 diabetes, over a 20-year period. The label is expected to save $31 billion in net healthcare costs and $61.9 billion in societal costs.
A new strain of yeast can produce tagatose in much larger quantities than traditional enzymatic manufacturing techniques, making it a cost-effective alternative to sugar or high-fructose corn syrup. The glycemic index of tagatose is lower than that of sucrose and fructose, carrying a lower risk for developing Type 2 diabetes.
Researchers used mass cytometry to analyze millions of cancer and immune cells from 140 patients, discovering unique cellular compositions in each tumor. The study found that aggressive tumors are dominated by a single type of cell, while immune therapy may work for previously unsuitable breast cancer patients.
A new review suggests that social communication played a significant role in shaping the modern human face. The study, led by University of York researchers, concludes that our faces evolved not only due to factors like diet and climate but also to facilitate nonverbal communication and establish large social networks.
Nearly 2,200 adolescent homicides were analyzed; 150 were committed by an intimate partner, with nearly all female victims killed by firearm. The study highlights the need for understanding early adolescent dating relationships to inform prevention and intervention efforts.
Research on Caenorhabditis elegans reveals dopamine's role in sex-specific behaviors, such as food finding and mating strategies. The study demonstrates how dopamine acts through different molecular pathways to give rise to these differences.
Reducing household fine particulate matter (PM2.5) emissions in India could decrease mean annual ambient PM2.5 exposure by over 17%, averting premature mortality and meeting the national air quality standard for 103 additional districts. Complete mitigation of emissions from cooking alone would be necessary to achieve this goal.
A Rutgers-led study found that a two-hour introductory mindfulness class can be just as effective as an eight-week immersive course in reducing stress and depression among medical students. The research suggests that even brief meditation practices can lead to improved mental well-being, making it accessible for time-crunched individuals.
Researchers at ICFO have developed a graphene-enabled photodetector that operates at room temperature, is highly sensitive, and very fast. This breakthrough enhances the performance of existing terahertz detectors, paving the way for the creation of fully digital low-cost camera systems.
The 2018 Mississippi State University Row Crop Short Course presented topics such as nematode management, weed control, off-target movement of herbicides, and the economic outlook for row crops. Presentations are now available online through the "Focus on Cotton" series.
A team of researchers discovered a primitive class of meteorite containing a slice of carbon-rich material similar to extraterrestrial dust particles thought to have originated in comets near the outer edges of the Solar System. This finding provides insights into the Solar System's architecture and formation.
Global climate models can adequately simulate temperature variability at timescales of years to multiple millennia. The study suggests that with correct initial and boundary conditions, particularly in the deep ocean, forecasting temperature variations becomes more feasible.
A study analyzing vital registration, census, and survey data from 202 countries estimates sex ratio at birth for all countries between 1950 and 2017. The study reveals significant regional variations and findings a total of 23.1 million missing female births worldwide.
Researchers found three techniques: ambidextrous practices, secure networks, and stealthy defiance, which helped individuals resist strict rules and structures, leading to rule relaxation and market changes. These actions were crucial for consumers and individuals with limited resources to participate in shaping the market.
A large clinical trial found that statins reduce the risk of cardiovascular events in moderate-risk rheumatoid arthritis patients by 40%, but the difference was not statistically significant. Statins also lower LDL cholesterol and C-reactive protein levels, making them a safe treatment option for these patients.
A study found that regular cannabis users require significantly higher doses of sedatives like fentanyl and propofol for routine procedures. This may lead to increased risk of adverse side effects due to dose-dependent side effects.
Researchers found E-selectin in bone vascular environment supports early growth of cancer cells, promoting metastasis. Using sugar-mimetic compound Uproleselan, they show reduced bone metastasis and survival advantage in mice with human breast cancer cells.
A novel approach using pleasant odors could help smokers quit by reducing craving urges. Pleasant aromas significantly decreased urge scores in participants, with those smelling pleasant odors showing a greater reduction than tobacco or blank scents.
Researchers at UCLA designed a device that harnesses the charge from falling snow to create electricity. The snow-based triboelectric nanogenerator can work in remote areas without batteries, providing a continuous power supply for applications such as monitoring winter sports or tracking athletes.
