A multicenter clinical trial demonstrates insulin secretion from engrafted stem cells in patients with type 1 diabetes. The study shows 20% reduced insulin requirements and 13% more time spent in target blood glucose range over a one-year follow-up period.
Researchers at Georgia State University have developed a new candidate antiviral drug, 4’-FlU, which shows potent activity against SARS-CoV-2 and other respiratory RNA viruses. The study demonstrates that 4’-FlU induces termination of the viral polymerase, aborting replication and offering a strong therapeutic asset.
Researchers provide evidence that mammalian and avian primitive streaks evolved independently, using different mechanisms to form the body plan. They suggest alternative landmark for ethical oversight in human embryological research.
Women living in neighborhoods with more green space experienced fewer PMS symptoms, including anxiety, depression, difficulty sleeping, and breast tenderness. Long-term exposure to green space was found to have beneficial effects on psychological symptoms of PMS.
Researchers found that increasing food amount elevates intestinal absorptive surface and function due to enhanced PPARα expression. Food restriction reverses this process, suggesting potential avenues for limiting obesity.
The state of Georgia could dramatically reduce its greenhouse gas emissions by using onsite electric power, creating new jobs and a healthier public. CHP systems can be 85-90% efficient, reducing peak demand on the grid and providing ultra-high system efficiencies, cleaner air, and more affordable energy.
Researchers found that genomic screening can identify patients at risk for heart disease due to amyloidosis. The study used data from the MyCode Community Health Initiative and electronic health records to determine how often patients with specific transthyretin variants showed signs of cardiomyopathy.
A cluster-randomized controlled trial in rural Bangladesh shows that proper mask-wearing significantly reduces symptomatic SARS-CoV-2 infections. Mask distribution and promotion increased community-wide mask-wearing by 29% and reduced reported COVID-like illness, especially among high-risk individuals.
A team from UNIGE found that dopaminergic neurons in the reward system are responsible for motivating social interactions. The study used mice to demonstrate how these neurons release dopamine, crucial for motivated behaviors and learning.
A study found that nearly two-thirds of US states failed to follow CDC guidelines for prioritizing cancer patients for COVID-19 vaccinations. The lack of clarity in defining qualifying cancer diagnoses led to unequal vaccination priority, leaving vulnerable patients at risk.
Researchers at UC3M found that Facebook ads can target a specific person with just four rare and specific interests. This nanotargeting ability exposes users to new risks, including potential identification without consent. The study highlights the need for advertising platforms to protect individual privacy.
After the 2012 US Preventive Services Task Force (USPSTF) statement discouraging routine prostate-specific antigen (PSA) testing, rates of prostate cancer screening and biopsy decreased across racial groups. However, Black men had higher rates of local and metastatic prostate cancer despite similar screening rates.
Researchers found that teams with autonomy to choose ideas or team members perform better than those without autonomy. Choosing ideas leads to a stronger match of interests and prior network contacts, boosting confidence and motivation. However, overconfidence can lead to complacency when too much autonomy is given.
Researchers at University of Helsinki have developed a new method to speed up calculations on quantum computers, reducing the number of measurements required and increasing efficiency. This breakthrough could lead to faster and more sustainable quantum computing.
Researchers developed a molecular device that converts infrared light to visible light, expanding detection capabilities. The device uses tiny vibrating molecules and metallic nanostructures to enhance conversion efficiency.
Researchers at the University of Cambridge have developed a new concept for detecting infrared light by converting it into visible light, easily detectable by modern cameras. This innovation enables the detection of mid-infrared light using molecular frequency upconversion with dual-wavelength hybrid nanoantennas.
Genetic variants at 67 genomic regions were found to contribute to increased risk of age-related hearing loss. Visualized proteins reveal molecular components critical for sound conversion and transmission.
Researchers at Tel-Aviv University have shed light on the Sigma-1 receptor's topology and function in neurodegenerative diseases. The study reveals that the receptor is retained in the endoplasmic reticulum and its amino end faces the cytoplasm, providing a crucial mechanism for therapeutic approaches to alleviate suffering from ALS.
A new technique using thin-film neural networks (TFNNs) improves processing times for all-optical neural networks and enables fast optimization of photonic devices. The approach accelerates the design and fabrication of multilayer thin films, mimicking human retina cells.
A study by the University of Toronto's Rotman School of Management found that predictive analytics can increase revenue by $500,000 to $1 million for manufacturers who invest in IT capital, educate their workforce, and implement high-efficiency manufacturing processes. The research team surveyed over 30,000 manufacturers and found that...
