A landmark study found gestational diabetes during pregnancy is associated with declines in intellectual function for mothers and higher risks of developmental, behavioural and autism spectrum disorders in children. Mothers with GDM scored 2.47 points lower on cognitive assessments than peers without GDM.
The Global RETFound initiative aims to develop the world's first globally representative AI foundation model in medicine, addressing health inequalities and AI bias. The project involves a diverse dataset of over 100 million fundus photographs sourced from 65+ countries.
The Ellen Siow Professorship aims to advance education and research in neuro-oncology, specifically glioblastoma. This will drive the development of innovative programmes and interventions, fostering progress that benefits people in Singapore and beyond.
Researchers developed a first-trimester blood test that accurately predicts gestational diabetes risk, using just seven biomarkers. The test's strong ability to distinguish high-risk from low-risk pregnancies could enable early interventions and reduce long-term health burdens.
A landmark study found that adopting five healthy lifestyle habits—healthy weight, no smoking, regular physical activity, high-quality diet, and moderate alcohol intake—can reduce cardiovascular disease risk by up to 86% in women with a history of gestational diabetes. Women who followed all these habits had no cardiovascular events ov...
The Journal of Medical Ethics has been ranked the world's leading bioethics journal according to 2025 Google Scholar Metrics. The journal is co-led by Associate Professor Brian D Earp and a new editorial team seeking to promote ethical reflection and conduct in scientific research and medical practice.
NUS Nursing introduces Singapore's first Doctor of Nursing Practice programme and three Master's programmes to enhance nursing expertise and leadership. The Doctor of Nursing Practice is a two-year part-time program empowering nurses to lead care through advanced clinical expertise and critical thinking.
The HELO survey reveals a population seeking optimal health and lifespan, yet lacking the necessary knowledge and access. Key findings include strong public interest in Healthy Longevity Medicine clinics across all age groups, with older adults showing clear enthusiasm for preventive care.
A NUS-led global study reveals that 30-minute functional MRI scans deliver up to 22% in cost savings while retaining or improving prediction accuracy. This finding could reshape how researchers design neuroscience and mental health studies, especially for hard-to-recruit populations.
A recent study by National University of Singapore researchers has shown that histone deacetylase inhibitors (HDACi) can protect neurons and limit brain damage following stroke by altering the gene expression of microglia. The treatment was found to reduce brain damage and improve recovery in stroke models, offering new hope for patients.
Researchers developed AI-driven platform IDentif.AI to uncover sex-specific drug combinations for aortic valve stenosis, a serious heart condition. The study found that female-biased combinations were more effective in addressing the disease in female cells, while male-biased combinations were more effective in male cells.
Researchers developed an improved biological ageing clock, LinAge2, that offers doctors a practical way to assess how quickly a person is ageing and what can be done to slow it down. The new algorithm-powered tool outperforms other clinical models in predicting long-term mortality and health outcomes.
A new review calls on endocrinologists to adopt environmentally responsible measures in their practice, reducing waste and emissions. Implementing strategies such as reusable medical devices, consolidating clinic visits, and improving medication adherence could cut emissions by up to 56%.
Prof Chen brings extensive experience to the role, with a focus on clinically translatable theranostics. He aims to catalyse collaboration and accelerate knowledge exchange in the global nanomedicine community.
The collaboration aims to create new research projects and foster career development opportunities for scientists and students. The partnership will leverage clinical data from NUH and NUHS to drive breakthroughs in human health and sustainability.
The partnership aims to leverage AI in developing innovative digital therapeutic solutions to prevent diseases in children. Researchers will use gamified digital therapy solutions on mobile devices to encourage healthier behaviors.
The World Sleep Society releases recommendations on wearable sleep trackers, providing clear guidelines for consumers, clinicians, researchers, and manufacturers. Key takeaways include choosing a device suitable for individual use cases and focusing on fundamental sleep measures rather than specific stages of sleep.
