A retrospective cohort study of 251 primary care physicians found significant variation in medical practice patterns across different doctors, but relatively stable patterns within an individual's practice over time. Researchers propose that personal behavioral characteristics may explain these variations.
University of Missouri scientists have discovered a genetically modified strain of salmonella that can target and kill prostate cancer cells, while leaving normal tissue intact. This breakthrough could lead to the development of personalized treatments tailored to individual patients' unique cancer characteristics.
A new deep-learning framework predicts gene regulation at the single-cell level, enabling the study of transcription factor binding. This breakthrough has the potential to advance disease understanding and treatment, particularly in cancer research.
Scientists have discovered a rare cosmic phenomenon - an 'Old Faithful'-like eruption of light flashing about once every 114 days on a nearly predictable schedule. The flare is caused by a black hole ripping at a star, creating a regular series of tidal disruption events.
A new study found that gut microbes can affect bone mass and structure in mice, with treatments altering the gut microbiome potentially aiding healthy skeletal growth. The findings suggest that microbes can be inherited or transmitted between individuals and impact skeletal development.
Most women experience nausea and vomiting symptoms within a three-day timeframe after ovulation, according to a new study from the University of Warwick. This narrower time frame suggests that scientists may be able to identify a biological cause for the condition, previously thought to have psychological roots.
A three-arm randomized controlled trial showed that participants had the most satisfaction and subjective understanding with the trust-enhanced e-consent after six months. Interactive consent forms beyond federal regulations can enhance patient-informed consent and trust in research.
A study published in CMAJ-OPEN found that over half of clinicians at the Peter Munk Cardiac Centre reported burnout and high levels of distress. The study used the Well-Being Index to measure stress, depression, and other factors. Lower levels of distress were associated with perceptions of fair treatment and adequate staffing levels.
Radiologists question the status quo to spark positive dialog and improve patient care. Featured articles debate the use of physician extenders and incorporation of AI algorithms into daily practice.
Researchers developed a simple barcoding system to reduce sequencing errors in Oxford Nanopore Technologies' MinION device, enabling accurate analysis of microorganisms like SARS-CoV-2. The new method achieves error rates below 0.005% and can process long stretches of DNA up to 10 times longer than conventional technologies.
A study of nearly 108,000 people found that moderate alcohol consumption is associated with a 16% increased risk of atrial fibrillation over 14 years. Regular drinking of even one small alcoholic drink per day may increase the risk, suggesting that low doses of alcohol can trigger atrial fibrillation.
A new approach to studying DNA packaging allows scientists to study individual cells and uncover the underlying mechanisms of chromatin folding. The technique reveals that Drosophila fly cells have structured domains similar to those found in mammalian cells, but with more ordered structures.
Researchers have developed a safe and efficient stem cell therapy to regenerate cardiac function in pediatric patients with dilated cardiomyopathy. The therapy, using cardio sphere-derived cells, has shown promising results in small human trials, reversing damage and improving heart function.
A mutation in the gene KCTD1 leads to kidney defects that can cause metabolic bone disease. The study reveals KCTD1's critical role in regulating electrolyte balance in the distal nephron.
Researchers at University of California - Santa Barbara have created a new way to detect dark ions using laser-cooled radium molecules. This breakthrough allows for precise measurements of ion motional frequency and mass, enabling sensitivity to time symmetry violations in quantum mechanics.
Boosting appreciation for insects is key to conservation. Simple actions like reserving 10% of a lawn for insects or cultivating native plants can provide crucial habitat and food reservoirs. Additionally, reducing nighttime light pollution and using insect-friendly soaps can help protect insect populations.
Experts argue that UK government's mass testing strategy in schools risks spreading COVID-19, particularly if pupils test negative and return to class. The 'serial-testing' approach is criticized for its reliance on inaccurate INNOVA rapid lateral flow tests, which may not rule out COVID-19 in symptomless individuals.
Researchers at UCI used advanced electron microscopy to study phonons near defects in cubic silicon carbide, a material used in electronic devices. The team's findings could improve thermal properties and provide insights into defect structures.
A recent study from North Carolina State University found that NRA stakeholders had conflicting emotions about the organization's response to mass shootings. Employees, donors, and volunteers reported both positive and negative feelings, with some even feeling more critical than supportive of the organization.
Scientists are using AI to identify insects at supernatural speed, opening up new possibilities for discovering unknown species and tracking their life across space and time. Insects have diverse life histories and roles in ecosystems, making manual observation and counting a time-consuming process.
