The liver's unique immune tolerance is driven by peptide hormones and bile acids, which activate anti-inflammatory responses and foster a tolerogenic phenotype in resident immune cells. This mechanism may explain the liver's reduced rates of transplant rejection but also poses challenges for treating liver infections.
This study reveals how lipid metabolism dysregulation promotes colorectal cancer liver metastasis through a novel YTHDF3-mediated mechanism. Lipid deposition enhances YTHDF3 expression, leading to its degradation and reduced PPARα, which decreases fatty acid oxidation metabolites.
A recent study reveals that FPR2 activation regulates the proliferation and differentiation of intestinal stem cells (ISCs) and transit-amplifying cells, leading to improved epithelial repair. The study also identified a potential therapeutic target for intestinal damage, highlighting the therapeutic potential of FPR2 agonists.
Plant-derived compounds interfere with bacterial quorum sensing to reduce human bacterial pathogens and antibiotic resistance in agricultural soils. The study shows that plant extracts can substantially reduce risks posed by these microbes by disrupting their communication and sharing harmful traits.
Researchers propose that self-sabotaging behaviors like procrastination and perfectionism are rooted in the brain's survival instincts. By processing underlying emotional pain, individuals can break free from self-sabotage loops through self-compassion.
The study investigates regional mechanical variability in porcine pia–arachnoid complex (PAC) using a region-by-region, multi-scale design. Regional differences in mechanical properties are linked to biochemical distributions via two-photon imaging and RNA-seq.
The review explores how multiplayer games, social robots, and virtual agents can advance artificial empathy in therapy and healthcare by embedding interpersonal interaction. It highlights the need for deeper, more seamless closed-loop interaction and emphasizes the importance of emotion recognition, trust, engagement, and rapport.
Autumn straw returning reduces airborne diseases like northern leaf blight by 12.24%, while spring returning is more effective against soil-borne ear rot. The optimal depth for soil-borne pest control is 45 cm, with a combination of full-amount and autumn returning being most beneficial for yield.
HALIMA, a hybrid array for lifetime measurement of neutron-rich nuclei at IMP, enables precise sub-nanosecond measurements using the four-fold FF/β-Ge-LaBr <sub>3 </sub>(Ce)-LaBr <sub>3 </sub>(Ce) coincidence technique. The system reduces Compton continuums and enhances selectivity via fission fragments implantation.
Researchers analyzed brain connectivity data to understand how the brain integrates fast and slow signals. They found that differences in neural timescales across individuals vary in their cognitive abilities.
Jundong Li, an associate professor at the University of Virginia, has received the 2025 Tao Li Award for his significant contributions to data mining and machine learning. His research focuses on developing models that can extract actionable insights from structured data, particularly graphs.
Mircea Stan, a University of Virginia professor, has been awarded the National Academy of Inventors fellowship for his innovative work on low-power computer technology. His contributions have enabled significant energy savings and improved performance in electronic systems.
A recent study by Alice Carter reveals that filamentous algae blooms in the Upper Clark Fork River have a minimal impact on the river's metabolism and function. Instead, smaller epilithic algae are quietly driving the ecosystem, producing healthy conditions for the food web.
Rebuilding coral reef fisheries can help fight global hunger and improve nutrition by increasing sustainable fish yields by nearly 50%. Countries with higher malnutrition indexes can benefit most from recovered reef fish stocks, which could provide enough servings for several million people annually.
A study published in Neurology found that people with weaker and more fragmented circadian rhythms, as well as those who experience a later peak of activity, have an elevated risk of dementia. The study involved over 2,000 participants and followed them for three years to track the development of dementia.
Researchers identify two archetypes of growth arrest that lead to persistence: regulated and disrupted states. The former provides protection from antibiotics, while the latter is marked by vulnerabilities, particularly impaired cell membrane stability. This distinction has significant implications for developing targeted therapies.
Researchers at EPFL developed thermal paper coatings using lignin, a major component of wood, which have low or no toxic signatures. The new formulations match commercial thermal paper performance while showing improved safety profiles.
Researchers used dosage-sensitive genes to detect whole-genome duplication events in ancient angiosperm evolution. Their findings suggest a single ancestral WGD event in seed plants, rather than two independent events, with no additional WGD occurring during angiosperm evolution.
