Electrospinning fabricates electroactive fibrous scaffolds that mimic the structure of the extracellular matrix while providing electrical activity, enabling non-invasive and self-powered tissue repair. This technology promotes diverse intelligent applications in tissue regeneration, including conductive, piezoelectric, and triboelectr...
Researchers develop a novel approach to precisely encapsulate individual probiotics into microgels, enhancing survival and targeted delivery in the gastrointestinal system. The study demonstrates improved therapeutic efficacy in treating IBD using this technology.
A new metamaterial design enables real-time stiffness visualization and self-sensing capabilities, paving the way for intelligent systems. The research team created a linear relationship between stiffness and active hinges, allowing for precise tuning and adaptation in mechanical systems.
Researchers developed a new type of bio-hybrid actuator using locust hind legs, achieving remarkable leaping capabilities and ultra-low power consumption. The actuators enable high maneuverability and autonomous self-righting capabilities, making them suitable for confined space exploration and precision medical delivery.
Researchers have optimized the thermoelectric performance of SnSe using liquid phase sintering, introducing excess metallic tin to fill intrinsic vacancies and reduce electron trapping. This process results in a lattice thermal conductivity as low as 0.21 W·m⁻¹·K⁻¹ at 793 K, achieving an exceptional ZT value of approximately 1.9.
Researchers developed a triple-electrode integrated functional electrode for synchronized monitoring of neural signals and dopamine release during sleep-wake transitions. The study highlights the critical role of dopamine in regulating sleep-stage transitions and identifies distinct neuronal populations involved in this process.
Researchers developed a unified multimodal framework to analyze joint aging changes in brain function and structure. The study identified two primary aging patterns: synergistic declines in motor control and higher-order cognition, and contradictory adaptations in visual areas.
A large-area uniform three-dimensional covalent organic framework membrane is fabricated to stabilize Li-metal electrodes via solvation cages. The membrane features non-interpenetrating topology, promoting rapid ion transport and stabilizing the lithium metal anode.
Researchers developed an organ-on-a-chip platform to study the gut-islets axis and its regulation by hormones. The system successfully reproduced key features of the axis, including bile acid-induced GLP-1 release and insulin secretion enhancement.
Researchers developed a multi-dimensional analysis model to understand self-driving vehicles' behavior, incorporating perceptual and behavioral intelligence. The model enables rigorous evaluation of interactive cognition abilities, supporting human-vehicle-friendly interaction and fostering public trust.
A deep learning framework called PRTS accurately predicts single-cell-resolution spatial transcriptomics from H&E-stained histology images. The model identifies 21 cell subtypes in mouse brain and maintains prediction accuracy in human breast and lung cancer tissues.
A new approach integrates multimodal data, AI, and insights from traditional Chinese medicine to predict cancer risk and identify early biomarkers. This 'pan-cancer exceedingly-early' strategy offers a promising avenue for personalized early prevention.
A new AI framework uses a pre-trained viral protein language model to predict the adaptation risk of unknown viruses. The framework, called GIVAL, achieves high accuracy and robustness even with incomplete data, providing critical support for early warning and proactive prevention and control of viral infectious diseases.
Researchers are exploring ways to create green, closed-loop electrical insulation systems with excellent performance and recyclability. Bio-based monomers and mineral-based silicones are replacing petrochemical feedstocks, while advanced processing techniques enable self-healing and physicochemical recycling capabilities.
Researchers have developed dual-function biomaterials that can suppress tumors and regenerate bone, offering a promising strategy to address the challenges of postoperative osteosarcoma. The materials are designed to enhance antitumor efficacy while minimizing systemic toxicity, and also provide structural support for bone regeneration.
The study demonstrates the auditory cortex's ability to integrate fine-scale and coarse-scale temporal cues during synchronization, with better performance in macaques compared to the middle glandular body. The nonlinguistic oddball paradigm shows promise for clinical applications in psychiatric disorders and future research should exp...
Single-crystal HfB2 nanorods exhibit enhanced mechanical properties, with a 4.1% increase in hardness and 37.6% improvement in fracture toughness. The nanorods also demonstrate excellent ablation resistance, impeding oxygen atom penetration and reducing mass ablation rates.
