Researchers from the University of Copenhagen have made a groundbreaking discovery about malaria, showing that the parasite can cross the blood-brain barrier using a mechanism employed by immune cells. This breakthrough provides new insights into the disease process behind cerebral malaria and its severe neurological consequences.
A study analyzing satellite data found that algal blooms in the Red Sea are linked to industrial aquaculture and have increased in frequency and size over recent decades. The researchers developed an algorithm to detect these blooms and propose a real-time monitoring system to protect the marine environment.
A Rutgers study highlights the association between social determinants of health and COVID-19 outcomes, particularly for Black Americans. Counties with higher percentages of adults without a high school diploma and households without internet access had significantly higher COVID-19 death rates.
The study found strong appreciation of natural features in Adelaide's northern metropolitan coastal wetlands, rating them highly for personal wellbeing. Residents developed an attachment to the coastline through activities, valuing these places as they became familiar with them.
A study found that teens in Oregon counties with high retail outlet densities for marijuana and alcohol had increased co-use and beliefs favoring use. The results suggest that social access to these substances is more likely than commercial.
The phase III CROWN study showed that lorlatinib significantly improved progression-free survival compared to crizotinib in patients with previously untreated advanced ALK-positive NSCLC. Patient-reported outcomes also indicated comparable time to treatment deterioration for lung cancer symptoms between the two treatments.
Researchers at Flinders University have discovered a new role for fibrinogen in reducing inflammation and protecting against disease. Fibrinogen's ability to neutralize harmful chemicals like hypochlorite could lead to new biomarkers and therapies for kidney, heart, and other diseases.
Increased snow depth in northeastern China led to a continued warming trend in soil temperatures, contradicting observed surface air temperature cooling trends. This finding suggests the importance of snow cover in regulating soil temperatures and its implications for agriculture during periods of reduced global warming.
A study in 73 Barcelona districts found that population density, income, and education affected COVID-19 spread. The analysis revealed distinct patterns in the two pandemic waves, with younger populations and educational institutions contributing to higher infection rates.
Researchers discovered that three patients with DOCK8 deficiency spontaneously repaired their faulty genes through somatic reversion, restoring normal immune function. This breakthrough has implications for future therapies and treatments for the often-fatal disease.
A recent study published in Nature Communications found that the Radar COVID app can detect close contacts of infected individuals twice as accurately as manual tracing systems. The trial on La Gomera island detected an average of 6.3 close contacts per infected individual, compared to 3.5 using only manual tracing.
The LCMC3 study showed that neoadjuvant atezolizumab was well tolerated and met its primary endpoint, achieving a major pathologic response rate of 21% in patients without EGFR/ALK mutations. The therapy also showed high complete resection rates and low perioperative morbidity and mortality.
A study at Boston Children's Hospital found that a multidisciplinary ERAS program reduced opioid use, improved pain control, and expedited recovery for select congenital heart surgery patients. The program implemented strategies like early extubation, blood conservation, and smaller surgical incisions to enhance patient outcomes.
Researchers at Nagoya University have discovered two types of fibroblasts, meflin and gremlin 1, that play a crucial role in regulating colorectal cancer progression. Altering the balance between these cells could be an effective strategy for preventing cancer progression.
A host immune classifier test may help guide immunotherapy treatment decisions for patients with newly diagnosed non-small cell lung cancer. The test, which measures inflammation in the body, is associated with longer overall survival and better treatment response.
Researchers analyzed mRNA expression levels of molecular markers ERCC1 and thymidylate synthase in patients with resected stage II-III non-small cell lung cancer. The study found no correlation between these markers and overall survival, contradicting previous hopes for a personalized chemotherapy approach.
A recent study found a 53% decrease in adult cardiac surgery volume nationwide, with a 65% reduction in elective cases. The pandemic also led to an unexplained increase in deaths after coronary artery bypass grafting, with significant declines in case volume and patient outcomes.
A nationwide lung cancer LDCT screening study found the effectiveness of low-dose computed tomography (LDCT) screening in a pre-defined, never-smoker population. The study revealed that family history significantly increased lung cancer risk, and most participants had stage 0 or 1 disease.
A recent study has found that women are less likely to receive guideline-recommended approaches for coronary artery bypass grafting (CABG), resulting in worse outcomes. This disparity may be attributed to delayed diagnosis of heart disease, which leads to undertreatment and poorer surgical results.
The Checkpoint Blockade for Inhibition of Relapsed Mesothelioma (CONFIRM) study demonstrated that nivolumab significantly improves overall and progression-free survival in patients with relapsed malignant mesothelioma. The treatment also showed a consistent safety profile without new adverse effects.