A team of anthropologists offers powerful evidence that Sahelanthropus tchadensis, a seven-million-year-old fossil, was bipedal. The analysis confirmed the presence of traits essential for walking upright, including a femoral tubercle and gluteal muscles. This finding suggests that bipedalism evolved early in our lineage.
Scientists reconstructed ancient genomes of Human betaherpesvirus 6A and 6B from archaeological human remains, confirming their integration into the human genome thousands of years ago. The findings suggest that HHV-6A lost its ability to integrate into human DNA over time.
Researchers found that tangled or irregular collagen at old uterine scars breaks down normal boundary between uterus and placenta, creating permissive environment for abnormal attachment. Persistent inflammation and immune cells also interfere with normal scar remodeling.
Researchers create a novel mathematical framework to control biological noise, enabling precise single-cell control. The 'Noise Robust Perfect Adaptation' technology suppresses stochastic fluctuations while maintaining stable average behavior, with promising applications in cancer therapy and synthetic biology.
A cohort study found that most children received their first dose of MMR vaccine on time, but the proportion not receiving it by age 2 has increased. Children who missed early vaccinations were more likely to not receive any MMR vaccine by age 2.
Researchers at St. Jude Children's Research Hospital created CHANGE-seq-BE to evaluate the activity and specificity of base editors, a genome editing technology, ensuring safety and accuracy. The technique outperformed conventional approaches and has already been used in clinical work.
A population-based study found that US preterm birth rates have increased among low-income households, with racial disparities exacerbating the issue. The study highlights the need to address racism in reducing preterm birth disparities.
Researchers have developed new PET imaging tracers to detect and treat colorectal, thyroid, and lymphoma cancers. The tracers enable targeted radiation delivery, personalized dosing, and improved detection of inflammation in large blood vessels and liver lesions.
A University of Toronto-led study has discovered a potential biomarker linked to multiple sclerosis disease progression that could help identify patients most likely to benefit from new drugs. The findings were validated in both mouse models and humans, suggesting a possible surrogate marker for leptomeningeal inflammation.
A study found that many Norwegian mothers do not attend postnatal check-ups, with women citing a lack of information about the service and fear of discussing sensitive topics. The study suggests that providing clear information and supporting women in discussing their birth experiences could improve attendance rates.
Quick clay's instability is caused by salt ions washing out, making it prone to catastrophic landslides. Researchers aim to find more environmentally friendly stabilization methods using molecular dynamics simulations.
Researchers have discovered a new method for generating highly stable and precise microwave signals through self-induced superradiant masing. This phenomenon produces long-lived bursts of microwave emission without external driving, paving the way for technological advances in fields like medicine, navigation, and quantum communication.
Two studies found that elevated bacteria levels in tumors weaken immune response, driving resistance to immunotherapy. Researchers are now exploring how to identify patients most likely to benefit from immunotherapy and develop targeted interventions to restore its effectiveness.
A study demonstrates how optimized genomic prediction models can reliably forecast complex agronomic traits in rapeseed. The research achieves high prediction accuracy for multiple economically important traits, particularly flowering time and yield components.
Researchers at KAIST have developed a new therapeutic approach that converts dormant immune cells inside tumors into potent anticancer agents. By reprogramming tumor-associated macrophages, they created CAR-macrophages that recognize and kill cancer cells while activating surrounding immune responses.
Scientists at Lund University have created a new method to directly reprogram glial cells into parvalbumin neurons, which can help regulate brain activity and potentially treat disorders such as schizophrenia and epilepsy. The breakthrough could lead to therapies that replace lost or damaged brain cells in the future.
This study showcases the potential of MOF–NP composites to accelerate key nitrogen electrochemical reactions under mild conditions. The analysis highlights how these hybrid materials improve reaction selectivity, stabilize intermediates, increase Faradaic efficiency, and support strong long-term durability.
Lattice-anchored iridium enhances metal-oxygen covalency and preserves structural integrity under harsh acidic conditions, while Ir at surface hollow sites degrades cobalt and oxygen migration. Long-term tests show improved stability for lattice-anchored iridium OER catalysts.
Researchers developed a methylurea-assisted electrolyte that forms a robust solid electrolyte interphase directly on the zinc surface, dramatically improving zinc reversibility. This engineered SEI enables long-life anode-free zinc batteries with unprecedented cycling life and exceptional durability.