A tiny piece of a comet has been discovered inside a primitive meteorite, providing insights into the solar system's structure and evolution. The finding is significant as it reveals details about how our solar system took shape during its early stages.
A University of Michigan researcher has found that the mechanics producing wheezing and crackling noises with every breath are likely a cause of injury and inflammation. This new understanding could change how lung diseases are treated and represent a paradigm shift in doctor-patient interactions.
A team of researchers unveiled an image of the shadow cast by a black hole at the center of galaxy Messier 87, using the Event Horizon Telescope and supercomputers like Stampede1 and Stampede2. The image confirms that supermassive black holes exist and match the appearance expected from simulations.
A new study found that female rats exposed to maternal immune activation during pregnancy exhibit autism- and schizophrenia-like behaviors, similar to their male siblings. The researchers argue that this limitation may contribute to conflicting results in the field of psychiatric disorders.
Researchers discovered a gene that enables bacteria to resist linezolid in cats and dogs at a UK animal hospital, suggesting potential transmission between animals and humans.
Researchers at MUSC found that procedure time is vital in thrombectomy success, with diminishing returns after the 60-minute mark. The study suggests that surgeons should pause and reassess if a procedure is worth continuing beyond this point.
A Phase 1 clinical trial of CAR-T therapy found an 88.2% overall response rate in patients with relapsed/refractory multiple myeloma. The treatment, called LCARB38M, targets the B-cell maturation antigen and achieved a stringent complete response in 13 patients.
Researchers successfully engineered and printed a 3D vascularised engineered heart with cells, blood vessels, ventricles, and chambers that matches the immunological, cellular, biochemical, and anatomical properties of the patient. The use of native patient-specific materials is crucial to eliminating implant rejection risks.
Activists argue that pre-treatment mental health assessments of trans people are dehumanizing and unjustified, treating self-reports of gender dysphoria as if it were a mental illness. Informed consent should replace these assessments, respecting patients' autonomy and lived experience.
A new CRISPR/Cas9 system allows for precise gene knock-in in live cancer mouse models, improving efficiency and control over gene insertion. The system was used to model intrahepatic cholangiocarcinoma, a type of liver cancer, and successfully induced tumor formation in mice.
Scientists successfully blocked cancer-fighting gene silencing protein UHRF1, restoring hundreds of protective genes in human colon cancer cells. The findings suggest a new strategy for fighting cancers by targeting this protein.
A recent study by Dr. David Munoz reveals the APOE ε4 allele affects sleep patterns differently in women and men with Alzheimer's disease. The research found carriers of this gene variant experience more nighttime disturbances than non-carriers, highlighting a gender-based effect on sleep behavior.
Researchers discovered that impaired FUS protein-protein interactions contribute to ALS degeneration, but drug-induced autophagy reduces pathological processes linked to aberrantly accumulated FUS. Stimulating autophagy rescued RNA-binding proteins and reduced neuronal death in cell culture experiments.
Researchers at SLAC National Accelerator Laboratory have made the first high-definition 'movie' of ring-shaped molecules breaking open in response to light. The results provide high-resolution details of the reaction, showing how bonds break and atoms jiggle around for extended periods of time.
A new study proposes a blueprint for conserving habitat across the Western Hemisphere to protect migratory birds. The research uses eBird data to calculate how much land must be conserved for each species, finding that working lands are more efficient than protected areas.
Researchers from Michigan State University used satellite imagery to quantify nitrogen losses in Midwestern corn fields. They found that nearly $1 billion worth of fertilizer is wasted annually, resulting in 6.8 million metric tons of greenhouse gas emissions.
Scientists at Hebrew University create decoy molecules that trick RNA-binding proteins into binding with them, inhibiting their cancer-promoting activity. The technology has shown promise in slowing or stopping the growth of brain and breast cancer cells in mice.
Researchers at TU Wien develop innovative light-emitting diode by harnessing radiative decay of exciton complexes in ultra-thin layers, enabling precise control over desired light wavelengths.