Researchers developed three advanced strategies to create ordered membrane electrode assemblies for high-efficiency anion exchange membrane water electrolysis. The first strategy uses nanoimprinting, while the second employs integrated membrane electrodes. The third strategy leverages 3D interlocked interfaces, achieving exceptional pe...
Researchers have discovered triaptosis, a novel cell death mechanism that selectively targets and kills cancer cells, offering a new hope in oncology. This process is mechanistically distinct from all previously known cell death pathways and holds considerable promise for combination with immunotherapy.
Researchers developed an innovative treatment platform combining a multichannel 3D-printed bioactive scaffold with siRNA delivery for enhanced axon regeneration and improved motor function in spinal cord injury rats. The therapy addressed multiple pathological barriers, including insufficient intrinsic axonal regeneration, lack of dire...
Robotic exoskeletons enhance cancer patients' mobility, muscle strength, and gait training while providing personalized support and real-time feedback. This innovation integrates traditional therapies, nutritional support, and cognitive behavioral therapy to improve therapeutic outcomes.
Research highlights the connection between fungi and cancer, revealing that fungal microbiome can promote tumour progression and activate immunosuppressive pathways. Modulating the fungal microbiome may enhance antitumour immunity, with preliminary validation from preclinical and clinical trials.
Researchers focus on unraveling immunoregulatory mechanisms in sepsis, exploring the NF-κB and JAK/STAT signaling pathways. Emerging treatments aim to mitigate hyperinflammation and prevent organ failure through personalized, multi-target modulatory approaches.
Researchers discovered a dual mechanism by which Oroxylin A inhibits SIRT7, reprogramming HSCs through PRMT5 succinylation-driven senescence and ecto-calreticulin-dependent NK cell immune clearance. This approach provides a promising candidate for anti-fibrotic therapy.
Metasurfaces overcome THz biosensing challenges by leveraging resonance modes, graphene enhancement, and CNT films. Graphene-based sensors achieve high detection limits, while CNT film sensors exhibit good biocompatibility and sensitivity. All-dielectric metasurfaces also show promise with low loss and high Q-factor.
A novel post-translational modification, lactylation, plays a critical role in the pathogenesis of aortic dissection. Lactylation of mitochondrial adenosine triphosphate synthase subunit alpha impairs ATP production and increases reactive oxygen species generation.
Researchers introduce parity metamaterials that achieve ultrabroadband undistorted transmission with tunable reflection control, offering a new strategy for acoustic stealth and wave manipulation. The materials suppress specular reflection signals, enhancing stealth and achieving 'acoustic invisibility' akin to biological camouflage.
Researchers have developed novel nanomaterials to combat myocardial ischemia-reperfusion injury, demonstrating significant cardioprotective effects in preclinical models. These nanoplatforms improve drug enrichment efficiency and reduce systemic toxicity, showing considerable clinical translation prospects.
Research reveals DKK3's role in AAA progression through phenotypic switching of vascular smooth muscle cells, driven by the TGFβ3-Smad2/3 axis. This study identifies DKK3 as a potential therapeutic target for maintaining VSMC homeostasis in AAA.
Researchers developed a machine learning-driven design for a high-energy NASICON cathode that surpasses previous materials in terms of specific capacity, average operating voltage, and rate capability. The new cathode addresses sustainability concerns by replacing toxic vanadium with more environmentally friendly elements.
The research team developed a unique alginate-collagen interpenetrating network (IPN) hydrogel system that mimics the mechanical properties of tissues. Fibroblasts cultured on the hydrogels exhibited unprecedented behavioral patterns, including cell aggregation and reprogramming-related gene expression upregulation. The positive feedba...
A recent study used AI algorithms to analyze medical imaging and predict treatment response in patients with locally advanced nasopharyngeal carcinoma. The AI-based radiomics model achieved high accuracy in predicting treatment response and prognosis, revealing a link between imaging-derived features and the tumor microenvironment.
