A new study has uncovered previously hidden patterns of plankton adaptation in response to environmental changes. The analysis showed that plankton lipid profiles are closely linked to their environment, with adaptations including shortening fatty acid chains in cold polar oceans.
A potent combination of antimalarial compounds blocks parasite transmission in mosquitoes while circumventing insecticide resistance. The new strategy retains activity even after a year and efficiently kills parasites even when applied to the female mosquito up to four days in advance of infection.
A synthetic lichen system developed by Texas A&M researchers enables concrete to heal itself without outside intervention. This innovation uses cyanobacteria and filamentous fungi to produce crack-filling minerals, setting it apart from previous self-healing concrete endeavors.
The ASCENT-04/KEYNOTE-D19 study shows that sacituzumab govitecan plus pembrolizumab improves progression-free survival and response rates compared to chemotherapy. Nearly 60% of patients responded, with durable responses lasting up to 16.6 months.
WANG Qi's research bridges TCM and digital technology, creating a digital constitution collection platform for objective diagnostics and a 'TCM Constitution Knowledge Graph' linking TCM with modern diseases. This work secures TCM's evolving role in contemporary healthcare through rigorous data + clinical iteration.
A phase II clinical trial shows that combining immune checkpoint inhibition with avelumab and cetuximab significantly improves progression-free survival compared to avelumab alone for patients with advanced cutaneous squamous cell carcinoma. The combination also leads to a confirmed objective response rate of 27.6%.
A phase 2 trial found that combining avelumab and cetuximab significantly extended median progression-free survival in patients with advanced cutaneous squamous cell carcinoma. The combination showed synergistic effects, suggesting a potential new standard of care for this patient population.
Researchers have developed a novel combination therapy, MAG 7, comprising seven drugs to target various biologic elements in pancreatic cancer. The study aims to induce ER stress and kill cancer cells through UPR pathways.
The Class of 2025 represents Duke-NUS' commitment to broadening the skillset and experience of its students. This cohort includes five MD-PhD graduates and PhD candidates from various programmes, showcasing the school's dedication to diversity and multi-disciplinary skills.
A new study finds that fathers who ate healthier during their teenage years were more likely to encourage positive food habits in their children. The researchers also discovered that the children of these fathers were significantly more likely to meet dietary recommendations for fruits and vegetables.
The genome of Merremia boisiana, a fast-growing tropical vine, has been fully assembled, revealing key genes involved in hormone biosynthesis and stress response. This breakthrough provides insights into the plant's ecological adaptability and offers potential tools for crop improvement and biodiversity conservation.
A study by Göttingen University researchers combined satellite data with manual measurements to better understand forest soil moisture. The findings show that soil moisture is strongly influenced by weather and season, not exact location, and highlight the importance of monitoring soil moisture over time for effective forest management.
This study reveals that endophytic fungi from halophytes can improve maize growth and salt tolerance by regulating ion homeostasis. Eight endophytic fungal strains showed enhanced growth under saline conditions, with one strain improving K+/Na+ ratio and salt tolerance in maize.
A new therapy combining pembrolizumab with targeted therapies before surgery improved tumor removal and overall survival for patients with BRAF-mutated anaplastic thyroid cancer. The treatment increased response rates and showed better outcomes compared to standard therapy.
The American Society for Nutrition released a clinical advisory outlining eight key nutritional priorities to support GLP-1 therapy, including personalized diets, micronutrient prevention, and adequate protein intake. Studies have shown that patients receiving combined pharmacologic and lifestyle interventions achieve greater weight lo...
Student researchers from UTA present their original research at various conferences, including the American Chemistry Society conference and Pittcon Conference. This provides opportunities for them to network with professionals and potential employers, as well as gain hands-on experience in their field.
Researchers have developed an integrated metasurface-integrated quantum analog computing system, simplifying phase reconstruction and achieving high signal-to-noise ratio at low photon levels. This technology has broad application potential in fields such as optical chips, wave function reconstruction, and label-free biological imaging.
A plant-based diet with soybeans can significantly reduce severe hot flashes by 92% and promote weight loss of approximately 8 pounds. The level of food processing does not affect these benefits, suggesting that increasing plant foods is independent of processing level.
A new classification system for nasal deformities in infants with cleft lip and/or palate has been proposed, offering a reliable and practical tool for standardized assessment. The system provides a user-friendly approach to evaluating nasal deformities, promoting consistent diagnosis and treatment planning.
