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Institute for Clinical Evaluative Sciences


One in five pregnancies miss timely syphilis screening in Ontario

A study found that one in five pregnancies in Ontario did not receive syphilis screening in the first trimester, with delayed screening more common among equity-deserving populations. The rate of congenital syphilis in Canada increased by 220% since 2018, highlighting the need for improved prenatal screening.

SourceInstitute for Clinical Evaluative Sciences·JournalCanadian Medical Association Journal·TypeObservational study·DateMay 19, 2026

Patients with higher markers of marginalization more likely to rely on emergency departments for concussion care, study finds

A new study found that patients experiencing socioeconomic marginalization are more likely to seek initial concussion care in hospital emergency departments, leading to lower follow-up rates. Patients without family physicians were up to 70% less likely to follow up.

SourceInstitute for Clinical Evaluative Sciences·JournalJAMA Network Open·TypeObservational study·DateApr 22, 2026

More Ontarians are being diagnosed with psychosis than those born in earlier decades

A new study found a significant increase in psychotic disorders among Ontarians born after 1980, with incidence rates rising by 60% for those aged 14-20. The study suggests that recent birth cohorts may be experiencing increased exposure to risk factors such as early life substance use and older-aged parents.

SourceInstitute for Clinical Evaluative Sciences·JournalCanadian Medical Association Journal·TypeObservational study·DateFeb 2, 2026

Patients with intellectual and developmental disabilities substantially over-represented among long-stay psychiatric inpatients

Individuals with intellectual and developmental disabilities account for more than one in five patients who have been in Ontario's mental health beds for over a year. Enhancing specialized supports both in hospital and community settings can reduce their length of stay and admission rates.

SourceInstitute for Clinical Evaluative Sciences·JournalThe Canadian Journal of Psychiatry·TypeObservational study·DateSep 29, 2025

Surrogates more likely to be diagnosed with mental illness, study finds

A recent study published in JAMA Network Open found that gestational carriers are at a higher risk of developing new-onset mental illness during and after pregnancy. The study analyzed data from over 767,000 births in Ontario, Canada and found that nearly 1 in 5 gestational carriers had a prior mental illness diagnosis before pregnancy.

SourceInstitute for Clinical Evaluative Sciences·JournalJAMA Network Open·TypeObservational study·DateJul 25, 2025

Underserved youth less likely to visit emergency department for concussion in Ontario, study finds

A new Ontario study reveals socioeconomic disparities in concussion-related emergency department visits among children and youth. The study found that children from higher socioeconomic status groups had significantly more concussions requiring ED visits compared to those from lower socioeconomic status groups.

SourceInstitute for Clinical Evaluative Sciences·JournalInjury Prevention·TypeObservational study·DateJul 11, 2025

Transgender and gender diverse people less likely to receive follow-up after a mental health hospitalization

A study found that transgender and gender diverse individuals have lower access to appropriate mental health care and support following a psychiatric hospitalization, yet better follow-up after an emergency department visit. The study suggests that transphobia in the hospital system contributes to this disparity.

SourceInstitute for Clinical Evaluative Sciences·JournalTransgender Health·TypeObservational study·DateMar 12, 2025

Inadequate postpartum screening for hypertension and diabetes a ‘missed opportunity’ for women, study suggests

A new study published in Circulation suggests that less than one in five patients are tested for cardiovascular risk factors following pregnancy-related hypertension or diabetes. This leaves women without adequate screening for high blood pressure, lipids, and sugars, increasing their risk of future stroke or heart disease.

SourceInstitute for Clinical Evaluative Sciences·JournalCirculation·TypeObservational study·DateFeb 17, 2025

Contribution of cannabis use disorder to new cases of schizophrenia has almost tripled over the past 17 years

A new study found that cannabis use disorder is increasingly associated with new schizophrenia cases in Ontario, with the proportion rising from 4% to 10%. The trend has tripled over the past 17 years, with heavy cannabis use linked to worsening symptoms and increased risk of psychosis.

SourceInstitute for Clinical Evaluative Sciences·JournalJAMA Network Open·TypeObservational study·DateFeb 4, 2025

Multiple sclerosis linked to higher risk of mental illness during and after pregnancy

A new study found that people with multiple sclerosis experience a significantly higher risk of perinatal mental illness compared to those with other chronic conditions. Depression and anxiety were the most common conditions reported, with half of people with MS living with a mental illness in the first year postpartum.

SourceInstitute for Clinical Evaluative Sciences·JournalNeurology·TypeObservational study·DateJan 22, 2025

Abnormal electrolyte levels in people with eating disorders may increase risk of death, poor health outcomes

A new study found that individuals with eating disorders have a higher risk of death and poor health outcomes due to abnormal electrolyte levels. The research, led by ICES and The Ottawa Hospital, included over 6,000 individuals with an eating disorder, revealing that 32% had abnormal electrolyte levels.