Researchers identified a mechanism for how genetically defective cells mutate to survive stressful situations, such as drug treatment. Understanding this resistance mechanism could lead to the development of new strategies to delay or prevent cancer drug resistance.
A study found significant declines in daily steps and increases in clinical depression risk among college students one year into COVID-19. Physical activity levels failed to return to pre-pandemic levels, while screen time remained higher than before.
Researchers discovered a newly defined domain in a protein that regulates gene expression under high-energy conditions. Cells adapt to changing nutrient environments by switching between specialized gene expression programs, which are triggered by different molecular tags on histones.
A study by Brynn Kimber and team reveals killer whales spending more time in the Arctic due to reduced sea ice, posing new threats to prey species. The warmer climate is altering the predators' hunting patterns, leading to increased risks for endangered bowhead whales.
A new study demonstrates that restoring Indonesian peatlands can reduce the impacts of peatland fires on the environment, climate, and human health. The analysis suggests that effective restoration will outweigh the cost of restoration, providing economic savings of up to $8.4 billion.
A recent study published in PLOS Pathogens found that the COVID-19 Delta variant may have a reduced ability to be neutralized by vaccines. The researchers analyzed serum samples from vaccinated individuals and found that the Delta variant was more effective at evading vaccine-induced immunity than other variants, such as Beta and Alpha.
Researchers developed a new method to significantly enhance thermoelectric voltage at low temperatures by creating laminate structures with transition metal oxide and insulating layers. The 'phonon-drag effect' is responsible for the enhancement, where flowing phonons drive electrons to produce extra thermoelectric voltage.
A subminiature multifunctional brain chip has been developed to analyze brain activity from multiple aspects. The chip integrates a fluid channel for extracting cerebrospinal fluid, injecting medicine, and measuring brain signals, minimizing brain damage and enabling precise analysis of neurotransmitters and brain signals.
Researchers have identified pigtailed macaques as a suitable animal model for studying two emerging tick-borne hemorrhagic viruses, Kyasanur Forest disease and Alkhurma hemorrhagic disease. The study found that infected macaques exhibited symptoms similar to those in humans, including loss of appetite, dehydration, and hemorrhaging.
Research from Flinders University found self-regulatory control and evaluative bias towards soft drinks associated with increased consumption. The study aimed to identify new methods to help habitual soft drink users regulate their intake. Young adults are the core consumers of soft drinks, posing a major public health problem.
Researchers found that adding a specific bacterium to the gut microbiome of mice with colon cancer increased immune cell activity and reduced tumor size. The study suggests leveraging gut microbiota to enhance anti-tumor immunity in advanced colon cancer, offering a promising new approach for treatment.
Researchers at Johns Hopkins Medicine have discovered that manipulating certain nerve cells may trigger the formation of new heart muscle cells, restoring heart function after heart attacks. The study found that removing specific genes associated with circadian rhythms increased neonatal heart size and cardiomyocyte numbers by up to 10%.
A new study from Pusan National University suggests that phonological awareness (PA) and phonics instruction can significantly improve the reading skills of English language learners. The meta-analysis of 46 studies found a moderate effect of PA and phonics on word reading, but a larger impact on pseudo-word reading.
A Norwegian study reveals that out-of-hours emergency doctors with higher admission rates inflict significant unnecessary costs on hospitals. The study found that patients seen by these doctors have a greater chance of hospital stays, particularly those over 69 years old.
Scientists from Tokyo Institute of Technology have developed a genetically encoded probe to visualize active transcription sites in living cells. The probe successfully identified phosphorylated Ser2 in RNA polymerase II, allowing for the localization of elongation phase transcription sites in real-time.
Scientists from TUM and Google Quantum AI used a highly controllable quantum processor to simulate exotic particles called anyons, which can emerge as collective excitations in two-dimensional systems. The study reveals the properties of these particles through braiding statistics, a key feature of topologically ordered states.
A global study found that one in 11 stroke survivors experienced anger or emotional upset in the hour leading up to their event, with a 30% increased risk. Heavy physical exertion was also linked to an approximately 60% increase in intracerebral hemorrhage risk.
A global group of researchers, industry stakeholders, and consumers have launched a networking hub to ensure the quality, accuracy, and accessibility of wearable fitness devices. The network aims to develop a standardized testing pathway and improve data standardization across devices.
A deep-learning model called D-SCRIPT predicts protein-protein interactions from primary amino acid sequences with high accuracy. The model enables the detection of functional subnetworks and can be applied to many species, including those with rare or lacking PPI data.
