A new study found that amyloid-beta and tau proteins affect brain activity differently, with increased levels leading to hyperactivity and decreased levels resulting in hypoactivity. Participants with higher rates of this brain slowing showed greater cognitive decline in attention and memory.
A team of researchers found evidence of a lush, diverse rainforest on the Falkland Islands up to 30 million years ago. The South Atlantic archipelago was covered in cool, wet woodland similar to present-day rainforests found in Tierra del Fuego.
A recent study found a correlation between higher anti-PD-1 autoantibody levels and lower survival rates in patients with advanced liver cancer, suggesting these autoantibodies as potential biomarkers for predicting treatment response. The discovery aims to improve treatment regimens for patients with liver cancer.
Astronomers have discovered the largest pair of black hole jets yet, stretching 23 million light-years and equivalent to 140 Milky Way galaxies. This finding suggests that these massive jet systems may have played a significant role in shaping galaxies in the early universe.
A recent study found significant therapeutic inertia in the treatment of women with multiple sclerosis (MS), leading to delayed or reduced use of disease-modifying treatments. The research highlights gender disparities that could impact long-term health outcomes for women of childbearing age, particularly due to concerns about pregnanc...
Rice University researchers have identified a new parasitoid wasp species, Chrysonotomyia susbelli, found on the university grounds in Houston, Texas. The discovery reveals an intricate ecosystem involving galls and cynipid gall wasps, with potential for many more undiscovered species.
A class of diabetes medications called SGLT2 inhibitors may reduce the risk of dementia and Parkinson's disease. The study found that people taking these drugs had a 20% lower risk of developing Alzheimer's disease, 30% lower risk of vascular dementia, and 20% lower risk of Parkinson's disease.
A new study published in Frontiers in Immunology reveals that certain food proteins like milk and meat can help keep gut tumors from growing by triggering the intestinal immune system. This discovery has potential clinical implications for patients with gastrointestinal conditions.
A recent study published in PLOSONE reveals that young, bred corals from the Coral Seeding approach are more resistant to bleaching under extreme heat stress. This finding provides evidence that assisted coral recruits can play a crucial role in securing the future of coral reefs.
A recent study by FAU researchers links copper regulation to neurodegenerative disorders like Alzheimer's. The team discovered that a specific gene, swip-10, plays a crucial role in maintaining the balance of copper in cells, which can prevent mitochondrial dysfunction and oxidative stress.
Researchers at Kobe University have created a new test feed for the fungal molecular machine, allowing them to observe its close-to-natural action. This breakthrough enables the characterization of the enzyme's reaction speed and affinity, crucial parameters for industrial application.
A study published in PLOS ONE suggests that South African rock art from the 19th century may be inspired by an extinct species of tusked animal called a dicynodont. The artwork, created by the San people, features a long-bodied animal with downward-turned tusks that is comparable to fossilized remains found in the region.
A recent study published in JAMA Surgery analyzed 333 slap fighting competitions and found that more than half of sequences resulted in visible signs of concussion. The research also showed that nearly 80% of fighters demonstrated a visible sign of concussion at least once in the series of matches.
Researchers identified key control sites regulating gene expression in cells, including those controlling ancient viral sequences. Mutating these sites caused defects in cell differentiation and survival, as well as spurious activation of genes across the genome.
The Cancer Cooperative Group System is being re-engineered to bring new money to correlative science research through public-private partnerships, aiming to remove barriers for researchers to access biological samples. This will facilitate the integration of innovative science into cancer clinical trials.
Researchers at UMass demonstrated the effectiveness of homemade play putty as an interface to measure electricity or bioelectrical potentials from a human body. The material effectively captured various electrophysiology measurements, including EEG for brain activity and ECG for heart recordings.
The NEXUS exposomics coordinating center aims to deepen understanding of how environmental and social determinants impact health. Led by USC's Rima Habre, the center brings together diverse scientists to study place-based exposures using geospatial methods.
Researchers at the Plasticity and Remodeling of Neural Circuits laboratory aim to stimulate myelin plasticity to regenerate affected nerve fibers in MS patients. The team will explore gene therapy, pharmacological approaches, and rehabilitation strategies to enhance myelin repair.
A new synthesis method, template synthesis, enables the creation of multilayered perovskites with unique ferroelectric properties. The number of layers affects the material's behavior, switching between conventional and indirect ferroelectricity models.
Researchers from Brigham and Women's Hospital used advanced machine learning to increase the accuracy of a national cardiovascular risk calculator while preserving its interpretability. The results showed higher accuracy overall in an electronic health records cohort, reclassifying one out of ten patients into a different risk category.