SourceInstitute for Clinical Evaluative Sciences·JournalThe Lancet Psychiatry·TypeObservational study·DateSep 17, 2024

Single dose of mpox vaccine effective in preventing infection, study finds

A single dose of the Modified vaccinia Ankara-Bavarian Nordic (MVA-BN) vaccine was found to be 58% effective in preventing mpox infection in a recent study published in BMJ. The study used real-world health data to estimate the vaccine's effectiveness against mpox infection and included over 3,200 men who received the MVA-BN vaccine.

SourceInstitute for Clinical Evaluative Sciences·JournalBMJ·TypeObservational study·DateSep 11, 2024

Infections following hip replacement associated with an increased risk of death, study finds

Patients with periprosthetic joint infection (PJI) after total hip replacement have a five-fold increased risk of mortality within 10 years. Researchers found that PJI patients had a significantly higher 10-year mortality rate than those who didn't develop an infection, highlighting the need for prevention efforts and best practice gui...

SourceInstitute for Clinical Evaluative Sciences·JournalJournal of Bone and Joint Surgery·TypeObservational study·DateSep 4, 2024

Health care delivered in a patient’s preferred language could decrease emergency department visits, hospitalizations and death

A new study found that long-term care residents who receive primary care from family physicians speaking their language have lower rates of emergency department visits, hospitalizations, and mortality. However, outcomes for Francophones were not impacted by language concordance.

SourceInstitute for Clinical Evaluative Sciences·JournalBMJ Public Health·TypeObservational study·DateJun 24, 2024

New evidence suggests link between teen cannabis use and psychotic disorders may be stronger than previously thought

A new study suggests that teens using cannabis are at an 11 times higher risk of developing a psychotic disorder compared to those not using cannabis. The research found a strong association between cannabis use and risk of psychotic disorder in adolescence, but not in young adulthood.

SourceInstitute for Clinical Evaluative Sciences·JournalPsychological Medicine·TypeObservational study·DateMay 22, 2024

Publicly funded fertility program linked to a decrease in rate of multifetal pregnancy

A new study found that publicly funded fertility programs in Ontario led to a significant decrease in the rate of multifetal pregnancies, but ovulation induction and intrauterine insemination remained contributors. The study also showed improvements in assisted reproductive technology contributing to the decline.

SourceInstitute for Clinical Evaluative Sciences·JournalJAMA Network Open·TypeObservational study·DateApr 25, 2024

People experiencing homelessness more likely to develop dementia at younger ages, study finds

A new study found that people experiencing homelessness have a higher prevalence of dementia, especially in younger age groups. The researchers suggest that unhoused individuals should be screened for dementia at younger ages due to the complexity of diagnosing the condition in this population.

SourceInstitute for Clinical Evaluative Sciences·JournalThe Lancet Public Health·TypeObservational study·DateMar 27, 2024

Eating disorder hospitalizations on the rise, affecting 'atypical' groups the most

A new study reveals a disproportionate increase in pediatric eating disorder hospitalizations, particularly among males, younger teens, and those with eating disorders other than anorexia or bulimia. Hospitalizations rose by 139% over 17 years, with the greatest increases seen for these atypical groups.

SourceInstitute for Clinical Evaluative Sciences·JournalJAMA Network Open·TypeObservational study·DateDec 4, 2023

Rising rates of benzodiazepine toxicity among young people spark concern

A new study found a 67% increase in hospital encounters for benzodiazepine-related toxicity among young adults and a 44% rise in youth aged 18 or below in Ontario between 2013 and 2020. The increased risk is attributed to the growing presence of non-pharmaceutical benzodiazepines in the unregulated opioid supply.

SourceInstitute for Clinical Evaluative Sciences·JournalCanadian Journal of Public Health·TypeObservational study·DateJun 15, 2023

Decision support tool used in the emergency department reduces rates of death or hospitalization after heart failure

A new decision support tool used in emergency departments has been shown to reduce 30-day all-cause death or cardiovascular hospitalization rates by 12% in heart failure patients. The validated tool, developed using data analytics, helps clinicians determine risk categories and inform admission or discharge decisions.

SourceInstitute for Clinical Evaluative Sciences·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateNov 5, 2022

Virtual care associated with significant environmental and patient cost savings

A study by researchers at ICES, Lawson Health Research Institute, and Western University found that virtual care during the pandemic led to significant environmental and patient cost savings. Virtual visits represented approximately 0.2% of total annual carbon dioxide emissions in Ontario and estimated $63 million in patient cost savings.

SourceInstitute for Clinical Evaluative Sciences·JournalJAMA Network Open·TypeObservational study·DateOct 20, 2022

Pregnant women with mildly abnormal blood sugar levels at higher risk of developing type 2 diabetes

Researchers from Institute for Clinical Evaluative Sciences found that even mild abnormalities in glucose testing during pregnancy increase the risk of developing type 2 diabetes. Women with these mild abnormalities are 2.5 times more likely to develop type 2 diabetes compared to those with normal glucose testing.

SourceInstitute for Clinical Evaluative Sciences·JournalDiabetic Medicine·DateMay 20, 2009