A study suggests that a change in vasectomy guidelines has resulted in fewer repeat semen analyses, potentially reducing unnecessary tests and costs. The updated guideline recommended less stringent criteria for confirming the success of vasectomy.
A new study finds that more than half of doctors, nurses, and emergency responders involved in COVID-19 care are at risk for one or more mental health problems. The researchers found a comparable risk to rates observed during natural disasters, highlighting the need for evidence-based interventions.
Researchers discover that a gel containing GzmB inhibitor VTI-1002 reduces skin blistering by 50% and protects skin integrity, offering hope for targeted treatments for pemphigoid diseases. Current corticosteroids often cause severe side effects, making alternative therapies needed.
A mathematical model developed by researchers predicts that autologous gene-edited stem cell transplants could achieve viral control after antiretroviral therapy withdrawal. The conditions required for this include a sufficient dose of edited stem cells and allowing them to repopulate the blood before ART is stopped.
Researchers at the University of Bonn have developed four nanobodies that effectively target the spike protein of SARS-CoV-2, offering a promising therapeutic option. These nanobodies can be produced in large quantities and are less likely to cause unwanted complications, making them an attractive alternative to traditional antibodies.
Researchers at Aarhus University are working on a new project, AquaCleaner, to develop a sustainable method for breaking down per- and polyfluoroalkyl substances (PFAS). The proposed cascade treatment strategy uses enzymatic defluorination and a novel nanomaterial-based catalyst to eliminate PFAS.
Over a 15-year period, the total number of unique patients seeing PCPs decreased by 2.5%, while frequency of contact dropped from 4.3 to 3.7 visits per patient, contributing to the primary care decline.
A new humanized mouse model has revealed that tumor-infiltrating mast cells are connected to immune checkpoint inhibitor resistance in melanoma. Combining anti-PD-1 therapy with small molecule inhibitors able to deplete mast cells caused complete regression of tumors and prolonged survival in mice.
Experts warn that the Innova lateral flow test lacks supporting evidence and may cause serious harm. The government's plan to widen its use risks misleading the public about test accuracy and implications. Experts call for pause in rollout and clearer messaging on risks until better data is available.
Researchers have designed a new type of antiperovskite that could help replace flammable organic electrolytes in lithium ion batteries. The compound, containing a hydrogen anion and 'soft' chalcogen anions like sulphur, provides an ideal conduction path for lithium and sodium ions.
A rapid review of nine studies concludes that cloth masks are associated with significantly higher viral infections than exclusive use of medical masks. The review also found that cloth masks provide an inferior fit and are less effective at filtering viral particles compared to standard medical or N95 masks.
A growing body of evidence links poor gut health to severe COVID-19 prognosis. Studies show that altered gut microbiota can exacerbate the severity of infection by enabling the virus to access internal organs. Interventions like probiotics or fecal transplants may help patients, according to expert Heenam Stanley Kim.
Researchers at Pohang University of Science & Technology have developed a highly efficient nickel-based catalyst system that produces high-purity hydrogen fuel with reduced overvoltage. The catalyst combines earth-abundant nickel with oxophilic transition metal elements to optimize adsorption abilities.
Researchers found that gut microbes in anorexia patients are less diverse and more abundant in 'harmful' species. Transferring fecal samples from anorexia patients to mice resulted in similar symptoms, suggesting a link between gut bacteria and anorexia symptoms. Targeting the microbiome may be a viable treatment for anorexia.
A new report warns of significant increases in osteoporosis patients and fragility fractures in Eurasian countries, with expected demographic changes and poor diagnostic resources exacerbating the problem. The report highlights the need for urgent action to address this growing health issue.
A study examining national register data from Denmark found individuals with autism spectrum disorder (ASD) have higher rates of suicide attempts and completion compared to those without ASD. Potential risk factors for suicidal behavior in individuals with ASD were identified in the research.
Hydrogen sulfide has been shown to improve cognitive and motor function in mice with Alzheimer's disease by 50%. The compound reversed behavioral outcomes of the disease. Research also revealed a change in enzyme activity that could lead to new therapies.
Stroke survivors regained clinically significant arm movement and control using a brain-machine interface coupled with a robotic device. The therapy showed potential for long-term benefits, suggesting a novel approach to rehabilitation.
A new study suggests that farmers' individual practices, such as continuous maize cultivation, can contribute to the spread of western corn rootworm resistance. Regular crop rotation and planting non-Bt maize can effectively manage rootworm and delay resistance development in surrounding populations.
Seventy experts argue that misunderstandings around attachment research are hampering its accurate implementation in family courts. The group outlines three principles from attachment research to guide decision-making, including the child's need for familiar caregivers and the benefits of networks of familiar relationships.
