Senescence unfolds in stages, not all at once, and can be suppressed without reversing the cells' permanent growth arrest. Different therapies create different forms of senescence, but ultimately lead to the same inflammatory response.
Researchers use antibiotics to clarify RNAP function, discovering that the enzyme works only if a certain moving part briefly swings into place to stabilize RNA synthesis. The findings reveal a previously unknown mechanism of RNA synthesis shared across diverse forms of life.
Researchers found that older adults with multiple chronic conditions are less alike, raising questions about one-size-fits-all clinical recommendations. The study suggests basing guidelines on each person's unique multimorbidity rather than chronological age alone.
Research found that six sets of 30-second sprints altered nearly a quarter of proteins in the bloodstream, while 90 minutes of moderate cycling changed fewer than one-quarter of one percent. Sprinting triggered changes in more than 200 metabolites and was associated with lower risk of cardiovascular and metabolic disease.
Researchers have produced the first complete genome assembly of the zebra finch, unveiling thousands of previously hidden genes and chromosome structures. The study resolves decades-long uncertainty over gene loss and provides insights into avian sex chromosomes and centromere architecture.
A new study discovered that an arginine-deficient diet stunts the production of MHC-1 protein, which alerts the immune system to dangers such as tumors or viral infections. Increasing arginine intake may improve immune function and potentially treat cancer and viral infections.
Researchers have developed a new tool, FlatMux, that captures electrical activity from almost 200 neurons simultaneously across cortical layers and at depths up to 500 micrometers. This platform enables recordings of neurons' location and cell types, revealing how brain functions emerge from highly interconnected networks.
Researchers found that flies use brain circuitry for spatial navigation to remember where a plume boundary lies and steer back to it. By tracking the edge of an odor plume, flies store a directional memory that allows them to navigate towards the scent source even in turbulent conditions.
Researchers at Rockefeller University discovered that MLL4 drives disease progression in specific leukemia types while acting as a tumor suppressant in solid tumors. The findings provide new insights into the molecular mechanisms underlying MLL4's context-dependent functions in cancer.
A new study reveals that caregiving behaviors in ants are regulated by neural mechanisms that change over the course of an ant's lifetime. The researchers found two brain signaling molecules, Neuropeptide F and Allatostatin A, that act as opposing regulators of behavior, depending on the ant's internal state.
Researchers developed a protein-tracing platform that maps fat and liver cell communication, tracing proteins back to their cells of origin. The platform linked 65 signals to human conditions, including type 2 diabetes and cardiovascular disease.
A new study has overturned longstanding ideas about how germinal centers function, revealing that they are far more selective than once thought. The findings suggest that the immune system ultimately produces stronger antibodies by repeating a noisy, almost random process over and over across many germinal centers.
Researchers discovered that a common rifampicin-resistance mutation in tuberculosis creates subtle metabolic weaknesses, which could be exploited with future combination therapies. The most common mutation slows bacterial RNA polymerase, creating vulnerabilities that other therapies may target.
Researchers at Rockefeller University have discovered the neural substrates underlying thought symbols for the first time. The study found that the ventral premotor cortex, a region in the frontal lobe, plays a key role in generating mental representations of actions, enabling compositional generalization and creative thinking.
Researchers have developed two new tools to study the molecular changes and intercellular dynamics of aging. IRISeq uses DNA barcodes to map tissue organization without a microscope, revealing inflammatory cellular neighborhoods in the aging brain.
A recent study by Rockefeller University researchers provides the most comprehensive view to date of how HIV-1 escapes broadly neutralizing antibodies. The study identified over 100 mutations that enable viral strains to resist these antibodies, with some requiring only a single amino acid change.
Researchers have captured an unprecedented view of gene transcription by observing RNA polymerase mid-reaction. The findings provide a universal blueprint for gene expression and clarify how the enzyme initiates its core reaction through a water-mediated mechanism.
Researchers have overturned decades-long assumptions about why HBV fails to infect mouse liver cells, pointing towards a new disease model. The study suggests that the problem lies in a late step during the viral entry process, which could be disrupted by certain mechanisms.
Researchers at Rockefeller University have captured the first snapshot of a mechanical signaling complex in action, revealing that compression is the key to transmitting mechanical information. The study has implications for cancer and other diseases, and could lead to new treatments.
Researchers have made a breakthrough in developing a novel platform that harnesses the immune system's ability to produce therapeutic proteins. By editing hematopoietic stem cells with CRISPR gene-editing tools, they were able to create a long-term, boostable source of antibodies capable of protecting against deadly influenza infection...
Researchers developed a platform called PerturbFate to map genetic variations and identify common control points driving changes in cell behavior. The study shows that targeting these shared regulatory nodes can lead to combination therapies for complex diseases like cancer, with potential applications beyond melanoma drug resistance.
Researchers created a mouse model of virus-driven liver cancer that closely mirrors human disease, allowing for the study of how viruses and immune systems work together to trigger cancer. The model has the potential to improve diagnosis and treatment options for liver cancer patients.
Researchers identified distinct genetic sequences that propel critical memories into years-long timeframes underpinning chronic disease. The study provides valuable inroads for developing new therapeutic strategies for chronic inflammation.
Microtubules are regulators of enzymatic reactions through reshaping geometry of enzyme's substrate proteins attached to them. The discovery sheds new light on one-way chromosome attachments and quality-control system that helps prevent chromosome-segregation errors, a hallmark of many cancers.
Researchers found that ants continually update their sense of nestmate identity and tolerance for outsiders through repeated exposure, revealing a flexible behavioral foundation for studying social recognition. This discovery opens the door to exploring the neural circuits behind ant social behavior.
