Researchers discovered that cancer cells use an antioxidant protein to suppress T cells, allowing them to evade the immune system. This finding identifies a promising new target for cancer immunotherapy, potentially helping to overcome treatment resistance and improve patient outcomes.
A large-scale study on Oregon psilocybin services found sustained benefits for anxiety, depression, and PTSD, with few adverse events. Participants reported lasting improvements in mental health and wellness, and the study provides valuable insights for policymakers considering expanded access to psychedelics for mental health conditions.
A global study suggests that traumatic brain injury causes vary widely worldwide, with motor vehicle crashes being the biggest single cause globally. The study found that causes of traumatic brain injury differ by country, with high rates of ground-level falls among older adults in wealthier countries.
Researchers at Oregon Health & Science University have made a groundbreaking discovery in animal models that a one-time treatment regimen can permanently clear HIV from newborns. The study's findings have the potential to advance quickly to human clinical trials, offering new hope for millions of people worldwide who require lifelong t...
A new study by Oregon Health & Science University reveals that large corporations are shaping how kids in Medicaid receive care, leading to varying patterns in behavioral health services. The research highlights the need for closer scrutiny of managed care organizations' corporate strategies versus their public mission.
A study by Oregon Health & Science University found that early sensitive caregiving can buffer children against negative effects of prenatal inflammation, reducing their risk for ADHD. The research suggests that both prenatal and postnatal interventions can mitigate ADHD symptoms in young children.
Researchers at Oregon Health & Science University mapped six major conformations of a membrane protein related to learning, memory and fear behavior. The findings provide a blueprint for designing new drugs to inhibit this channel in cases of stroke.
A large national study found that veterans diagnosed with cancer are at a higher risk of suicide attempts, especially in the months following diagnosis. The risk can persist for years and is highest among younger veterans, women, and those with certain types of cancer.
A study by Oregon Health & Science University found that state-level abortion bans in the US are associated with a reduction in evidence-based medical care for miscarriage management. This has led to more women waiting longer for treatment and fewer choices, potentially putting their health and fertility at risk.
A new study reveals that the cancer-causing protein MYC plays a direct role in fixing damaged DNA in tumor cells. This allows cancer cells to survive chemotherapy and other treatments, contributing to tumor resistance and poor patient outcomes. The findings could lead to new therapies targeting MYC's repair function.
Researchers at OHSU have developed a sophisticated blood test that can detect early signs of pancreatic cancer with a 97% accuracy rate, distinguishing it from benign conditions. The technique uses nanoparticles shed by tumors into blood, offering a non-invasive way to identify the disease.
A new method called scSurvival uses single-cell genetic data to identify which cells inside a tumor are most strongly linked to patient survival. The approach pinpoints harmful and helpful cell populations that can drive disease progression, enabling better understanding of why patients with the same cancer have different outcomes.
A new study published in the Proceedings of the National Academy of Sciences found a link between elevated serotonin levels and tinnitus behavioral symptoms. The research suggests that clinicians should recognize and validate patient reports of medication-associated increases in tinnitus when prescribing antidepressants like SSRIs.
A new study co-led by OHSU scientist Catherine Galbraith introduces a series of fluorescent dyes that enable the observation of dynamic biological processes in living cells. These tools allow scientists to study cancer-related processes, such as DNA packaging and gene expression, in real-time.
Oregon Health & Science University has received significant NIH funding to develop advanced microphysiologic models that mimic how cancers grow and respond to treatment within bone tissues. Two new awards focus on osteosarcoma and prostate cancer, aiming to improve understanding of disease spread and treatment responses.
Researchers at OHSU have uncovered that pancreatic tumors co-opt regulatory immune cells, leading to resistance against immunotherapy. A promising strategy involves reprogramming these cells to support anti-tumor activity, potentially making immunotherapy viable for treatment-resistant cancers.
Researchers at OHSU have discovered a previously unknown system of internal 'trade winds' that help cells rapidly move essential proteins to the front of the cell. This breakthrough reveals that cells don't rely on random diffusion but instead create targeted streams of fluid to push proteins forward.
Researchers found that mild hypoxia in preterm babies can compromise neural communication, impacting the hippocampus region responsible for memory and learning. Abnormal neuronal maturation and loss of synaptic function may lead to academic difficulties and behavioral concerns later in life.
Researchers analyzed electronic health records from over 39,000 adults with diabetes, finding that those who lost insurance had poorer blood sugar control and needed more intensive medications. The study suggests that coverage gaps pose a direct threat to health, particularly for low-income patients.
Researchers analyzed Oregon Medicaid case data and found that severe burns requiring hospital-level care are a growing threat in the overdose epidemic. People who smoke drugs like fentanyl and methamphetamine account for most of these cases, with butane torches posing a significant risk due to locking mechanisms.
Researchers at OHSU found that sympathetic nerves support pancreatic tumor growth by communicating with cancer cells and nearby fibroblasts. The study suggests that removing these nerves may lead to smaller tumors, particularly in female mice.
A study from Oregon Health & Science University reveals low rates of routine screening for anxiety and intimate partner violence in primary care settings due to lack of awareness and workflow challenges. The research team developed step-by-step guides for clinicians to improve screening rates.
A federally funded research initiative at Oregon Health & Science University examines the safety and effectiveness of state-regulated access to psilocybin, a psychedelic substance used for treating mental health conditions. The five-year study aims to assess the impact of legal psychedelic services on substance use disorders.
A new study by OHSU-led researchers found that nearly one-third of physicians enrolled in Medicaid don't actually care for a single patient covered by Medicaid insurance. This 'ghost' phenomenon hinders access to healthcare, leading to delayed or foregone care and ultimately increasing costs.
