A new study confirms the safety and success of transcatheter edge-to-edge procedures for repairing leaky mitral valves. The minimally invasive procedure was shown to be successful in nearly nine out of ten patients, with strong safety and efficacy outcomes despite advanced age and comorbidities.
Women who experience adverse pregnancy outcomes are at a higher risk of developing stroke, with those having recurrent issues facing a twofold increase. Lifestyle interventions and sharing pregnancy history with doctors may help reduce this risk, according to the study published in the journal Stroke.
Researchers found that fatty liver cells secrete proteins and genetic material that promote the spread of colorectal cancer to the liver. This condition is likely underdiagnosed, affecting over 40% of patients with colorectal cancer, according to a new study published in Cell Metabolism.
A new study by Cedars-Sinai Medical Center finds that people with long COVID-19 produce higher levels of antibodies against the virus than those without. The elevated antibody levels persist for months longer than expected after receiving a COVID-19 vaccine, sparking further research into the condition.
Researchers at Cedars-Sinai created computational models to bridge the gap between
A multicenter international study found that medical management is a viable alternative to surgery for patients with pituitary apoplexy. The study compared outcomes in 97 patients with the condition and found no significant difference between surgical and nonsurgical treatment options.
Cedars-Sinai investigators have discovered a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using human induced pluripotent stem cells. The new approach uses cells derived from iPSCs that are renewable, scalable, and can delay disease progression in rodents.
Researchers at Cedars-Sinai Medical Center identified a genetic variant associated with increased risk of developing perianal Crohn's disease, a debilitating manifestation of Crohn's disease. The study highlights the importance of targeting the alternative complement pathway and Complement Factor B (CFB) in treating this condition.
A study published in Cancer Research Communications found that vitamin D receptor genetic differences in African American men may make them more vulnerable to prostate cancer. The researchers suggest that revised nutritional guidelines for vitamin D intake may be necessary to address these disparities.
Cedars-Sinai Medical Center is launching a historic Ax-2 mission that aims to produce induced pluripotent stem cells in microgravity for the first time. The upcoming mission will utilize astronauts to generate these stem cells, paving the way for potential treatments and research opportunities.
A new study published in Nature finds that artificial intelligence (AI) surpasses human sonographers in accurately assessing cardiac function from echocardiogram studies. The research, conducted at the Smidt Heart Institute, demonstrates AI's potential to improve the quality and effectiveness of heart evaluations.
A study by Cedars-Sinai Medical Center found a 38% increase in sudden cardiac arrest among all Ventura County residents and a 77% increase among Hispanic residents during the first two years of the pandemic. Overall survival from sudden cardiac arrest declined from 15.3% to 10%.
A new study by Cedars-Sinai investigators found that ChatGPT can provide easy-to-understand information about basic knowledge, lifestyle, and treatments for cirrhosis and liver cancer. The AI system has the potential to play a role in clinical practice and empower patients with knowledge about their disease.
Researchers from the Smidt Heart Institute found that individuals with spherical hearts are 31% more likely to develop atrial fibrillation and 24% more likely to develop cardiomyopathy. The study identified four genes associated with cardiomyopathy and a greater risk of developing atrial fibrillation.
A new study by Cedars-Sinai investigators has determined that the pre-supplementary motor area (pre-SMA) plays a primary role in weighing value-based choices, such as choosing which book to read or which slot machine to play. The discovery could help understand neurological disorders like addiction and obsessive-compulsive disorder.
Researchers discovered that androgen therapy alters the organization of cells within breast tissue, reducing signs of estrogen influence and changing protein production. The findings could lead to new therapies for estrogen receptor-positive breast cancer.
Researchers have mapped changes to the retina that correspond to brain changes in Alzheimer's disease patients, opening a path to earlier diagnosis and more effective treatments. The study found accumulation of toxic proteins in retinas of patients with Alzheimer's disease and mild cognitive impairment, causing severe cell degeneration.