Researchers developed an AI platform that tracks cancer biomarkers to personalize treatment dose adjustments for patients with advanced solid tumors. The study resulted in optimal doses being administered to 97.2% of patients, with average reductions of 20%.
A new study reveals menopause symptoms disrupt professional and personal lives of female employees in the region. Asian women report higher symptom burden compared to Caucasian counterparts, with nearly half experiencing disruptions to work performance and daily activities.
Researchers found that sleep duration returns to baseline within two days, but changes in sleep timing and structure can take more than a week, with eastward travel causing the most disruption. The study analyzed 1.5 million nights of data from wearables like Oura Ring.
A study confirms plasma p-tau217 as a blood-based biomarker for early Alzheimer's detection in Asian populations. Higher levels correlate with faster cognitive decline, suggesting its potential role as both diagnostic and predictor tool.
Researchers have made progress in understanding how Streptococcus pneumoniae constructs its capsule, a critical target for vaccine development. The study identified three categories of transporters that facilitate sugar building block transport, with relaxed specificity transporters posing potential risks to bacterial growth.
The Systems Metabolomics Centre will focus on three key areas: profiling populations of healthy people and those living with specific illnesses, leveraging state-of-the-art metabolomic technologies to drive biomarker discovery and metabolism research. The centre aims to develop non-invasive tests, detect diseases earlier and guide doct...
A new study found that poor sleep health is associated with a higher risk of developing Type 2 diabetes among women with a history of gestational diabetes. Women who slept six hours or fewer per night had a 32% higher risk compared to those who met the recommended seven to eight hours of sleep.
Scientists at NUS Medicine have developed a novel approach using nasal bacteria to deliver therapeutic molecules directly to the brain, reducing appetite and improving glucose metabolism in preclinical studies. The engineered bacteria leverage the olfactory mucosa's unique properties to deliver medication with enhanced bioavailability.
A new study from NUS Medicine has found that the protein Spns1 plays a key role in recycling fats out of cell compartments called lysosomes, preventing diseases like lysosomal storage disorders. The research uses cryoelectron microscopy to understand how Spns1 transports fats and highlights its importance for cellular health.
NUS Medicine has launched a new centre to bolster global pandemic preparedness and response to infectious disease emergencies. The Centre for Infectious Disease Emergency Response (CIDER) will serve as an education and operational hub for public health professionals, researchers, and policymakers.
A collaborative study investigates how advanced AI tools can make it easier to evaluate interventions for ageing, providing personalised recommendations. The researchers identified eight critical requirements for effective AI-based evaluations and found that following specific guidelines improved the quality of the recommendations.
Researchers found that short-course antibiotics can be as effective as traditional longer treatments in preventing death and recurrence of pneumonia. This approach offers significant value for healthcare systems by reducing hospital expenditure while maintaining excellent patient outcomes.
A recent NUS Medicine study found that a molecule called DUSP6 plays a major role in helping colorectal cancer grow, with higher levels linked to poorer prognosis and decreased survival. Researchers suggest blocking DUSP6 could lead to new therapies for CRC treatment.
Researchers discovered a brain functional connectome phenotype related to multiple cerebrovascular disease markers that contributes additively to cognitive decline and neurodegeneration alongside Alzheimer's disease. The study highlights the role of cerebrovascular disease in reshaping our understanding of dementia.
The National University of Singapore's HRPC has been designated as the GHHIN Southeast Asia Hub, aiming to mitigate extreme heat risks through research, policy, and partnerships. The hub will focus on addressing unique regional challenges such as high humidity, urbanization, and socioeconomic disparities.
Engineered yeast cells can form cooperative groups that perform complex tasks and self-regulate in response to external signals. This approach enables precise production of therapeutic compounds, reducing waste and increasing treatment efficacy.
Dr. Vincenzo Sorrentino's research targets the mitochondria-proteostasis axis to promote healthy longevity, addressing significant challenges in Singapore where life expectancy gap poses a threat. He joins a diverse group of researchers to tackle universal challenges and build towards a healthier future for Singapore.
