A novel stem cell-gene therapy has been shown to be safe in humans, with no serious side effects reported in the first trial. The treatment targets motor neurons that die in patients with amyotrophic lateral sclerosis (ALS), a fatal neurological disorder.
A new study from the Smidt Heart Institute shows that when height is accounted for, women are 50% more likely to develop atrial fibrillation (AFib) than men. The study's findings suggest that medical practitioners must remain vigilant in promoting AFib prevention and early interventions among both female and male patients.
Researchers developed a polygenic risk score to predict sudden cardiac death in coronary artery disease patients. The study found that patients with high genetic risk scores had a 77% increased risk of sudden cardiac death.
A new study from Cedars-Sinai researchers found that 56% of people infected with the Omicron variant were unaware they had COVID-19. The study suggests that a lack of infection awareness contributed to the fast spread of Omicron.
Researchers at Cedars-Sinai Medical Center have developed a new method to identify which human gut microbes contribute to inflammatory diseases. By analyzing protein levels in blood serum, the team discovered specific bacteria that trigger immune activation and inflammation.
Researchers at Cedars-Sinai created complex computer models of individual brain cells using artificial intelligence. These models capture the electrical signals that neurons fire to communicate with each other, allowing researchers to replicate brain activity at the single-cell level.
Researchers at Cedars-Sinai Cancer identified genetic signatures linked to patient response to immunotherapy in bladder and other cancers. High DDR1 expression is associated with 'cold' tumors, while high DDR2 is linked to 'hot' tumors.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
Middle-aged women are at increased risk of serious health outcomes due to weight gain. New guidelines recommend counseling healthy weight management for all middle-aged women.
Researchers at Cedars-Sinai Medical Center found that people with hypertension are more likely to require hospitalization for COVID-19, regardless of vaccination status. The study, published in Hypertension, highlights the importance of avoiding infection and seeking medical attention if symptoms persist.
A preclinical study found that antibiotics have sex-specific effects on the gut microbiome of lab rats, resulting in significant changes in diversity. The findings could have implications for using antibiotics to treat or prevent bacterial infections in humans.
A preclinical study by Cedars-Sinai Cancer and Johns Hopkins University has discovered a novel three-step treatment that disrupts the pancreatic tumor microenvironment in laboratory mice. The treatment, which combines anti-PD-1 immunotherapy antibody, FAKi, and CXCR4, prevents cancer metastasis and bolsters the immune system.
Researchers propose a theory on how SARS-CoV-2 infects the body, leading to hyperactivation of the immune system and post-COVID syndromes. The hypothesis suggests that molecular motifs on the spike protein interact with immune cells, causing an overreaction and mistakenly attacking organs.
Researchers have discovered a protein produced by soft-tissue sarcoma tumors that changes the biology of surrounding immune cells, promoting tumor growth. The study could lead to improved treatments for this rare and aggressive cancer type.
Researchers at Cedars-Sinai Cancer have identified a novel immune checkpoint pathway that could lead to better understanding and treatment of hepatocellular carcinoma. The study suggests that blocking this pathway, combined with immunotherapy, may provide a new therapeutic strategy for liver cancer.
A new study led by Cedars-Sinai research suggests that androgen hormones interfere with the body's ability to fight bladder cancer, explaining why males experience higher cancer rates. Androgen deprivation therapy may improve treatment outcomes for male patients.
Researchers at Cedars-Sinai have discovered that zinc, a common mineral, plays an important role in reversing lung damage and improving survival for patients with idiopathic pulmonary fibrosis (IPF). By identifying a molecular pathway involving zinc, the team hopes to develop new therapies to reverse IPF-related lung damage.
A new study found significant racial disparities in receiving immunotherapy for advanced liver cancer, with Black and Hispanic patients having lower access to the treatment. The analysis showed that immunotherapy was more effective than chemotherapy in improving survival rates.
A Phase II clinical trial found that an immunotherapy drug combination extended the lives of patients with non-small cell lung cancer, improving survival by 14.5 months compared to standard care therapy. The treatment also reduced chemotherapy use and side effects.
A study by Cedars-Sinai researchers confirms that counting metastatic lymph nodes is a dominant predictor of cancer death, improving staging and treatment for solid tumors. The simple process can be applied in virtually all medical settings without increased cost or complexity.
Researchers at Cedars-Sinai have comprehensively mapped molecular activity in the brain and spinal cord that regulates body's response to central nervous system (CNS) disorders. They discovered a critical role of astrocytes, specialized support cells, in regulating outcomes for CNS disorders.
Researchers at Cedars-Sinai have identified a key gene, NLRP11, that plays a crucial role in the innate human immune system. Deleting this gene prevented an immune sensor from triggering an inflammatory response, highlighting its potential as a target for therapies to prevent or treat inflammatory diseases.
A combination of hormone therapy and pelvic lymph node radiation treatment significantly improved survival rates among patients with postoperative prostate cancer, extending their lives by nearly five years. This study published in The Lancet found that nearly 90% of clinical trial patients remained free from progression for five years.
A recent study at Cedars-Sinai Medical Center found that biologic drugs for inflammatory bowel disease may improve the T-cell immune response in patients vaccinated against COVID-19. This could potentially offer protection against severe disease. The study suggests that these treatments may be used to monitor vaccine and booster outcomes.
Recent studies from Cedars-Sinai have shed light on the importance of a gene in embryo development and its potential link to physical abnormalities. Additionally, research has shown that getting vaccinated against Covid-19 can strengthen immune responses in patients with inflammatory bowel disease. The institution is also working on ne...
A new study identified the Cnpy4 gene as a crucial modulator of the Hedgehog signaling pathway, which regulates growth and development during embryonic stages. This discovery could lead to potential new treatments for cancers related to Hedgehog signaling and birth defects involving extra fingers or toes.
