A new study has identified interleukin 11 as a key player in the development of colorectal cancer. IL-11-producing cells, known as cancer-associated fibroblasts, were found to promote tumor growth and support the disease microenvironment.
A new global study replicates earlier research in the US, finding that people's perceptions of their opponents are often exaggerated and misinformed. The study suggests that informing individuals about the true feelings of those on the opposite side can mitigate polarization.
A phase 1 clinical trial found that stereotactic body radiation therapy (SBRT) is safe for treating patients with multiple metastases. The treatment used precisely targeted beams of high doses of radiation to destroy tumors, reducing damage to noncancerous tissue.
Researchers found that juvenile tyrannosaurs were slimmer and relatively faster for their body size compared to their massive parents. The study suggests that as these animals grew older, their feet became more bulky, aligning with previous findings on growth patterns.
WeHI researchers used monobodies to 'freeze' MLKL at different stages of its activation, mapping how its three-dimensional structure changed. This revealed potential target sites for drugs that could block necroptosis, a key contributor to inflammatory diseases.
The Atlas of Living Australia (ALA) is a national biodiversity database that provides reliable data for scientists, policy-makers, and environmental planners. It contains nearly 95 million occurrence records of over 111,000 species, showcasing its potential to support the development of science and decision-making.
Researchers have identified a hidden region on the SARS-CoV-2 Spike protein that is masked by metabolites, making it inaccessible to antibodies. This finding highlights the importance of targeting this region in developing new vaccines.
A new study published in PLOS Genetics found that lithium can improve fear memory and hippocampal neurogenesis in mice with symptoms similar to Bardet-Biedl Syndrome. The researchers suggest that this may be an effective treatment for intellectual disability caused by the disorder.
A new research chair led by INRS Professor Monique Lacroix aims to develop standardized natural antimicrobial solutions for ensuring food safety and quality. The project will investigate the stability, interactions, and applications of various natural extracts and bio-based technologies.
Researchers develop nanoparticles that penetrate human cells and destroy bacteria, offering new hope against antibiotic resistance. The particles use cerium oxide to create reactive oxygen species that kill germs, reducing the likelihood of resistance development.
According to a new study, nearly 20% of groundwater wells globally are at risk of drying up if groundwater levels decline. This is largely due to increasing demand and inadequate governance or management, putting critical vulnerabilities to even modest reductions in groundwater levels.
Researchers at Tokyo Institute of Technology discover that hydrostatic pressure can dynamically control the conformations of artificial molecules called foldamers, which mimic proteins. This finding opens doors to future development of pressure-sensitive materials and has implications for understanding biological processes.
Researchers have discovered significant subconcussive changes in cognitive brain function in male youth ice-hockey players following repetitive head impacts. The study, which monitored brain vital signs during pre- and post-season play, found more pronounced changes in Junior A players compared to Bantam age group members.
Researchers have made a significant step in understanding dark energy using the eBOSS survey, detecting its existence at a 11-sigma significance. The study employed multi-tracer analysis to mitigate systematics and achieve robust cosmological results.
Researchers at Brigham and Women's Hospital have developed personalized, 3D-printed shields to shield patients undergoing radiation therapy. The device can reduce tissue injury by up to 15% in the gastrointestinal tract for prostate cancer patients, and by up to 30% in the mouth for head and neck cancer patients.
A Phase 3 trial to test the safety and efficacy of Zyesami and remdesivir for life-threatening cases of COVID-19 has begun enrolling patients. The trial aims to provide additional protection for lung cells and increase treatment options for critically ill patients.
The EU is funding a research project led by Saarland University's Jan Reineke to develop safer and more secure computer systems. The goal is to redefine the interface between software and hardware, making it both efficient and secure for critical areas like airbag controls and energy supply.
Scientists developed zinc-modified aluminum oxide membranes for heavy metal removal, achieving high efficiency rates. The membranes showed antifouling properties and were reusable up to three cycles.
The study found that the vaccine is highly effective across all age ranges, with 92% effectiveness in preventing symptomatic disease in individuals 70 years and older. Vaccine effectiveness varied among subpopulations, with slightly lower rates in multi-morbid populations and immunosuppressed individuals.
The audiobook memoir tells the remarkable story of Dr. Jan Vilcek's life, from hiding from Nazis to researching cytokines and interferon that led to infliximab's development. The Vilcek Foundation partnered with actor Daniel K. Isaac to narrate the audiobook, available on Audible, iTunes, and Amazon.