Researchers developed a kinetic activation strategy to regulate in-plane transition-metal ion migration and trigger controlled local structural rearrangements. This approach enabled reversible lithium storage beyond the long-standing 1.1 stoichiometric limit, reaching 348 mAh g⁻¹.
Researchers from Nankai University developed a breakthrough strategy to prevent voltage decay in lithium-rich layered oxides by using trace dopants placed at tetrahedral sites, suppressing both in-plane and out-of-plane TM migration. The study demonstrates a new atomic-scale stabilization mechanism for over 250 cycles.
Researchers develop copper-modified cobalt oxyhydroxide catalyst for clean glucose oxidation, achieving high formate yield and reducing energy input. The membrane-free system delivers over 500 μmol h⁻¹ cm⁻² of hydrogen, offering a scalable and economically competitive route to green hydrogen.
The American Society for Radiation Oncology (ASTRO) has rebranded its research foundation as Speed of Light – The ASTRO Foundation, marking a renewed focus on advancing research and improving patient care. The new initiative aims to strengthen research collaborations and investments to drive progress in radiation oncology.
Researchers found that combining LiDFOB and LiPF₆ in a dual-salt electrolyte regulates electrode interfaces, forming a double-layer cathode electrolyte interphase and a LiF-rich solid electrolyte interphase. This design lowers interfacial impedance, promotes uniform Li deposition, and enhances durability under cycling.
Researchers discovered that electrowetting increases active surface area and restructuring the electric double layer, leading to enhanced charge storage. Mesopores combined with multivalent ions support stronger ion packing and dual-ion adsorption, delivering higher capacitance.
In situ EC-SERS captures fingerprint vibrational signals of trace and transient interfacial species under operational conditions. This technique reveals how electrocatalyst properties and interfacial environments govern fuel cell, water electrolysis, and CO2RR related reactions.
Leukemia prevalence increased by 28.0% globally from 1990 to 2021, alongside a 16.2% decline in disability-adjusted life years (DALYs). Chronic lymphocytic leukemia (CLL) is the most prevalent subtype, while acute myeloid leukemia (AML) contributes the largest proportion of DALYs.
Insilico Medicine and Hisun Pharma successfully nominated a preclinical candidate using AI-powered R&D in just 8 months after forming a strategic collaboration. The collaboration showcased the acceleration and efficiency gains that AI can bring to drug development, enabling the companies to enhance innovation in early-stage drug discov...
Researchers at the Francis Crick Institute have created a human 'lung-on-chip' model with genetically identical cells from a single donor, simulating breathing motions and lung disease. The device, built by AlveoliX, holds promise for testing treatments for infections like tuberculosis and delivering personalized medicine.
Researchers at EAST have successfully accessed a theorized 'density-free regime' for fusion plasmas, achieving stable operation at densities beyond conventional limits. This breakthrough provides new insights into overcoming one of the most persistent physical obstacles on the path toward nuclear fusion ignition.
A new study found that people have moved pigs across the Pacific for millennia, introducing invasive species to Indonesia and beyond. The research used genomic analysis to track pig movements, revealing a complex history of human activity in the region.
A genomic study reveals that pigs in the Pacific islands descended from domestic pigs brought by Austronesian-speaking groups from Southeast China and Taiwan about 4,000 years ago. This suggests that humans played a significant role in introducing pigs to new regions, with limited genetic mixing with local populations.
A new study reveals Africa's oldest known in situ cremation pyre containing the remains of an adult, dated around 9,500 years ago. The discovery suggests that ancient African hunter-gatherer communities had complex ritual practices involving posthumous removal and reburial of body parts.
A newly identified genetic variant has been found to reduce the risk of leukemia by slowing the growth of mutated blood stem cells. The variant, rs17834140-T, weakens the activity of a key gene in stem cell maintenance, leading to suppressed competitive growth of mutant stem cells.
A Saturn-mass rogue planet has been detected via microlensing event observation from both Earth and space, enabling direct measurement of its mass and distance. The discovery provides key findings on the diverse pathways of planetary ejection, shedding light on how planets can form and become isolated.
Researchers found coral reefs impose daily rhythms on nearby microbes, reshaping their composition and abundance. This daily pattern is stronger than seasonal differences, suggesting time of day is a critical factor in studying reef-associated microbial communities.
The first Editorial of 2026 discusses AI's impact on the scientific community. The journals use select AI tools, with encouraging results in data sharing among published research articles.