The NIH summit recommends a precision medicine approach to Alzheimer's treatment and prevention, with a focus on developing interventions tailored to an individual's unique risk profile. The recommendations aim to build a collaborative research ecosystem capable of delivering urgently needed cures for people at all stages of the disease.
Researchers at EPFL have developed ultra-sensitive sensors using elastic fibers filled with electrodes, capable of detecting pressure and strain. The fibers can be used in smart clothing, prostheses, and artificial nerves for robots, with potential applications including touch keyboards and compression detection.
The National Hurricane Center has issued a Tropical Storm Watch for parts of Mexico and Cuba as Subtropical Storm Alberto strengthens in the Atlantic Ocean. The storm is forecast to produce large rainfall totals and life-threatening flash floods and mudslides, particularly in the northeastern portions of the Yucatan Peninsula.
A new system called SCRaMBLE allows researchers to transform yeast at the molecular level, enabling fast-tracked engineering cycles and novel genome combinations. This technology has significant implications for industrial biotechnology, including the production of medicines and fuels.
A new study published in Psychiatric Services found that a mobile health (mHealth) intervention was equally effective to a traditional clinic-based group intervention for individuals with serious mental illness. The mHealth approach, FOCUS, improved treatment engagement and recovery outcomes at six-month follow-up.
A study found that star-shaped bread is particularly appealing to children, leading to potential healthier food choices. Children preferred natural brown bread colors over yellow-colored turmeric bread.
Researchers at the University of Minnesota have discovered a new ferromagnetic material, ruthenium (Ru), which is the fourth single element to exhibit unique magnetic properties at room temperature. This breakthrough could lead to improvements in sensors and devices in the computer memory and logic industry.
A review of 40 studies from 16 countries found that models differed in their assumptions about market conditions, vehicle prices, and other factors. This led to vastly different projections of future electric vehicle market shares, ranging from a few percent to over 50% by 2030.
A team of clinical neurologists, molecular biologists, and computer scientists have uncovered the earliest events in motor neuron disease using stem cell technology and RNA sequencing data. They discovered that a protein called SFPQ is lost from the nucleus in diseased motor neurons, leading to their death.
Research on permanent pacemaker implantation after TAVR shows a significant impact on patient outcomes, with those requiring implants experiencing poorer survival rates and longer hospital stays. The study's findings highlight the need for closer monitoring and management of conduction disturbances following TAVR procedures.
A new study replicating the famous marshmallow test finds that delaying gratification at a young age has a small and limited association with later cognitive and behavioral outcomes. The ability to resist temptation does predict adolescent math and reading skills, but not later behaviors or personality traits.
A new study has mapped over 3.4 million acres of Europe's last wild forests, revealing that primary forests are widely distributed throughout the continent. The study highlights the importance of preserving these remaining fragments of primary forest, which provide exceptional ecological values and habitat for biodiversity.
Research at the University of Exeter and Edith Cowan University found that goal conflict and ambivalence are associated with symptoms of anxiety and depression. The study involved over 200 young adults aged 18-35, who reported experiencing psychological distress due to conflicting goals.
Researchers at Karolinska Institutet discovered a previously unknown group of brain cells responsible for initiating and organizing aggressive behavior in mice. By stimulating or inhibiting these cells, the team was able to control aggression and even invert hierarchical status between dominant and submissive males.
Researchers found that the yeast protein Nhp6 helps unfold nucleosomes in humans, similar to its function in yeast. The study suggests that humans may possess a homologue of Nhp6 that assists the FACT complex in regulating gene transcription and detecting damaged chromatin.
Mekunu is now classified as an Extremely Severe Cyclonic Storm, with maximum sustained winds near 115 mph and a central pressure of ~964 hectopascals. The storm is forecast to make landfall near Salalah, Oman early on May 26, posing a significant threat to shipping in the Gulf of Aden.
A novel computational approach has been developed to calculate optimal personalized brain stimulation treatment for Alzheimer's disease. The new framework incorporates patients' MRI scans and physiological brain signaling measurements to identify specific brain regions that would benefit from stimulation.
Researchers at the University of British Columbia have created a low-cost membrane that can switch between oil-removal and water-removal modes using a single electrical charge. The membrane achieved near-perfect separation of light and heavy oils from water, with an 98% purity rate.
A new study from University of Chicago researchers finds that 'traffic jams' in the jet stream can cause abnormal weather patterns, such as blocking events. The research develops a mechanistic model to predict long-term weather patterns, including droughts and floods, by comparing the jet stream to highway traffic.
