Researchers have identified neural networks behind conscious recollection of information, shedding light on how memories are retrieved for decision-making. The study found that specific neurons in the medial frontal cortex coordinate with those in the hippocampus to create 'memory pathways,' which are selectively switched on when needed.
A study at Cedars-Sinai Medical Center found that only two asymptomatic pregnant women out of 82 tested positive for COVID-19, with the remaining 80 women being symptom-free. The findings suggest that hospitals may not need to conduct universal testing on all admitted pregnant patients.
Four critically ill COVID-19 patients improved significantly after receiving the experimental therapeutic CAP-1002, which contains cardiosphere-derived cells. The treatment helped reduce inflammation and showed no adverse effects, with all patients discharged from the hospital.
A study analyzing patients treated with remdesivir found clinical improvement in 68% of hospitalized COVID-19 patients. The experimental therapy also showed potential in reducing the need for mechanical ventilators and hospital discharge.
New research reveals rising sudden cardiac death rates among women, with the disorder often being their first sign of heart disease. The study highlights the importance of identifying novel risk factors and diagnostics to reduce this risk.
A new minimally invasive treatment has shown significant improvement in symptoms and quality of life for patients with thyroid eye disease. The drug, teprotumumab, blocks inflammatory autoimmune pathophysiology and has the potential to alter the course of the disease.
A Cedars-Sinai team will investigate the interplay between dietary fat and fatty liver disease to understand how cancer spreads to the liver and find ways to block it. The study aims to identify key mechanisms that allow cancer to spread to the liver and develop potential treatments.
A new study published in NEJM compares minimally invasive TAVR to traditional open-heart surgery and finds no statistically significant difference in mortality or disabling stroke rates. The study, involving over 2,000 patients, also shows improvements in disease-specific quality-of-life measures.
Researchers at Cedars-Sinai Medical Center found that people with Parkinson's disease before age 50 were born with disordered brain cells. The study suggests a potential new treatment using PEP005, which reduced alpha-synuclein levels and countered abnormal enzyme activity in dopamine neurons.
A new study from the Smidt Heart Institute found that women's blood vessels age faster and are more susceptible to high blood pressure earlier in life. The research highlights sex differences in cardiovascular physiology and disease, emphasizing the need for tailored treatment approaches.
A new study by Cedars-Sinai researchers found that abnormal electrical pulses from specific brain cells cause temporary memory disruptions in epilepsy patients. The study's findings could lead to better treatments for cognitive impairment in epilepsy patients, with the potential to improve their quality of life.
A nationwide survey of over 71,000 people found that more than half of GERD patients who took proton pump inhibitors still reported persistent symptoms. The study also identified categories of people less likely to respond to the medication, including younger people and those with irritable bowel syndrome or Crohn's disease.
A landmark study suggests that e-cigarette use is associated with coronary vascular dysfunction at rest, even in the absence of physiologic stress. The researchers found that blood flow decreased after both inhalation and handgrip stress in e-cigarette users compared to traditional cigarette smokers.
Researchers at Cedars-Sinai have developed a rapid method to genetically alter laboratory mice, producing personalized models of complex cancers. The technique overcomes drawbacks in current techniques and can be used to modify patient-derived cells.
Scientists developed a novel nanotechnology-based approach that successfully delivered checkpoint inhibitors directly to brain tumors, triggering a local immune response and inducing tumor cell death. The treatment has shown promising results in laboratory mice, providing hope for longer survival rates for patients with glioblastoma
A new study by Cedars-Sinai Smidt Heart Institute reveals that patients with a bicuspid aortic valve who undergo TAVR have the same survival and complication rates as those without the defect. The analysis of over 2,700 patients found no significant difference in death rates between the two groups.
Researchers created a living blood-brain barrier that functions as in the human body, opening new avenues for studying brain disorders and predicting drug effectiveness. The breakthrough uses induced pluripotent stem cells and Organ-Chips technology.
