A clinical trial led by University of Oklahoma Health Sciences is investigating a new device designed to restore ovulation in women with polycystic ovary syndrome (PCOS)-related infertility. The REBALANCE trial aims to assess the safety and effectiveness of the device, which uses electrothermal energy to prompt ovulation.
Min Li will receive the 2024 Palade Prize for his contributions to pancreatology, recognizing his pioneering work on pancreatic cancer and metabolic reprogramming. He has been continuously funded by the National Cancer Institute for 15 years and has published over 200 high-impact articles.
Metformin, a widely prescribed diabetes drug, may increase risks of obesity and diabetes in newborns when given to pregnant women. The study found that the drug accumulated in the fetal kidneys, liver, and other organs, leading to growth restriction, which has been linked to an elevated risk of obesity and insulin resistance in childhood.
A multicenter national clinical trial is being conducted to study whether giving antibiotics at the start of labor induction can decrease C-sections in pregnant women with obesity. The trial aims to enroll nearly 800 women and analyze infection rates, complications, and microbiome changes.
The PICCOLO project aims to improve understanding of clouds and convective storms in the tropics, with the ORCESTRA campaign utilizing sea-borne and air-borne teams to collect data. Researchers collected detailed information on precipitation, cloud microphysics, and convective dynamics.
Researchers investigate how liver necroptosis triggers inflammation in both organs, leading to cognitive impairment. Studying aging mouse models, they found that liver necroptosis causes systemic inflammation affecting brain function.
A team of OU scientists, led by Nathan Snook, will use deep learning techniques to analyze numerical simulations of tornadoes. The goal is to improve tornado forecasting by identifying key factors that influence their formation.
A University of Oklahoma researcher found that menthol cigarettes are more addictive and appealing than non-menthol cigarettes, especially among racial and ethnic minorities and the LGBTQ population. Participants were willing to work harder for puffs of menthol cigarettes, indicating a heightened risk of nicotine dependence.
The University of Oklahoma Health Sciences has received a $5.3 million National Institutes of Health grant to support advanced cancer research in Oklahoma. The grant will help early-career researchers establish independently funded laboratories and build technology infrastructure specific to cancer investigations.
A new study by University of Oklahoma researchers identifies key measurements of brain blood flow and ability to compensate as better predictors of mild cognitive impairment than traditional risk factors. The findings provide hope for preventing or treating memory problems early before they progress to dementia.
A researcher has developed a novel drug delivery system that transports medications to the inner ear to prevent cisplatin-induced hearing loss. The system uses hydrogels and nanoparticles to deliver drugs that block calcium damage or protect hair cells, showing promising results in early-stage studies.
Researchers predict the existence of a new type of exciton with finite vorticity, called a 'topological exciton,' in Chern insulators. This prediction has the potential to enable the development of novel optoelectronic devices for quantum computing.
A University of Oklahoma researcher has been awarded a NIH grant to evaluate thousands of natural products with therapeutic potential. The goal is to identify specific components of these products that have anticancer properties and understand how they work.
A University of Oklahoma researcher is investigating how prenatal inflammation increases the risk of neurodevelopmental disorders like ADHD and autism. She hopes to find a way to promote fetal resilience to inflammation using antioxidants like PQQ.
The study establishes criteria for identifying extranodal extension on imaging, allowing radiologists to make accurate calls and provide patients with less invasive treatments. This shift towards practice change has the potential to reduce side effects and improve outcomes for patients with HPV-associated head and neck cancers.
A University of Oklahoma study finds that offering small financial incentives to smokers with low socioeconomic status can double their quit rates. The study's findings come from a clinical trial where participants who received pharmacotherapy, counseling, and financial incentives had significantly higher smoking cessation rates.
A new study from the University of Oklahoma found that measuring circulating microRNAs is likely as effective as measuring blood sugar levels in determining how young people with type 2 diabetes will fare. The study also found a 20% decrease in beta cell function during the first six months of treatment.