The University of Queensland's technology uses lasers to track microscale particles with world-record precision, measuring viscosity a thousand times faster than ever before. This breakthrough may lead to a fundamental revision of scientists' understanding of cells, enabling faster and more accurate pharmaceutical testing.
Researchers at the University of Münster studied the impact of plant seed provenance on pollinator diversity and frequency. They found that plants from different regions influenced pollinators' visits to flowers, with some regions offering more frequent interactions.
Researchers created mini-chambers on a microfluidic device where human motor neurons and skeletal muscle cells grew, forming neuromuscular junctions. The study found that ALS motor neurons formed fewer connections and regenerated axons less efficiently than healthy ones.
A pilot program in five Australian nursing homes shows personalized music selections reduce resident agitation and staff stress levels, leading to improved wellbeing and reduced medication use.
Grasses can incorporate DNA from other species into their genomes through lateral gene transfer, giving them an evolutionary advantage. This process may allow crops to adapt to new environments quicker and be more resistant to climate change.
A worldwide study of 2,100 pregnant women found that those who contracted COVID-19 during pregnancy were 20 times more likely to die than those who did not contract the virus. The study also showed that infected mothers and their newborns experienced preterm birth, preeclampsia, and ICU admissions.
Researchers at Harvard Medical School identified a signaling molecule called neuropeptide-Y (NPY) as the key driver of hunger-dependent odor attraction. Mice with NPY deficiency showed reduced preference for food odors, highlighting the crucial role of NPY in enhancing food attraction when hungry.
A new study published in Frontiers in Sports and Active Living found that advanced shoe technology from Nike reduced running times for both elite male and female competitors. Female elite athletes experienced the largest improvements, with seasonal best times decreasing by 1.7 to 2.3 percent between 2016 and 2019.
Researchers found people with higher omega-3 EPA and DHA blood levels lived longer than those with lower levels. A high Omega-3 Index, around 8% or higher, was associated with a 13% lower risk of death from all causes.
A $17 billion investment in NIH-funded research on vaccine technologies provided a foundation for the rapid development of COVID-19 vaccines. The study highlights the critical role of government-funded research in ensuring vaccine readiness.
Researchers have discovered a new way to control light emission from materials by stacking films at a twist angle, enabling efficient and systematic control of optical properties. The discovery has significant implications for applications in medicine, environmental technologies, and information systems.
Scientists discover a way to repurpose fibroblasts to regenerate wounded skin without scarring. By blocking the YAP pathway, researchers encourage cells to retain their identity as ENFs, enabling regeneration of structures like sweat glands and hair follicles.
Research led by University of Bristol scientists reveals that male dolphins categorize allies according to a shared cooperative history. Dolphins respond strongly to friends who have consistently helped them in the past, while ignoring those who haven't, indicating a social concept of 'team membership'.
For the first time, scientists have successfully used transient grating spectroscopy with ultrafast X-rays to explore material properties at the atomic level. This method allows for the observation of individual atoms and selective measurement of specific chemical elements in a mixture of substances.
Astronomers used ALMA to discover a rotating baby galaxy, providing insights into the early Universe. The galaxy, RXCJ0600-z6, is about 1/100th the size of the Milky Way and has a mass of 2-3 billion times that of our Sun.
A new method called XYZeq allows researchers to map variation across cells in a tissue or tumor, gaining insight into their spatial location and function. The technique enables the analysis of cellular patterns in complex environments like cancerous tumors and other organs.
Increased tourniquet use in Los Angeles County has improved patient survival and reduced the need for blood transfusions. The study found that patients with prehospital tourniquets had lower mortality rates, fewer delayed amputations, and lessened blood transfusion requirements.
Researchers propose a transdisciplinary approach to education, combining arts and sciences to teach connected themes like climate change. This approach aims to better prepare children for future crises and encourages them to think creatively about problems.
Researchers aim to develop a human-centered platform that motivates patients with mild cognitive impairment to stick to a therapeutic regimen of mobile game-playing. Neuro-World games have shown promise in improving cognitive function and predicting expected improvement in patients with MCI.
A study by Virginia Commonwealth University researchers found that romantic relationships can help alleviate the negative impact of trauma on drinking behavior among college students. The study, which involved nearly 9,000 participants, discovered that students who experienced interpersonal trauma during college consumed more alcohol t...
