Researchers found that prostate-specific antigen (PSA) levels need to be 10 times lower than most physicians generally target for the best patient outcomes. The study also showed that adding drugs called androgen receptor pathway inhibitors to hormone therapy can help patients reach optimal PSA levels. Additionally, a new tool called t...
Researchers at Cedars-Sinai Medical Center tested a novel drug called TY1, which targets an immune system pathway, and found it reduced inflammation and DNA damage in immune cells. The drug also improved heart function and physical activity in laboratory mice with a condition mimicking systemic sclerosis, suggesting a potential future ...
Women with family history of cancer who test negative for BRCA gene mutations face a higher lifetime risk of breast cancer than the general population. The study found that women with variant of unknown significance also have an increased risk, varying from 25% to 30%. Family history substantially affects individual breast cancer risk,...
A Phase III clinical trial has demonstrated that a new cell therapy called deramiocel can slow the weakening of skeletal muscles by 54% and preserve heart function, slowing progression of cardiomyopathy. The therapy, based on Marbán's discoveries, takes a different approach from other treatments for Duchenne muscular dystrophy.
Researchers have identified a genetic mutation that may explain spontaneous cerebrospinal fluid leaks in the spine. The study found that about 1 in 5 patients with this condition had changes in the FBN2 gene, which disrupts connective tissue and increases the risk of leaks.
Researchers have developed a new treatment for pregnant women with severe early preeclampsia, which removes a harmful protein from the mother's blood and lowers blood pressure. The approach was found to safely extend pregnancy by an average of 10 additional days, giving babies more time to develop before birth.
A recent study led by Cedars-Sinai Health Sciences University found that the same brain neurons are activated when people perceive and imagine objects. The research provides a detailed understanding of the neural mechanism underlying visual perception and creation of mental images in the human brain.
A large study led by Cedars-Sinai Health Sciences University found that long-term use of antidepressants and some antidiarrheal medications may be associated with a higher risk of death. The study analyzed nearly two decades of electronic health records from over 650,000 US adults with IBS.
Researchers at Cedars-Sinai Medical Center have discovered that gut bacteria produce nicotinic acid, a molecule that activates a protective mechanism in colon cells, reducing the risk of tissue injury and disease. This finding has important implications for understanding how intestinal disorders, such as Crohn's disease, develop.
Researchers at Cedars-Sinai Medical Center discovered how transplanted neural stem cells interact with host retinal cells to preserve vision. The study, published in Nature Communications, found that the cells provide protective proteins, restore retinal cells, and reduce cellular stress.
Researchers discovered Chlamydia pneumoniae can cause inflammation, nerve cell death and cognitive decline in Alzheimer's disease. The study suggests targeting chronic bacterial infection may represent a new treatment strategy.
Researchers at Cedars-Sinai Medical Center have identified a mechanism that could help treat patients with spinal cord injuries, stroke, and neurological conditions. Astrocytes, a type of cell in the central nervous system, play a critical role in responding to damage and disease, sending signals to immune cells to clean up debris resu...
Researchers developed a 13-point risk score to predict PanNET recurrence, based on male sex, tumor size, WHO grade, and lymphovascular invasion. The tool will help physicians identify high-risk patients for closer monitoring.
A new study from Cedars-Sinai found a 118% increase in visits for general illness and significant spikes in heart attack and lung complication cases following the January 2025 LA fires. Fine particles released by wildfires can cause injury, particularly to the heart and lungs.
Scientists have developed an experimental drug called TY1 that repairs DNA damage and promotes healing in damaged tissue. The breakthrough could lead to new treatments for heart attacks, autoimmune diseases, and other conditions.
Researchers found that senescent blood vessel cells play a key role in developing metabolic disorders like diabetes. Transplanting these cells into lean mice caused inflammation and metabolic dysfunction.
A clinical trial showed a new drug combination reduced deaths in patients with recurrent prostate cancer after surgery or radiation therapy. The combination of hormone therapy and enzalutamide cut the risk of death by 40%, offering a meaningful treatment option for high-risk patients.
A new study published in JAMA Oncology found that vaccinated cancer patients are at lower risk for hospitalization and severe illness from COVID-19. The research analyzed data on over 161,000 cancer patients treated during 2022 and 2023, showing a significant reduction in hospitalizations by 29%.
A preclinical study has identified a signaling pathway involving GAS6 and AXL proteins that enables rapid healing of oral mucosa wounds. The findings suggest that manipulating this pathway could help reduce skin scars.
Researchers at Cedars-Sinai created a lifelike model of motor neurons that die in patients with ALS, allowing them to detect differences between healthy and diseased cells. The study suggests that excessive glutamate signaling may be a contributing factor to the disease.
Cancer cells and immune cells without the Y chromosome tend to have poorer outcomes, making them more aggressive. Researchers hope to adapt therapies to account for this loss to improve treatment effectiveness.
A Cedars-Sinai study finds AI treatment recommendations were graded higher than physician decisions in virtual urgent care settings. AI excelled at identifying critical red flags and suggesting antibiotic treatments, but physicians better assessed patient histories and adapted recommendations.
A new study from Cedars-Sinai examined the effectiveness of a specialized diet in improving symptoms of gastrointestinal disorders linked to an imbalance in gut microbiota. The research found that most participants reported tolerating the diet well and experienced significant relief from common symptoms like bloating and discomfort.
A new technique that rapidly increases production of anti-inflammatory cells promotes healing from heart attacks in mice. The researchers developed an infusion method using extracellular vesicles containing the BCYRN1 RNA molecule to boost regulatory T-cell production.
A new study by Cedars-Sinai reveals that significant percentages of older men with intermediate- and high-risk prostate cancers are being subjected to aggressive treatments that may not extend their lives, highlighting the need for a more personalized approach to cancer treatment. The study suggests that better estimation, communicatio...