Researchers found altered proteins in women's blood during the third trimester, correlating with brain signaling activity and pro-inflammatory pathways. The study aims to develop early diagnosis and treatment protocols for perinatal mood disorders.
Researchers found a significant increase in new-onset diabetes after COVID-19 infection, with vaccination prior to infection showing protective effects. The study suggests that COVID-19 infection could be acting as a disease accelerator, amplifying risk for diabetes diagnosis.
Researchers studied brain activity in rats as they learned a fine motor task, discovering synchronous low-frequency oscillatory activity that coordinated neural spiking in the motor cortex and cerebellum. This activity may serve as a biomarker for skill learning and a target for electric stimulation to promote motor recovery after stroke.
A recent study confirms that pancreatic cancer rates are rising faster in women than men, particularly among younger women and Black women. The rate of pancreatic cancer among women under the age of 55 increased by 2.4% compared to men of the same age, highlighting a significant disparity in mortality rates between the sexes.
Researchers have generated large-scale muscle-controlling nerve cells from ALS patients, revealing striking differences in gene expression between males and females. The study, published in Neuron, used over 450 lines of stem cells to create motor neurons that can potentially lead to the development of new therapeutics.
Researchers at Cedars-Sinai Cancer have developed a non-invasive test that can detect and profile prostate cancers in microscopic amounts. The test, known as the EV Digital Scoring Assay, has the potential to spare patients from unnecessary treatment-related side effects and direct them to effective therapies.
The Geriatric Fracture Program at Cedars-Sinai Medical Center has been shown to reduce hospital stays by 2.12 days and lower hospital-related costs by $5,316 for patients aged 65 and older. The program's comprehensive care approach, including bone strength assessments and fall prevention strategies, is effective in improving outcomes.
A study of 4,078 cases found that sports-related cardiac arrests in people 65 and older are rare, occurring in only 1.9% of cases. Those who experienced exercise-related cardiac arrests tended to have fewer cardiovascular risk factors and better health outcomes.
Researchers identified a panel of novel blood biomarkers associated with sudden cardiac arrest, which have the potential to enhance clinical prediction. Additionally, an AI-powered ultrasound technology can accurately identify coronary artery calcium buildup, potentially replacing CT scans as a diagnostic tool.
Researchers found that patients diagnosed with behavioral-variant frontotemporal dementia may have a cerebrospinal fluid leak, which can be treated. The study discovered CSF-venous fistulas in nine patients, who had their symptoms reversed after surgical closure.
Researchers found that patients with low comorbidity groups who received more frequent phone calls had improved outcomes, including reduced mortality and longer hospital stays. The intervention involved regular calls from nurses to monitor patient response and address any unusual symptoms.
Researchers have discovered a biological pathway that governs the life and death of stem cells, which may lead to new treatments for cancer and regenerative therapies. By manipulating cell signaling, scientists can normalize the creation of new cells, preventing excessive growth and ensuring proper tissue regeneration.
A new analysis by Cedars-Sinai investigators shows that similar levels of COVID-19 antibodies are reached over an extended period of time in different population groups. Individuals with autoimmune diseases and solid organ transplant patients experience lower long-term antibody levels.
Researchers at Cedars-Sinai have created a detailed molecular profile of endometriosis, identifying key differences between major subtypes and potential therapeutic targets. The new database will lead to improved care for millions of women suffering from the disease.
Researchers found that people with higher levels of Coprococcus tended to have higher insulin sensitivity, while those with Flavonifractor had lower insulin sensitivity. The study aimed to understand the relationship between microbiome composition and diabetes development.
A recent study published in JAMA Network Open found that women who followed a Mediterranean diet before conception had a significantly lower risk of developing preeclampsia during pregnancy. The study also showed that a higher intake of vegetables, legumes, and fish was associated with a lower risk of adverse pregnancy outcomes.
Smidt Heart Institute researchers have identified a way to control the natural 'fight back' response of heart cells against RNA therapies, leading to increased effectiveness. By targeting specific microRNAs, they were able to stabilize the heartbeat and boost gene expression.
