Cancer mortality rates have decreased for breast cancer and leukemia, despite increasing incidence, while colorectal cancer has become the leading cause of death among US young adults. Colorectal cancer surpasses lung, breast, and prostate cancers as the leading cancer-related death in people under 50 years old.
A new study reveals that gut microbiota directly affects intestinal stem cell function, leading to impaired regeneration after injury. Restoring a more youthful microbiota can reverse the age-related decline in ISC activity.
Skin pigmented spots feature immune cell infiltration, branched blood capillaries, and a disrupted skin barrier, necessitating innovative skincare strategies. The study highlights the need for multi-action ingredients that soothe inflammation, normalize blood vessels, and maintain a healthy skin microbiome.
Commercially insured patients frequently bypass rural hospitals between 2012 and 2021, generating large payments for receiving hospitals. The findings highlight the need for addressing this issue to alleviate financial distress on rural healthcare facilities.
Researchers propose a new conceptual framework for neutrophils, highlighting their dynamic and adaptable nature. The study reveals neutrophils' functional diversification and immunological memory capabilities, opening avenues for innovative therapeutic strategies.
A study reveals that expanding existing mines worsens environmental and social risks over time, with many operations concentrated in high-risk contexts. The practice tends to draw less regulation due to its routine nature, unlike new mining projects.
A new study finds that soil salinization influences inorganic carbon storage, particularly in regions with elevated salinity. The research reveals a conditional relationship between salinity and inorganic carbon, highlighting the need to incorporate soil chemical processes into global carbon assessments.
The ISSCR has released a comprehensive roadmap for developing pluripotent stem cell-derived therapies, outlining critical scientific, manufacturing, and regulatory guidance. The Best Practices document provides a risk-based, end-to-end development strategy to support informed decision-making across seven essential areas.
Research published in Scientific Reports found that ancient giant kangaroos could withstand the strain of hopping due to robust hindlimbs. The study's findings suggest that these animals were unlikely to rely solely on hopping for locomotion over longer distances, but may have used short bursts of hopping to evade predators.
A retrospective study of 161 cases found that dermatofibrosarcoma protuberans (DFSP) of the head and face favors the cheek region, particularly in older patients. The dominant site accounted for 65.38% of all head-and-face DFSPs, suggesting regional anatomic or biological factors influence tumor development.
A new USC white paper reveals that PBMs' reported profit margins are influenced by accounting practices, making it challenging for policymakers to understand the true cost drivers. The researchers suggest requiring financial transparency from PBMs to develop a better picture of their operations and costs.
Scientists studying giant fossilized kangaroos discovered that they could still hop, contradicting previous beliefs. The analysis of foot bones and ankle tendons revealed that these prehistoric kangaroos had adapted differently to manage their enormous size, enabling them to bounce.
Researchers have characterized the association between cellular senescence and human brain structure in both development and late life. The study found that senescence-related gene expression is linked to brain volume and cortical organization, with distinct roles depending on cell type and stage of life.
Researchers have found that chemicals in exhaled breath can reveal the composition of the bacteria living in the intestines, providing a potential non-invasive test for monitoring and diagnosing gut health issues. Breath samples from children with asthma were able to predict the presence of the bacterium linked to the condition.
Researchers found that TL1A, a key immune signaling protein, stimulates the growth of new white blood cells in the bone marrow, which then promote tumor formation in the gut. The study suggests that blocking TL1A activity could be an effective strategy to treat IBD and prevent associated colorectal tumors.
A new study finds that hospitals treating more patients with Medicare Advantage plans face higher readmission penalties despite taking similar actions to prevent repeat hospitalizations. The analysis highlights the need to incorporate Medicare Advantage data into the Hospital Readmissions Reduction Program.
Dr. Manuel A. Friese has been recognized for his groundbreaking work studying the interactions between inflammation and nerve cell death, which drives disease progression in multiple sclerosis (MS). His research aims to identify new therapeutic targets and bring the field closer to stopping disease progression.
The study demonstrated that black ginseng extract reduces MMP-1 expression and suppresses PGE2 levels in human foreskin fibroblasts, promoting skin homeostasis. It also identified rare ginsenosides as key molecules involved in the anti-inflammatory effects of BGE.
Cancer researchers have identified a key mechanism by which cancer cells protect themselves from the immune system. The study found that MYC protein can bind to RNA molecules, eliminating alarm signals that would activate the immune defense.
Researchers developed a novel, computer-based method called CoBiSe to design and produce genetically encoded fluorescence-based biosensors for rapid and simple production. The new iron sensor 'IronSenseR' detects iron (II) with high sensitivity without binding to iron (III) or other metal ions.
