Scientists have developed network-based models to prioritize novel viruses for their zoonotic transmission risk, with coronaviruses found to be the riskiest. The models also ranked paramyxoviruses, such as those causing measles and respiratory tract infections, as high priorities.
Mandated PDMP use in US states reduced opioid prescriptions by 6.1% but led to a 50.1% increase in heroin-related deaths, according to researchers from the University of Texas at Dallas.
Researchers found that lifespan estimates could inform veterinarians whether to screen for CCD in older dogs. Dogs' cognitive function declines as they age, and signs of CCD include memory deficits, loss of spatial awareness, and sleep disruption.
Magnetic antiskyrmions are stabilized in magnetic crystals and exhibit unique properties. The Forschungszentrum Juelich team successfully demonstrated the existence of these objects through high-resolution electron microscopy and advanced simulations.
Researchers at Georgia State University have developed a single, universal flu vaccine candidate that induces immunity to conserved M2 ectodomain and multi-subtype neuraminidase proteins, providing broad cross-protection against antigenically diverse influenza A and B viruses in mice. The study shows promising results in young and aged...
Researchers at Cornell University have discovered a new CRISPR system called Craspase, which has the potential to develop promising antiviral and tissue engineering tools in animals and plants. The study uses cryo-electron microscopy snapshots to explain how Craspase identifies RNA targets and activates proteases.
Researchers at MIT developed an AI model that can detect Parkinson's disease from breathing patterns, using a neural network to assess the presence and severity of the condition. The device is non-invasive and can be used in patients' homes without any bodily contact.
Researchers discovered the Griffin Warrior likely grew up near the seaside city he would rule and was from wealthier social status. Ancient DNA analysis showed that around 5,000 years ago, people with ancestry from Eastern Europe spread across the European continent and into Western Asia.
A new study reveals that the protein CHIP can regulate insulin receptor signals more efficiently alone than in a paired state. This finding suggests that maintaining a balance between monomeric and dimeric states of CHIP is crucial for proper cellular function.
A study by University of Kansas faculty member Daniel Thomas III founds Black male teacher-coaches in predominantly white private schools employ unique civic-oriented practices to counter historical anti-Blackness. They engage students and athletes in social activism, community service, and critical civic engagement.
Researchers developed an AI algorithm that can learn independently from multiple medical institutions without compromising data privacy. The algorithm outperformed traditional methods and has the potential to revolutionize digital medicine by reducing radiologists' workloads and making AI-based solutions more affordable.
Researchers at KIST have developed a hybrid membrane distillation module that combines solar energy with hydrothermal heat pumps to reduce thermal energy consumption during the desalination process. The technology has shown improved production rates and reduced energy usage compared to traditional methods, making it a potential solutio...
The James Webb Space Telescope has captured clear evidence of carbon dioxide in the atmosphere of a gas giant planet outside the solar system. The detection, made using the telescope's Near-Infrared Spectrograph, provides insights into planetary composition and formation.
New research from Washington University in St. Louis shows significant pH differences within nanopores, impacting engineering processes like clean-water generation and decarbonization technologies. Understanding these findings can improve predictions and system performance.
Researchers successfully produced mice with novel and sustainable karyotypes, mimicking evolutionary changes on a million-year scale. Chromosome-level engineering enables insight into how rearrangements influence evolution and potentially correct misaligned chromosomes.
A new study by University of Pennsylvania researchers found that people share information that is meaningful to themselves or their friends and family. The study analyzed the behavior of over 3,000 individuals and discovered that sharing activates reward centers in the brain and is driven by social relevance.
A new study published in the journal Addiction found that recreational cannabis legalization in US states led to a 20% increase in cannabis use frequency, particularly among identical twin pairs. The study analyzed data from over 1,400 individuals and suggested that recreational legalization caused an increase in cannabis use.
A Kaiser Permanente study found that patients in home-based cardiac rehabilitation had fewer hospitalizations than those in center-based rehab, with benefits seen across diverse patient populations. The home-based program improved accessibility and outcomes for high-risk patients.
Researchers identified five new hepatoblastoma tumor signatures that could help predict responses to chemotherapy treatments. The study used single-cell transcriptomic techniques to analyze tumors from infants and children, providing a window into normal development and cancer.
A new class of light-activated hemithioindigo molecules developed by Rice University scientists kill specific Gram-positive bacteria and their biofilms. The molecules induce reactive oxygen species that chemically attack and destroy drug-resistant cells, offering a safer alternative to conventional antibiotics.