A new RAND Corporation study finds that primary care services account for only 2.12% to 4.88% of total medical and prescription spending among Medicare beneficiaries. This estimate is lower than previous studies, and highlights the importance of investing in primary care for better outcomes and lower costs.
The study found that suppression of glutamatergic pyramidal neurons in the medial prefrontal cortex inhibits both acquisition and expression of cocaine-associated memories. In contrast, GABAergic neurons were not affected. This suggests that mPFC pyramidal neurons are a potential therapeutic target for treating drug addiction.
A new study reveals that flowering plants employ different genetic strategies to maintain a 'core genetic circuitry' that ensures stem cell function, even in the presence of defects
Children born to mothers with gestational diabetes are nearly twice as likely to develop diabetes before age 22. Early detection is crucial, as many cases are diagnosed when symptoms like frequent urination and weight loss arise.
A landmark clinical trial shows that canagliflozin lowers the risk of kidney failure by 30% in people with Type 2 diabetes and kidney disease. The study also found a significant reduction in cardiovascular events, providing a promising new treatment option for patients at high risk.
Researchers have discovered that small molecule compounds can alter the spatial organization of the genome, potentially leading to new epigenetic cancer drugs. This breakthrough opens up a promising approach to treat cancer by changing the 3D genome structure.
Research by SDSU finance professors found that mutual fund managers invest more in firms with similar political leanings, leading to lower returns and higher volatility for clients. The study analyzed over 1,300 active mutual funds and 16,655 firms, revealing a partisan bias among fund managers' portfolios.
Measles and diphtheria have re-emerged in Venezuela with a disproportionate impact on indigenous populations, with over 7,500 measles cases reported and 100 deaths attributed to the disease. Diphtheria cases also surged, with 96% of reported cases originating from Venezuela, exposing 3 million vulnerable children to the disease.
A new study suggests that extreme heat and precipitation in early childhood can lead to lower educational attainment, even among better-off households. The research found that climatic conditions affect education negatively in multiple ways, particularly in Southeast Asia and West and Central Africa.
A new study found that leaders in groups of animals are more vulnerable to attack from predators due to their riskier position within the group. Researchers used virtual prey in aquarium tanks and found leaders were more likely to be attacked than followers, with isolated individuals also being at higher risk.
Researchers confirm a long-hypothesized limit for weather prediction, first proposed in the 1960s, which is approximately two weeks on average. They used state-of-the-art models to test this limit and found that reliable forecasts are now possible nine to 10 days out in mid-latitudes.
The study found that certain genes, specifically transcription factors, code for proteins that fine-tune gene expression during the medusa stage. Jellyfish have a unique genetic toolkit, distinct from corals and anemones, which enables their development and growth.
Researchers found a new, more powerful variant of an antimicrobial resistance gene in Staphylococcus epidermidis, making it harder for the bacteria to be killed by chlorhexidine bathing. The discovery was an unexpected result of a study on central venous catheter infections.
A new study from Stanford University's Immigration Policy Lab found that providing low-income immigrants with free access to application assistance boosts naturalization rates. The gentlest kind of nudge—simple, well-placed information—most effectively targets those who are less educated and have lower incomes.
A study published in Annals of Internal Medicine found that low scam awareness in older adults may be an early sign of impending mild cognitive impairment and dementia. The researchers observed a significant association between low scam awareness and Alzheimer disease pathology in the brain.
A comet fragment has been found inside a carbonaceous chondrite meteorite, La-Paz 02342, revealing unique properties of the cometary dust speck. The discovery provides insight into the formation of primitive materials and their preservation in meteorites, shedding light on the solar system's origins.
Researchers aim to identify effective strategies for reducing violence in internationalized civil wars, which have the most fatalities and are difficult to resolve. The project will analyze conflict management approaches, create a barometer to measure changes in conflict levels, and provide policy recommendations.
A team of MU neurobiologists have annotated the sequences of 47 ion channels across the lamprey genome, shedding light on their role in nervous system function and recovery from spinal cord injury. This advancement paves the way for further investigations into the molecular aspects of the nervous system.
