A new report reveals a protein, deltaNp63, that directs myeloid-derived immunosuppressor cells (MDSCs) to the primary tumor and metastatic sites, promoting tumor growth and metastasis. Blocking deltaNp63 or MDSCs reduced tumor growth and metastasis in a mouse model of triple-negative breast cancer.
Tropical Cyclone Luban is moving slowly towards Oman, expected to make landfall as a tropical storm before Oct. 14. The cyclone has strong winds and a ragged eye, but lacks thunderstorm development.
A new study reveals bacterial DNA is transferred to phages at frequencies 1,000 times higher than previously thought, allowing for rapid adaptation and gene dissemination. This discovery has significant implications for the spread of antibiotic resistance and other survival factors among bacteria.
The global cesarean section rate has increased from 12% in 2000 to 21% in 2015, with significant disparities in use between regions and socioeconomic groups. The authors call for improved quality childbirth care globally and emphasize the need for C-sections only to be performed when medically required.
Researchers are using pulsed electric fields to treat tumors, inducing cell death and stimulating the immune system. The technology delivers genes encoding cancer-fighting proteins into tumor cells, increases drug efficiency, and affects cell signaling.
Researchers created a new camera inspired by mantis shrimp vision, improving dynamic range up to 10,000 times higher than commercial cameras. The camera detects light polarization and can spot hazards three times farther away than color cameras used on cars today.
A high-fat diet in female mice affects their offspring's obesity, insulin resistance, and addictive-like behaviors for three generations. The study found that only females showed addictive-like behaviors, while males showed obesity characteristics in the third generation.
Scientists at UNC School of Medicine discovered that cystic fibrosis drugs targeting the faulty CFTR protein work best when patients' airways are inflamed, not when taking anti-inflammatory medications. This research has significant implications for treatment strategies in managing cystic fibrosis.
Researchers discover plant-based compound rutin reduces bleeding and inflammation caused by snake venom, offers potential co-treatment with antivenom for snakebite patients in countries without access to antivenom. The study's findings indicate a great potential for rutin as an ancillary drug in conjunction with antivenom therapy.
A large cohort of women under 50 showed a significant association between obesity and early onset colorectal cancer. Higher BMI, weight gain since age 18, and current body mass index were linked to increased risk of early onset CRC.
Research by Johannes Kohl identified the medial preoptic area (MPOA) neurons bearing Galanin as critical for parental behavior in mice. The study found that individual pools of these neurons control specific components of parenting, such as motor control and natural reward circuitry.
Researchers at MIT have developed a self-healing material that can grow, strengthen and repair itself by reacting with carbon dioxide from the air. The material, made from a polymer and chloroplasts, becomes stronger as it incorporates the carbon.
A recent study by Johannes Kohl highlights the function of a small population of neurons in the medial preoptic area that control parenting behavior in mice. The research found that individual pools of these neurons were activated during discrete parenting events, suggesting they control specific components of parenting.
Researchers at Johns Hopkins University have successfully grown human retinas in a dish, providing insights into how cells enable color vision. The study found that thyroid hormone plays a crucial role in determining the fate of these cells, with implications for understanding and potentially treating eye diseases.
A Clemson University team has developed a polymer that can heal itself like skin, bringing the technology closer to industrial-scale production. The discovery could significantly reduce production costs for self-healing materials used in various industries.
The research found that earlier women had their first period, their sons started puberty earlier, and later women had their first period, their sons started puberty later. The association was also seen in daughters.
A recent grant from the National Institutes of Health will enable a three-year project to explore the sex differences in oxytocin system development. The study aims to understand how oxytocin affects the female and male brain's neural regulation of social behavior.
A CU Denver researcher is conducting clinical research to develop an evidence-based treatment for comorbid pain and opioid addiction. The study aims to reduce substance abuse and pain relapse among patients with chronic pain, using a combination of therapies including cognitive behavioral therapy.
Researchers have developed a laboratory model that accurately evaluates MCL-1 inhibitors, enabling the identification of right patients for these drugs. The model predicts how cancer patients will respond to the drug in the clinic, allowing for effective treatment and potential breakthroughs in cancer therapy.
A new study found that consumer genomic databases can identify nearly anyone in a population once genetic data covers 2%, raising significant privacy concerns. The results highlight the power of rapidly growing consumer genomic datasets and suggest a need for policies to ensure genetic privacy.