Researchers developed a novel drug that increases LAMP2A receptors, revitalizing chaperone-mediated autophagy and removing toxic protein aggregates. In mouse models of Alzheimer's, the drug reversed key symptoms, suggesting potential for human treatment.
Researchers from Ruhr-University Bochum and collaborators isolated a PS II transition complex with three helper proteins using cryo-electron microscopy. The study reveals a novel protective mechanism that prevents the formation of aggressive oxygen species during assembly, allowing for a more efficient and stable machine.
The Protein Data Bank (PDB) is celebrating 50 years of sharing scientific knowledge, with millions of users accessing its data for fundamental biology, energy, and biomedicine. The event highlights the PDB's role in understanding protein folding, including SARS-CoV-2, and structural biology's impact on medicine and drug discovery.
A new study by Simon Fraser University finds that ancient Indigenous-managed forests, or
A new species of deep-sea dumbo octopus has been identified using a combination of non-invasive and minimally invasive techniques. The study utilized MRI, micro-CT, and gene analysis to gather morphological and molecular information on the specimen without causing harm.
The NRG-BR001 trial found SBRT to be safe for patients with multiple metastases, with no dose-limiting toxicities and over 50% of participants alive at 2 years. The study used extensive radiation QA processes and was the first to require 3D image guidance during treatment.
A new study published in Astrobiology finds that Martian meteorites contain the necessary ingredients to support microbial life, including water and radioactive elements. The researchers believe that wherever there's groundwater on Mars, there's a good chance of finding habitable environments for subsurface microbial life.
Researchers at Northwestern University have discovered a new biomanufacturing platform that can increase protein-based vaccine yields by five-fold and reduce production costs to $1 per dose. The technology utilizes enriched cell-free extracts with cellular membranes, significantly broadening access to potentially lifesaving medicines.
Researchers at University of Helsinki and Aalto University created an AI model that can predict T cell targets for previously unmapped viruses, including COVID-19. The model helps understand how T cells identify their targets using a key-lock principle.
A case series reports acute ischemic stroke incidence in male patients aged 50 years or younger during the convalescent phase of COVID-19. Risk factors and features of the stroke are also discussed in detail.
Researchers are using 3D printed models to study ground motion after earthquakes, providing a novel platform for seismic experiments. The models replicate complex topographical features and allow scientists to simulate how seismic waves interact with the Earth's surface.
Salk researchers have traced the development of spinal cord neurons using genetic signatures, revealing new ways of classifying and tagging subsets of cells. The findings offer a precise way to study the function of spinal cord neurons and their role in regulating body movements.
A major study reveals COVID-19 survivors have an almost 60% increased risk of death over six months compared to the general population. The research catalogued numerous diseases associated with long-term complications of COVID-19, pointing to a massive health burden.
Researchers successfully generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos. The study provides strong evidence that the system is a good model for studying early embryo development, shedding light on the mechanisms of totipotency and the causes of early pregnancy loss.
A synthetic DNA vaccine for MERS-CoV induced robust antibody neutralizing antibodies and cellular immune responses, protecting against MERS-CoV in NHP models. The low-dose regimen with intradermal delivery was more impactful in controlling disease than the higher dose delivered intramuscularly.
Researchers used engineering tools to investigate the pelvic floor hypothesis, which states that trade-offs exist between supporting childbirth and protecting organs. A larger pelvic floor would facilitate easier childbirth but risk deforming under weight, causing organs to fall downward.
Nagoya University researchers discovered a molecular pathway that enhances chemotherapy resistance in some pancreatic cancer patients. Targeting the taurine upregulating gene 1 (TUG1) RNA could improve patient response to therapy and increase overall survival.
Researchers used asteroseismology to measure the spin of older stars, finding they rotate faster than predicted by magnetic braking theories. The study provides new insights into the weakening effects of magnetic braking on older stars.
A UT Southwestern Medical Center review of Texas Cancer Registry data found that Black and Hispanic patients under 40 with cancer have lower survival rates compared to their white counterparts. The study also showed that poverty and lack of insurance coverage exacerbate these disparities.
Researchers from Sandia National Laboratories used 22-foot-wide tethered balloons to collect dust samples, confirming the new solar-power technology's safety. The technology stores heat in heated particles, which can store energy for days or weeks, stabilizing power output.