A new research project aims to develop an eye drop that can detect the fluorescent signal of a protein associated with Alzheimer's disease. If successful, this low-cost and accessible screening tool could help identify patients in their earliest stages of the disease, enabling them to receive early treatment.
Researchers at OHSU have identified specific sites on the NMDA receptor that could potentially reverse the progression of the disease if blocked, offering new hope for treatment and early detection. The discovery was made using near-atomic imaging and raises the potential for a blood test to detect the condition.
A study by Oregon Health & Science University found that states with abortion restrictions have worse maternal health outcomes for patients using fertility treatment. The research analyzed over 400,000 births conceived through fertility treatments and found a statistically significant increase in serious maternal health complications.
Researchers at OHSU discovered a promising new drug combination that may help people with acute myeloid leukemia (AML) overcome treatment resistance by pairing venetoclax, a standard AML drug, with palbociclib, a cell-cycle inhibitor approved for breast cancer. The study found that this combination produced significantly stronger and m...
A recent study has found that rates of opioid use during pregnancy have risen two-fold over the past decade, with significant increased risks of maternal and infant health complications. The study emphasizes the urgent need for accessible, wraparound health care for mothers and families affected by opioid addiction.
A systematic evidence review finds that cannabis products with higher levels of THC provide short-term pain relief, but at the cost of increased side effects. CBD-based products, on the other hand, show almost no benefit in reducing pain.
A randomized controlled trial found that lipoic acid had a small beneficial effect on slowing brain atrophy in people with progressive multiple sclerosis. However, it did not improve walking speed as the primary clinical outcome. The study suggests that lipoic acid may be worth further investigation for its potential benefits.
CEMIP is associated with the breakdown of myelin, a protective sheath around nerve cells. Elevated levels of the enzyme inhibit myelin regeneration in people with multiple sclerosis. Researchers hope targeting CEMIP may promote central nervous system repair and slow disease progression.
A recent study published in SLEEP Advances found a strong correlation between insufficient sleep and decreased life expectancy. The research, conducted by Oregon Health & Science University, suggests that catching at least seven hours of sleep per night can improve overall well-being and longevity.
A new study examining millions of electronic health records suggests a strong link between untreated obstructive sleep apnea and an increased risk of developing Parkinson's disease. Researchers found that those with untreated sleep apnea were nearly twice as likely to develop Parkinson's as those who treated it with CPAP.
A recent study found that regularizing bedtime without changing sleep duration can significantly lower blood pressure in individuals with hypertension. Participants who stuck to a consistent bedtime for two weeks experienced drops in their blood pressure, particularly during nighttime hours.
A study published in JAMA Network Open reveals significant racial disparities in cesarean births, with Black individuals facing a higher risk of the procedure despite efforts to decrease overall rates. The research highlights the need for upstream interventions and education to address structural racism in maternal health care.
Researchers at OHSU develop a promising drug SU212 to treat intractable cases of triple-negative breast cancer. The molecule binds to and degrades the enzyme enolase 1, suppressing tumor growth and metastasis in humanized mouse models.
New review highlights advances in New Approach Methodologies and tissue engineering, offering powerful tools to study early stages of cancer development. Lab-grown models replicate human body environment, unlocking clues about cancer initiation. These models also support discovery of new biomarkers for earlier detection.
A new study reveals that a specific E. coli strain can block the gut's defense mechanism by injecting a protein called NleL, allowing it to spread more easily. This discovery could lead to new treatments that target how bacteria cause disease.
OHSU researchers have developed a unique proof of concept to treat infertility by turning skin cells into eggs capable of producing early human embryos. The technique, known as mitomeiosis, combines the processes of mitosis and meiosis to create gametes.
A study published in JACC Advances suggests that a regular sleep schedule can reduce the risk of clinical events in adults with heart failure. The research found that even moderately irregular sleep doubles the risk of another clinical event within six months.
A nationwide study found a 31.8% increase in people shifting from no birth control to the over-the-counter oral contraceptive pill after its FDA approval. The pill is particularly beneficial for racial and ethnic minority groups, adolescents, and those with limited financial resources.
A new study found that over 1 in 10 Medicaid-enrolled youths experiencing a mental health crisis are kept in hospital emergency rooms for three to seven days. The research highlights the shortage of appropriate care in Oregon and nationwide, with experts warning that boarding kids can worsen their conditions and demoralize families.
Researchers developed OmicsTweezer, a tool that uses machine learning and single-cell data integration to analyze human tissue. The tool can estimate cell type composition in tumors and surrounding tissues, which could help pinpoint potential therapeutic targets.
A review led by Oregon Health & Science University researchers suggests that the US could save $1 billion a year by dropping adult tetanus and diphtheria booster shots if childhood vaccination rates remain strong. The safety of this approach depends on maintaining high childhood vaccination coverage.
Scientists have discovered the structure and shape of key receptors in the cerebellum, a region critical for movement, balance, and cognition. This finding could lead to the development of therapies to repair damaged synapses and improve brain function.
A new clinical trial found that taking semaglutide once weekly significantly improves blood sugar levels and leads to substantial weight loss in adults with Type 1 diabetes. The study involved 72 participants across four medical centers and showed a 36% improvement rate compared to the placebo group.
Researchers have identified a type of chemical compound that kills malaria-causing parasites in mosquitoes when applied to insecticide-treated bed nets. The breakthrough could significantly blunt malaria transmission and potentially replace traditional prevention methods.
Researchers found that astrocytes transmit signals, revealing new ways the brain processes information. The study provides direct evidence for the real-time action of astrocytes in live brains of fruit flies, suggesting their role in mediating neurophysiology and behavior.
Researchers created a new nanoparticle that combines focused ultrasound and chemotherapy to destroy tumors more precisely and prevent recurrence. The treatment shows promising results in preclinical models, offering a potential breakthrough in cancer therapy.