Researchers developed an algorithm to identify different regions within tumors using nearly 6,500 digital slide images. The algorithm can predict recurrence-free survival and help guide therapy for patients with colon cancer.
The primer highlights how citizens can contribute meaningfully to scientific research, enabling inclusive decision-making and closing data gaps. Citizen science promotes open data practices, advancing collaborations between various actors and making science more participatory and inclusive.
Researchers uncover crucial role of enzyme NAGK in converting bacterial cell wall component MDP into its phosphorylated form, activating immune receptor NOD2. This process prevents bacteria from entering the intestinal wall and triggering inflammatory responses.
Astronomers using JWST have detected unambiguous evidence of carbon dioxide in the atmosphere of WASP-39b, a Saturn-mass exoplanet. The discovery provides valuable insights into giant planet composition and heavy element abundance, with implications for understanding how planets form.
The study examines the complex factors contributing to vaccine hesitancy, including mixed media messages and concerns about effectiveness and safety. The researchers found that highly educated individuals were among those hesitant to receive the vaccine, highlighting the need for targeted education approaches.
Scientists have elucidated the regulatory functions of Pan1p, a key player in late-stage clathrin-mediated endocytosis. The protein drives actin assembly and disassembly, facilitating vesicle internalization.
Researchers at RIKEN have achieved error correction in a three-qubit silicon-based system, a major step toward large-scale quantum computing. This accomplishment demonstrates control of one of the largest qubit systems in silicon, providing a prototype for quantum error correction.
Researchers have successfully created a 'meat-like' seasoning by cooking mealworms with sugar, producing a sustainable alternative to traditional meat protein sources. The team identified 98 volatile compounds and optimized 10 reaction flavors that were deemed favorable by consumer panels.
Researchers have designed a new online/offline tag generation algorithm to improve preprocessing efficiency and protect medical data privacy. The proposed scheme achieves better auditing performance than previous schemes, addressing the contradiction between high real-time requirements and limited computing power in HealthIIoT devices.
A new study by Marshall University researchers found that inhibiting Na+/K+ ATPase alpha 1 subunit proteins dramatically inhibited in vivo thrombosis in male mice. The study suggests that targeting this protein could lead to a novel anti-thrombotic therapy with fewer side effects.
Research reveals that smaller artificial cells lead to greater separation of molecules, allowing for a new approach to manipulate material properties. This discovery has potential applications in pharmaceuticals and cosmetics industries.
Scientists at UC San Francisco and Gladstone Institutes use CRISPR-based edit to render therapeutic T cells more resilient, overcoming a major factor limiting cancer immunotherapies' success. The discovery may help improve treatment of both solid and liquid tumors.
Older adults who engage in weekly leisure time activities such as walking, jogging, or playing tennis may have a lower risk of death from any cause, cardiovascular disease, and cancer. Achieving recommended physical activity levels through various activities can lead to significant reductions in mortality risk.
Researchers found that Māui dolphins' diets became less diverse between 2008 and 2020, mainly due to the establishment of a marine sanctuary that restricted fishing in their habitat, leading to an increase in preferred prey.
Researchers developed a new Integrated Ozone Depletion metric to measure ozone-destroying substance impacts on the ozone layer. The IOD considers emission strength, atmospheric duration, and ozone destruction, providing a straightforward tool for evaluating ozone layer protection measures.
A University of Houston engineer has developed technology to determine which patients are likely to respond to CAR T-cell therapy for lymphoma, saving time and increasing success rates. The TIMING method analyzes interactions between T cells and tumor cells, identifying a key ligand molecule that predicts patient response.
Researchers propose various immune therapy designs to treat Chronic Hepatitis B, with a focus on improving treatment outcomes and reducing adverse effects. Immune therapies offer an alternate approach to antiviral drugs, which have limitations such as cost and low efficacy.
Australian researchers have discovered a new mechanism by which T cells can react to lower doses of antigens, leading to a 50-fold increase in T cell activation sensitivity. This finding opens up new possibilities for developing more effective immunotherapies.
A new Australian study reveals that despite growing interest in nature-based learning, teachers need professional development to effectively integrate it into their teaching practices. The research found that seven out of ten teachers felt limited by their knowledge and confidence in using nature play areas to support curriculum goals.
A study by DTU and SSI found that COVID-19 caused a significant loss of healthy life in Denmark, with an estimated 30,000 years lost. The majority of deaths occurred among elderly men, while younger populations were largely unaffected.