Scientists have developed a novel strategy to extract and analyze membrane proteins, which are critical targets for therapy. Azo, a photocleavable surfactant, enables effective mass spectrometry analysis of whole proteins, opening up new opportunities to study membrane proteins.
A study found that state-level legalization of gay marriage led to a significant decrease in implicit and explicit anti-gay bias across the US. The effects were consistent across models, suggesting that legislation locality may moderate local biases.
Researchers at the University of Otago and Indian Statistical Institute have discovered distinct epigenetic markers in oral cancer tissues that are associated with patient survival. The findings, published in the journal Epigenomics, could help save thousands of lives by identifying cancer cells early.
Google searches have identified popular North American bird species, with large birds and those visiting feeders drawing more attention. The study found that owls were the subject of public curiosity, while conservationists can use this information to focus efforts on lesser-known species.
A new study published in the Journal of Hepatology reports that whole-exome sequencing (WES) can diagnose the genetic cause of liver disease in a significant proportion of adult patients. The analysis identified four monogenic disorders in five unrelated adults, enabling new treatment options and shedding light on underlying molecular ...
Booz Allen Hamilton received the 2019 INFORMS Prize for its pioneering integration of operations research (O.R.) and analytics programs. The company consolidated its O.R. talent into a single, centralized organization to enhance cross-disciplinary exchanges and accelerate internal research projects.
Scientists at NRL discovered a new method to passivate defects in next generation optical materials, improving optical quality and enabling miniaturization of light emitting diodes. The technique produces a 100-fold increase in material's optical emission efficiency, paving the way for high-efficiency optoelectronic devices.
Researchers found that tropical fire ants in Florida can coexist with both single- and multi-queen colonies. In multi-queen colonies, all reproductive queens are genetically identical and reproduce asexually.
Researchers at the University of Pittsburgh School of Medicine have found that responsive neurostimulation can remodel the brain to be less susceptible to seizures. By analyzing individual brain activity recordings over time, the study shows that stimulation changes brain networks, making it harder for seizures to spread.
A new study by McGill University researchers found that state legislation played a significant role in reducing anti-gay bias in the US. By analyzing data from over 1 million respondents, the team discovered that laws supporting same-sex marriage led to a sharp decline in biases, with the effect being roughly double the previous rate.
Research in a Washington river basin reveals that early 20th-century timber harvesting, particularly splash-damming, led to increased bedrock erosion and reduced floodplain areas. This study suggests that brief human activities can have lasting impacts on the landscape.
Research shows low-intensity ultrasound can modulate normal brain function, affecting counterfactual thinking and alternative choice. This technique may revolutionize non-invasive treatment for mental health conditions like depression and Parkinson's.
Daniela Rubatto's research provides a new way to connect minerals' ages to their formation conditions, reconstructing the speed and duration of rock travel within the Earth's crust. Her innovative method uses an ion microprobe to extract valuable information from minerals, contributing to better understanding geological processes.
Researchers found that being part of a group provides safer protection from predators, with prey positioned in the middle of schools having the safest position. The study revealed that predators are more likely to attack isolated individuals than those in groups, highlighting the benefits of collective behavior.
A £1.8m funding boost will help researchers at the University of Edinburgh improve diagnosis and treatment outcomes for Crohn's disease, a condition affecting 120,000 people in the UK. The study aims to develop a non-invasive test using blood or stool to determine if the inflamed bowel wall has healed after treatment.
A new study by the University of Stirling has identified a silence around suicidality among children and young people, with many feeling they cannot access help or are not listened to by healthcare professionals. The research emphasizes the importance of using explicit language, such as 'suicide,' in mental health conversations.
A new study published in Pediatrics found that adolescents with cognitive impairments and intellectual disabilities have similar weight-loss outcomes after bariatric surgery as those with typical cognitive function. The study's authors recommend a case-by-case approach to determining eligibility for weight-loss surgery.
Researchers found that older brains with low TRIM9 levels are prone to extensive swelling following stroke, but increasing the gene's expression improves recovery. The study aims to identify what triggers TRIM9 gene expression to develop potential treatments.
