Scientists successfully reconstructed the biosynthetic pathway for oxindole alkaloids in yeast, producing complex molecules with therapeutic potential. The study opens new avenues for sustainable manufacturing of high-value natural products.
Researchers developed a new biosynthetic route to produce optically pure S-2-Hydroxyisovalerate, a chiral α-hydroxy acid essential for various applications. The platform uses a microbial factory capable of producing gram-per-liter levels of S-HIV from renewable carbon sources.
Researchers have created a yeast platform capable of producing calycosin-7-glucoside, a valuable isoflavonoid from Astragalus membranaceus. The optimized strain achieved a titer of 0.22 mg/L within 48 hours, providing a scalable alternative to plant-derived production and reducing dependence on medicinal plant cultivation.
A new study published in Communications Psychology found that verbal justifications supporting memories remain rich, detailed, and consistent even after a delay of 24 hours. The study suggests that memory justifications provide a temporally stable window into episodic memory, making them a reliable basis for evaluating memory credibility.
Research reveals that understanding marine mammal social networks is critical for predicting and managing disease outbreaks in oceans. Highly connected individuals, or 'super spreaders,' play a significant role in disease transmission.
Scientists engineer a rigid protein ruler to probe antibody shape and limit unwanted motion, supporting innovative antibody drug design. The study introduces protein-based molecular rulers that can accurately measure inter-site distances and restrict flexibility.
Researchers developed a highly sensitive blood test that can detect initial thrombin generation, a key trigger in blood clot formation. The test distinguishes between pathway-specific clotting abnormalities and suggests personalized treatment strategies, potentially predicting clinical outcomes.
Researchers have shown that human hearts can regrow muscle cells after a heart attack, paving the way for new treatments to reverse heart failure. The discovery was made possible by pioneering techniques that use living tissue samples taken from patients during bypass surgery.
Researchers from Kanazawa University and partners have discovered chorus emissions in Mercury's magnetosphere, exhibiting similar chirping frequency changes to Earth's magnetosphere. This breakthrough provides the first reliable evidence of intense electron activity at Mercury, expanding our knowledge of planetary space environments.
This review highlights the rise of self-sustaining luminescent tracing, enabling long-term, non-invasive monitoring in complex organisms. The fungal bioluminescence pathway represents a paradigm shift, offering advantages such as reduced toxicity and improved signal stability.
Scientists reconstructed the complete biosynthesis of polyphyllin II in yeast using plant transcriptomics and enzyme engineering. The study demonstrated the full heterologous production of polyphyllin II, enabling a sustainable alternative for producing complex medicinals.
Researchers achieve high product yield and sulfation quality in engineered yeast, enabling sustainable production of high-quality chondroitin sulfate without animal sources. The optimized strain delivers 7.13 g/L CSA with a stable sulfation degree of 48.4%, promising cleaner and more sustainable products.
Researchers propose a hierarchically converged defect-engineering strategy to construct a multidimensional ZnO/Bi₂O₃/BiOCl/BP/MXene heterojunction photoelectrode framework. This targets modulation increases the electrochemically active surface area, optimizes energy-level alignment, and establishes efficient carrier transport pathways.
Researchers developed AI-powered in silico labeling to analyze cell images without staining, preserving cell health. The system leverages context, such as cell shape and position, to accurately stain rare processes like cell division.
Researchers reprogrammed E. coli to convert renewable sugars into lauryl glucoside, a widely used non-ionic surfactant in cosmetics and personal care products. The engineered strain achieved measurable production levels, revealing substrate availability as a key bottleneck.
A review highlights AI-driven protein design as a key driver of next-phase plant natural product biosynthesis. Researchers are using integrated toolkits to discover missing enzymes, decode catalytic mechanisms, and engineer robust pathways.
Predictions for lung cancer death rates among EU and UK women indicate stabilization of mortality rates at 12.5 deaths per 100,000 in 2026. Lung cancer remains the leading cause of cancer death for both sexes in the EU, with mortality rates continuing to decline among men.
A bottleneck in hydrogen distribution is jeopardizing billions in clean energy due to slower development of pipeline networks and liquefaction plants. This critical issue could undermine major investment programs and make hydrogen uncompetitive if addressed.
Researchers overcome spatial resolution limit of sum-frequency generation (SFG) spectroscopy by utilizing plasmonic near-field confinement. This breakthrough enables direct visualization of nanoscale orientation heterogeneity in interfacial molecular domains.
An updated Cochrane review of 21 clinical trials involving over 2,100 adults found no high-quality evidence that cannabis-based medicines reduce neuropathic pain more than placebo. Small improvements were reported by patients using products with both THC and CBD, but these changes were not clinically meaningful.
Researchers found that autistic and non-autistic individuals produce distinct emotional facial expressions, with autistic adults exhibiting more unique and complex expressions. The study suggests that these differences in facial expressions may contribute to difficulties in recognizing each other's emotions.