A new study suggests that the solar system's transit through the four primary spiral arms of the Milky Way galaxy may have seeded enhanced production of continental crust on early Earth. The researchers found a correlation between periods of increased crust generation and the solar system's movement into spiral arms, possibly due to co...
Researchers discover 20 compounds behind vanilla's flavor complexity, including previously unknown ones, and find that certain compounds impact consumer acceptability. The new profile could help producers identify high-quality extracts and improve curing methods.
A recent study by Medical University of Vienna researchers has identified a crucial dual function of neutrophils in liver regeneration after partial hepatectomy. The findings suggest that these immune cells produce factors necessary for liver growth, enabling the organ to recover quickly from tissue damage.
A substance produced by gut microorganisms, TMAO, can lead to scarring and vascular damage in scleroderma. The Western diet rich in meat contributes to TMAO formation, which reprograms cells to become scar-forming myofibroblasts.
Scientists at Baylor College of Medicine and the Broad Institute have identified biological markers associated with chemotherapy resistance in triple negative breast cancer. The study found that deletion on chromosome 19, specifically the LIG1 gene, is linked to resistance to treatment and poor clinical outcomes.
A study of 3,192 participants found that both psychedelic drugs and near-death experiences can decrease fear of death and increase feelings of spirituality. However, those with non-drug near-death experiences reported a more meaningful experience overall.
New research from Curtin University reveals that comets may have formed Earth's early continents when the Solar System passed through densely populated areas of the Milky Way Galaxy. The study found a rhythm of crust production every 200 million years matching the system's transit through galaxy arms.
A new polymeric coating can detect damage and heal itself like human skin, reducing waste generation in various industries. The coating changes color when damaged, enabling immediate detection, and can self-heal multiple times using a thermoset polymer.
A study of 137 children with early-onset psychosis found that over 70% had copy number variants, a common cause of neurodevelopmental disorders. The research suggests that chromosomal microarray testing can bring closure to families and improve treatment outcomes.
Researchers at WVU are using robots to analyze potential hazards and provide walkability maps in retail environments, aiming to reduce occupational injuries. The team plans to test the robots after hours in an actual retail space, combining camera data with wheel speed measurements to estimate slip risks.
A recent study found associations between socioeconomic stressors and specific N-glycosylation patterns in Black and White women, suggesting that molecular markers may be linked to socioeconomic status. The research also identified differences in glycosylation patterns in normal breast tissue based on body mass index (BMI) and ancestry.
Researchers at The University of Texas at Austin are developing controllable synthetic cells with the goal of improving cancer treatment and regenerative medicine. By controlling these cells, they aim to eliminate exhaustion and targeting errors, making them more effective.
Researchers found that appetite changes in depression are linked to specific changes in the brain's reward system, including a weaker connection between the reward system and areas processing taste stimuli. The study suggests precision medicine approaches could lead to more targeted therapies for individual symptoms of depression.
Researchers at Washington University School of Medicine have discovered a new pathway that could help prevent Alzheimer's dementia. Increasing the clearance of waste products in the brain by ramping up a genetic quirk known as readthrough may be effective for other neurodegenerative diseases, such as Parkinson's disease.
Research finds that feelings of guilt from keeping everyday consumer behaviors a secret can lead to greater relationship investment. Participants reported engaging in mundane secrets like sneaking pizza or watching ahead on a TV show, which drove them to invest more in their relationships.
A USC study of eligible voters in the 2020 election highlights how many Americans overlook external factors like child care constraints and transportation difficulties that affect voter turnout. In contrast, participants cited beliefs as a major driver of turnout, with only 12% mentioning friction.
African American adults with higher levels of religiosity and spirituality may be more likely to meet key cardiovascular health metrics. The study found associations between religious behavior, spirituality, and improved health outcomes in terms of diet, physical activity, and smoking.
Researchers at MIT have developed a new kind of battery using abundant and inexpensive materials, offering a potential solution for large-scale backup power systems. The battery's molten salt electrolyte has been shown to prevent dendrite shorting, a common reliability issue in lithium-ion batteries.
Kelp forests, which sequester large amounts of atmospheric carbon, may struggle to trap it due to accelerating decomposition rates in warmer waters. A study found that sea temperature has a strong influence on decomposition rates, with kelp fragments degrading more slowly in cooler waters.
The University of Guam is conducting a four-person research team's study on the genetics of corals from the Northern Mariana Islands to understand coral population connections, diversity, and adaptations. The study aims to identify potential reserves for declining reefs and assess the impact of warming waters.