Researchers found that half of patients prescribed statins failed to achieve 'healthy' cholesterol levels within two years, increasing the risk of cardiovascular disease and stroke. Patients who did not respond well had a 22% higher risk of developing cardiovascular disease compared to those who reached the target.
Continuing PCV in Kenya is estimated to prevent over 100,000 cases and save 14,000 lives annually. The vaccine's full price is less than Kenya's GDP per person, making it a cost-effective option.
HRL Laboratories' breakthrough alloy is the world's first printable high-strength aluminum, registered with the Aluminum Association. The registration validates its commercial value and enables companies to access the alloy through specific powder numbers.
Researchers at Newcastle University found a significant discrepancy between reported and actual catches of vulnerable species like sharks and rays in small-scale fisheries. The study highlights the urgent need for global efforts to assess their impact on the environment.
Researchers found that reframing how students view food-marketing campaigns can spur adolescents to make healthier dietary choices for an extended period. Teenage boys reduced their daily purchases of unhealthy drinks and snacks in the school cafeteria by 31 percent, while girls' purchases remained similar.
Researchers at UNC and TMIMS discovered that IRF1 protein regulates RARRES3 enzyme, making liver cells hostile to hepatitis A infection. The study provides implications for cellular responses to other RNA viruses like dengue and Zika.
Moffitt researchers discovered that melanoma cells become resistant to BRAF inhibitors through a conserved stress response mechanism involving AP-1 activation and histone deacetylase 8. This finding suggests that HDAC inhibitors may be able to overcome resistance mechanisms, leading to potential new treatments.
A study found kin relationships among people buried in Neolithic megalith tombs, indicating a societal role for these enigmatic structures. The genomic data revealed affinity to farming groups with past admixture with hunter-gatherer groups, highlighting a previously unknown role for megaliths in Neolithic societies and families.
Biomedical engineers at Duke University developed a method to improve CRISPR accuracy by adding a short tail to the guide RNA, creating a 'lock' that prevents off-target activity. The approach increases accuracy by an average of 50-fold across five different CRISPR systems.
A new study published in Geosphere investigates how scientists perceive interactions with policy makers, revealing five distinct models: a beacon, collaborator, educator, outcast, and investigator. The researchers emphasize the importance of understanding individual perspectives to effectively engage scientists in policy decisions.
A new American Cancer Society study highlights the need to better identify patients with metastatic cancer who may not benefit from aggressive treatment. The study found wide variations in treatment patterns among patients who died within a month of diagnosis.
Researchers at the University of Edinburgh found that a beetle's diet during sexual development affects its adult breeding habits. Females prefer to mate with well-fed males to optimize offspring health.
Researchers have discovered a hill-like bump of electric charge at the X-point in tokamaks, which prevents plasma particles from traveling straight between upstream and downstream areas. This finding could lead to more accurate predictions about exhaust and make future large-scale facilities less vulnerable to internal damage.
Researchers at Rutgers University have identified a new factor essential for maintaining stem cells in the brain and gut, whose loss contributes to anxiety and cognitive disorders. The study reveals that this gene product supports multiple types of adult stem cells, including those critical for cognitive function and intestinal renewal.
The discovery of an Earth-sized planet and a warm sub-Neptune-sized world in the HD 21749 system marks a significant milestone for NASA's TESS mission. The planets have distinct orbital periods, with the sub-Neptune taking 36 days to complete its orbit.
Research by Laurie Weingart and Matthew Cronin focuses on respect to promote learning and consensus building in science communication. The study highlights the importance of bridging representational gaps, or rGaps, which occur due to fundamental differences in values, perspectives, and knowledge bases.
Women may be at greater risk of developing surgical site infections after coronary bypass surgery, re-vascularization of arterial occlusion, and hernia repair. Men are more likely to develop infections after orthopaedic and trauma procedures.
Researchers discovered the diameter of a giant red giant star 2,674 light-years away and a sun-like star at 700 light-years, setting a record for the smallest star measured. The team used asteroid occultations to calculate the stars' sizes with high accuracy.
