LAM-002A has shown promise in reducing SARS-CoV-2 virus levels in infected individuals, with Yale leading a Phase II trial to test its safety and efficacy as a COVID-19 treatment. The study aims to enroll 142 newly diagnosed patients to assess the drug's effectiveness in preventing disease progression.
Joslin Diabetes Center researchers discover targeting renalase protein strengthens beta cells against stress and autoimmune attack. An FDA-approved drug, pargyline, is shown to protect human cells, potentially slowing disease progression in a clinical trial.
A study analyzing US survey and tax data reveals a strong relationship between rising income inequality and lower college enrollment and completion rates among disadvantaged groups. The research highlights the significant impact of income inequality on educational opportunities in the United States.
Researchers discovered that almost 20% of patients with unexplained intestinal polyps had tumors with mutations similar to those caused by colibactin, a bacterial toxin. Regular tooth brushing may have prevented the bacterial infection that triggered these cancer-causing DNA mutations.
The study found higher medical and non-medical prescription stimulant use among heterosexuals and certain LGB subpopulations in states without MCLs. States with MCLs had lower odds of medical stimulant use, while bisexual men reported higher non-medical prescription stimulant use.
Researchers created a self-healing polymer that can repair itself in one second, while retaining its original strength, and is also biodegradable and recyclable. The material mimics the squid's ability to heal itself in nature, with potential applications for robotic machines, prosthetic legs, and personal protective equipment.
A deep learning algorithm can quickly and accurately screen cancer patient biopsies for genetic alterations that inform treatment options and likelihood to respond to specific therapies. The study found detectable mutations in 13 out of 14 tested tumor types, including lung, colorectal, breast, and gastric cancers.
A recent study found a significant increase in the number and rate of suicide-related calls to US Poison Control Centers involving over-the-counter analgesics. The trend was driven by increasing exposures among 6-19-year-old females, with children aged 6-19 accounting for half of all cases.
Researchers will analyze massive atmospheric data using machine learning methods to identify patterns and understand processes, facilitating the development of new models for tackling scientific problems in atmospheric physics.
The University of Tennessee Extension's Cotton Nitrogen Management publication has been awarded a Blue Ribbon by the American Society of Agricultural and Biological Engineers. The publication, authored by Lori Duncan and Tyson Raper, provides recommendations for optimizing nitrogen use efficiency in cotton production.
A new study published at the 2020 Alzheimer's Association International Conference suggests that receiving at least one flu vaccination can lower the risk of developing Alzheimer's disease over a lifetime. The research found that people who received a flu vaccine were 17% less likely to get Alzheimer's disease.
Researchers from the University of Texas at Austin developed a computer model that connects distinct patterns in sedimentary deposits to shifts in climate and tectonic activity. The model, which uses a 3D source-to-sink approach, allows scientists to simulate the world under different tectonics and climate conditions.
A Phase 3 clinical trial has begun to test the safety and efficacy of the mRNA-1273 vaccine in preventing symptomatic COVID-19. The trial enrolls approximately 30,000 adult volunteers and aims to determine if the vaccine can provide long-lasting protection against the virus.
A study examining changes in spanking of children over 25 years found that it decreased significantly in the US. The study analyzed data from 1993 to 2018 and found a decline in spanking rates among parents across different demographic groups.
A Baylor University study led by Cathryn Townsend challenges the long-held notion that the Ik ethnic group in Uganda is selfish and loveless. The research found that sharing and cooperation are integral to Ik culture, with a strong emphasis on supernatural punishment for those who do not share.
Researchers developed two approaches to control plant proteins related to hydrophobic pollutant transport. A pesticide that suppresses MLP gene expression reduced hydrophobic pollutant accumulation, while an MLP-binding pesticide inhibited binding to pollutants. This breakthrough enables safer crop production on contaminated soil.
Researchers from NC State University demonstrate a technique to produce streams of liquid metal at room temperature by applying a low voltage, lowering its surface tension across three orders of magnitude. The study reveals the potential applications for this technique in creating stretchable wires and studying fluid behavior.
Scientists have identified a highly conserved envelope protein in both SARS-CoV-2 and SARS-CoV-1, which could be targeted with existing drugs to prevent acute respiratory distress syndrome. Researchers plan to conduct trials using FDA-approved medications and aim to utilize their data for vaccine design.
A new study published in JAMA Network Open found that maternal depression during and after pregnancy significantly increases the odds of depression in offspring during adolescence and adulthood. The research, which examined over 15,000 children, shows that perinatal depression can have a lasting negative impact on mental health.