A systematic review of quantitative studies on the relationship between education and political violence found that increasing education levels in the population reduces most forms of armed conflict. The study also highlights the importance of addressing systemic inequalities in access to education between religious and ethnic groups, ...
Researchers developed a transgenic mouse model of Parkinson's disease, replicating PD-like motor symptoms and α-synuclein aggregation. The study suggests that stabilizing normal αS tetramers may prevent or delay PD onset.
Scientists have developed a smart microscope that provides a 4D view of embryonic development in living mice. The microscope uses algorithms to track the embryo's position and size, creating high-resolution images of its development over a critical 48-hour window.
Bryan Gervais' study examines the impact of elite incivility on partisanship, revealing that counter-attitudinal incivility induces anger, leading to more partisan attitudes. The research also highlights the role of social media in amplifying incivility and polarization.
A genetic mutation in IFNλ4 reduces its effectiveness against the hepatitis C virus in humans compared to chimpanzees and African Pygmies. This discovery highlights a potential weakness in human immunity to certain viral infections.
Researchers discovered that mast cells release histamine from the gut, triggering the formation of oleoylethanolamide, which stimulates ketogenesis and supports brain and muscle function during prolonged fasts or intense exercise. This finding challenges the long-held assumption that mast cells are solely responsible for allergic respo...
Researchers from Japan have developed a way to better measure and manipulate conductive materials through scanning tunneling microscopy. The team designed a custom terahertz pulse cycle that quickly oscillates between near and far fields within the desired electrical current.
Cognitive decline was slowed after patients underwent cataract surgery and adopted hearing aids. The rate of decline was halved following cataract surgery and 75% less following the adoption of hearing aids, according to researchers at the University of Manchester.
Scientists have designed an ion gel with excellent toughness and self-healing properties, promising potential for building flexible electronic devices. The material can quickly heal on its own without external stimuli and exhibit high thermal stability and ionic conductivity.
A study highlights strategies to help teens with type 1 diabetes manage high cholesterol and blood pressure, including offering realistic guidance, encouraging regular exercise, and promoting healthy eating habits. The research emphasizes the importance of personalized approach and team effort in addressing these conditions.
Researchers developed a new method to use metabolites to predict diabetes and cardiovascular disease risk in people with obesity. The study analyzed over 2,400 participants and found that specific molecular signatures could identify individuals at higher risk of developing these diseases.
Acetaminophen's breakdown product activates glutathionylation, affecting mitochondrial energy production and leading to metabolic dysfunction. This discovery explains the drug's toxicity at high doses and may apply to other drugs with similar structures.
Researchers at the University of Sussex have created a large dataset that can be used to develop smartphone apps that detect transportation modes, predict road conditions, and offer route recommendations. The dataset has achieved high accuracy rates in recognizing modes of transport, paving the way for innovative mobile applications
A new study by Duke University and the University of York estimates that long-term ozone exposure in Europe, the USA, and China led to 266,000 premature mortalities in 2015. The research uses observed air quality data instead of chemical transport models, finding smaller human-health impacts compared to prior modeling results.
Shivam Arora, a dual-degree track graduate student, has won a $12,000 fellowship to conduct applied research in public-sector airport-related aviation issues. He plans to develop factor models for fixed-income securities issued by airport-affiliated entities.
A recent study uses metabolome analysis to identify a link between metabolite changes and weight, revealing that genetics don't correlate closely with obesity. The research suggests new ways to measure obesity and health risks beyond traditional BMI measures.
Tropical Storm Nadine is being torn apart by wind shear in the Eastern Atlantic Ocean, according to NASA-NOAA's Suomi NPP satellite. The storm's low-level center is nearly 50 nautical miles southwest of the nearest deep convection, indicating strong weakening.
A new study led by Harvard T.H. Chan School of Public Health researchers found a link between state-level gun ownership and police shooting deaths, with the strongest association among armed victims. The rate of fatal police shootings was 3.6 times higher in states with high gun prevalence.
Researchers at University of Illinois have discovered how to integrate ducted fans into wing sections to improve aircraft propulsive efficiency by ingesting low-speed air. This innovation modifies aerodynamic behavior, lift, drag, and pitching moment characteristics.
A new study suggests that ultrasound measurements after surgery can predict the likelihood of arteriovenous fistula maturation in individual dialysis patients. At 6 weeks after AVF creation, ultrasound measurements of AVF blood flow, diameter, and depth predicted future AVF maturation with moderate accuracy.