The University of Cincinnati's Department of Operations, Business Analytics and Information Systems has been awarded the 2019 UPS George D. Smith Prize for its innovative curriculum, which prepares students to become effective practitioners in business analytics. The prize recognizes the department's long history of excellence in worki...
Researchers propose a unified approach to optimize radar polarimetry data for precise weather forecasting. This combines observation-based retrievals with model-based analysis to improve quantitative precipitation estimation, warnings, and forecasts.
A team of scientists has discovered that the neuronal transport factor Staufen2 scans and binds to its target transcripts in a more complex manner than previously thought. This finding opens up new approaches to improve our understanding of RNA transport and synaptic plasticity, which is essential for memory and learning.
A new study identifies four key factors influencing transgender youth's decision on fertility preservation, including family values, cost, and concerns about worsening gender dysphoria. The findings highlight the need for standardized protocols in primary care counseling and support for young adults navigating this complex issue.
A novel microscopy technique, developed by Rockefeller scientists, integrates approaches to build a more cohesive picture of the brain. It captures cellular activity across large volumes of neural tissue, allowing researchers to generate a picture of rapid cellular activity across multiple layers of brain tissue.
Scientists have created a genetically engineered bacterium that can specifically kill multiple antibiotic-resistant bacteria without harming beneficial bacteria. The novel tool, based on the CRISPR-Cas9 system, has shown a minimal rate of emergence of new resistance and has potential applications in treating infectious diseases.
Researchers successfully created self-assembled structures using oppositely charged synthetic proteins, enabling the formation of hierarchical ordered, symmetrical structures. This breakthrough could lead to the development of novel architectures for bio-enabled sensing and functional coatings with unique properties.
Researchers combined CRISPR with drug discovery to understand how AML treatment works and which weaknesses can be exploited. The study revealed that LSD1-GFI1B relationship is critical for AML survival, enabling more targeted treatments.
The Innovative Medicines Initiative has launched a five-year project to generate exploratory and confirmatory data for novel safety biomarkers. This will improve the diagnosis and management of acute and chronic diseases, as well as reduce safety attrition in drug development.
A new study by University of Lincoln researchers suggests that extreme temperatures can impact the reproductive behavior and physiology of males before females, potentially leading to infertility. The study found that rising temperatures hampered sperm production in male Indian meal moths, affecting their ability to mate.
The US Department of Energy has awarded 86 grants totaling $95 million to small businesses in 21 states. These Phase II research and development grants will support scientific innovation and create jobs. The selected projects include advanced materials, energy storage, and IoT applications.
A researcher at the University of Texas at Arlington has received a four-year grant to investigate protein regulation in programmed cell death. Understanding how these proteins are regulated could lead to drugs targeting specific cancer cells.
The Louisville Metropolitan Sewer District and Tetra Tech won the 2019 INFORMS Edelman Award for their successful implementation of Csoft, a software solution that maximizes storage, conveyance, and treatment capacities to better protect the environment. The project has saved over $200 million in infrastructure costs and improved commu...
Researchers found that a significant proportion of patients and healthcare workers shed the flu virus without displaying symptoms, making it difficult to control its spread. The study, conducted at a tertiary hospital in Zurich, tracked over 700 healthcare workers and inpatients during two consecutive influenza seasons.
Researchers have identified a rarely-seen type of DNA mutation as the cause of an inherited metabolic disorder, a condition where the body can't break down specific nutrients. The gene responsible for the disorder is intact but a repeat expansion error prevents it from functioning.
Research from Indiana University's Kelley School of Business found that transparency in charitable organizations on crowdfunding platforms increases donations and fundraising. Regular operational updates significantly increase financial benefits, with each work-related word in updates boosting donations by $65 per month.
Astronomers used asteroid occultations to measure the smallest apparent size of a star on the night sky, revealing the diameter of a giant star and a sun-like star. The new method provides ten times better resolution than standard lunar occultation methods.
A proposed ban on menthol cigarettes by the FDA is expected to survive a lengthy legal process, according to a Rutgers paper. The study concludes that an FDA rule banning menthol cigarettes is likely to be upheld due to strong scientific evidence and legal power.
