The ASCENT-04/KEYNOTE-D19 study shows that sacituzumab govitecan plus pembrolizumab improves progression-free survival and response rates compared to chemotherapy. Nearly 60% of patients responded, with durable responses lasting up to 16.6 months.
WANG Qi's research bridges TCM and digital technology, creating a digital constitution collection platform for objective diagnostics and a 'TCM Constitution Knowledge Graph' linking TCM with modern diseases. This work secures TCM's evolving role in contemporary healthcare through rigorous data + clinical iteration.
A phase II clinical trial shows that combining immune checkpoint inhibition with avelumab and cetuximab significantly improves progression-free survival compared to avelumab alone for patients with advanced cutaneous squamous cell carcinoma. The combination also leads to a confirmed objective response rate of 27.6%.
A phase 2 trial found that combining avelumab and cetuximab significantly extended median progression-free survival in patients with advanced cutaneous squamous cell carcinoma. The combination showed synergistic effects, suggesting a potential new standard of care for this patient population.
Researchers have developed a novel combination therapy, MAG 7, comprising seven drugs to target various biologic elements in pancreatic cancer. The study aims to induce ER stress and kill cancer cells through UPR pathways.
The Class of 2025 represents Duke-NUS' commitment to broadening the skillset and experience of its students. This cohort includes five MD-PhD graduates and PhD candidates from various programmes, showcasing the school's dedication to diversity and multi-disciplinary skills.
A new study finds that fathers who ate healthier during their teenage years were more likely to encourage positive food habits in their children. The researchers also discovered that the children of these fathers were significantly more likely to meet dietary recommendations for fruits and vegetables.
The genome of Merremia boisiana, a fast-growing tropical vine, has been fully assembled, revealing key genes involved in hormone biosynthesis and stress response. This breakthrough provides insights into the plant's ecological adaptability and offers potential tools for crop improvement and biodiversity conservation.
A study by Göttingen University researchers combined satellite data with manual measurements to better understand forest soil moisture. The findings show that soil moisture is strongly influenced by weather and season, not exact location, and highlight the importance of monitoring soil moisture over time for effective forest management.
This study reveals that endophytic fungi from halophytes can improve maize growth and salt tolerance by regulating ion homeostasis. Eight endophytic fungal strains showed enhanced growth under saline conditions, with one strain improving K+/Na+ ratio and salt tolerance in maize.
A new therapy combining pembrolizumab with targeted therapies before surgery improved tumor removal and overall survival for patients with BRAF-mutated anaplastic thyroid cancer. The treatment increased response rates and showed better outcomes compared to standard therapy.