Researchers developed a small-molecule substrate-based fluorescent probe to visualize the nanoscale organization of glucose and serine transporters in breast cancer cells. The study found that SerT clustering correlates positively with function and is crucial for maintaining cellular serine homeostasis.
Researchers developed a novel real-time biosensing platform for detecting liver function impairment via WGM laser technology, enabling highly sensitive detection of ALT. The system uses functionalized liquid crystal microcavities to generate an optical response to pH variations induced by the ALT-catalyzed enzymatic reaction.
Researchers at Beihang University have made new progress in understanding the relationship between collagen fiber arrangement and pathological calcification in atherosclerosis. The study found that CFA disruption is closely linked with inflammatory responses, SMC phenotype switching, osteogenic gene expression, and vascular calcificati...
Researchers propose a novel lower-limb motion capture system using flexible pressure sensors, achieving accurate joint position estimation with an average prediction error of only 7.8 pixels. The system enables seamless interaction and natural control in the metaverse.
Research reveals omega-3 fatty acids directly regulate mammary gland lipogenesis and development through the Gαs-mediated cAMP–EPAC signaling pathway, promoting milk fat synthesis and epithelial cell migration. This discovery provides potential clinical targets for enhancing maternal lactational ability.
Atomically thin 2D metals exhibit unique properties, making them suitable for applications in electronics, electrochemistry, and catalysis. Five synthesis methods, including confinement techniques and van der Waals squeezing, are explored to fabricate 2D metals with distinct properties.
Researchers developed a cylindrical air damper to improve the self-stabilization performance of flapping-wing micro-aircraft. The Tumbler FWMAV demonstrated breakthrough stabilization performance, with vertical stabilization duration improved by 5-fold and horizontal offset motion reduced by ±100 mm.
Macrophage lysosomes regulate reactive oxygen and nitrogen species production, with pH influencing the balance between killing microbes and avoiding self-harm. The study provides insights into immune regulation using nanoelectrochemical sensors.
Researchers discovered PRMT5 regulates ACSL4 methylation, which promotes ferroptosis in renal cell carcinoma. Inhibiting PRMT5 increases ferroptosis and enhances immunotherapeutic treatment efficacy.
Research focuses on lysosome, iron, and mitochondria connections in osteoclasts. Lysosomes regulate intracellular iron mobilization and mitochondria rely on iron for energy metabolism.
Mitochondrial dysfunction is linked to various diseases, including neurodegenerative disorders and cancers. Mitochondria can be transferred between cells via tunneling nanotubes, restoring cellular respiratory function. Understanding mechanotransduction pathways involving mitochondria is essential for developing effective therapies.
This article introduces post-quantum cryptography, emphasizing its mathematical foundation in lattice theory and positive definite quadratic forms. The study explores the shortest vector problem (SVP) and closest vector problem (CVP), crucial problems for further development of lattice-based cryptography.
A new luteolin nanomedicine is designed to deliver the fat-clearing compound precisely to atherosclerotic plaques, boosting fat clearance and improving artery stability. The treatment reduces plaque size, lipid burden, and inflammation, making it more stable and reducing the risk of rupture.
This novel framework, MMHNN, reduces computational overhead while preserving essential molecular interactions. It offers clearer interpretability of molecular interactions, paving the way for efficient and scalable modeling of intermolecular relationships.
Researchers develop AI-based model for structural analysis of antibodies, offering precision in less time. The S2ALM model integrates sequence and structure, predicting missing information with high accuracy.
Researchers develop a novel process to convert polyethylene and polypropylene into valuable olefins, producing fewer unwanted byproducts. The method uses inexpensive base-metal catalysts, operates under mild conditions, and achieves high yields of propylene and isobutylene.
Researchers developed a novel 3D printing technique called IPS 3DP to create personalized implants with specific mechanobiological properties. The method enables the creation of structurally complex hydrogels with hierarchical microstructures and strain-stiffening behavior, paving the way for advanced biomedical applications.
Researchers developed a bio-inspired bistable robotic gripper with tunable energy barrier, achieving rapid, compliant, and powerful grasping behavior. The gripper can adapt to different tasks and environments through dynamic energy barrier modulation, enabling efficient interaction with objects.