Researchers from Rockefeller University have developed a new method to fight cancer by using dendritic cells to activate T cells. This technique offers the promise of new therapies for cancer, AIDS, and autoimmune diseases, potentially overcoming the need for designer immunotherapy.
Rockefeller University researchers identify a critical link between autoantibodies and inflammation, suggesting novel ways to uncouple this connection. They found that preventing the activation of antibody receptors by autoantibodies is an effective way to treat autoimmune diseases like lupus.
A recent study has found that a mutation in the HNF4alpha gene causes MODY1, a rare form of Type 2 diabetes. The defect impairs glucose homeostasis and glycolysis pathways.
Researchers at Rockefeller University are conducting a study to examine the potential of three plant-derived compounds - curcumin, rutin, and quercetin - to prevent colorectal cancer. The study aims to determine whether these compounds can safely inhibit the development of colon polyps and reduce cancer risk.
A team of researchers will examine the blood samples and medical histories of 2,000 people who have experienced an early heart attack. The goal is to locate and determine the structure and function of genes that contribute to heart disease.
A mutated gene in the glutamate receptor family causes faulty nerve cells to die due to false detection of neurotransmitters. The discovery may help understand how to slow down or stop this process, preserving neurons.
A study published in the Proceedings of the National Academy of Sciences found that mice with resistance to leptin are more likely to become obese. The researchers used a novel technique called ICV infusion to deliver leptin directly into the brain, which resulted in significant weight loss and fat reduction in lean mice.
A study from Rockefeller University found that a specific altered gene, COMT, may increase the risk of OCD in men. The researchers discovered that this gene affects the production of dopamine and norepinephrine, leading to a biochemical imbalance that contributes to the development of OCD.
Researchers at Rockefeller University have determined the three-dimensional structure of Hck, a cancer-causing protein that plays a key role in regulating cell behavior. The study reveals that the protein's shape is controlled by the SH3 domain, which enables it to transform cells into cancerous ones.
Scientists have isolated and cloned the gene responsible for Fanconi anemia (FA), a rare disorder causing severe bone marrow failure, birth defects, and leukemia. The discovery enables the development of a quick diagnostic test for 65% of FA patients and may lead to better treatments, including gene therapy.
A new study by Rockefeller University and Harvard School of Public Health found that steamed shrimp is not harmful to cholesterol levels when consumed as part of a low-fat diet. In fact, the researchers suggest that it may even have beneficial effects on heart health due to its high content of n-3 fatty acids.
A new study reveals that a protein called apolipoprotein E (apoE) can protect cultured nerve cells from the damaging effects of oxygen molecules associated with Alzheimer's disease. The apoE protein has different levels of antioxidant activity, with E2 being the most effective.