A new technique using environmental DNA analysis reveals nuanced information about invasive round goby fish populations, allowing for population estimates and origin prediction. The method has the potential to overcome logistical challenges in studying elusive species, improving conservation outcomes.
A study led by Penn State researchers found that climate change poses a significant threat to wild bee communities due to rising temperatures and precipitation patterns. The team's analysis of 14-year data sets revealed that temperature and precipitation were the most critical factors influencing wild bee abundance and species diversity.
Researchers found that social media-based diagnoses were accurate about 60% of the time, similar to teledermatology consultations. Dermatologists' active involvement in crowdsourced responses led to more accurate diagnoses.
A study found that during the COVID-19 shutdown, more than a third of couples relied on women to provide most or all child care. Egalitarian strategies, such as alternating work days and needs-based alternation, were associated with better outcomes for couples, including lower marital tension and improved job performance.
Research found that patients with anorexia nervosa unconsciously assess their proportions to be larger than they actually are, leading to a distorted body schema. Virtual reality and cognitive behavioral therapy may help correct this distortion by influencing the representation of the body.
Researchers at UCF used advanced light to identify 46 molecules in the flames of a promising biofuel, diisobutylene (DIB). This study aims to help engineers and scientists craft a complete understanding of DIB combustion properties, leading to more efficient fuel development.
Scientists have developed a method to track marine life in the Arctic using water samples, revealing insights into climate change impacts on bowhead whales and biodiversity. By analyzing environmental DNA in water bottles, researchers can monitor population diversity and patterns of migration.
Researchers at Nagoya University have discovered a novel approach to tile functional nanosheets in a single layer using a one-drop method. This process could lead to the development of next-generation oxide electronics, enabling transparent and flexible devices.
Astronomers have identified the most distant quasar known, powered by a supermassive black hole weighing over 1.6 billion times the mass of the Sun. The discovery provides insight into the formation of massive galaxies in the early universe and challenges theories of black hole growth.
China's kidney disease burden is expected to increase significantly, with an estimated 874,373 patients receiving dialysis by 2025. The study used insurance claims data to estimate the national prevalence of dialysis in China.
Researchers used CRISPR/Cas9 genome editing to increase formicamycin production in Streptomyces formicae bacteria, which could lead to new antibiotics against MRSA. The over-producing strain can be used to purify enough formicamycins to study their mode of action and development as antibiotics.
A new protocol has been established to evaluate patients for elective surgeries following COVID-19, taking into account the high risk of complications and clinical uncertainty. The guidelines include minimum recovery times, patient history assessments, and objective testing to determine safe surgery procedures.
Researchers at Cedars-Sinai Medical Center have found that mixing exosomes with the protein casein can effectively treat muscular dystrophy and heart failure in laboratory mice. The study could lead to clinical trials of oral treatment for patients.
Scientists propose that widespread semiconducting minerals can absorb sunlight and drive reduction reactions similar to those in biological photosynthesis. These minerals may have played a transformative role throughout primitive Earth, driving the evolution of early lifeforms.
A new technique, vocal passive elastography (V-PE), uses ultrasound imaging and singing to determine the presence of a tumor in the thyroid gland. By analyzing the speed of shear waves created by vibrations from a person's voice, researchers can measure the elasticity of surrounding tissue.
Research identifies fetal APOL1 kidney risk alleles as contributing factors for preeclampsia in African-American mothers, while maternal-fetal genotype discordance is also linked to this risk. The study suggests a connection between APOL1 genetic variants and preeclampsia, particularly among mothers of African ancestry.
Research reveals that macrophages, key immune cells, respond to pathogens and stress through circadian-controlled metabolism. The study showed an incredible amount of circadian timing in macrophage behavior, but the clock regulated immunity in unexpected ways.
The American Society of Hematology, International Society on Thrombosis and Haemostasis, National Hemophilia Foundation, and World Federation of Hemophilia have developed joint clinical practice guidelines for von Willebrand Disease (VWD). The guidelines provide recommendations for diagnosis and management, including the use of injecta...
A MicroLED neural probe for neuroscience has been developed to control and record neural activity in the brain. The probe uses high-efficiency MicroLEDs to activate neural activity with sufficient light output, enabling researchers to study higher brain functions and their relationship with animal behaviors.
Researchers have uncovered new functions of integrin and talin, a cytoskeletal protein that regulates cell adhesion and migration. The study's findings provide insights into the activation of integrins mediated by talin, essential for various cancers.