Researchers estimate aerosol emissions from simulated individuals with asymptomatic to moderate COVID-19. The study aims to provide insight into the potential for airborne transmission of the virus.
Researchers at Tokyo Tech and YNU discovered a peculiar spin transport mechanism in the Kitaev model, which allows 'spin packets' to travel through seemingly unpassable regions of a quantum spin liquid system. This breakthrough has potential applications in spintronics and quantum computing.
Researchers found distinct responses to ultraviolet and other colors of light between day- and night-biting mosquito species. The study's findings have important implications for using light to control harmful insects.
A team of researchers from SMART has developed a novel approach to induce strong and broad immunity against the dengue virus. Sequential immunization was found to be more effective in inducing higher levels of neutralizing antibodies to all four DENV serotypes than traditional tetravalent-formulated immunization.
Seagrass die-off in Morro Bay has caused extensive erosion, altering sedimentation patterns and habitat changes. Restoration efforts have shown mixed success, with some regions experiencing partial recovery.
Recent advances in early child development can help understand the pandemic's consequences. The COVID-19 pandemic has accelerated research into empirically supported interventions for children affected by adversity, potentially benefiting this population in the long term.
New research from the University of Zurich and Radboud University found that people's capacity for hedonism contributes at least as much to a happy life as successful self-control. Distracted thoughts can undermine immediate pleasure, while consciously planning downtime can help enjoy it more
The team discovered a technique to compress brain signals, focusing on neural activity spikes called threshold crossing rate or TCR, which requires less data while still being able to predict firing neurons. By listening to a specific feature of neuron data called spiking-band power, the SBP method is highly accurate and takes in one-t...
A collaborative study between UH researchers and Sumida Farm reveals the farm's adaptability to environmental changes through strong community connections. The team analyzed farm history, groundwater pumping, and climate data to identify trends in productivity.
A new study identifies weak concrete and heavy trucks as the top reasons for sewer line failure. The researchers used statistical analysis to show that these factors are most likely to trigger a problem among common causes of sewer pipe failure.
Researchers reconstructed natural runoff history for the middle reach of the Yellow River from 1492 to 2013 CE, finding reduced runoff and sediment load due to human activities. The study provides an important model for distinguishing anthropogenic influence from natural variability in global change studies.
A machine-learning approach analyzing 2,413 measures from 11,196 couples identified key predictors of relationship quality. Life satisfaction and emotional health were strong individual characteristics associated with relationship quality.
A new study published in Politics and Gender found that men are more likely to endorse COVID-19 conspiracy theories than women. The researchers suggest that learned helplessness and conspiratorial thinking contribute to this gender gap.
GW University will participate in a Phase 3 clinical trial of the mRNA-1273 vaccine to test its safety and efficacy in humans. The trial aims to enroll 500 participants, including those at high risk for severe illness due to age or comorbidities, to develop a vaccine that can effectively protect these populations.
Four simple criteria have been established to accurately use the term 'probiotic': purity, safety, clinical trial support, and maintenance of viability in products. This clarity will provide consumers with better transparency about expected benefits and allow them to make informed choices.
Researchers at UCalgary's Snyder Institute for Chronic Diseases have unlocked new insights into the regulation of immunity against chronic infectious diseases. The study found that immune responses thought to be non-protective are actually essential in regulating excessive inflammation, which can facilitate infection.
A new study uses satellite data to understand global cloud composition during the industrial revolution, finding that early-industrial aerosol concentrations were much higher than estimated by climate models. This could mean human-generated atmospheric aerosols are not having as strong a cooling effect as previously thought.
A new study by Iowa State University researchers reveals that individuals tend to select retirement funds ending in zero, leading to an incompatible level of risk and potentially lower total wealth at retirement. The findings suggest that demographic factors such as age, income, and education can influence the likelihood of this 'zero'...
A new study describes a novel label-free imaging technique that can differentiate active T cells from those in a quiescent state. The method, which uses autofluorescence detection, is non-damaging and doesn't alter the behavior of the cell, offering advantages over traditional antibody-based methods.
The Einstein-Mount Sinai Diabetes Research Center has received a $9.5 million grant from the NIH to support research in type 1 and type 2 diabetes, obesity, and metabolic disorders. The center will utilize a new shared Immuno-Technology Core (ITC) to pursue innovative projects, including immunotherapeutics and intermittent fasting diets.
A new study using optical tweezers reveals the sensitivity of photoreceptors to mechanical stimuli, opening up new questions on their function. The researchers detected specific molecules sensitive to mechanical stress and observed variations in electrical signals.