Researchers at UC Riverside identified a cortical region in mice that transforms sensory input into movement, opening new directions for studying sensory-motor transformations. The discovery could lead to targeted therapy for patients with sensory- and motor-related brain deficits.
Researchers discovered that the RPS-12 protein triggers triple-negative breast cancer and possibly other malignancies by activating an important signaling pathway. The protein's overproduction also leads to developmental abnormalities in fruit fly eyes.
A new University of Michigan study found that verbal reasoning can have both positive and negative outcomes on children's emotional development. While it promoted prosocial behavior, it also increased aggression and distraction. Positive discipline methods like providing structure and open communication are recommended instead.
Researchers at Aarhus University are developing a new type of battery that can be recharged in just six minutes and has a range of 350 kilometres. The goal is for the battery to have a lifespan of at least 20 years and be virtually maintenance-free.
Researchers at Tokyo Institute of Technology produced and characterized novel organic molecules with a long helical structure, revealing special interactions between coils that can exhibit interesting optical and chemical properties. The longer compounds also displayed face-to-face stabilizing interactions between different helical lay...
A study found that Black and Hispanic children are less likely to undergo medical imaging tests compared to White children. The disparity is attributed to both unnecessary testing in White children and underuse in minority children, potentially due to implicit bias among providers.
The Autonomous Vehicle Assistant (AVA) smartphone app provides navigational assistance for people with disabilities and seniors to use self-driving cars. The app offers a multisensory interface, GPS technology, real-time computer vision, and artificial intelligence to support navigation and vehicle access.
A new study from the University of East Anglia suggests that genetic testing before prescribing common medicines could benefit four million UK patients annually, leading to better patient outcomes and reduced hospital visits. The testing process is simple and cost-effective, making it a promising technology for the NHS.
Researchers investigate photonics as a solution to develop fast and energy-efficient computing systems inspired by the human brain. By mimicking biological processing systems, they aim to reduce energy losses and improve processor speeds.
Researchers have completed a multi-level hydrological tracking of the Yangtze River to investigate cloud formation during the intense mei-yu rainy season. The effort will enable more accurate forecasts of this key meteorological phenomenon in East Asia.
A team of researchers found that immature beta-cells can contribute to proper insulin release when paired with more mature counterparts. By balancing the proportion of 'weak' and 'strong' beta-cells, islet function can be restored under conditions of metabolic stress.
A recent US study reveals that heterosexual men are the most passionate sports fans, with 60% of participants identifying as enthusiastic. However, women and members of the LGBTQ+ community also show a strong interest in sports, with 40% of heterosexual women and 30% of gay men reporting similar enthusiasm.
A new study found that mobile apps with artificial intelligence improve the health status of migrants by 5.3%, while also increasing social integration by 2.7%. The study, conducted at Anglia Ruskin University, surveyed new migrants and refugees in Greece over a 10-month period.
Researchers at Newcastle University and James Cook University have created a comprehensive database of coral spawning information, spanning over 40 years. The Coral Spawning Database (CSD) provides insights into environmental cues influencing spawning timing, such as temperature and daylight patterns.
The production of post-lithium-ion batteries faces significant challenges, requiring intensive research and development activities to develop new manufacturing competences and machines. Currently, the vast majority of production capacities for alternative battery technologies, such as solid batteries or lithium-sulphur batteries, are n...
A recent study published in Annals of Internal Medicine found that community and demographic factors, such as contact with a confirmed or suspected COVID-19-positive case outside the workplace and Black race, were stronger predictors of COVID-19 infection than occupational exposure among healthcare workers. The study also highlights th...
Researchers analyzed county-level data to find associations between social risk factors, demographic characteristics and COVID-19 cases and deaths. The study revealed significant links between socioeconomic factors and mortality rates, highlighting the need for targeted public health interventions.
Researchers propose that human behavior, including psychological and socioeconomic factors like hunting and poaching, plays a significant role in shaping wildlife movement. The study highlights the importance of considering 'anthropogenic resistance' in connectivity-planning to ensure sustainable landscapes for both humans and wildlife.
BIOinFOOD's new test uses genetically modified brewer's yeast to detect SARS-CoV-2 presence in saliva, promising high sensitivity and speed. The test is expected to be available by mid-2021 and may use red light for easy identification.
Researchers from the Hubrecht Institute mapped the recovery of the heart after a heart attack, highlighting the importance of cardiomyocyte communication in forming scar tissue. The study provides new insights into the complex process of heart recovery, shedding light on potential therapeutic targets to improve outcomes.
Researchers found that reindeer lichens have unexpected levels of genetic diversity, indicating more gene-mixing among individuals. This contradicts the long-held assumption that these organisms mainly reproduce asexually.