The Life Sciences - Life Writing research training group will receive EUR 2.2 million in funding to explore the correlation between new biomedicine developments and human boundary experiences. The program aims to generate alternative perspectives on what it means to be human, combining natural sciences, medicine, and humanities.
A recent study analyzing over 3.7 million hospital admissions found that overweight and obese patients had a lower risk of dying from sepsis compared to those with normal weight. The study also showed improved survival and reduced readmission rates for these groups.
A new scientific statement from the American Heart Association highlights the unique health risks faced by South Asian Americans, including higher rates of atherosclerosis and heart attacks. The statement emphasizes the importance of lifestyle changes, such as dietary modifications and increased physical activity, to reduce this risk.
Researchers developed a microdialysis technique to measure brown fat's chemical make-up, discovering its activation under both cold and warm conditions. The findings offer potential targets for therapies boosting brown fat's energy-burning power for weight loss.
Aphids rely on symbiotic bacteria to produce essential nutrients from sugar-rich diets. Researchers found that DNA methylation patterns in aphid cells influence gene expression related to nutrient production.
Researchers tracked a group of young storks as they migrated to Africa and Europe, finding that leader birds lead the way to thermals. The study reveals how flying skill affects wintering grounds, with flappy birds opting for shorter journeys.
Scientists at Osaka University have discovered a novel particle acceleration mechanism using micro-bubble implosion, emitting high-energy protons at unprecedented levels. This breakthrough could clarify unknown space physics and lead to new applications in medical treatment and industry.
Researchers found African Americans and Latinos had higher levels of chronic stress and unhealthy behaviors, increasing their risk for depression. However, engaging in unhealthy behaviors did not increase depression risk in African Americans but rather reduced it due to chronic stress.
Scientists from Kyushu University and The University of Manchester identify caesium-rich micro-particles in Fukushima soils, which could pose long-term health risks to humans if inhaled. The new method allows for quick counting of particles and quantifying radioactivity associated with them.
A Montana State University professor has won a five-year, $3.12 million grant to conduct research on sexual and reproductive health among American Indian youth in Montana and abroad. The 'We Are Here Now' study aims to improve the health and well-being of indigenous youth through community-based participatory research.
Researchers found that gut bacteria can control antitumor immune responses in the liver by regulating bile acid metabolism and NKT cell accumulation. This discovery has implications for understanding liver cancer mechanisms and potential therapeutic approaches.
A team of astronauts working together for months in a confined space will be critical to Mars mission success. The psychology of teamwork is crucial, with characteristics such as emotional stability, agreeability, and resilience being key factors.
A gene regulation network in Acinetobacter baumannii boosts both virulence and antibiotic resistance when faced with antibiotics. The network, known as BfmRS, controls key processes involved in cell envelope construction and division, leading to increased drug resistance and disease severity.
Research finds that working adults without paid sick leave benefits are three times more likely to live below the poverty line. They also face higher rates of food insecurity and require more welfare services, with increased medical expenses and lack of preventive care contributing to these outcomes.
A significant proportion of patients with suspected sepsis do not have their lactates measured within the recommended timeframe, leading to delayed antibiotic therapy and increased risk of in-hospital death. Earlier lactate measurements correlate with quicker treatment with antibiotics and better outcomes.
A consensus statement from pediatric and law experts defines abusive head trauma (AHT) as a medical diagnosis, not a legal determination. Key findings include few infants with AHT having isolated injuries without retinal hemorrhages or other signs of abuse.
Researchers have developed an ingestible sensor that can detect disease-driving molecules in the gut, providing real-time data to doctors. The device, called Ingestible Micro-Bio-Electronic Device (IMBED), uses bacteria engineered to sense biomolecules, which activate when target molecules diffuse across a semipermeable membrane.
A QUT study found that cyclists are more seriously hurt in crashes with motor vehicles at intersections with 'Stop' or 'Give-way' signs than at intersections with traffic signals. The study, analyzing 13 years of Queensland police crash records, found drivers were most often at fault at these intersections.
A large Danish study of over 18,000 patients found that being overweight or obese is associated with reduced mortality after hospitalization for infectious diseases. Patients who were overweight or obese had a 40% and 50% lower risk of death compared to those of normal weight.
A study of over 7,000 low-income urban mothers found that fewer than 5% started folic acid supplementation before pregnancy. Despite the high risk of neural tube defects, many women did not take prenatal vitamins preconception or during pregnancy. The research team also found that black and Hispanic mothers had lower plasma folate conc...