A Rutgers-led study found that pollen genes in certain corn strains undergo natural mutations, which may lead to better breeding and crop development. In contrast, other strains show no detectable gene mutations.
A new study finds that hospitals serving richer patient populations will face increased financial penalties under the revised system, while those with poorer patients will see reduced penalties. The changes aim to address concerns about the original program unfairly penalizing safety-net hospitals.
According to a new study, first-year doctors in internal medicine programs spend an average of 87% of their work time away from patients. The majority of this time is spent interacting with electronic health records or engaging in indirect patient care. Multitasking is also common throughout the day.
A new study published in Games for Health Journal found that allowing dark play in a serious video game has no significant effect on its effectiveness. The researchers analyzed the effects of dark play on medical students' ability to advise care, learning motivation, and attitudes towards delirious patients.
Researchers found that eliminating routine but low-value preoperative tests for cataract surgery patients can lead to significant cost savings. The study showed a savings of $67,241 over three years at one medical center, without measurable negative effects on patients.
Researchers propose a novel method from physics that makes economic effects of major events computable for the first time. The new method calculates resilience and outputs, testable predictions can be made and visualizations help understand economies.
Researchers reveal how the modern human face evolved over four million years, influenced by dietary changes, tool use, and social interactions. The study's findings suggest that the face's shape and features reflect our species' adaptability to different environments and cultural contexts.
Research reveals a correlation between exposure to extreme temperatures and precipitation, and reduced educational attainment among children in the tropics. Exposure to higher-than-average temperatures in utero and early childhood correlates with fewer years of education, particularly in Asia.
A consortium of researchers identified a rare but important gene target, NRG1, responsible for development of various cancer types. The study suggests that targeting this gene fusion could effectively shut down cancers, offering a new therapy possibility.
A breakthrough treatment has been found to protect against kidney failure and cardiovascular complications in people with diabetes. The study showed a significant reduction in kidney failure and cardiovascular events, such as heart attacks and strokes, by up to 30%.
A new algorithm can detect the molecular signature of a cancer-driving defect, identifying patients who could benefit from treatment with PARP inhibitors. The algorithm has the potential to expand greatly the pool of patients eligible for this therapy.
The study found that phenolic compounds in purple corn altered the development of fat cells and reduced inflammation and insulin resistance. Different combinations of anthocyanins showed varying effects on these biomarkers.
A study published in Nature Communications suggests that volcanic eruptions in the Siberian Traps led to a global catastrophe known as the Great Dying, which killed off 95% of life on Earth. The eruptions released massive amounts of mercury vapor into the atmosphere, causing acid rain and warming the planet.
Researchers at UC Santa Barbara have conducted the first global assessment of plastic's life cycle greenhouse gas emissions, finding that current strategies are insufficient to curb emissions. Recycling and replacing fossil-based energy with renewable sources offer promising solutions, but significant reductions will require unpreceden...
Dr. Blake Richards has made significant contributions to mathematical models of learning and memory in the brain, providing insights into the neurobiological basis of animal and human intelligence. His work explores the neural basis of deep learning and its potential to revolutionize our understanding of the brain.
Researchers developed a novel recombinant vaccine called NIPRAB that shows strong immunization against Nipah virus in animal models. The live vaccine is safe in mice, eliciting a strong antibodies response and reacting to similar viruses like Hendra and Rabies.
A recent study synthesizes research on severe haze pollution in Northern China, highlighting its complex interaction between human activities and atmospheric conditions. The findings suggest that improving haze prediction and developing effective regulatory policies require additional knowledge and public awareness campaigns.
Researchers identify essential protein PCMD-1 in controlling cell division at the centrosomal level, which is also linked to a genetic disease called primary microcephaly. The study provides insights into how centrosome assembly is regulated and has significant implications for understanding human developmental defects.
A new study has identified a brain activity pattern, called frontal alpha asymmetry (FAA), that predicts anger experienced during dreaming. Individuals with greater alpha-band brain activity in the right frontal cortex during REM sleep and pre-sleep wakefulness tend to have more angry dreams.