Recent research shows differences in Russian and US approaches to emotion, with Russian parents reading stories featuring negative emotions to their children. This highlights cultural nuances in socializing emotions before school age.
A study by FAU Harbor Branch reveals that even properly functioning septic systems contribute to nitrogen pollution in the Indian River Lagoon. Groundwater samples showed higher dissolved nutrient concentrations than surface waters, indicating contaminated groundwater as a major source of nutrient loading.
Researchers from Osaka University have successfully grown high-quality magnetite thin films on a hexagonal boron nitride substrate without compromising the film's properties. This breakthrough enables the development of flexible spintronics devices with preserved electronic and magnetic properties.
A new study reveals the vital role primary school teachers play in supporting families during home schooling, particularly for middle-income families who struggle to balance work and childcare responsibilities. The research highlights the range of resources and services provided by teachers to help mitigate socio-economic disadvantages.
The Patient-Centered Outcomes Research Institute (PCORI) Board approved funding for nine new comparative clinical effectiveness research studies addressing various health conditions. These studies focus on telehealth and mobile health strategies, reducing disparities in maternal health, and improving care for people with intellectual a...
A study by the Paul Scherrer Institute finds that blue hydrogen can play a positive role in the energy transition under certain conditions, especially when carbon capture and storage is used effectively. However, methane leakage along the supply chain can reduce its climate benefits.
A new study reveals Native American deaths from COVID-19 are substantially higher than other racial groups, with poorer living conditions and limited access to healthcare exacerbating the issue. The researchers advocate for increased funding and policies to improve public health and address these structural inequalities.
A blood test for HPV-associated head and neck cancer was found to be more accurate, faster, and cheaper than conventional methods. The test detected DNA fragments of HPV in the blood and was combined with routine imaging and physical exam findings for a fully non-invasive diagnostic approach.
Researchers have identified a genetic variant in the B4GALT1 gene that may confer protective effects against cardiovascular disease, characterized by lower LDL-C levels and decreased fibrinogen. The discovery could inform novel therapeutic approaches to decreasing or preventing CVD.
Scientists used single-cell sequencing to analyze over 150,000 cells from 11 tumor samples, discovering novel mechanisms of tumor development and identifying potential targets for therapy. The findings may lead to personalized medicine and improved treatment options for gynecologic cancers.
Researchers have discovered that certain microbes can prevent Clostridioides difficile infection by consuming nutrients essential for its growth. This new understanding challenges existing approaches to probiotic treatment options, which focus on restoring secondary bile acids.
Researchers found 2.4 times the rate of arbovirosis as originally reported, including coinfections, suggesting underestimation of the incidence of the three viruses. The study enriches epidemiological information on these arboviruses, which can help improve estimates of burden and resource allocation.
Room attendants, largely feminized and immigrant workers, face precarious conditions, including physical labor exploitation and lack of social protection. Las Kellys employs three types of subversion tactics to redefine their work, highlight central roles, and fight for dignity.
Researchers examined the risk of developing diabetes-associated eye disorders among children diagnosed with type 1 or type 2 diabetes. The study found a significant association between diabetes diagnosis and increased risk of diabetic retinopathy and glaucoma in childhood.
The study found that many museums struggled to adapt their in-person programs to online format, leading to decreased engagement and revenue. However, some institutions successfully transitioned to virtual programming, offering creative and engaging content for underserved audiences.
The US FDA's early approval of Aduhelm sparked worries about the lack of post-approval studies. Insufficient company incentives and patient participation hinder meaningful trials.
A study by Imperial College London found that the first SARS-CoV-2 spike protein encountered through vaccination or infection influences subsequent immune responses to current and future variants. This 'immune imprinting' affects the rate of decay of protection and impacts antibody levels over time.
Researchers found that damaged telomeres increase the expression of ACE2, the human SARS-CoV-2 cell receptor, leading to increased viral susceptibility in the elderly. This DNA damage response is triggered by telomere shortening and dysfunction in aging cells.
Research found a significant correlation between increased atmospheric temperature and asthma attacks in children. Lower SO2 levels during the state of emergency also contributed to reduced asthma exacerbations, suggesting that environmental factors play a crucial role in asthma management.
Researchers create a porous microneedle to deliver CAR T cells into solid tumors, improving anti-tumor effects. The strategy showed enhanced tumor infiltration and amplification of CAR T cells in melanoma models.
Researchers found that macrophages play a central role in COVID-19-related respiratory failure, leading to fibroproliferative ARDS and prolonged ventilation. Extensive tissue damage and scar tissue formation are characteristic of severe lung failure.