Cedars-Sinai OB-GYN experts present research on improving preeclampsia detection through AI-powered analysis of electronic health records. They also explore the relationship between incomplete information on vaccine side effects and COVID-19 vaccine hesitancy, highlighting the need for targeted preventive therapies. Furthermore, the te...
Hospitalizations for hypertensive crises more than doubled between 2002 and 2014, despite reports of overall progress in blood pressure control. The study found that women had similar hospital mortality rates to men, but with a higher risk of dying during a hypertensive crisis.
A national analysis of lung transplantations performed in the US between August 2020 and September 2021 shows that 7% of lung transplants were performed to treat COVID-19-related lung damage. The study suggests that lung transplantation may be a safe option for select patients with severe, irreversible lung damage.
Researchers discovered a protein, syndecan-2, that helps identify and deploy blood stem cells for treatments. Transplanting only cells expressing syndecan-2 could make blood stem cell transplants more efficient and less toxic.
Researchers at Cedars-Sinai have identified opportunities to use microgravity in space for large-scale stem cell production, disease modeling, and biofabrication. This could lead to breakthroughs in regenerative medicine and the development of new treatments.
Researchers found that people infected with COVID-19 develop a wide variety of autoantibodies up to six months after recovery, and these autoantibodies persist over time. The study suggests that understanding these autoantibody responses could help identify ways to treat and prevent long-term symptoms.
Researchers have discovered that ovarian cancer begins with cancerous lesions in the fallopian tube linings of women with BRCA-1 mutations. The study's findings hold promise for predicting which women will develop ovarian cancer years or decades in advance, allowing for early detection and prevention strategies.
Aging is associated with increased levels of local non-pituitary growth hormone in the colon, which contributes to epithelial damage. Targeting this growth hormone action with available drugs may lead to a novel anti-aging therapeutic strategy.
Cedars-Sinai researchers discovered that interleukin-6 mediates delirium-like phenotypes in mice with urinary tract infections, highlighting a potential therapeutic target. The study suggests that modulating immune responses may help alleviate UTI-induced delirium.
A recent study by Cedars-Sinai Medical Center found that COVID-19 mRNA vaccines induced detectable antibodies in 99% of patients with bowel disease, regardless of their immunocompromising therapies. Researchers also noted a correlation between the antibody response and effective immunity in the community.
A recent study by the Smidt Heart Institute found that middle-aged and older women are being diagnosed with 'broken heart' syndrome more frequently—up to 10 times more often—than younger women or men of any age. The incidence has been rising steadily since before the COVID-19 pandemic, suggesting a possible link between stressors, brai...
Research by Christine M. Albert and team found that the risk of developing atrial fibrillation is dependent on the dose of omega-3 fatty acids, contradicting previous studies. High doses may increase risk, while lower doses appear to be safe for most patients.
Aging significantly alters the small bowel microbiome, leading to critical changes. Researchers at Cedars-Sinai Medical Center examined age-related shifts in the gut microbiome, highlighting the importance of understanding these changes.
A new study found women with recurrent urinary tract infections are unhappy with limited management options and fear the potential adverse effects of antibiotics. Researchers recommend modifying management strategies to address their concerns and devoting more research to improving non-antibiotic options for prevention and treatment.
A new study published in JAMA shows that minimally invasive aortic valve replacement can help patients with a wide range of heart conditions, offering a new hope for those affected by aortic dissections and aneurysms. The procedure, pioneered at Cedars-Sinai Medical Center, has been shown to be effective in treating complex cases.
A study published in the Journal of Clinical Investigation has identified potential biomarkers for COVID-19 condition in children, known as Multisystem Inflammatory Syndrome in Children (MIS-C). The researchers hope that these biomarkers can help predict the severity of the disease and inform treatment decisions.
Research reveals that genetics determine hypertension more in women than men, with sex-specific genetic risk traits strongly associated with early-onset hypertension. This finding has important implications for patients and physicians, emphasizing the need for closer monitoring of hypertension risks in women.
