Researchers found that space travel can make cellular mitochondria dysfunctional due to changes in gravity, radiation exposure, and other factors. This has significant implications for future space travel and medical science on Earth.
Scientists have developed a novel approach to reprogram T cells into long-lived, highly active 'super immune cells' that can fight multiple types of cancer. This breakthrough could lead to more effective and durable anti-cancer responses with existing treatments.
Georgetown University researchers successfully used RNA molecules to suppress SARS-CoV-2 protein production, potentially leading to an inhalable drug that mitigates viral chaos. The approach targets viral machinery within cells via siRNA, degrading messenger RNA and reducing infection spread.
Researchers found that people born without upper limbs who use their feet to reach engage the same brain area as those with hands, revealing a higher-level motor function. This discovery advances basic science and offers potential clinical advances in improving limb prostheses.
The report highlights a failure in global preparedness during the COVID-19 pandemic, emphasizing governance failures. Experts recommend strategies to re-center governance, including reforming international regulations and increasing funding for the WHO.
A study at Georgetown University found that individuals with strong implicit pattern learning abilities are more likely to hold stronger beliefs in a higher power. The research spanned two cultural groups and found a connection between cognitive processes and religious belief.
In a groundbreaking study, researchers found that children's brains use both hemispheres to process language, whereas adults typically rely on one hemisphere. This discovery suggests that children's brains are more adaptable and resilient, allowing them to recover from neural injuries more effectively.
Georgetown researchers caution that weather does not significantly impact COVID-19 transmission and that lockdowns and re-openings have a stronger influence. The authors suggest that policy should not be tailored to current understandings of the COVID-climate link.
A Georgetown University Medical Center-developed online COVID-19 symptom tracking tool enables individuals to monitor their symptoms while maintaining confidentiality. The system assigns a unique identifier and provides actionable reports on symptoms requiring medical attention.
A Georgetown University Medical Center study reveals that veterans with Gulf War illness (GWI) and patients with Chronic Fatigue Syndrome (CFS) exhibit distinct brain activity patterns after moderate exercise. The finding could lead to improved treatment for veterans with GWI by diagnosing CFS as a separate disorder.
A study published in the journal Aging, Neuropsychology, and Cognition found that children who attend school for longer periods have better memory abilities in old age, particularly for women. More years of early-life education counteract age-related memory losses, suggesting a protective effect against Alzheimer's disease.
Researchers found nilotinib reduced amyloid burden and tau tangles in neurons, suggesting it may aid in Alzheimer's treatment. The study also showed improved hippocampal volume loss and reduced phospho-tau-181 levels, hinting at a potential disease-modifying effect.
A unique microscope, called DIVER, uses phasor approach to fluorescence lifetime imaging (FLIM) to examine kidney tissue samples. The device can quickly analyze scarring in damaged kidneys, providing valuable insights for treatment decisions.
Global health scholars warn of impending crisis in Africa due to slow access to COVID-19 supplies, echoing the experience during the early stages of the HIV/AIDS pandemic. Several African countries have prepared disease response capacities, but geopolitical power struggles hinder supply acquisition.
Experts warn that immunity passports pose significant practical, equitable, and legal issues. Vaccination certificates, on the other hand, may be a crucial tool to incentivize vaccination and end the pandemic. The success of public health practices depends on public trust and addressing inequities.
Research at Georgetown University Medical Center found that nicotine increases craving for benzodiazepines, known as benzos, in rats, leading to increased consumption. Boosting a specific protein KCC2 appears to restore normal brain function and decrease benzo consumption.
A study published in Military Medicine found that nearly all veterans with Gulf War illness (GWI) reported experiencing moderate to severe fatigue, sleep, and pain symptoms. The survey, which included 485 veterans, also revealed a high prevalence of cognitive dysfunction and anxiety.
Researchers found that certain bacteria, including F. nuc and Moraxella osloensis, are more prevalent in younger patients' tumors than older patients', suggesting a potential link between gut bacteria and the rising incidence of colorectal cancer in people under 45.
Researchers developed a small molecule drug CTPI-2 that targets Slc25a1 gene involved in lipid and glucose metabolism, preventing liver damage, obesity and glucose intolerance in mice. The study showed promising results, confirming the importance of this gene in fatty liver disease.
Researchers found that combining valproic acid and hydralazine reversed some aspects of breast cancer in offspring of high-risk mice, but increased risk in those not fed a high fat diet during pregnancy. The study suggests potential implications for breast cancer risk in humans, particularly related to prenatal exposure to certain chem...
Scientists at Georgetown University Medical Center have discovered that a specific set of neurons in the brain can be targeted to stop seizure activity. The study's findings provide new hope for treating epilepsy, an incurable condition affecting millions worldwide.
A recent clinical trial found that nilotinib increases dopamine levels and reduces neurotoxic proteins in people with Parkinson's disease. The study also showed potential in halting motor and non-motor decline, making it a promising treatment option.
Researchers at Georgetown University Medical Center used fMRI to categorize Gulf War illness patients into two distinct groups based on brain activity changes after exercise. The study suggests that different brain regions are associated with two subtypes of GWI, leading to potential new diagnosis and treatment strategies.
A clinical trial found that palbociclib can be safely taken by African American and other women with benign ethnic neutropenia who have advanced breast cancer. The trial showed that 58% of participants had the gene alteration associated with lower neutrophil counts, but none developed life-threatening infections or discontinued treatment.
A new study from Georgetown University Medical Center found that 38 patients with follicular lymphoma who were in remission for at least two years did not show any evidence of the disease in their blood. This suggests that these patients may be disease-free and could have a lifelong disease status.
