Carbon dots bring testing to paper strips and swabs by emitting bright blue fluorescence under UV light but becoming dimmer in the presence of vitamin B12. The team created two simple formats, filter-paper strips and cotton-swab sensors, to make detection faster, cheaper, and easier to use outside conventional workflows.
Researchers developed a label-free platform combining microfluidic cell sorting with AI to enrich and identify rare CTCs. The integrated strategy uses inertial microfluidic enrichment and YOLOv8-based deep learning for bright-field image recognition, achieving 96.0% accuracy in distinguishing tumor cells.
A review in Biomedical Analysis highlights the integration of microfluidic technologies to bring flow cytometry closer to point-of-care testing, enabling blood cell counting, leukocyte differential analysis, and imaging-based white blood cell classification
A new reference material for angiotensin II testing has been developed to improve comparability and standardization in laboratory results. The material, characterized using two independent approaches, has shown excellent stability and homogeneity, making it a valuable tool for method validation and quality control.
Emerging non-endocytic delivery strategies enable direct cytosolic delivery of proteins, nucleic acids, and gene-editing tools, providing new opportunities for biomedical therapies. The review discusses their application prospects in gene therapy, macromolecular drug delivery, and cellular engineering.
A comprehensive review in Biomedical Analysis assesses the current state and future of direct mass spectrometry for quality control, safety, and authentication of herbal medicines. The technology offers a dynamic way to ensure the safety and proper processing of potent herbal medicines by monitoring toxic compounds in real-time.
Researchers developed a nanoparticle system that uses cancer cells' own copper resources to activate cuproptosis, eliminating tumor cells while protecting healthy tissue. The targeted nanoparticles showed enhanced cellular uptake and were more lethal to breast cancer cells than non-targeted versions.
Researchers developed a pH-triggered nanocomposite that synchronizes the release of therapeutic agents, combating bacterial biofilms and oxidative stress. The platform accelerates healing and promotes tissue repair in infected wounds.