A new smartphone app using AI technology has been found to be as accurate as expert gastroenterologists in characterizing stool specimens. The app's ability to provide detailed descriptions of constipation, diarrhea, and normal stools surpasses that of patient reports.
Two preclinical studies have identified potential new therapies for patients with Allan-Herndon-Dudley syndrome (AHDS), a brain development disorder that causes severe intellectual disability and movement problems. A gene therapy approach has shown promise in improving cognitive and motor functions, while repurposing a common drug may ...
A recent national survey suggests that few cardiologists and care team members are trained in cardio-obstetrics, a specialty combining cardiology, obstetrics, and primary care. Only 29% of clinicians reported receiving cardio-obstetrics teachings during training.
A new study found that deaths from alcohol use disorder increased dramatically during the pandemic, with a 25% higher rate in 2020 and 22% higher in 2021 compared to projected rates. Young adults aged 25-44 experienced the steepest upward trend in alcohol use disorder mortality.
Scientists at Cedars-Sinai Medical Center used advanced brain imaging techniques to study the impact of prenatal opioid exposure on infant brain development. The study found that treatment with medications like buprenorphine and methadone can minimize brain abnormalities in newborns exposed to opioids prenatally.
Researchers at Cedars-Sinai discovered how the brain uses a group of neurons in the frontal lobe to monitor performance, enabling humans to learn from mistakes and develop specific skills. This mechanism allows for flexibility in learning new tasks and adjusting focus based on conflict or difficulty encountered.
A new quality improvement study from Cedars-Sinai found that comprehensive nurse training is key to successfully screening women for postpartum depression. The initiative identified framing the screening as part of family wellness and normalizing the transition to parenthood as helpful strategies.
Researchers at Cedars-Sinai have developed an AI tool that accurately predicts pancreatic cancer patients based on CT scan images. Lowering blood cholesterol has also been shown to slow the growth of prostate cancer by enhancing immune cell action. Additionally, a new study found that an ultrasound probe plugged into a smartphone can b...
A new study indicates that artificial intelligence can accurately predict who will develop pancreatic cancer based on pre-diagnostic CT scan images. The AI tool was trained to analyze textural differences in the pancreas and achieved an accuracy rate of 86% in identifying those who would eventually develop the disease.
A new cell therapy has shown promising results in slowing the progression of Duchenne muscular dystrophy, a rare genetic disorder. The treatment uses heart cells to improve skeletal muscle and heart function, offering a potential cure for advanced disease cases.
Researchers have discovered that vesicles from human heart cells can repair damaged tissue and prevent lethal heart rhythm disorders. The treatment, using cardiosphere-derived cells (CDCs) and their secreted exosomes, showed improved heart rhythms and reduced scarring in animal models.
A new clinical trial found that the drug mavacamten alleviates shortness of breath in patients with obstructive hypertrophic cardiomyopathy. The treatment also improves symptoms and heart failure biomarkers.
Researchers analyzed interviews with participants and found that the program's success was due to its community context, support network, and direct contact with pharmacists. The team plans to track barbershop patrons and explore how public health measures during COVID-19 impacted community-based health interventions.
Cedars-Sinai researchers created a clinical risk assessment algorithm that identifies patients at highest risk of treatable sudden cardiac arrest. The algorithm, based on 13 clinical, electrocardiogram, and echocardiographic variables, has the potential to enhance prevention and treatment options for this fatal condition.
A new therapy combination of immunotherapy, chemotherapy and an anti-inflammatory drug may improve immune response in patients with muscle-invasive bladder cancer. The treatment activates cells to fight tumor growth, potentially leading to better outcomes for patients who don't respond to current treatments.
Researchers developed an AI algorithm that can measure coronary plaque buildup in five seconds, predicting heart attack risk within five years. The tool was trained on images from 921 people and matched results with invasive tests considered highly accurate.
When the eyes land on a face, certain cells in the amygdala react and trigger memory-making activity. Theta wave activity is also reset or restarted, preparing the hippocampus to receive new socially relevant information.
Researchers at Cedars-Sinai have identified a potential new therapy for COVID-19, created by reengineered human skin cells. The substance, dubbed ASTEX, stops SARS-CoV-2 from reproducing itself and protects infected cells in human lung cell samples.
Cedars-Sinai researchers identified two types of brain cells that divide continuous human experience into distinct segments, enabling the brain to recall memories. The discovery provides new hope for treatments of memory disorders like dementia and Alzheimer's disease.
Cedars-Sinai investigators discover that inhibiting RIPK2 function with drugs or CRISPR/Cas9 reduces prostate cancer metastasis in mice, offering new hope for advanced prostate cancer treatment. Targeting this protein could extend patients' lives by several years.
A new collection of scientific articles reviews the past decade of research on women's cardiovascular health, identifying key differences between men and women. The studies highlight critical gaps in current knowledge and emphasize the need for a more tailored approach to diagnosing and treating heart disease and stroke risk in women.
A new AI algorithm developed by physician-scientists can effectively identify and distinguish between two life-threatening heart conditions: hypertrophic cardiomyopathy and cardiac amyloidosis. The algorithm uses specific features from cardiac ultrasound videos to flag high-risk patients, enabling earlier diagnosis and treatment.
A new pathway has been discovered to explain how excessive alcohol consumption damages the liver, specifically through mitochondrial dysfunction. By targeting an enzyme called MATα1, researchers believe they can develop a new treatment for people suffering from alcohol-associated liver disease.
A new cloud-based data resource has been developed to help identify new subtypes of amyotrophic lateral sclerosis (ALS), a fatal neurological disorder. The tool, part of the Answer ALS collaborative effort, uses biological and clinical data from over 1,000 patients to better understand the disease.