Researchers have developed a new treatment for diabetic retinopathy that addresses the root cause of the disease, preventing progression and potential blindness. The anti-ceramide immunotherapy has been shown to be effective in animal and cell culture models, offering a safer alternative to current treatments.
A recent study from the Women's Health Initiative found that both obesity and metabolic syndrome increase breast cancer risk, but in distinct ways for different subtypes. The research highlights the importance of controlling waist circumference and metabolic conditions to reduce breast cancer risk.
The University of Oklahoma has been awarded a $1.2 million grant to lead a Phase 1B clinical trial for the treatment of prostate cancer when it begins to spread beyond the prostate. The trial combines two existing drugs, relugolix and enzalutamide, which may provide more effective treatments for aggressive prostate cancer patients.
A new study reveals that a cancer drug can improve insulin sensitivity and lower blood glucose levels, but eliminating a specific gene related to fat metabolism worsens insulin resistance. The research highlights the interconnectedness of fat metabolism in organs and the need for simultaneous treatment of obesity and insulin sensitivity.
Researchers at the University of Oklahoma have created a new structured clinical interview to screen for multiple sleep problems in children. This tool allows clinicians to assess children for various sleep disorders simultaneously, providing a more comprehensive view of their sleep issues.
Researchers found that endothelial cells in breast cancer tumors are two times more likely to interact with medicine-carrying nanoparticles than healthy endothelial cells. This discovery could lead to more efficient and targeted delivery of cancer nanomedicines.
Researchers have discovered that complementary genes in bacteria and algae living in the same algal colonies coordinate the use and movement of nutrients within the colony. This discovery could lead to new ways to prevent harmful algal blooms, improving water quality and habitat for aquatic organisms.
Researchers at the University of Oklahoma are developing evidence-based mobile health interventions to treat substance use disorders. By leveraging smartphones, they aim to create highly tailored interventions delivered at the right time for individuals, reducing stigma and improving treatment outcomes.
Patients who quit smoking before starting chemotherapy or radiation responded better to treatment, were less likely to need their voice boxes surgically removed, and lived significantly longer than those who continued to smoke. Quitting smoking also improved quality of life for seven years after treatment.
A multidisciplinary team is developing computational models to predict heart valve leakage in children with specific birth defects. The models use 2D and 3D echocardiogram data to simulate the shape of valves and potential weak spots, enabling surgeons to plan surgeries more effectively.
A new study reveals that 'crosstalk' between pancreatic cancer cells and macrophages is the first step towards the onset of cachexia. The research provides evidence of an underlying mechanism for the development of this debilitating muscle-wasting condition, which affects pancreatic cancer patients.
Researchers at the University of Oklahoma have discovered how pancreatic cancer cells exploit an acidic environment to their advantage, finding ways to survive and grow. This knowledge is crucial for developing new therapeutic approaches to target the cancer.
Research by the University of Oklahoma reveals that Americans have broad public support for fusion energy, but limited knowledge and frequent misconceptions. The study's findings emphasize the importance of addressing public confusion and desire for safety to expand fusion energy support.
Researchers found that next-generation sequencing (NGS) identified more patients with microsatellite instability than immunohistochemistry (IHC), potentially leading to thousands of missed diagnoses and patients receiving incorrect treatment. NGS could guide the standard of care towards using this test method instead of IHC.
A study led by the University of Oklahoma's Christian Lemon investigates the role of TRPM8 receptors in oral temperature perception. The research found that these receptors are crucial for distinguishing warm temperatures from cooling sensations. Without TRPM8, the brain tends to blur the lines between warmth and coolness.
A recent study published in Psychology and Aging found that people who identify themselves as looking younger have more positive experiences related to aging, such as being asked for advice and wisdom. On the other hand, those who feel older experience more negative interactions and age-based discrimination.
