Immunology Frontier Research Center (IFReC) - The University of Osaka

Taming overactive immune systems with antibodies: hope for autoimmune diseases

A multi-institutional team has discovered a novel immune regulatory mechanism mediated by antibodies that selectively shut down overactive immune responses. The 'immune-induced TCR-like antibody' (iTab) can reduce disease severity and delay its onset in a mouse model of autoimmune disease.