Researchers found that a small region of the PRC2 complex, called the SBD, is crucial for its function and can be targeted by cancer inhibitors. The SBD's absence halts the growth of aggressive lymphomas and normalizes gene expression, mimicking the effects of powerful clinical cancer inhibitors.
Chris Impey, Distinguished Professor of Astronomy at the University of Arizona, will receive the Lewis Thomas Prize for his work on exobiology and his ability to connect complex scientific ideas to a broad public audience. His books explore fundamental questions about the origins of life and the search for extraterrestrial life.
Researchers created a cell-free system to study transcription drivers and revealed fundamental features of the transcription cycle in Mycobacterium tuberculosis. The method enabled precise design of therapeutics targeting key processes, which could help combat this pathogen.
Researchers at Rockefeller University create comprehensive atlas of cell changes with age, revealing synchronized changes across organs and sex differences. The study identifies vulnerable cell types and molecular hotspots that could be targeted with drugs to slow aging.
A new study suggests that preexisting autoantibodies in a small subset of the population can cause severe reactions to the live-attenuated Chikungunya vaccine. Researchers recommend screening people with these autoantibodies before vaccination, especially for those over age 65.
A protein called Replication Factor C has been found to remain bound to a DNA sliding clamp even after loading it onto DNA, facilitating the copying process. This discovery challenges decades of textbook knowledge in basic biology and could inform research into cancer and neurological disorders.
The Vertebrate Genome Laboratory will apply AI to automate manual genome curation processes, expanding genomic representation across underrepresented branches of the Tree of Life. This project aims to generate high-quality genomes for tens of thousands of species, enabling discoveries in biodiversity conservation and medicine.
Researchers at Rockefeller University discovered that fruit flies use a two-neuron system to calculate wind direction, leveraging double-duty signaling mechanisms. This finding redefines our understanding of how neurons compute direction and navigate their environment.
Researchers found that the loss of beige fat increases the sensitivity of blood vessels to angiotensin II, leading to hypertension. The team identified QSOX1 as a key enzyme involved in this process, which is normally kept off by beige fat.
Researchers at Rockefeller University have made a breakthrough in understanding how the brain controls facial expressions, discovering a complex network of neural circuits involved. Contrary to long-held assumptions, both lower-level and higher-level brain regions are involved in encoding different types of facial gestures.
Researchers identified the Homer1 gene as a key player in shaping attention, revealing its potential therapeutic benefits for ADHD. Lower levels of specific versions of Homer1 improved focus by reducing brain noise in mice, suggesting a novel approach to calming the mind and improving attention.
Researchers at Rockefeller University discovered that the T cell receptor springs open when activated by an antigen, contrary to previous studies. This finding could lead to next-generation treatments for a broader group of cancer patients.
A new study demonstrates a one-two punch approach to combatting drug-resistant tuberculosis by pairing rifampicin with AAP-SO2, which exploits the weaknesses of resistant bacteria. The combination effectively kills more bacteria than either drug alone, increasing potency and reducing resistance.
Researchers created a reference brain by merging 40 ant brains, revealing surprising variations in brain size and a distinct tilt in higher-order processing regions. The study provides new insights into the neuroscience of individuality within animal societies.
Researchers discovered that the nuclear pore complex is a dynamic system with a ring-shaped scaffold surrounded by flexible FG domains. The complex's architecture and crowded environment work together to selectably allow transport receptors and their cargo to pass through.
A new study in Molecular Cell reveals that cellular aging is controlled by the ATM kinase response to withered telomeres. Cells grown under low oxygen conditions are more tolerant of short telomeres, while high oxygen accelerates cellular aging due to hyperactive ATM.
Researchers used a single-molecule platform to watch individual mammalian transcription complexes, revealing the molecular engine's acceleration, pauses, and gear shifts. The study found key regulatory proteins govern Pol II movement, with P-TEFb as a master switch and PAF1C as the main accelerator.
A new study demonstrates that long-term memory is formed by a cascade of molecular timers unfolding across brain regions. Key regulators promote memories into progressively more lasting forms or demote them until they are forgotten.
Researchers used light-inducible gene expression to demonstrate that gastrulation in human embryos requires an interplay between chemical cues and mechanical forces. The study found that mechanical tension fine-tunes downstream biochemical signaling pathways, leading to the formation of body axes.
Rockefeller researchers found a molecular switch in breast cancer cells that reprograms gene expression towards tumor growth and stress resistance. This switch is mediated by the MED1 subunit of RNA polymerase II and can be activated under stressful conditions, leading to faster-growing and more stress-resistant tumors.
Scientists from Rockefeller University have developed a powerful upgrade to IVIG therapy, an engineered antibody that delivers the effectiveness of IVIG at a fraction of the dose in mice. The new molecule is synthesized without human plasma and has shown significant improvement over current IVIG treatments.
The Aedes aegypti Mosquito Cell Atlas provides comprehensive cellular-level resolution of gene expression in every tissue, from antennae to legs. This atlas has yielded new insights into the genetic secrets of Aedes aegypti, including novel cell types and subtle differences between male and female mosquitoes.
Researchers have captured a key part of the ribosome formation process, revealing how cells coordinate, regulate, and safeguard protein factory creation. The 'molecular movie' shows the role of Mtr4 enzyme and Utp14 protein in assembly, as well as an elaborate system of built-in safeguards.
A study by Rockefeller University researchers reveals that female mosquitoes dictate mating success with a physical movement of their genitalia. This behavior, which occurs in both Aedes aegypti and Aedes albopictus species, is critical for successful mating, making the role of females more active than previously thought.
Researchers unveiled an integrative experimental and computational map of macromolecular transport through nuclear pore complexes. The model identifies key design features that ensure NPC efficiency and resilience, revealing new avenues for medical innovation. It also provides insight into diseases like cancer, Alzheimer's, and ALS.