The study reveals that the crystallographic characteristics of dinosaur egg SEUs are identical to those of PEUs and modern bird eggshell units, suggesting a biogenic origin. The researchers also discovered grooves and vesicles in SEUs, consistent with organic matrix fiber degradation during fossilization.
Researchers at UT Health San Antonio discovered associations between blood lipid levels and Alzheimer's disease risk. Higher small dense cholesterol particles increased risk, while ApoB48 levels were associated with lower risk.
A groundbreaking review identifies the skin as a central hub for systemic inflammation regulation, linking it to multiple organs through bidirectional crosstalk. The study reveals IL-17A as a master regulator of multi-organ crosstalk, driving various diseases simultaneously.
Assistant professor of electrical and computer engineering Natasa Miskov-Zivanov is receiving a $581,503 NSF CAREER Award for her project that leverages AI to design more effective lymphocytes for cancer immunotherapies. The system aims to accelerate the process of designing new therapeutic cell designs.
DB-1310, a HER3-targeted antibody-drug conjugate, has shown real potential as a new treatment option for patients with advanced solid tumors that have progressed after standard therapies. In an international clinical trial, DB-1310 demonstrated significant tumor shrinkage and delayed cancer growth in 44% of EGFR-mutant NSCLC patients.
Cessation of public water fluoridation would lead to higher rates of tooth decay and increased healthcare costs in the US. The model suggests that current safe levels of fluoride have substantial ongoing benefits.
Researchers developed a smart hydrogel system that supports the growth of human salivary cells in three-dimensional spheroids. The system enables the formation of large, viable spheroids with high expression of key salivary proteins and demonstrates functional activity.
A new study predicts that limiting warming to 1.5°C could preserve over half of the world's glacier mass, but even at this level, 39% of glacier mass would still disappear due to delayed climate change reactions.
A new study led by University of Wisconsin-Oshkosh geologist Timothy Paulsen reveals evidence for lost mountains in Antarctica's past. The team analyzed mineral grains from igneous rocks in the Transantarctic Mountains, suggesting a more dynamic landscape history than previously recognized.
A study by Waseda University finds that competing corporate coalitions within boards impact a firm's spending decisions once profitability targets are met. Firms with stronger state-endorsement coalitions allocate more resources to social causes, while those with shareholder-value coalitions prioritize dividend payments.
A study conducted in collaboration with researchers from SWPS University found that practicing niceness can increase the propensity to cooperate by strengthening social bonds. The researchers conducted two studies, one measuring everyday niceness and its association with social connectedness and attitudes towards cooperation, and anoth...
A Virginia Tech professor has received a proof-of-concept grant to further develop a chemical compound that could help promote weight loss by increasing mitochondrial activity. The compound, named BAM15, shows promise in preclinical studies without affecting food intake or muscle mass.
A study unravels the complex molecular network controlling anthocyanin accumulation in horticultural plants, revealing pivotal roles of structural genes and transcription factors. The research provides valuable insights for breeding plants with improved coloration, stress tolerance, and enhanced nutritional value.
Researchers discovered a potential vulnerability in P. falciparum by inducing protein aggregation, leading to reduced parasite growth. The study may lead to novel antimalarial strategies targeting the parasite's internal protein folding machinery.
The partnership brings together two organizations with a shared commitment to scientific innovation, connecting Hertz Fellows with Breakthrough Energy's global network of climate and energy experts. The collaboration aims to advance transformative climate and energy solutions through joint programming, workshops, and shared resources.
Researchers at Osaka Metropolitan University found a mutant protein that helps plants fight mildew, but also accelerates leaf aging and yellowing. The discovery could contribute to crop yield improvement and sustainable agriculture.
A national survey of internal medicine physicians found that experiencing sacred moments is common among physicians. However, discussing these experiences with colleagues is infrequent, suggesting a potential impact on physician well-being.
This study investigates UGIT involvement in adult Egyptian UC patients, finding significant esophagitis and gastritis. The results demonstrate a strong association between colonic disease severity and UGIT endoscopic and histopathological findings.
A research team at KIST has developed a new water treatment material that can recover phosphorus with high efficiency and disinfect harmful microorganisms simultaneously. The material utilizes a 'sea urchin-shaped' nanostructure to achieve world-class phosphorus recovery performance.
Using site characterization data from multiple disciplines, researchers can now accurately predict the occurrence of marine landslides. The correct sequence of site investigations and integration of data is crucial for maximizing information and confidence in landslide models.
Researchers developed a new approach to identify healed diabetic foot ulcers at risk of reopening based on trans-epidermal water loss measurements. High TEWL values were linked to increased wound recurrence and shorter time to recurrence, suggesting functional skin barrier defects are a critical factor in wound healing.