Scientists have developed a novel immunotherapy approach that targets tumor macrophages, converting them from immune suppressors to killers. The therapy, using engineered CAR T cells, has shown promising results in preclinical models of metastatic ovarian and lung cancer.
A new study reveals that strong Central Pacific El Niños self-destruct due to negative feedbacks from distant oceans, while weaker events survive by forming a lasting partnership with the North Pacific climate pattern. This discovery enables forecasting months in advance with over 80% accuracy.
Science MMAI Gym trains LLMs in medicinal chemistry, biology, and clinical development with precision required in pharma R&D. Partner models emerge with up to 10x improvements in performance, matching state-of-the-art specialist models.
Myosteatosis is a key predictor of poor clinical outcomes across a spectrum of liver diseases, with associations to severe disease phenotypes, hepatocellular carcinoma, and increased mortality. Nutritional intervention, exercise prescription, and potential management strategies are proposed to address this condition.
The American Heart Association is hosting multiple pre-conference symposia at the International Stroke Conference in New Orleans, February 4-6, 2026. These symposia cover topics such as state-of-the-science stroke nursing, brain health, and addressing disparities in stroke care. The events are designed to advance stroke and brain healt...
Researchers developed a new imaging technology called fast-RSOM that captures detailed images of the smallest blood vessels directly through the skin. This technology can detect early signs of cardiovascular risk, enabling doctors to intervene sooner and guide personalized therapies.
Insilico Medicine presents three abstracts at the 2026 Crohn's & Colitis Congress highlighting clinical, preclinical safety, and efficacy data for ISM5411. The first-in-human Phase 1 results show no serious adverse events or deaths reported, with a favorable pharmacokinetic profile supporting gut restriction.
Researchers at UW-Madison have resurrected a 3.2-billion-year-old nitrogenase enzyme to improve our understanding of the origins of life on Earth and potentially recognize signs of life elsewhere.
A new study published in The Journal of Clinical Endocrinology & Metabolism found a causal link between high body mass index (BMI) and dementia. High blood pressure was identified as a driving factor behind the increased risk. Researchers suggest that preventing or treating obesity and high blood pressure could help reduce dementia risk.
Bacterial infections are common and severe complications in patients with liver cirrhosis, with a global prevalence of 35.1% reported. The most common infection sites were the gastrointestinal tract, ascites fluid, and urinary tract, with gram-negative organisms more frequent than gram-positive organisms.
A new study by Penn State researchers found that the level of transparency in artificial intelligence (AI) systems affects users' trust. When systems meet or exceed users' expectations, trust increases without needing detailed explanations. However, when expectations are not met, users require more information and a deeper understandin...
Fecal microbiota transplantation (FMT) holds promise in treating chronic liver diseases by restoring gut-liver axis balance. The consensus recommends FMT for various etiologies, excluding drug-induced liver injury, with strict donor selection and management guidelines to ensure safety.
A nationwide study found that Parkinson's disease is more common among individuals with higher socioeconomic status and in the northern provinces of the Netherlands. The risk increases with age, peaking between 75 and 85 years, and is higher among men.
A team of researchers at EPFL developed a robotic hand that can detach from its arm and 'crawl' to grasp multiple objects, overcoming human asymmetry and limitations. The device can perform 'loco manipulation' with seamless autonomy and has potential applications in industrial, service, and exploratory robotics.
A study reviews decades of research on Hsp70's role in neurodegenerative diseases, highlighting its protective effects and potential therapeutic value. The review reveals that different Hsp70 isoforms interact with co-chaperones and cellular pathways to determine protein clearance.
Smoking exposure induces tumor microenvironment promoting sorafenib resistance in HCC by modifying the 14-3-3η proteome. Arsenic trioxide suppresses tumor progression with synergistic effect when combined with sorafenib.
A new theory of proprioception challenges traditional understanding by incorporating frontier bionic evidence. The proposed framework reconceptualizes proprioception as a dynamic augmentable interface, enabling functional movement and potentially improving rehabilitation outcomes in sports injuries and neurological diseases. Researcher...
A team of researchers from Chonnam National University explores how boosting consumer trust can increase adoption of second-life EV battery tech. They found that transparent safety inspections and tailored messaging can improve adoption outcomes.
Researchers develop Dual Perigee, a lightweight algorithm that streamlines network connections to enable secure and low-latency data sharing in IoT networks. The study reduces block-related delays by 48.54% compared to standard approaches.
A study by Chungnam National University finds that climate adaptation can significantly reduce migration from drought and armed conflict in Africa. Countries with stronger adaptive capacity experience lower migration levels during crisis conditions, highlighting the importance of policies addressing environmental and security threats.