Researchers at University of Oklahoma discover that climate warming accelerates soil priming in temperate grassland ecosystem, leading to increased soil carbon release. This finding highlights the crucial role of soil priming in terrestrial carbon cycle feedback processes and climate regulation.
Head and neck cancer patients exposed to secondhand smoke during chemotherapy have reduced treatment effectiveness. Secondhand smoke alters protein expression, restricting chemotherapy's ability to kill cancer cells. This raises concerns about cancer prognosis and the importance of smoking cessation.
A University of Oklahoma researcher has made promising discoveries on the role of vitamin B6 in pancreatic cancer. By understanding how pancreatic cancer cells deplete vitamin B6, she developed a three-part strategy to impede their growth and enhance immune function.
A team of researchers has developed a novel mixing device that produces nanomedicines directly at the point of care, enabling rapid and cost-effective synthesis of personalized vaccines. The technology has potential implications for cancer therapies and infectious diseases.
A new study from the University of Oklahoma College of Medicine suggests that ear clip stimulation of the vagus nerve significantly lessens the symptoms of postural tachycardia syndrome (POTS). The treatment decreased heart rates and adrenaline surges, improving quality of life for people with POTS.
Novel research by University of Oklahoma-led team improves understanding of ammonia oxidation, a critical component of the global nitrogen cycle. Different AOM lineages employ varying regulatory strategies to minimize competition, allowing coexistence in the same environment.
Researchers at the University of Oklahoma Health Sciences have developed a new imaging technique that can detect pancreatic cancer cells approximately 10 times more magnificently than current options. The approach combines contrast agent recognition with Multispectral Optoacoustic Tomography, enabling real-time detection and surgery pl...
A newly published study provides a high-resolution climatic record for ancient Italy, revealing phases of climatic instability that overlap with periods of social and political crisis. The marine core record also shows a strong association between episodes of rapid climate change and epidemics of infectious disease.
A University of Oklahoma study explores how environmental stresses influence microbial community assembly and structure in groundwater. The research found that stochastic processes are critical at low stress levels, but deterministic processes dominate at higher stress levels.
Researchers found differences in gene expression and cytokines between American Indians, African Americans, and white Americans in colon cancer specimens. These molecular differences may impact the effectiveness of existing colon cancer drugs, particularly for non-white populations.
A new research effort, led by University of Oklahoma's Zhibo Yang and San Diego State University's Laura-Isobel McCall, aims to investigate the role of bystander cells in infectious diseases. By examining metabolism changes in non-infected cells near infected cells, researchers hope to gain insights into possible disease progression.
The Deep Dust project is a $2.3 million grant that aims to analyze sediment cores from Oklahoma's Anadarko Basin, revealing the state of the planet 300-250 million years ago. The study will provide insights into tectonic and climatic shifts influencing biological systems.
A multidisciplinary study reconstructed the genomic history of the Balkan Peninsula during the first millennium CE, highlighting cosmopolitanism of the Roman frontier. The analysis revealed a large demographic contribution of people from Anatolia and cases of long-distance mobility from Africa and the steppes.
Native Americans in Oklahoma have approximately five times increased risk of heavy rainfall, with two-year floods projected to be 632.6% higher than the general population. The study aims to help Native American leaders develop disaster risk reduction plans and protect vulnerable communities.
A research team led by Michele Galizia aims to create polymer membranes that can efficiently separate gases, reducing energy consumption. The project has the potential to apply in various fields such as fossil fuels, healthcare, and the airline industry.
A case series published in The Journal of Clinical Psychiatry reveals semaglutide's potential therapeutic applications in managing Alcohol Use Disorder, demonstrating significant reductions in AUDIT scores. Further research is needed to validate these findings through larger clinical trials.
The University of Oklahoma research project aims to understand how microbes capture carbon dioxide molecules and incorporate them into biomass. The team is also exploring electron bifurcation, a process that enables fuel upcycling reactions, which convert waste molecules into fuel.