Researchers found that public interest in US bird species increases with body size and abundance, while endangered species attract high local interest. Certain well-known species are also popular nationwide, despite their limited range.
Analyzing nearly 6 million citations, Northwestern University researchers found that highly cited papers cite relatively recent work and go on to become highly cited themselves. This suggests that top scientists are adept at identifying promising research.
A study published in the National Tax Journal found that allowing donors to claim charitable donations earlier, such as before tax season, increases donations by nine percent. Researchers from UBC Okanagan and other institutions used a policy experiment in Quebec to test this idea.
A small study published in the British Journal of Sports Medicine suggests that doubles badminton players are at greatest risk of potentially serious eye injuries during matches. Protective eye wear is highly recommended for all competitors to prevent such injuries, which can cause permanent vision loss and even blindness.
A new study in Nature Communications finds that the collective attention span is narrowing, with increasingly steep gradients of attention given to each cultural item. The accelerating vicissitudes of popular content are driven by the rapid exhaustion of limited attention resources, as suggested by a mathematical model with three basic...
A study found that celebrity fat-shaming events increased women's implicit negative weight-related attitudes, with more notorious incidents producing greater spikes. The research suggests that cultural emphasis on the thin ideal contributes to eating disorders, particularly among young women.
The North Atlantic warming hole has a significant impact on the North Atlantic jet stream, leading to changes in atmospheric circulation and storm tracks. The cooling pattern caused by the warming hole is predicted to become greater and more apparent as the century progresses.
Scientists found evidence of water vapor in lunar exosphere after analyzing data from NASA's LADEE mission, which orbited the Moon from October 2013 to April 2014. The team detected dozens of events where meteoroids struck the Moon's surface, releasing a short-lived water vapor that could be used as a resource for future human explorat...
Researchers from UNIGE discovered that bacteria can thrive in the Dead Sea's sediments, surviving extreme conditions by feeding on ancient corpses. This finding has significant implications for searching for life on other planets and highlights the importance of understanding how microorganisms adapt to hostile environments.
Researchers at Chinese Academy of Sciences develop CRISPRed wheat with tolerance to sulfonylurea, imidazolinone, and aryloxyphenoxy propionate-type herbicides. The trait offers low-risk weed control for millions of multi-cropping farmers in China.
Researchers have developed synthetic peptides that target and inhibit small, toxic aggregates of amyloid beta, implicated as the toxic elements behind Alzheimer's disease. The peptides reduce amyloid beta-triggered toxicity in human neural cells and inhibit oligomers in laboratory animal models.
A new assessment tool, measuring a child's environment (EDN), can predict optimal development outcomes. The tool, tested in three countries, examines elements like breastfeeding, touch, and social support.
Researchers identified a helicase gene, ReqQ, involved in gene conversion and crossover frequency, the first of its kind in plants. This breakthrough may help breeders break up linked regions, increasing desirable genes without sacrificing vital plant functions.
The American College of Physicians recommends strengthening the Affordable Care Act to address gaps in coverage and ensure universal access. ACP calls for bolstering the insurance market, expanding Medicaid, and increasing competition to provide quality care for all Americans.
Research led by The University of Tokyo Institute of Industrial Science found that China and India's rapid urbanization, especially in China, and rural development in India were major enablers of the success in achieving MDG Target 7C-Water. Economic development was also found to be imperative in expanding drinking water coverage.
A recent study found that fentanyl-related deaths in West Virginia increased by 122% between 2015 and 2017, despite a decline in prescription opioid deaths. The surge in fentanyl deaths is attributed to illegal imports from China and the potency of the drug itself.
A study found that a resting heart rate of 75+ beats per minute in mid-life is associated with a doubling in the risk of an early death from all causes. Men in their 50s with increased heart rates are at heightened risk of developing heart disease over the next 11 years.
Researchers from University of Science and Technology of China successfully developed a ruthenium-based single-atom alloy catalyst accelerating water electrolysis with lower overpotential. The catalyst shows improved stability and activity compared to commercial RuO2, making hydrogen production through water electrolysis more efficient.