A Phase II study led by Cedars-Sinai demonstrates that a monoclonal antibody treatment is safe and effective at helping people with moderate to severe ulcerative colitis reach clinical remission. The therapy targets TL1A, a protein that contributes to the severity of the disease.
A new study by Cedars-Sinai Cancer investigators found that most patients with stage 1 and stage 2 pancreatic cancer are upstaged after surgery. Lymph node involvement is often missed in the staging process, leading to inaccurate diagnoses and poorer survival rates.
A study published in Nature found that immune cells called CD8+ T cells prevent lung healing and repair post-infection, leading to pulmonary fibrosis. This discovery may lead to new therapeutic treatment options for patients with long COVID.
Researchers identify neural basis for abstraction and inference processes in the human brain, showing coordinated brain cell activity represents learned knowledge. The study used artificial intelligence to extract relevant responses from thousands of brain cells.
A nationwide study found a significant increase in GLP-1RA prescriptions for weight loss management, with a notable uptick since 2020. The researchers hope their findings will inform healthcare policies to ensure equitable access to these essential treatments.
Current prostate cancer screening guidelines may not be effective for transgender women taking estrogen, as it can lower PSA levels, making it difficult to detect early-stage cancer. The study aims to provide more appropriate screening guidelines for this population.
Researchers discovered a group of neurons that help coordinate brain focus and storage functions for short-term information retention. These 'category' and 'phase-amplitude coupling' (PAC) neurons work together to enhance recall, offering new insights into Alzheimer's and ADHD treatments.
New research from Cedars-Sinai found that glucagon-like peptide-1 receptor agonists (GLP-1RAs) used to treat diabetes and obesity increase the risk of aspiration pneumonia following endoscopy. The study recommends patients taking these medications stop their medication in advance of procedures to avoid complications.
Researchers discovered a sensor that switches on when cells want to regenerate and off when they are restored. Deactivating SOX9 can promote kidney recovery in injured kidneys, offering new targets for drug development and non-invasive biomarker discovery.
A new study found that women receive greater cardiovascular gains from exercise compared to men, with women achieving similar benefits from exercising just under 2.5 hours per week versus five hours for men. Women also gain more benefit from muscle-strengthening activities when doing fewer sessions per week.
A Cedars-Sinai study shows that behavioral activation therapy is as effective as antidepressant medications in treating symptoms of depression in patients with heart failure. The study found a significant reduction in depressive symptoms in both patient groups, with improvements in physical and mental health-related quality of life.
Researchers analyzed cells within triple-negative breast cancer tumors before and after radiation therapy with immunotherapy, identifying three patient groups with distinct responses. The study found that combining radiation therapy and immunotherapy may improve tumor-fighting immune response prior to surgery for some patients.
A phase I clinical trial has shown that infusions of cardiosphere-derived cells are safe and may improve cardiopulmonary health in people with pulmonary arterial hypertension. The study found encouraging changes in heart function and walking distance in patients who received the treatment.
A new study finds that systemic therapies for advanced prostate cancer are equally effective for Black men as they are for white men, regardless of socioeconomic status. The research suggests that disparities in healthcare can be eliminated with equal access to treatment.
Cedars-Sinai Cancer investigators have identified two promising new treatment options for men with recurrent prostate cancer, improving metastasis-free survival and quality of life. The combination therapy reduced the risk of metastasis or death by 58%, while enzalutamide alone was effective in preventing cancer spread or death.
A new AI algorithm developed by Cedars-Sinai can detect atrial fibrillation in people without symptoms, improving stroke prevention. The algorithm was trained on over a million electrocardiogram readings and accurately predicted cases of atrial fibrillation within 31 days.
A new study from Cedars-Sinai finds that Hispanics and Latinos with chronic kidney disease are at significant risk for sudden cardiac arrest. The study highlights the importance of close monitoring and managing renal disease to prevent this deadly condition.
A novel study published in The Lancet finds that redo TAVR with balloon-expandable valves is both safe and effective for select patients who require a repeat procedure. The study, led by Cedars-Sinai, showed no difference in death or stroke rates between redo and first-time TAVR at 30-day and one-year marks.
Researchers found that women are more likely to experience symptoms like shortness of breath and flu-like symptoms before a cardiac arrest, whereas men tend to experience chest pain. The study aims to improve the prediction and prevention of sudden cardiac death by identifying warning signs.
Researchers at Cedars-Sinai have identified two disease-associated changes to the cornea in diabetes patients that delay wound healing. The study proposes three therapeutic pathways that reversed these changes and partially restored wound-healing function, offering new potential treatments for diabetes.
Researchers identified methylation in normal tissues in some patients with mismatch repair deficiency, leading to undiagnosed Lynch syndrome. This study suggests revising current screening guidelines to include this poorly recognized cause of hereditary cancer.
A new analysis found that COVID-19 vaccination significantly reduced income-related disparities in disease incidence between low- and high-income communities in Los Angeles. Vaccination efforts in underserved communities were crucial in reducing these disparities.
A recent study published in the peer-reviewed journal Hypertension found that apparent resistant hypertension (aRH) is more common than previously reported, affecting nearly 1 in 10 hypertensive patients. Investigators also discovered that patients with well-managed aRH are more likely to be treated with mineralocorticoid receptor anta...
Researchers found that loss of the Y chromosome in bladder cancer cells allows them to evade the immune system, leading to aggressive growth. However, this loss also renders the disease more responsive to a standard treatment called immune checkpoint inhibitors.
Researchers uncover cellular process that triggers inflammation, a vital immune response that can also lead to chronic inflammation and diseases like Type 2 diabetes and heart disease. By targeting this pathway, they hope to find treatments to curb chronic inflammation.