A study published in Health Economics found that individuals with early-stage Alzheimer's disease face a heightened risk of adverse financial outcomes due to compromised decision-making and exploitation. The researchers tracked financial data before diagnosis and found significant reductions in liquid assets and net wealth.
Two new studies found that Gulf War Illness (GWI) and chronic fatigue syndrome (CFS) are distinct disorders with unique effects on the brain. GWI was associated with decreased activation in the cerebellum, while CFS had increased activation in this region after exercise.
Researchers found that the brain's inability to process information quickly enough can lead to a bottleneck in visual processing, resulting in missed stimuli. By reducing interference between feedforward and feedback signals, they observed improved detection and categorization performance.
Researchers developed an agent that reduces toxic protein buildup in animal models of Parkinson's and Alzheimer's diseases, improving cognitive and motor behavior. The new compound CM101 specifically targets DDRs to switch on the garbage disposal in brain cells.
Researchers found a panel of 17 small RNA molecules influenced by genetic alterations in cancer cells, which could lead to targeted treatments for Latinas with TNBC. The study suggests that racial and ethnic differences in miRNA expression may impact breast cancer incidence rates.
Researchers at Georgetown University Medical Center found that exposure to polychlorinated biphenyls (PCBs) impairs brain function in mice by activating pathways that neutralize toxins and causing oxidative stress in astrocytes. This study suggests a potential contributing factor to neurodegenerative disorders.
Researchers at Georgetown University Medical Center developed a virtual review method that reduces the time needed to assess a cancer patient's tumor profile and suitability for clinical trials from 14 to 4 days. The method also increased the number of cases that could be assessed, with over 2,000 clinical trials evaluated.
A new study published in Human Brain Mapping found that the cerebellum is not engaged during reading in both typical readers and children with dyslexia. The research suggests that difficulties in phonological processing, a key feature of dyslexia, are more closely related to brain regions in the left cortex.
A new study suggests that older women with chronic illnesses, such as cardiovascular disease or diabetes, may not derive significant benefits from regular screening mammograms. The research found a nearly 90-fold difference in mortality rates between breast cancer and non-breast cancer causes among women aged 75 and older.
The pending Altria-Juul deal could lead to increased e-cigarette use or less cigarette use, depending on regulations and policies. Georgetown University professor David Levy explores the motivations behind the $12.8 billion purchase and its potential impact on public health.
A team of researchers at Georgetown University Medical Center has identified a chain of molecules critical for pancreatic ductal adenocarcinoma (PDAC) growth and survival. Inhibiting this 'Yap' biological network may effectively regress early-stage PDAC, and pairing it with other drugs could halt more advanced stage tumors.
Resistance to carbapenems and polymyxins is geographically widespread in Southeast Asia, with overlapping distributions in eight countries. The study highlights the urgent need for robust antimicrobial resistance surveillance and improved infection prevention and treatment practices globally.
A study published in Nature Immunology reveals that immune cells' activation state prior to anti-PD-1 therapy is crucial for cancer response. The researchers found a way to overcome resistance by activating T cells through vaccines, suggesting a new approach to enhance PD-1 inhibitors.
A new, non-invasive bladder cancer treatment method uses a 'liquid biopsy' from urine to identify molecular underpinnings of each patient's unique bladder cancer. The technique, called conditional reprogramming or CR, has shown promising results in detecting and treating the disease.
A study by Georgetown University Medical Center found that facial cosmetic surgery in men increases perceptions of attractiveness, likeability, social skills, and trustworthiness. The researchers also discovered that chin augmentation was the only procedure without a significant impact on perceived masculinity or attractiveness.
A recent study found that nursing home care costs are high and rising faster than other medical care and consumer prices. The study revealed significant price variation across states, with Texas having the least expensive out-of-pocket cost ($131 daily) and New York State having the most expensive ($334 daily).
A study found that indoor tanning addiction is associated with modified genes related to dopamine activity and depression symptoms, increasing the risk of skin cancer. The researchers collected saliva samples from 292 non-Hispanic white women and found a strong link between genetic mutations and tanning addiction.
Researchers found that only 35% of probiotic products were supported by clinical evidence, highlighting the need for clearer labeling. Products with fewer strains and lower cost were more likely to be backed by evidence, but consumers must still do their own legwork to find trustworthy products.
Cancer patients with HIV and viral hepatitis can also reap benefits of immunotherapy, study suggests. These patients respond as well to immune checkpoint inhibitors as those tested in clinical trials.
A survey of community oncologists found significant knowledge gaps in using genetic testing to decide cancer treatment. Researchers urge immediate education on molecular profiling to direct targeted therapies.
A study of 1,989 HIV+ women found that while 71% achieved viral suppression, others struggle with mental health, unstable housing, and lack of social support. The researchers suggest 'wrap-around' services addressing these issues are crucial for universal treatment and viral suppression.
A new study reveals that up to 90% of individuals at risk for Huntington's disease choose not to take a gene test, primarily due to uncertainty about treatment options and the inability to undo the knowledge. The study suggests that supportive counseling is necessary to help these individuals make informed decisions.
A study published in Developmental Cell suggests that pairing YAP/TAZ inhibitors with another drug, such as trametinib, may extend their benefit to patients. The researchers found that YAP/TAZ promotes growth by regulating glucose metabolism in cancer cells.
A new study suggests that genetic testing, such as Oncotype DX, can help women with early-stage hormone-positive breast cancer avoid chemotherapy and save on treatment costs. The test is estimated to cost around $3,400, and its use could lead to a 8% reduction in chemotherapy costs, resulting in savings of about $338 million annually.
A recent study by Georgetown University Medical Center found that only a quarter of PCORI-funded trials between 2015-2018 examined primary care, while specialty care received the majority funding. The study's authors argue that this is wasteful, as most healthcare is accessed within primary care settings.