Researchers successfully delivered anti-cancer ASO molecules to lung tumor sites using human red blood cells, demonstrating potent anti-cancer effects against NSCLC. The approach utilizes EGFR-targeting moieties to home in on cancerous cells, offering a potentially powerful treatment modality for personalized cancer medicine.
Researchers from NUS and Harvard T.H. Chan School of Public Health found that breastfeeding significantly reduces cardiovascular disease risk among women with type 2 diabetes and gestational diabetes. A healthy Mediterranean diet with low persistent organic pollutant exposure also lowers the risk of GDM.
The study marked a significant milestone in lipidomics, establishing reference values for ceramides and plasma lipids involved in cardiovascular disease risk prediction. The global network of laboratories achieved better-than-anticipated comparability in results using different methods and instrumentations.
Researchers have developed a novel gene therapy approach that targets and breaks down faulty ribonucleic acids in the KCNA2 gene, which is associated with recurring seizures. The therapy has shown promise in reducing excessive neuron activity linked to epilepsy.
A new study by NUS Medicine reveals that Singaporean families with young children successfully adapted to the pandemic's challenges, with 31% showing economic security and relational strengthening. Families with strong relational factors, such as maternal self-efficacy and quality family time, demonstrated higher relational resilience.
A new CAR-T cell therapy targeting CD7 on leukaemia cells has shown promising results in treating T-ALL patients who have exhausted all standard treatment options. The therapy achieved complete remission in 16 out of 17 patients, with some remaining in remission for over five years.
Researchers developed a breakthrough nanoparticle technology that offers an effective solution to diagnose and treat atherosclerosis in a non-invasive manner. The innovative theranostic approach can target atherosclerotic plaques and deliver therapeutic agents directly to inhibit the progression of atherosclerosis.
Researchers at NUS Yong Loo Lin School of Medicine have developed a novel EV-based delivery platform that enhances the effectiveness of cancer immunotherapy while reducing side effects. The approach uses modified nano-sized cell particles to carry immune-boosting molecules, leading to better therapeutic outcomes and lower drug doses.
A groundbreaking study has provided novel insights into the molecular underpinnings of gastric cancer peritoneal spread, paving the way for more effective treatments. The research also demonstrated the safety and potential efficacy of a new treatment approach in a clinical trial.
A team at NUS Yong Loo Lin School of Medicine leveraged an artificial intelligence-derived platform, CURATE.AI, to guide treatment for a patient with Waldenström macroglobulinemia, a rare blood disorder. The trial demonstrated substantial improvement in red blood cell levels and minimised side effects.
Research highlights the need for further study on the impact of sustained heat exposure on hormone release and action. Heat exposure is associated with decreased fertility, increased risks of pregnancy complications and menopause symptoms, as well as worsened conditions like thyroid disorders and diabetes mellitus.
Researchers found significant discrepancies between actual and labelled amounts of Nicotinamide Mononucleotide (NMN) and Urolithin A (UA) in anti-ageing supplements. The discrepancies ranged from none to 28% more than stated amounts, highlighting a critical issue in the supplement industry.
Researchers developed two clinical ageing clocks, PCAge and LinAge, that use blood tests, a urine test, and a health questionnaire to estimate future mortality risk. These clocks show significant predictive efficacy in characterising individual future ageing trajectories.
A researcher's 7-month journey of 20-hour fasts, fitness regimen, and clean eating shows significant improvements in weight loss, grip strength, and overall health. The study uses digital health technologies to monitor biomarkers and achieve a personalized 'metabolic switch', promoting sustained user engagement for better health outcomes.
A study found that neural balance, measured by the E/I ratio, is associated with brain maturity and better cognitive ability. Research suggests that as children develop, their E/I ratios decrease, leading to improved performance in cognitive tests.
Researchers developed a prodrug delivery method using a commensal Lactobacillus strain that binds specifically to cancer cells, releasing the chemotherapy drug SN-38 directly at the tumour site. This approach reduces tumour growth by 67% and increases chemotherapy drug effectiveness by 54% in preclinical models of nasopharyngeal cancer.