Researchers found that forests dominated by arbuscular mycorrhizal fungi trees release more nitrogen gases than those associated with ectomycorrhizal fungi, negatively impacting air quality. Meanwhile, AM-associating tree roots enhance soil carbon storage by releasing protected carbon, highlighting the complexity of forest ecosystems.
Two ADAURA analyses presented at the International Association for the Study of Lung Cancer's 2020 World Conference on Lung Cancer (WCLC) Singapore support the use of Osimertinib as a new treatment strategy for patients with surgically resected, Stage IB to IIIA non-small cell lung cancer. The data show significant disease-free surviva...
A team of researchers analyzed sediment cores from the Mediterranean Sea and combined them with Earth system models to reconstruct major environmental changes in North Africa. The study reveals that rivers were active in the region thousands of years ago, driven by slight changes in Earth's orbit and polar ice sheet variations.
A recent study discovered that SORLA protein plays a crucial role in the growth of breast cancer cells in the brain and their resistance to HER2 therapy. Removing SORLA from cancer cells sensitizes them to anti-HER2 treatment, offering new possibilities for targeting drug-resistant cancers.
The invasive Prosopis juliflora tree seriously diminishes water resources in the Afar Region of Ethiopia, consuming up to 3.1-3.3 billion m3/yr and generating US$ 320 million and US$ 470 million net benefits per year. The study highlights the need for a coordinated control program to contain its spread and reduce density.
Research from Imperial College London found tropical cyclones are getting 30km closer to coastlines per decade, increasing the risk of damage and 'near-misses'. The study suggests changes in atmospheric patterns may be driving this trend, which could have profound implications for coastal communities worldwide.
A new study published in the Proceedings of the National Academy of Sciences presents a computationally-based modeling approach that simulates infant language learning. The researchers found that infants do not learn consonant- and vowel-like phonetic categories, but rather learn to distinguish between speech sounds in a more nuanced way.
The AAVCOVID vaccine program has received a $2.1 million grant to support phase I clinical trials overseas, with single-dose vaccines that can be stored at room temperature for up to one month. This stability could enable distribution in regions with limited infrastructure.
A new scanless high-speed holographic fluorescence microscopy system has been developed with submicron resolution, enabling 3D sensing of nanoparticles and color-multiplexed holographic fluorescence imaging. The system achieves measurements in less than 1 millisecond using digital holography and a phase modulator.
The study reveals that methane emissions from human activities, particularly oil and gas sectors, coal mining, and ruminant farming, have led to its long-term growth. The findings highlight the need for targeted emission reduction strategies in these key sectors to mitigate climate change.
A nationwide survey conducted by UC Davis found that over a third of Americans are unlikely or hesitant to get the COVID-19 vaccine due to concerns about its safety and effectiveness. The study also identified demographic characteristics, media consumption habits, and political affiliations as factors influencing vaccination intentions.
Researchers investigating lung cancer treatment during the pandemic found that patients with lung cancer experience higher levels of psychological distress and anxiety about accessing care. The study also revealed that patient advocacy organizations face challenges in providing support due to decreased funding.
A study found that unemployment insurance and a $600 weekly federal supplement reduced food insecurity in low- and middle-income households affected by COVID-19. The research investigated the association between these programs and food insecurity among job losers.
A study by University of Iowa researchers found that administering a neuroprotective compound during pregnancy can prevent long-term neurodevelopmental problems associated with prenatal stress. The research showed that the compound, P7C3-A20, protected the developing brain from damage caused by chronic prenatal stress.
A new study estimates that methane emissions from coal mines are approximately 50 percent higher than previously calculated. Methane is about 25 times more powerful than carbon dioxide when it comes to warming the planet over a long period.
The BioNTech-Pfizer COVID-19 vaccine retains its immune protection against the B.1.1.7 viral variant, suggesting it can prevent 'escape' from vaccine-mediated protection. The study's findings support the use of mRNA-based vaccine technology for adapting to new virus strains.
Researchers found that high-dose gait training with robotic exoskeletons during acute inpatient rehabilitation can improve motor function and functional independence in stroke patients. The study demonstrated the potential of overground walking in an exoskeleton to increase therapy dose without extending rehabilitation duration.
A recent study in Frontiers in Ecology and Evolution reveals that alpine plant diversity will decrease once glaciers disappear, with up to 22% of species facing local extinction. The research highlights the 'winners' and 'losers' among plant species, with some benefiting from global warming while others will suffer.
A new study by NIH scientists reveals that prion disease affects the eye first, specifically targeting cone photoreceptor cells. The researchers used confocal microscopy to identify prion protein deposits in cones and rods, finding early damage in cilia and ribbon synapses.