A recent study found that organic matter carried from rivers into the Arctic Ocean creates more clouds and keeps the region cooler. Aerosol particles formed by this biological matter act as 'seeds' for cloud formation, increasing their ability to form bright, long-lasting clouds.
A new Perspective article explores the role of biofilms in health during long-duration spaceflight and how this research can reshape our understanding of microbial communities on Earth. The study highlights the importance of biofilms in enabling human and plant health, particularly in space-based environments.
Researchers found that combining selective CDK2 inhibitor BLU-222 with CDK4/6 inhibitors produces strong, durable anti-tumor effects across preclinical models of breast cancer. This approach targets cancer cells' reliance on CDK proteins and restores control over the cell cycle in resistant tumors.
Research reveals that chemotherapy alters the gut microbiota, producing indole-3-propionic acid, which travels to the bone marrow and rewires immune cell production. This leads to a metastasis-refractory state in preclinical models and improved survival outcomes in patients with colorectal cancer.
Smartwatches with PPG and ECG functionality improve atrial fibrillation detection, detecting it four times more often than standard care. Researchers detected heart arrhythmia in 21 patients using smartwatches compared to five in those receiving standard care after six months of monitoring.
A new study has found that living walls can significantly enhance urban biodiversity by attracting pollinators and other wildlife. The research revealed that soil-based living walls with plants in soil attracted more wildlife than those with artificial substrates, and specific plant species like ivy and honeysuckle were most effective.
Researchers have developed a new AI method called Riff-Diff to construct artificial biocatalysts, resulting in enzymes that are significantly faster, more stable and versatile. The technology allows for precise design of protein structures around active centres, making enzyme design more accessible to the wider biotechnology community.
A team of researchers from Institute of Science Tokyo developed a novel enzyme, MAN, that efficiently converts common nucleotide substrates into RNA nucleotides with remarkable efficiency. This method simplifies the production of RNA building blocks by using inexpensive and stable polyphosphate as a phosphate donor.
Researchers at Kobe University have identified a specific bacterial strain, Staphylococcus epidermidis and Corynebacterium tuberculostearicum, as the primary causes of foot odor in Nagashima-type palmoplantar keratosis. Topical application of benzoyl peroxide reduces odor by decreasing C. tuberculostearicum levels.
Researchers found that humans in northern Mozambique use distinct calls, trills, grunts, whoops, and whistles when communicating with honeyguide birds. These regional dialects allow communities to coordinate cooperation with greater honeyguides, revealing a striking parallel to human language diversification.
Researchers have developed a new way to produce fluorescence by using molecular stacking, which can lead to the creation of smarter and more sensitive pressure sensors. The study focused on two crystalline organoboron compounds that exhibit piezofluorochromism, changing color in response to pressure.
Researchers at Université libre de Bruxelles discover a single thermodynamic quantity that explains how membranes exchange lipids and how this process affects biological behavior. This framework has far-reaching implications for understanding various biological mechanisms and potentially controlling their behavior.
Researchers explore microneedle technology as a novel delivery system for efficient and minimally invasive intradermal drug delivery. The review highlights the design of functional microneedles with specific structures to overcome biological barriers in various tissues, improving therapeutic outcomes.
The latest research on water striders, a true bug family, sheds light on their evolutionary history, revealing that most lineages originated up to 50 million years ago. The study, led by Dr. Michael Raupach, used genome analysis to reconstruct the family tree and identify key drivers of biodiversity.
Researchers have developed a new class of engineered nanoparticles that can bind to and degrade specific disease-related proteins. This technology has the potential to treat diseases such as dementia and brain cancer by eliminating harmful proteins.
Researchers used a custom-designed microscope to image individual lunar regolith grains, revealing the carriers and origins of their magnetism. The study provides insights into the Moon's internal structure and thermal evolution history.
Researchers visualized how light is transformed inside a chiral metasurface in both real space and real-time, achieving nanometer spatial resolution and femtosecond temporal resolution. The team found that the asymmetric near fields are a genuine signature of the chiral geometry.
Researchers have made progress in creating human milk oligosaccharides through bioengineering, enabling the industrial-scale production of complex HMOs. This allows infant formula to mimic human milk's compositional complexity, potentially offering benefits for gut microbiota development and immune protection.
A Murdoch University review found that people with MS experience difficulties navigating society and feel ashamed about their condition. The study highlights gaps in the ICF framework, which may not capture the full emotional and social burden of living with MS.
A study from Flinders University found that patients with progressive disease, which describes the way cancer grows, have varying survival rates depending on whether their existing tumours re-grow or new ones appear. Understanding this progression can help doctors make better decisions about future treatment strategies.