A novel imaging technique using scorpion venom-derived protein BLZ-100 has shown promise in detecting and removing brain tumors. The agent binds to tumor cells and glows under near-infrared laser stimulation, enhancing surgical visualization. Clinical trials demonstrate the imaging system's safety and effectiveness.
Researchers have identified 34 genes associated with an increased risk of developing the earliest stages of ovarian cancer. The study uses alternative splicing analysis to pinpoint these genes, which can help identify women at high risk and pave the way for new therapies.
A recent study found that nearly 18% of multiple sclerosis patients were misdiagnosed before receiving treatment at two major Los Angeles medical centers. The study revealed that many patients spent an average of four years being treated for MS before receiving a correct diagnosis.
A new study found that increasing levels of protein MFN1 can counterbalance mutated protein MFN2 in Charcot-Marie-Tooth disease and improve mitochondrial function. This approach may also be effective for other neurodegenerative diseases, including Alzheimer's and Parkinson's, which affect millions of people worldwide.
A study found that a protein associated with cancer growth is linked to idiopathic pulmonary fibrosis, a chronic and progressive lung condition. Introducing normal cells to inhibit the protein PD-L1 may reduce disease severity in laboratory mice and human tissue samples.
A study by Cedars-Sinai Medical Center has identified a drug called dasatinib that could enhance the effectiveness of immunotherapies for various types of cancers. The researchers found that combining dasatinib with anti-PD-1 therapy increased sensitivity in cancer cells, making it a promising approach to improve treatment outcomes.
A study at Cedars-Sinai Medical Center found that transplanting young bone marrow into old mice preserved their memory and learning abilities. The research suggests that specific properties of youthful blood cells may be responsible for this effect.
Patrick D. Lyden, MD, is recognized for his contributions to stroke treatment and management through the development of tPA and refinement of the National Institutes of Health Stroke Scale. He continues to advance stroke care through clinical trials and research on neuroprotection.
A recent study found that the MELD score does not fully identify patients with life-threatening syndrome ACLF-3, which involves multiple organ-system failures. ACLF-3 patients have a higher risk of being removed from the waitlist or dying while waiting for a transplant.
A recent study by the Smidt Heart Institute at Cedars-Sinai shows that a pharmacist-led intervention at barbershops can significantly lower blood pressure in high-risk African-American men. After 12 months, the average systolic blood pressure fell by nearly 29mmHg in the intervention group.
Researchers at Cedars-Sinai Medical Center have discovered neurons that signal the detection of errors, offering insights into executive function capabilities and possible treatments for conditions like obsessive-compulsive disorder and schizophrenia. The study also found a single-neuron correlate of self-monitoring for errors in humans.
A new study has identified a novel molecular driver of lethal prostate cancer and a molecule that could be used to attack it. The findings, if confirmed in humans, could lead to more effective ways to control certain aggressive types of prostate cancer.
Research studies by Cedars-Sinai's Sumeet Chugh's team identify associations between sudden cardiac arrest and multiple sclerosis, left ventricular hypertrophy, and obesity. Patients with MS have a five-fold higher incidence of sudden cardiac arrest, while those with LVH are at higher risk due to electrocardiography risk scores.
Patients with common heart failure are more likely to experience lethal heart rhythms, according to research from Cedars-Sinai Medical Center. The study found that those with heart failure with preserved ejection fraction (HFpEF) are twice as likely to suffer from pulseless electrical activity or asystole, which can be fatal.
A team of researchers has discovered a biomarker, named cBIN1 Score, that measures muscle deterioration and protein regulation in the heart, indicating onset of heart failure. This simple blood test can aid doctors in diagnosing at-risk patients before symptoms appear.
EDAS surgery reroutes brain arteries to create new pathways for blood and oxygen, significantly decreasing stroke recurrence rates by 9.6% compared to intensive medical management alone. The study's findings are promising for applying EDAS to severe atherosclerosis of the brain arteries.