A recent study published in Nature Cardiovascular Research found a link between COVID-19 and postural orthostatic tachycardia syndrome (POTS), with patients infected five times more likely to develop the condition. Vaccination was also linked, but at a lower risk, emphasizing the importance of vaccination in reducing POTS.
Researchers at Cedars-Sinai found that estrogen can prevent symptoms of delirium in mice with urinary tract infections, reducing IL-6 levels in the blood and protecting neurons. The study suggests estrogen may be a tool to mitigate delirium, particularly in older women with UTIs.
A Cedars-Sinai study found that even subtle forms of liver disease directly impact heart health, with elevated FIB-4 scores associated with abnormalities in heart function and vascular dimension. Cardiac MRI scans revealed that nearly 86% of patients had at least one heart abnormality.
Researchers found that women experiencing prolonged mental health issues after childbirth had genetic evidence of higher immune system defense mechanism activation. The study also identified reduced antiviral immune response genes, which may offer protection from pathogens.
A new theory proposes that irritable bowel syndrome (IBS) may be caused by the body's inability to manage gravity. The hypothesis suggests that gravity can compress the spine, decrease flexibility, and cause organs to shift downward, leading to IBS symptoms.
A new protocol at Cedars-Sinai improves the timeliness of treatment for women with severe pregnancy-related hypertension, reducing maternal stroke risk. Despite racial disparities in hypertension rates, the initiative found no significant delays in treatment based on race or ethnicity.
A new study published in Clinical Gastroenterology and Hepatology found that nearly 1 in 7 Americans experience bloating on a weekly basis. Women were more than twice as likely as men to report feeling bloated, and lifestyle changes, such as exercise and dietary modifications, can help manage symptoms.
A study found that seven major cardiovascular societies favor men and white individuals when awarding recognition, with women receiving significantly fewer awards than men across all categories. Researchers attribute this disparity to implicit bias, which may prevent underrepresented groups from advancing in their careers.
A new study by Cedars-Sinai investigators has identified risk factors for developing diabetes in people with chronic pancreatitis, including smoking and being overweight. The findings suggest that models can be built to predict diabetes risk, allowing clinicians to connect patients with weight loss or smoking cessation programs.
Researchers developed an AI tool that analyzes plaque features on coronary CT scans to predict reduced blood flow, potentially reducing invasive tests. The tool could help doctors determine the next step in treatment plans and risk-stratify patients correctly.
A Cedars-Sinai study found that a specific protein imbalance can predict the risk of developing severe preeclampsia. The blood test measures the ratio between two proteins involved in blood vessel development, which accurately predicted preterm preeclampsia with severe features over 90% of the time.
A small clinical trial showed 40% of patients experienced progression-free survival when treated with a CD105 inhibitor, which prevented cancer cells from making splice variant proteins. This approach may resensitize select patients to androgen suppression therapy.
At AHA22, Smidt Heart Institute experts will cover various cardiology topics, including atrial fibrillation treatment and high-impact trials in intervention and surgery. Experts like Christine Albert, Joanna Chikwe, and Jon Kobashigawa will present their research on the effects of Omega-3 fatty acids and stroke management.
Two new discoveries led by Cedars-Sinai Cancer investigators improve understanding of ovarian cancer's development and suggest personalized therapeutic approaches. They identified four new genetic regions linked to increased ovarian cancer risk and found that some tumors may develop resistance to chemotherapy from an early stage.
The Alpha Stem Cell Clinic will develop preclinical studies into early and later phase clinical trials with the goal of establishing advanced regenerative medicine treatments. The clinic will also foster greater collaboration with eight similar clinics across the state and educate the public about stem cell and related therapies.
During the early months of the COVID-19 pandemic, patients with hypertension took less frequent blood pressure measurements and reported higher readings. Blood pressure control worsened due to disruptions in healthcare access, including telemedicine and home monitoring.