A new test developed by UCSF scientists can predict a woman's risk of preterm birth with over 80 percent accuracy when taken between 15 and 20 weeks pregnant. This information enables doctors to treat women at high risk for preterm birth, potentially preventing severe complications.
Research tracking juvenile storks reveals that birds at the head of a flock use thermal winds more efficiently and flap less. The study suggests that individual variation in flight performance is linked to differences in finding and exploiting thermals.
Researchers found that the ketogenic diet alters gut microbiota in mice, leading to reduced seizures. Specifically, two types of bacteria - Akkermansia muciniphila and Parabacteroides species - play a key role in providing protection against seizures.
St. Jude Children's Research Hospital is launching St. Jude Global, a $100M initiative aiming to increase access to care for children with cancer globally within the next decade. The program focuses on education, capacity building, and research to improve childhood cancer survival rates worldwide.
A comparative study of 37 plant genomes reveals that the capacity to form root-nodule partnerships has repeatedly been lost during evolution. Despite providing fixed nitrogen, these symbioses no longer benefit many plants due to parasitic bacteria invasion or other factors.
Researchers discovered that tau protein mutations can increase cancer risk by up to 3.72 times, highlighting a new association between neurodegenerative disorders and cancer. The study's findings suggest that clinicians should monitor patients with tau mutations for their cancer risk, in addition to attending to neurodegeneration.
Researchers at UTA found a strong immune response in diseased corals leads to lower expression of genes associated with growth and reproduction. This trade-off may impact coral resilience and ecosystem recovery under climate change pressure.
Researchers analyzed 736 ZIKV positive patients and found that older veterans with underlying health issues were more likely to be hospitalized. Patients presenting with neurological symptoms were also more likely to be hospitalized. This study helps providers evaluate and treat patients with ZIKV infection.
Triple-negative breast cancer patients have fewer effective treatments due to high levels of immune suppressor cells. Researchers identified a metabolic pathway linking glycolysis and C/EBP-beta expression, which supports suppressor cell growth and reduces patient outcomes.
Scientists have discovered that up to 25% of new ocean floor is formed by mantle material without magmatic processes, challenging current understanding. This phenomenon occurs at paces of less than two centimeters per year, particularly in regions like the Cayman Trough.
Researchers found that obese children who consume at least two servings of cow's milk daily have better blood sugar control and lower fasting insulin levels. In contrast, those consuming less than recommended amounts had higher insulin levels, indicating increased risk of metabolic syndrome.
Researchers at UMass Lowell are using origami to create new biomaterials that can grow cells for repairing or regenerating tissues such as skin, bone, cartilage, and blood vessels. The team's paper-based platforms have shown promise in biocompatibility and potential applications for wound care.
A Drexel University study found that new parts of the brain become active when students learn physics, suggesting that learning is an imaginative process. The study used fMRI to measure blood flow in the brain and found increased activity in areas linked to problem-solving and memory.
Researchers found that banded mongooses inherit their feeding preferences from their escorts, not biological parents, and these learned behaviors last a lifetime. The study also suggests cultural inheritance may play an important role in many animal species, shaping individual diversity.
Researchers found that slight changes to warning appearance help users pay attention and adhere to warnings 76% of the time. In contrast, static warnings were only adhered to 55% of the time, highlighting the importance of visual novelty in sustaining user attention.
A new study by Maziar Heidari and colleagues introduces an adaptive resolution simulation technique that couples accurate models with simpler, idealized representations of solids. This approach enables efficient computation of thermodynamic properties at a reduced computational cost.
A recent study by researchers at the University of Hawaii at Manoa identified areas with high recovery potential for coastal fishery stocks on each island. The study reveals that areas such as east Kaua'i, southeast O'ahu, and Ma'alaea bay support abundant fish populations, which could be replenished to overfished areas.
Researchers have developed molecular nanoswitches that can switch between two states using an applied voltage, enabling the development of novel electro-optical devices. This breakthrough could replace silicon-based components with organic molecules, reducing component sizes in electronics.
Scientists found that non-diploid cells have unstable centrosomes and microtubules, leading to abnormalities in cell replication. This understanding could lead to new cancer treatment strategies.
Researchers at the University of Vienna discovered a mechanism that regulates HSCs' delicate balance between activation and dormancy, ensuring proper blood cell production. The study found that a feedback loop involving two intracellular signalling pathways maintains this balance, preventing exhaustion and potential death.
Researchers created a 'quick and robust' blood test that can detect liver fibrosis, the first stage of liver scarring, from a blood sample in 30-45 minutes. The new method uses polymers coated with fluorescent dyes to bind to blood proteins, offering a simple and inexpensive way to diagnose disease.