A new study found that growth rates of brain circuits in infancy can predict a child's IQ and emotional behavior at age four. Researchers used MRI scans on infants and followed their development to identify early signs of mental, behavioral, or developmental disorders.
A new study by Cedars-Sinai finds that stress is a major contributor to sudden cardiac arrests, which are now more likely to happen outside of previously identified peak times. The research analyzed data from the Oregon Sudden Unexpected Death Study and found no evidence of increased cardiac arrests on Mondays
A new drug called Metavert has shown promising results in blocking pancreatic cancer growth in laboratory mice. The study also found that Metavert may prevent patients from developing resistance to currently used chemotherapies.
Researchers at Cedars-Sinai Medical Center discovered how hormone therapy can cause prostate cancer to spread by transforming some cancer cells into aggressive neuroendocrine cancer-type cells. A potential simple blood test may help predict when this type of therapy resistance will occur, according to the study.
Researchers at Cedars-Sinai Medical Center have developed a simpler and more accurate method to estimate body fat percentage than the widely used BMI. The new relative fat mass index (RFM) formula uses only height and waist circumference measurements, providing a better measure of body fatness without requiring expensive equipment.
A study found that fitness trackers can supplement current assessments of health status and physical function, showing increased daily activity correlates with positive patient ratings and lower adverse events. Wearable devices may help predict treatment complications and enable timely interventions.
Researchers have identified a new cellular pathway that may help explain how arterial inflammation develops into atherosclerosis, leading to heart attacks and stroke. The findings suggest that blocking interleukin-1 beta production could enhance niacin therapy and improve therapies for atherosclerosis.
Researchers at Cedars-Sinai have identified a link between the presence of hydrogen sulfide gas in the gut and diarrhea in patients with small intestine bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS). A new four-gas breath test device is being developed to improve diagnosis and treatment for these conditions.
A new study by Cedars-Sinai investigators found that online physician satisfaction scores tend to be skewed and can mislead patients. The study examined data from Healthgrades and found that ratings consistently skewed positively and had different distributions across specialties.
A Cedars-Sinai study found that prolonged air pollution exposure in the Los Angeles Basin triggers inflammation and cancer-related gene expression in rat brains, particularly due to nickel content. The research highlights the need for reducing ambient air pollution levels.
Researchers at Cedars-Sinai will compare evidence-based approaches for treating depressive symptoms in people with advanced heart failure, aiming to improve quality of life and outcomes. The study is part of a larger effort to address the significant challenge of treating depression in heart failure patients.
Researchers discovered that dopamine neurons respond to novel images but not familiar ones, indicating a key role in episodic memory formation. This finding has implications for understanding and treating diseases like Parkinson's, which often accompany cognitive issues such as memory problems.
Researchers at Cedars-Sinai Medical Center have developed a new method to study the brain's role in obesity by recreating brain neurons from obese patients' cells. The study found significant differences between super-obese and normal-weight neurons, suggesting genetic mutations may contribute to weight gain.
Researchers at Cedars-Sinai have discovered a new way to treat amyotrophic lateral sclerosis (ALS) by transplanting altered neural cells into the brain. Laboratory rats that received the transplants lived 8 percent longer and were free of paralysis 10 percent longer than untreated animals.
The new MR Multitasking technique allows for faster and more comfortable cardiac MRI tests by continuously acquiring image data, separating motion from other changes into multiple time dimensions. This method was found to be accurate in testing healthy volunteers and cardiac patients, completing tests in as little as 90 seconds.
Researchers have found that the human brain's tiny blood vessels can trigger the growth of spinal motor neurons, which control muscles, during early development. This discovery could provide insights into diseases such as amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders.
Dechen Lin receives grant funding to research esophageal adenocarcinoma, the most common type of esophageal cancer in the US. He aims to understand its evolution from Barrett's esophagus and develop prevention strategies.