Researchers developed a method to predict how different types of breast cancer will respond to treatment using lab-grown mini tumors. The organoids mimicked a tumor's response to treatment and identified candidate combination therapies for cancers that don't respond to standard treatment.
Researchers developed a new multiview DNN structure to capture complex 3D anatomy and physiology from multiple imaging views, improving diagnostic accuracy for cardiovascular conditions. The approach demonstrated better performance than single-view DNNs and provided a viable alternative for other medical imaging modalities.
Researchers from UC San Francisco successfully decoded brain activity patterns associated with walking, enabling the development of personalized neural biomarkers for movement state classification. This breakthrough could lead to more effective adaptive DBS systems that adjust stimulation in response to a patient's activity state.
Researchers at UCSF have discovered a novel combination of immunotherapies that can reprogram the immune environment of colon cancer tumors in the liver. This therapy often eliminated tumors entirely in preclinical models, showing promise for treating patients with advanced colorectal cancer.
UCSF researchers develop a new strategy to prime CAR T cell therapy by combining it with diabetes drugs, increasing the efficacy of NECTIN4-CAR T cells in treating urothelial carcinoma. The study shows that using thiazolidinediones enhances NECTIN4 expression, making tumor cells more susceptible to the treatment.
The global consensus conference aims to provide standardized, evidence-based recommendations for providers caring for women with IBD during pregnancy. The guidelines include continuing biologics throughout pregnancy and lactation, preconception counseling, and administering the rotavirus vaccine on schedule.
A new study reveals that Alzheimer's risk genes influence tau buildup and spread in distinct pathways, challenging traditional views of the disease. Four gene types were identified: Network-Aligned Vulnerability and Resilience, and Network-Independent Vulnerability and Resilience.
Researchers found that brain regions with higher cholesterol demands, like the Locus Coeruleus, are more vulnerable to Alzheimer's disease. The study suggests potential therapeutic targets for early treatment of the disease.
Researchers at UCSF are enrolling patients in a clinical trial to correct the genetic mutation causing sickle cell disease using non-viral CRISPR-Cas9 gene editing. The therapy aims to eliminate the need for a bone marrow transplant and create a new blood system free of the disease.
Researchers from UC San Francisco have found that Paxlovid treatment does not reduce the risk of developing long COVID. They also discovered a higher proportion of individuals with acute symptoms rebounding after treatment, and those who took Paxlovid were just as likely to develop severe Long COVID symptoms as those who did not.
A study published in JAMA Oncology found that regular screening is not enough to prevent advanced breast cancer diagnoses, particularly among women of color who are overweight or obese. The researchers recommend primary prevention strategies to reduce the number of advanced cancer diagnoses.
A new study by UCSF found that half of participants with extensive tobacco exposure had persistently high respiratory symptoms, yet performed well in COPD tests. The study highlights a gap in effective care for tobacco-exposed individuals and emphasizes the need for broader definition of smoking-related lung disease.
A large genome-wide association study identified novel PSA-associated variants and developed a polygenic score to correct for genetic variations in PSA levels. This approach improved biopsy referral decisions, reducing unnecessary procedures while detecting more aggressive tumors.
Research reveals that chronic heart rate failure during exercise is a common reason for long-term exercise intolerance in Long COVID patients. The study also found a correlation between early post-COVID inflammation biomarkers and reduced exercise capacity, suggesting potential therapeutic targets.
Researchers found that hydrocortisone was associated with a decrease in the need for vasopressor drugs and improvement in survival when used in combination with other corticosteroids. The study also suggests that combining fludrocortisone with hydrocortisone may provide a greater benefit in terms of survival.
Researchers developed an AI algorithm called CathEF to estimate left ventricular ejection fraction (LVEF) from standard angiogram videos, providing real-time information for clinical decision-making. The tool was trained on a large dataset and demonstrated strong correlations with echocardiographic LVEF measurements.
UCSF researchers identified glioma's cellular source of recurrent disease, finding cells shift to mesenchymal, radiation-resistant phenotype in response to standard therapy. Paracrine signals from tumor microenvironment drive this transition through AP1 pathway, leading to therapy resistance and tumor recurrence.
Researchers at UCSF have uncovered a cellular uptake pathway important for larger molecules, enabling the creation of new drugs for cancer and other diseases. The discovery of an endogenous pathway involving interferon-induced transmembrane proteins promotes the efficient entry of diverse linked chemotypes into target cells.
A UCSF-led team reveals that tumor immune microenvironments play a crucial role in the progression of pancreatic cysts to pancreatic cancer. The study suggests that therapies targeting regulatory T cells and myeloid-derived suppressor cells could inhibit malignant progression and treat high-risk disease.
Researchers analyzed 3D facial size and shape to quantify sex differences, providing data-driven anatomic guidance for gender-affirming facial surgery. The study shows significant differences in male and female craniofacial features, particularly in brow, jaw, nose, and cheek regions.
Scientists analyzed over 100,000 cells from 15 human brain metastases and identified two functional archetypes of metastatic cells, each containing both immune and non-immune cell types. These archetypes work together within single cells to shape inflammatory and proliferative processes co-existent in each metastatic tumor.
Researchers discovered that human lung stem cells can undergo abnormal differentiation in response to injury from diseases like COVID-19 and pulmonary fibrosis. This aberrant process prevents the restoration of normal lung function, but the study also identified a potential therapeutic target for reversing damage.
A new clinical syndrome of ICI-myocarditis has been identified, characterized by highly arrhythmogenic features. The study establishes specific electrocardiographic features to diagnose and prognosticate the syndrome, highlighting the need for further research on prediction and monitoring strategies.