Researchers at Cedars-Sinai are conducting a clinical trial to transplant neural progenitor cells into the brains of ALS patients to slow disease progression. The cells have been genetically reprogrammed to express GDNF, which may help keep motor neurons healthy and extend survival.
Research found that COVID-19 vaccines are safe for patients with inflammatory bowel disease (IBD), who experience chronic digestive symptoms. Most side effects were mild and short-lived, with gastrointestinal issues being the most common. IBD patients on biologic therapies reported even fewer side effects due to the modulating effect o...
A team of researchers has created a molecular catalog of cells in healthy lungs and those affected by cystic fibrosis. The study reveals new subtypes of cells and sheds light on the cellular changes that occur in the airways, providing potential targets for future genetic therapies.
Researchers have discovered a new way to transform tissue surrounding prostate tumors to help the immune system fight cancer. The technique, called epigenetic reprogramming, could lead to improvements in immunotherapy treatments for prostate cancer.
Researchers found that patients with medical risk factors or from underserved communities opted for telehealth appointments, which led to fewer diagnostic tests and medications. Despite the benefits of increased access to care, researchers note potential pitfalls and plan to examine patient outcomes.
A study by Cedars-Sinai researchers found that individuals with prior COVID-19 infections who received a single dose of the Pfizer-BioNTech vaccine developed an antibody response similar to those without prior infection. The findings suggest that a single booster dose may be sufficient for previously infected individuals.
Regular use of baby aspirin before a diagnosis of non-metastatic colorectal cancer is associated with better survival outcomes. The study found that low-dose aspirin use limits the spread of cancerous tumors pre-diagnosis, leading to lower death rates from the disease.
A pilot clinical trial found that progesterone injections improved lung function and reduced disease severity in male patients hospitalized with moderate to severe COVID-19. The study suggests a potential protective effect of female hormones against the disease.
A new study published in JAMA found that taking vitamin D or fish oil supplements does not lower the risk of developing atrial fibrillation. The research, led by Christine Albert, confirms previous findings and advises against using these supplements for prevention.
A new strain of the coronavirus in Southern California, CAL.20C, is rapidly spreading across the country and around the world, accounting for nearly half of current COVID-19 cases in the region. The strain has been detected in 19 US states and six foreign countries, suggesting travelers are carrying it to these destinations.
A new surgical technique, Encephaloduroarteriosynangiosis (EDAS), demonstrates reduced recurrent stroke rates from 37% to 10.7%. The EDAS procedure reroutes arteries to segments at risk of stroke, mimicking the process of 'gardening' for blood flow.
Research from the Smidt Heart Institute found that women have a lower normal blood pressure range compared to men, with systolic pressures above 110mmHg associated with increased risk of cardiovascular disease. The study's authors recommend reassessing blood pressure guidelines to account for sex differences.
Research from the Smidt Heart Institute found women are more likely to experience sudden death during nighttime hours, with a higher prevalence of lung disease and asthma. Prescribing physicians may want to be cautious when recommending brain-affecting medications to high-risk patients, especially women.
Scientists have identified neurons responsible for rapidly stopping behaviors and actions in patients with Parkinson's disease. These 'stop signal neurons' are critical in canceling planned movements, a skill that is lost in the condition. The discovery has the potential to improve deep brain stimulation treatment outcomes.
Researchers at Cedars-Sinai Medical Center have found that mixing exosomes with the protein casein can effectively treat muscular dystrophy and heart failure in laboratory mice. The study could lead to clinical trials of oral treatment for patients.
A study from Cedars-Sinai Medical Center found that people who move due to unaffordable housing are at increased risk of failing to receive necessary medical care, leading to long-term health problems. The research highlights the need for preventive action to mitigate the adverse effects of cost-related moves on healthcare access.
A new cancer therapy approach combines gemcitabine chemotherapy with celecoxib, an anti-inflammatory medication, to activate the immune system and fight cancer. The combination has shown potential in improving the percentage of patients who respond to immunotherapy drugs.