A recent study reveals severe disruptions in Artemisia annua's metabolic pathways, notably hindering artemisinin and other key secondary metabolites. The findings could pave the way for enhanced strategies to boost artemisinin yield, potentially transforming malaria treatment.
Scientists have developed AI models that can accurately predict future drought conditions, offering a more reliable alternative to traditional drought indices. The new methodology enhances forecasting accuracy and provides practical implications for water management and resource allocation.
A coral colony from Fiji has provided a new record of sea surface temperatures in the southwestern Pacific, revealing that 2022 was the warmest year in over 600 years. The reconstruction uses data from the giant coral Diploastrea heliopora, which records long-term climatic and environmental changes.
A new study found that patients with 4 or 5 identified risk factors, including age 18-24 years and schizophrenia spectrum disorders, had over 100 times the incidence of Neuroleptic Malignant Syndrome. The data provide a basis for early identification and monitoring of children and youth at elevated risk.
Nonfatal opioid overdoses in youth increased significantly during the pandemic, with a majority (86%) occurring among young adults and adolescents aged 12-17 experiencing a high-risk trend. Keeping naloxone at home is crucial to preventing overdose deaths.
Researchers identified over 3,000 harmful genetic changes in the RAD51C gene that increase ovarian cancer risk six-fold and breast cancer risk four-fold. These findings can help doctors and diagnostic laboratory scientists better assess cancer risk and provide more personalized care.
Researchers at Northwestern University have finally uncovered the mechanics of static electricity generated by rubbing objects together, explaining how forces on different parts of an object create electrical charges and a current. This breakthrough could lead to new solutions for industrial fires, pharmaceutical dosing, and other issu...
A newly discovered cluster-scale strong gravitational lens, the Carousel Lens, enables researchers to study cosmology and the properties of dark matter and dark energy. The unique alignment of seven background galaxies forms concentric circular patterns around a foreground galaxy cluster.
A study published in the journal Insects found that hemp leaf extract containing cannabidiol (CBD) is effective in killing mosquito larvae, including those resistant to typical insecticides. The research suggests CBD's potential as a safe and sustainable alternative for controlling mosquito populations.
The UC3M-Universia Chair aims to address the challenges of large tech companies' data use and create a new, transparent and fair personal data economy. Researchers will develop models and algorithms linked to AI that are interpretable and unbiased.
A new study found that Australians are wasting a third of all food in the country every year due to confusion over use-by and best-before dates. The research suggests that clearer date labels and more practical storage advice could help reduce food waste.
Scientists have developed an electrochemical approach using catalysts derived from used lithium-ion batteries to produce hydrogen peroxide. The method utilizes carbon nanostructures and cobalt, displaying catalytic properties in oxygen reduction reactions.
Researchers discover PG3 activates p21, PUMA, and DR5 in cancer cells through ATF4 and ISR, independent of p53. The study provides insights into a novel mechanism by which PG3 induces cell death.
A University of Maryland study highlights the complexity of designing wildlife corridors, which can vary widely in their effectiveness depending on the evaluation method used. The research found that none of the tested corridor designs captured all black bear movements, and some even failed to account for unique dispersal behaviors.
Researchers discovered that those following the MIND diet closely had a reduced risk of cognitive impairment compared to low-diet adherents. The high-diet group showed a 4% decreased risk of cognitive decline, with significant benefits for female participants and Black individuals.
Researchers discover 5-HT2A receptor selectively suppresses visual information strength without inhibiting parallel processes. This mechanism regulates the importance attached to incoming information, which could help develop new therapies for psychiatric diseases.
A recent study investigated Arabidopsis thaliana grown under different light conditions across generations, demonstrating how maternal environments shape offspring traits. The findings provide new insights into plant adaptation strategies for agriculture and ecological conservation.
A Kobe University study found that the widely used casual blood glucose testing method for screening pregnant women with gestational diabetes mellitus misses 70% of cases. The researchers recommend using more reliable tests to prevent pregnancy complications and type II diabetes in mothers and children.
Researchers isolated drug-resistant strains of SARS-CoV-2 from immunocompromised individuals who received antiviral treatments. The virus variants showed resistance to Paxlovid and remdesivir, highlighting the need for combination therapy to treat COVID-19 in highly vulnerable patients.
Researchers at the University of Birmingham used Porous Liquids to separate harmful alcohols from water mixtures, consuming up to 88% of the PL pore volume. This innovation can reduce alcohol content in drinks while retaining flavor profiles, aligning with growing consumer demand for low-alcohol beverages.