A WSU climate scientist analyzed The Great Drought of 1875-78, leading to the Global Famine that killed 50 million people. Climate conditions characterized as more severe than before could be replicated with global warming.
Researchers developed a computational method to link individuals in ancestry databases to those in law-enforcement databases, achieving accurate matches for over 30% of close relatives. The approach could have significant implications for forensic genetics and genomic privacy.
A physics model applied to a 'Super Court' of Supreme Justices found that consensus dominates the court's decisions, with strong correlations in voting persisting beyond individual justices' tenures. The study reveals that partisan issues are more complex than simple intuition suggests, and votes against prevailing opinions are probable.
Carnegie Mellon University researchers identified a molecule called BriC that plays a key role in bacterial communication and infection. BriC helps pneumococcus produce biofilms, making infections more robust, but may also be a target to render bacteria more sensitive to antibiotic treatment.
A recent study by researchers at George Washington University found that poor, elderly Puerto Ricans faced a persistent risk of dying after Hurricane Maria. The study estimates there were 2,975 excess deaths in Puerto Rico during the six-month period after the storm.
Chris Fox, a space buff since childhood, and his team discovered exoplanet Kepler 159d by analyzing the orbits of nearby planets. The exoplanet has a mass similar to Saturn's and likely consists of gases with no solid surface.
Astronomers have observed a massive star's death, creating a compact neutron star binary system. The explosion was unusually faint and the star had an unseen companion that siphoned away most of its mass.
Researchers at Duke University discovered a minimally invasive treatment using vagus nerve stimulation to reduce brain inflammation and cognitive decline after surgery. The study showed improved cognitive outcomes and reduced brain inflammation in mice with inflammation.
Researchers are exploring ways to speed up and enhance the recovery of the sense of taste after a significant injury. By understanding how IL-1 signaling works in the body, they hope to develop novel treatments to aid regeneration and recovery. In mice, studies have shown that IL-1 plays a crucial role in repairing the taste system.
Researchers discovered that silencing Farnesoid X Receptor (FXR) repressed HBV replication, while an FXR agonist reduced viral activity in mice. The study also found a link between immature bile salt pathway and chronic infection risk in newborns.
A recent study from CNRS has cast doubt on the connection between magnetite particles and Alzheimer's disease, as previous research suggested that magnetite could cause oxidative stress and lead to neuron degeneration. The new findings suggest that magnetite is unlikely to be involved in this process.
UTA professor Sahadat Hossain uses recycled plastic pins to strengthen MSE walls, increasing bearing and shearing capacity of foundation soils. The new method reduces excavation and replacement costs, improving pavement maintenance and reducing cracking.
Researchers have developed a novel vaccine that protects against both Lassa fever and rabies, with promising results in preclinical testing. The vaccine, called LASSARAB, uses a weakened rabies virus vector to elicit an immune response against both viruses.
The new guideline recommends moderate hypofractionation (240-340 cGy) as an alternative to conventional fractionation for men with early-stage prostate cancer. Hypofractionated radiation therapy can be completed in four to five weeks, compared to eight to nine weeks for conventional radiation.
A new study by the University of Texas at Austin found that proposed Title X guidelines restricting abortion counseling and referrals may adversely impact pregnant women's health care. The study, published in Contraception, compares pregnancy options counseling and referral practices at state-funded and federal organizations.
A survey found that many white Americans assume immigrants from certain countries are 'illegal' due to stereotypes and lack of documentation, leading to discriminatory treatment. The study highlights the impact of social perceptions on immigrant standing in American society, revealing a new source of ethnic-based inequalities.
Only one in three Chinese acute coronary syndrome patients receive cardiac rehabilitation guidance before discharge from hospital. Men are more likely to receive advice than women, but all heart attack patients need cardiac rehabilitation, and targeted efforts are needed to improve provision.
Researchers at the University of Würzburg and the Technion have successfully built a topological insulator operating with dual excitations, offering a novel platform for switched electronic systems and laser applications. The discovery showcases the potential of this material for advanced optoelectronic devices.
Researchers build systems reproducing quantum predictions with classical models, suggesting a boundary for 'true' quantum phenomena beyond single-particle interactions. Quantum entanglement remains an unexplained mystery.
Researchers found a species of blind cavefish lacking an ancient DNA repair system, previously known only in placental mammals. The discovery supports the 'nocturnal bottleneck' theory, suggesting ancestors of modern mammals lived in darkness before dinosaurs.