A widely used tuberculosis vaccine is associated with reduced likelihood of contracting COVID-19, according to a new study by Cedars-Sinai. The BCG vaccine was found to be effective in reducing SARS-CoV-2 antibody levels and the risk of coronavirus infections or severity of the disease.
A large-scale trial involving over 25,000 participants found no significant difference in the development of atrial fibrillation between those taking vitamin D or fish oil supplements and a placebo. Lifestyle modifications such as maintaining a healthy weight and controlling blood pressure may lower risk of atrial fibrillation.
A recent study conducted by Cedars-Sinai Medical Center found that older adults who joined group exercise classes experienced decreased loneliness and social isolation. The study tracked 382 participants and found a 6.9% decrease in loneliness and a 3.3% improvement in social connectedness.
A recent study published in Gastroenterology identified rare and common genetic variants that significantly increase the risk of developing life-threatening blood clots in IBD patients. The research suggests that genomic medicine could help lower this threat, enabling physicians to provide more precise care.
A new study from Cedars-Sinai found that the ACE2 enzyme, which helps coronavirus infect cells, also plays a role in gut inflammation and patient outcomes in inflammatory bowel disease. Treatment with anti-inflammatory drugs for IBD may aid recovery from COVID-19.
A Phase II clinical trial found that LY-CoV555, a monoclonal antibody, lowered viral load and reduced hospitalization rates in outpatients with mild to moderate COVID-19. The treatment was effective across all demographic groups, including high-risk patients.
A new study published in Journal of the American College of Emergency Physicians Open confirms that most patients with COVID-19 symptoms can recover safely at home. The study found that none of the patients died and fewer than 1% required intensive care.
Cedars-Sinai will investigate the diversity and determinants of immune-inflammatory response to SARS-CoV-2 in a diverse population, highlighting ethnic and racial disparities in COVID-19 risk and severity. The five-year grant aims to advance knowledge of immunology and coronavirus in the US.
A study at Cedars-Sinai found that most COVID-19 patients in Southern California were infected by a variant of the SARS-CoV-2 virus introduced from New York state via Europe, not directly from China. The genetic analysis identified unique clusters of cases linked to specific transmission routes.
Researchers identified Clostridium innocuum as the microbial invader triggering 'creeping fat' in Crohn's patients. The initial response is protective but can contribute to severe intestinal scarring and fibrosis.
A computer model reveals that a specific region of the SARS-CoV-2 spike protein acts as a superantigen, triggering a massive immune response and leading to severe inflammation in some COVID-19 patients. The study also suggests that therapies targeting toxic shock syndrome may be effective for managing MIS-C and cytokine storm in adults.
A Cedars-Sinai study found that robotic surgery for oropharyngeal cancer is associated with improved health outcomes, including better long-term survival rates and reduced risks of positive surgical margins. The procedure's increased use since FDA approval in 2009 was linked to these benefits.
A new analysis of data from the ALLSTAR study published in the European Heart Journal shows that cell infusions, also known as cardiosphere-derived cells (CDCs), can benefit patients with heart disease by reducing the volume of blood the heart holds and a blood protein that measures heart failure severity. The findings contradict previ...
A single-center observational study at Cedars-Sinai found that 23 out of 27 COVID-19 patients treated with tocilizumab experienced significant drops in body temperature and C-reactive protein levels. The medication was shown to reduce inflammation, oxygen requirements, blood pressure support, and risk of death.
Researchers analyzed extracellular vesicles in human prostate cancer cells to understand how cancer spreads. The findings suggest a new approach to diagnose malignancies without invasive biopsies.
A new study by Cedars-Sinai shows that SARS-CoV-2 can directly infect heart muscle cells, which may contribute to COVID-related heart disease. The research used stem cell technology to create heart cells susceptible to infection and found that treatment with an ACE2 antibody could blunt viral replication.