A recent study found an association between a healthy diet and reduced prostate cancer risk, as well as an increased risk with diets rich in sweets and beverages. The research team analyzed data from over 1,000 participants and identified key dietary patterns that may inform prevention strategies for prostate cancer.
Scientists have discovered that changes in brain cartilage cells regulate memory changes during sleep, making memories stronger and weaker. Sleep deprivation prevents these changes, suggesting that altering the structure of perineuronal nets may be one of the mechanisms behind sleep-induced memory consolidation.
Researchers invent new laser inversion technique to overcome SLS limitations, enabling simultaneous printing of multiple materials. The process allows for stronger, denser materials and complex multi-material parts without assembly, expanding industries such as aerospace, automotive, and robotics.
Researchers at the University of Texas at Austin found that articles published in journals accepting reprint fees are nearly three times more likely to be written by authors receiving industry payments. Journals with higher commercial practices have more author conflicts, suggesting a need for stricter open access publishing.
A new purification technique using molecular affinity interaction has been developed to purify therapeutic proteins with high efficiency and purity. The technique uses synthetic host molecules cucurbit[7]uril and adamantane to secure manufacturability, sterilization, and recyclability of purified materials.
A study found that antibiotics alone can successfully treat children with uncomplicated appendicitis, resulting in fewer disability days at one year. Non-operative management was also associated with fewer disability days for caregivers and similar healthcare satisfaction rates as surgery.
A phase I clinical trial found that the antiviral drug cocktail ledipasvir/sofosbuvir resulted in a 100% hepatitis C cure rate among nine pregnant volunteers, with none of their babies contracting the virus. The study suggests that pregnancy could be an excellent time to diagnose and cure hepatitis C infection.
Researchers uncovered evidence of Negev viticulture's rise from the 4th to 6th centuries CE, driven by Mediterranean trade. The industry declined due to climate change, plague, or sociopolitical changes, with no link to the Islamic conquest.
Researchers propose creating a global database of 2D crystal patterns and recipes to unlock the CVD process and environment for mass production. A Nakaya-like diagram has been developed to analyze these patterns, enabling scientists to infer clues about process variables.
A comprehensive review of vaccine data over 20 years found vaccines to be remarkably safe, with most safety issues identified through existing postmarketing surveillance programs. The study confirms the effectiveness of the vaccine approval system and postmarketing surveillance in ensuring public health benefits while minimizing risks.
Researchers have compiled an unparalleled inventory of the human gut ecosystem by sequencing over 200,000 bacterial genomes from more than 4,600 species. The new databases reveal tremendous diversity in human guts and pave the way for microbiome research.
Research published in the Journal of Neurology Neurosurgery & Psychiatry found that women smokers are four times more likely to have unruptured brain aneurysms than non-smokers. High blood pressure further increases the risk, with smokers being seven times more likely to harbour the condition.
Researchers created origami-built metamaterials that retain shape recoverability, directional mechanical properties, and reversible auxeticity. This breakthrough enables multifunctional applications in soft robotics and medical devices.
A team of researchers has presented a new look at the 'central engine' powering a massive solar flare, revealing an enormous electric current sheet and magnetic bottle-like structure. The study offers the first measurements characterizing the magnetic field and particles at the heart of the explosion.
Researchers discovered abnormalities in communication between brain cells and molecular changes affecting protein production due to dysfunctional CASK gene. The study also suggests an unexpected role for CASK in regulating energy production in cells, which may explain diminished brain size and dysregulated function.
Biased perceptions of hate crimes are linked to sympathies with supremacist groups and societal grievances, according to a study. Prejudice against minority groups influences perception of the motivations behind mass shootings.
Researchers at Cornell University have identified a problem that holds the key to whether all encryption can be broken. The study connects two areas of mathematics - cryptography and algorithmic information theory - to show that a natural computational problem characterizes the feasibility of basic cryptography.
A new study shows that community-based genetic screening can identify individuals at increased risk for three common inherited conditions, including Hereditary Breast and Ovarian Cancer, Lynch Syndrome, and Familial Hypercholesterolemia. The study found that up to 90% of carriers were not previously identified in a clinical setting.
An observational study found SARS-CoV-2 infection rates among asymptomatic healthcare workers and community residents in Texas to be concerning. The study's results highlight the need for enhanced safety measures to prevent transmission of the virus.
New research reveals that children, especially boys, exhibit strong gender stereotypes in job roles, leading to increased masculinity beyond age seven. The study suggests that voice pitch can be a useful tool to monitor and challenge implicit stereotypes.