This study identifies Paenarthrobacter nitroguajacolicus as a potential biocontrol agent against cucumber corynespora leaf spot fungus, promoting cucumber growth and reducing disease severity. BJ-5 inhibited the germination of fungal spores and caused atrophy in budding tubes, with an inhibition efficacy rate of 63%.
Researchers have developed a DNA origami-based sensor that can detect lipid vesicles and deliver molecular cargo with precision. The system uses single-molecule Fluorescence Resonance Energy Transfer (smFRET) to measure the distance between fluorescent molecules.
Researchers developed a multi-variable model called Hear-MHE that analyzes speech patterns to identify symptoms of minimal hepatic encephalopathy. The test shows promise in predicting overt hepatic encephalopathy and could lead to earlier diagnosis and improved treatment.
Researchers found that migrating blackbirds do not save energy in warmer climates, but instead reduce their metabolism before departure. The study reveals a previously unknown mechanism used by migrants to save energy prior to migration, and suggests alternative physiological adaptations may offset the energy costs of migration.
Scientists at Pusan National University have achieved a breakthrough in plant biotechnology by introducing foreign genes into cucumber pollen using DNA-coated magnetic nanoparticles. The new technique significantly streamlines crop genetic modification, offering a quicker and more accessible method to produce transgenic plants.
Researchers have identified a new epigenetic mark, 5-formylcytosine, which plays a crucial role in activating genes during early embryonic development. This discovery sheds light on the regulation of gene expression in vertebrates and has implications for our understanding of human development and disease.
Researchers from CNRS and Paris Institute of Planetary Physics developed an innovative imaging method to probe volcano internal structure. The study revealed a large magma storage zone beneath La Soufriere volcano, providing greater anticipation for volcanic eruptions.
A study published in JACC found that metal exposure is associated with progression of plaque buildup in the arteries, comparable to traditional risk factors like smoking and diabetes. The findings support considering metal exposure as a significant risk factor for atherosclerosis and cardiovascular disease.
Mutations in the fifth segment of the ryanodine receptor channel (S5) lead to altered gating mechanisms and muscle disorders. The study identified three mutations linked to malignant hyperthermia and eight associated with central core disease, highlighting a novel regulatory mechanism of the RyR1 channel.
A new knee exoskeleton has been developed to support the quadriceps muscles during lifting tasks, helping workers maintain better posture even when fatigued. The device, which uses a complex algorithm to predict assistance needs, enabled participants to lift faster and with improved posture.
Prehospital encounters for opioid overdoses increased among US youth from 2018 to 2022, particularly among adolescents aged 12-17, which showed an upward trend both before and during the pandemic. Overall, trends were largely driven by those aged 18-24.
Researchers found a significant reduction in nosebleed severity, fewer transfusions, and improved quality of life in patients with hereditary hemorrhagic telangiectasia treated with pomalidomide. The trial's results offer hope for people with this rare bleeding disorder.
A survey of UK general practitioners reveals that 20% of doctors use generative AI tools like ChatGPT in their practice. The study highlights the potential benefits of AI in reducing administrative burdens and supporting clinical decision-making, but also raises concerns about errors, biases, and patient privacy.
Researchers found that low extracellular sodium concentrations decrease specific mRNA expression and nitric oxide production in microglia, potentially contributing to hyponatremia-induced neuronal dysfunctions. Microglial activation can lead to inflammation and regulate neurotransmission.
A new study identifies multiple technologies to cost-effectively decarbonize the energy system, prioritizing their adoption and transition. The findings suggest a range of options to achieve near-cost-optimal futures, emphasizing research and development investments.
A University at Buffalo psychiatrist has been awarded $3 million to focus on the mental health of children with cystic fibrosis. The study will evaluate national prevalence of mental health concerns in children under 12, identify best screening methods and characterize issues seen in treated children. Early identification and addressin...
Researchers have developed a new optical atomic clock that uses a single laser and doesn't require cryogenic temperatures, achieving similar performance to traditional clocks. The innovative design eliminates the need for extreme cooling, allowing for hot atoms and a simplified clock architecture.
Researchers at PNNL create a uniform two-dimensional layer of silk protein fragments on graphene, enabling the design and fabrication of silk-based electronics. This biocompatible system has potential applications in wearable and implantable health sensors, as well as computing neural networks.
Researchers at Tel Aviv University discovered that aneuploid cells, which have an abnormal number of chromosomes, are more susceptible to certain types of anticancer drugs. The studies found that disrupting the MAPK pathway increases the sensitivity of these cancer cells to chemotherapy.
The grant will create the Urinary Stone Disease Hub, combining medical expertise across adult and pediatric urology and nephrology, informatics, and AI to establish a novel data resource. The hub will include clinically important information from CT images, clinical notes, stone composition, and 24-hour urine labs.