The ECORD event will explore the importance of scientific ocean drilling in understanding Earth's systems and addressing environmental challenges. Key findings include the establishment of the new International Ocean Drilling Programme (IODP3) and its potential impact on global scientific cooperation.
A new study found that routine testing for multiple infectious diseases among migrants can identify key infections earlier, improving health outcomes and reducing onward transmission. The Leicester screening programme, which tested 4004 migrant patients, revealed new diagnoses of TB, Hepatitis B and C, and HIV.
Researchers developed LUCAS, a rapid and portable diagnostic tool that creates stronger and longer-lasting bioluminescence signals, enabling accurate detection of SARS-CoV-2, HIV, HBV, and HCV in patient samples. The tool achieved an average accuracy of over 94% in detecting viruses within 23 minutes.
A recent study found that persistent Wnt signaling affects IVF embryo implantation and offspring metabolism. The researchers discovered that treating with the Wnt inhibitor IWP2 improves implantation, intrauterine development, and offspring metabolic abnormalities.
Professor Zhou's research project FoCo aims to improve the efficiency of optimizers used in large AI models, reducing high training costs and memory usage. The study has potential real-world benefits in dynamic environments such as self-driving cars, enabling faster deployment of safer and more responsive AI systems.
The American Heart Association condemns Big Soda's lawsuit against Santa Cruz's sugary drink tax, citing the industry's profits over health. The organization supports the city's efforts to curb sugary drink consumption and protect public health.
This book sheds light on <em>d</em>ōchō atusryoku</em>, a defining force in Japanese society that shapes politics, governance, and the legal system. It also explores how social conformity influences behavior through expectations rather than laws.
A new study by University of Cologne researchers found that teaching 'threshold concepts' like randomness and probability in a biological context improves students' understanding of biology. The study suggests that addressing these concepts can increase the complexity and coherence of concept networks.
Researchers from Mass General Brigham will present breakthroughs in cancer treatment, including an update on the INCIPIENT trial using CAR-T cells for glioblastoma. The team also developed a psychosocial digital application to support caregivers of patients undergoing hematopoietic stem cell transplantation.
A new app, BMT-CARE App, was tested in a randomized clinical trial to help caregivers manage stress and emotions related to bone marrow transplant patients. The app showed significant improvements in quality of life, burden, and mood symptoms compared to standard services.
Researchers studied obesity's impact on breast cancer, linked imaging patterns to lung disease survival, and tracked hidden inflammation in COVID-19 patients using advanced PET imaging techniques.
A new study reveals that singing to infants significantly improves their mood, reducing fussiness and stress. By incorporating music into daily routines, parents can create a positive environment for their baby's emotional development.
Researchers demonstrate a new strategy for magnetization reversal in multiferroic materials, allowing for more energy-efficient electronics. The study achieves this breakthrough by growing thin films in an unconventional crystallographic orientation, enabling the application of electric fields perpendicular to the film surface.
A team of NYU researchers created an automated modeling tool to estimate 311 under-reporting of heat and hot water problems in city buildings. The study found that some neighborhoods and addresses report problems at lower rates than others, leading to potential under-reporting of these issues.
Patients with breast cancer detected through routine screening mammography have improved clinical outcomes, including lower odds of advanced stage breast cancer and death. In contrast, symptom-detected cases were more frequent in older women and had higher mortality rates.
Gene editing technologies could enable climate-resilient crops, higher yields, and reduced fertilizers and pesticides. Researchers advocate allowing gene editing in organic farming to support the EU's goal of 25% organic agriculture by 2030.
A recent study using SWOT satellite data has revealed the existence of powerful submesoscale eddies in the ocean, which play a significant role in shaping the climate system. These smaller currents carry surprisingly large amounts of energy and influence marine food webs, weather patterns, and events like El Niño and La Niña.
A new model details the kinetics of exciton dynamics in OLED materials, enhancing lifetime and accelerating material development. The findings have potential to improve fluorescence efficiency, leading to more advanced OLED devices.
Researchers at Rutgers and Brookhaven National Laboratory have developed tools that can capitalize on metacaspase 9's ability to help plants combat a wide range of diseases. The enzyme plays a crucial role in programmed cell death, which is essential for fighting diseases and responding to stress.
The American Cancer Society estimates that 18.6 million people in the US live with a history of cancer as of January 1, 2025, and this number is projected to increase to over 22 million by 2035. The study highlights notable disparities in treatment for common cancers, including lung and colorectal cancer.